Heparin-binding protein (HBP) improves prediction of sepsis-related acute kidney injury

Annals of Intensive Care

Table 2 Risk model comparison with and without plasma HBP (n = 489)

	Value	95% CI
ROC area: risk model only	0.784*	0.734–0.835
ROC area: risk model + plasma HBP	0.819*	0.770–0.868
cfNRI event	37.4%	18.6–55.1
cfNRI non-event	24.6%	15.2–34.0
cfNRI total	62.0%	40.5–82.4
IDI event	0.042	0.02–0.63
IDI non-event	0.011	0.003–0.019
IDI total	0.053	0.029–0.075

Events refer to the development of the primary endpoint. Categorised plasma HBP based on quartiles was used in the analysis
cfNRI category-free net reclassification index, IDI integrated discrimination improvement
* The difference in ROC area between the risk model with and without plasma HBP was statistically significant (p = 0.03)