Clutter WE, Bier DM, Shah SD, Cryer PE. Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. J Clin Investig. 1980;66:94–101.
Article
CAS
PubMed
PubMed Central
Google Scholar
McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin. 2001;17:107–24.
Article
CAS
PubMed
Google Scholar
Shamoon H, Hendler R, Sherwin RS. Synergistic interactions among antiinsulin hormones in the pathogenesis of stress hyperglycemia in humans. J Clin Endocrinol Metab. 1981;52:1235–41.
Article
CAS
PubMed
Google Scholar
Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;355:773–8.
Article
CAS
PubMed
Google Scholar
Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc. 2003;78:1471–8.
Article
PubMed
Google Scholar
Mizock BA. Alterations in fuel metabolism in critical illness: hyperglycaemia. Best Pract Res Clin Endocrinol Metab. 2001;15:533–51.
Article
CAS
PubMed
Google Scholar
Uyttendaele V, Dickson JL, Shaw GM, Desaive T, Chase JG. Untangling glycaemia and mortality in critical care. Crit Care. 2017;21:152.
Article
PubMed
PubMed Central
Google Scholar
Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology. 2006;105:244–52.
Article
CAS
PubMed
Google Scholar
Krinsley JS. Glycemic variability: a strong independent predictor of mortality in critically ill patients. Crit Care Med. 2008;36:3008–13.
Article
CAS
PubMed
Google Scholar
Lanspa MJ, Dickerson J, Morris AH, Orme JF, Holmen J, Hirshberg EL. Coefficient of glucose variation is independently associated with mortality in critically ill patients receiving intravenous insulin. Crit Care. 2014;18:R86.
Article
PubMed
PubMed Central
Google Scholar
Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. JAMA. 2003;290:2041–7.
Article
CAS
PubMed
Google Scholar
Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359–67.
Article
PubMed
Google Scholar
Krinsley JS. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc. 2004;79:992–1000.
Article
PubMed
Google Scholar
Chase JG, Shaw G, Le Compte A, Lonergan T, Willacy M, Wong XW, et al. Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change. Crit Care. 2008;12:R49.
Article
PubMed
PubMed Central
Google Scholar
Chase JG, Pretty CG, Pfeifer L, Shaw GM, Preiser JC, Le Compte AJ, et al. Organ failure and tight glycemic control in the SPRINT study. Crit Care. 2010;14:R154.
Article
PubMed
PubMed Central
Google Scholar
Krinsley JS, Jones RL. Cost analysis of intensive glycemic control in critically ill adult patients. Chest. 2006;129:644–50.
Article
PubMed
Google Scholar
Van den Berghe G, Wouters PJ, Kesteloot K, Hilleman DE. Analysis of healthcare resource utilization with intensive insulin therapy in critically ill patients. Crit Care Med. 2006;34:612–6.
Article
PubMed
Google Scholar
Dickson JL, Gunn CA, Chase JG. Humans are horribly variable. Int J Clin Med Imaging. 2014; 1.
Chase JG, Le Compte AJ, Suhaimi F, Shaw GM, Lynn A, Lin J, et al. Tight glycemic control in critical care—the leading role of insulin sensitivity and patient variability: a review and model-based analysis. Comput Methods Programs Biomed. Elsevier Ireland Ltd; 2011;102:156–71.
Suhaimi F, Le Compte A, Preiser JC, Shaw GM, Massion P, Radermecker R, et al. What makes tight glycemic control (TGC) Tight? The impact of variability and nutrition in 2 clinical studies. J Diabetes Sci Technol. 2010;4:284–98.
Article
PubMed
PubMed Central
Google Scholar
Pretty CG, Le Compte AJ, Chase JG, Shaw GM, Preiser JC, Penning S, et al. Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control. Ann Intensive Care. 2012;2:17.
Article
PubMed
PubMed Central
Google Scholar
Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Taori G, et al. Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc. 2010;85:217–24.
Article
PubMed
PubMed Central
Google Scholar
Bagshaw SM, Bellomo R, Jacka MJ, Egi M, Hart GK, George C. The impact of early hypoglycemia and blood glucose variability on outcome in critical illness. Crit Care. 2009;13:R91.
Article
PubMed
PubMed Central
Google Scholar
Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, McArthur C, et al. Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012;367:1108–18.
Article
PubMed
Google Scholar
Griesdale DEG, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, et al. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. Can Med Assoc J. 2009;180:821–7.
Article
Google Scholar
Finfer S, Delaney A. Tight glycemic control in critically ill adults. JAMA. 2008;300:963–5.
Article
CAS
PubMed
Google Scholar
Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358:125–39.
Article
CAS
PubMed
Google Scholar
Treggiari MM, Karir V, Yanez ND, Weiss NS, Daniel S, Deem SA. Intensive insulin therapy and mortality in critically ill patients. Crit Care. 2008;12:R29.
Article
PubMed
PubMed Central
Google Scholar
Kalfon P, Giraudeau B, Ichai C, Guerrini A, Brechot N, Cinotti R, et al. Tight computerized versus conventional glucose control in the ICU: a randomized controlled trial. Intensive Care Med. 2014;40:171–81.
Article
CAS
PubMed
Google Scholar
Hamimy W, Khedr H, Rushdi T, Zaghloul A, Hosni M, Aal AA. Application of conventional blood glucose control strategy in surgical ICU in developing countries: is it beneficial? Egypt J Anaesth. 2015;32:123–9.
Article
Google Scholar
Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449–61.
Article
PubMed
Google Scholar
Stewart KW, Pretty CG, Tomlinson H, Thomas FL, Homlok J, Noémi SN, et al. Safety, efficacy and clinical generalization of the STAR protocol: a retrospective analysis. Ann Intensive Care. 2016;6:24.
Article
PubMed
PubMed Central
Google Scholar
Fisk L, Lecompte A, Penning S, Desaive T, Shaw G, Chase G. STAR development and protocol comparison. IEEE Trans Biomed Eng. 2012;59:3357–64.
Article
PubMed
Google Scholar
Dickson JL, Stewart KW, Pretty CG, Flechet M, Desaive T, Penning S, et al. Generalisability of a virtual trials method for glycaemic control in intensive care. IEEE Trans Biomed Eng. 2017;1–1.
Chase JG, Suhaimi F, Penning S, Preiser JC, Le Compte AJ, Lin J, et al. Validation of a model-based virtual trials method for tight glycemic control in intensive care. Biomed Eng Online. 2010;9:84.
Article
PubMed
PubMed Central
Google Scholar
Lin J, Razak NN, Pretty CG, Le Compte A, Docherty P, Parente JD, et al. A physiological Intensive Control Insulin-Nutrition-Glucose (ICING) model validated in critically ill patients. Comput Methods Programs Biomed. 2011;102:192–205.
Article
PubMed
Google Scholar
Stewart KW, Pretty CG, Tomlinson H, Fisk L, Shaw GM, Chase JG. Stochastic Model Predictive (STOMP) glycaemic control for the intensive care unit: development and virtual trial validation. Biomed Signal Process Control. 2015;16:61–7.
Article
Google Scholar
Lin J, Lee D, Chase JG, Shaw GM, Hann CE, Lotz T, et al. Stochastic modelling of insulin sensitivity variability in critical care. Biomed Signal Process Control. 2006;1:229–42.
Article
Google Scholar
Lin J, Lee D, Chase JG, Shaw GM, Le Compte A, Lotz T, et al. Stochastic modelling of insulin sensitivity and adaptive glycemic control for critical care. Comput Methods Programs Biomed. 2008;89:141–52.
Article
PubMed
Google Scholar
Evans A, Le Compte A, Tan CS, Ward L, Steel J, Pretty CG, et al. Stochastic targeted (STAR) glycemic control: design, safety, and performance. J Diabetes Sci Technol. 2012;6:102–15.
Article
PubMed
PubMed Central
Google Scholar
Evans A, Shaw GM, Le Compte A, Tan CS, Ward L, Steel J, et al. Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control. Ann Intensive Care. 2011;1:38.
Article
PubMed
PubMed Central
Google Scholar
Kalfon P, Preiser JC. Tight glucose control: should we move from intensive insulin therapy alone to modulation of insulin and nutritional inputs? Crit Care. 2008;12:156.
Article
PubMed
PubMed Central
Google Scholar
Amrein K, Ellmerer M, Hovorka R, Kachel N, Fries H, von Lewinski D, et al. Efficacy and safety of glucose control with Space GlucoseControl in the medical intensive care unit: an open clinical investigation. Diabetes Technol Ther. 2012;14:690–5.
Article
CAS
PubMed
Google Scholar
Van Herpe T, Mesotten D, Wouters PJ, Herbots J, Voets E, Buyens J, et al. LOGIC-insulin algorithm-guided versus nurse-directed blood glucose control during critical illness: the LOGIC-1 single-center, randomized, controlled clinical trial. Diabetes Care. 2013;36:188–94.
Article
PubMed
PubMed Central
Google Scholar
Pachler C, Plank J, Weinhandl H, Chassin LJ, Wilinska ME, Kulnik R, et al. Tight glycaemic control by an automated algorithm with time-variant sampling in medical ICU patients. Intensive Care Med. 2008;34:1224–30.
Article
CAS
PubMed
Google Scholar
Finfer S, Chittock DR, Su SY-S, Blair D, Foster D, Dhingra V, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283–97.
Article
PubMed
Google Scholar
Preiser JC, Devos P, Ruiz-Santana S, Melot C, Annane D, Groeneveld J, et al. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med. 2009;35:1738–48.
Article
CAS
PubMed
Google Scholar
Doig GS, Simpson F, Finfer S, Delaney A, Davies AR, Mitchell I, et al. Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial. JAMA. 2008;300:2731–41.
Article
CAS
PubMed
Google Scholar
Villet S, Chiolero RL, Bollmann MD, Revelly JP, Cayeux RNM, Delarue J, et al. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr. 2005;24:502–9.
Article
PubMed
Google Scholar
Krishnan JA, Parce PB, Martinez A, Diette GB, Brower RG. Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes. Chest. 2003;124:297–305.
Article
PubMed
Google Scholar
Heyland DK, Cahill N, Day AG. Optimal amount of calories for critically ill patients: depends on how you slice the cake! Crit Care Med. 2011;39:1.
Google Scholar
Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, et al. Permissive underfeeding or standard enteral feeding in critically ill adults. N Engl J Med. 2015;372:2398–408.
Article
CAS
PubMed
Google Scholar
Preiser J-C, van Zanten AR, Berger MM, Biolo G, Casaer MP, Doig GS, et al. Metabolic and nutritional support of critically ill patients: consensus and controversies. Crit Care. 2015;19:1–11.
Article
Google Scholar
Rice TW. Gluttony in the intensive care unit. Am J Respir Crit Care Med. 2013;187:223–4.
Article
PubMed
PubMed Central
Google Scholar
Weijs PJM, Stapel SN, de Groot SDW, Driessen RH, de Jong E, Girbes ARJ, et al. Optimal protein and energy nutrition decreases mortality in mechanically ventilated, critically ill patients: a prospective observational cohort study. JPEN J Parenter Enteral Nutr. 2012;36:60–8.
Article
CAS
PubMed
Google Scholar
Singer P, Anbar R, Cohen J, Shapiro H, Shalita-Chesner M, Lev S, et al. The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med. 2011;37:601–9.
Article
PubMed
Google Scholar
Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011.
Rice TW, Wheeler AP, Thompson BT, Steingrub J, Hite RD, Moss M, et al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA. 2012;307:795–803.
Article
PubMed
Google Scholar
Cahill NE, Dhaliwal R, Day AG, Jiang X, Heyland DK. Nutrition therapy in the critical care setting: what is “best achievable” practice? An international multicenter observational study*. Crit Care Med. 2010;38:395–401.
Article
CAS
PubMed
Google Scholar
Hann CE, Chase JG, Lin J, Lotz T, Doran CV, Shaw GM. Integral-based parameter identification for long-term dynamic verification of a glucose–insulin system model. Comput Methods Programs Biomed. 2005;77:259–70.
Article
PubMed
Google Scholar
Haidar A, Elleri D, Allen JM, Harris J, Kumareswaran K, Nodale M, et al. Validity of triple- and dual-tracer techniques to estimate glucose appearance. AJP Endocrinol Metab. 2012;302:E1493–501.
Article
CAS
Google Scholar
Cerra FB, Benitez MR, Blackburn GL, Irwin RS, Jeejeebhoy K, Katz DP, et al. Applied nutrition in ICU patients: a consensus statement of the American College of Chest Physicians. Chest. 1997;111:769–78.
Article
CAS
PubMed
Google Scholar
Fugleberg S, Kolendorf K, Thorsteinsson B, Bliddal H, Lund B, Bojsen F. The relationship between plasma concentration and plasma disappearance rate of immunoreactive insulin in normal subjects. Diabetologia. 1982;22:437–40.
Article
CAS
PubMed
Google Scholar
Thorsteinsson B. Kinetic models for insulin disappearance from plasma in man. Dan Med Bull. 1990;37:143–53.
CAS
PubMed
Google Scholar
Natali A, Gastaldelli A, Camastra S, Sironi AM, Toschi E, Masoni A, et al. Dose-response characteristics of insulin action on glucose metabolism: a non-steady-state approach. Am J Physiol Endocrinol Metab. 2000;278:E794–801.
Article
CAS
PubMed
Google Scholar
Chase JG, Shaw GM, Lotz T, LeCompte A, Wong J, Lin J, et al. Model-based insulin and nutrition administration for tight glycaemic control in critical care. Curr Drug Deliv. 2007;4:283–96.
Article
CAS
PubMed
Google Scholar
Heyland DK, Schroter-Noppe D, Drover JW, Jain M, Keefe L, Dhaliwal R, et al. Nutrition support in the critical care setting: current practice in canadian ICUs—opportunities for improvement? JPEN J Parenter Enteral Nutr. 2003;27:74–83.
Article
PubMed
Google Scholar
Thomas F, Pretty CG, Fisk L, Shaw GM, Chase JG, Desaive T. Reducing the impact of insulin sensitivity variability on glycaemic outcomes using separate stochastic models within the STAR glycaemic protocol. Biomed Eng Online. 2014;13:43.
Article
PubMed
PubMed Central
Google Scholar
Chase JG, Shaw GM, Lotz T, LeCompte A, Wong J, Lin J, et al. Model-based insulin and nutrition administration for tight glycaemic control in critical care. Curr Drug Deliv. 2007;4:283–96.
Article
CAS
PubMed
Google Scholar
Taylor BE, McClave SA, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient. Crit Care Med. 2016;44:390–438.
Article
PubMed
Google Scholar
Kreymann KG, Berger MM, Deutz NEP, Hiesmayr M, Jolliet P, Kazandjiev G, et al. ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr. 2006;25:210–23.
Article
CAS
PubMed
Google Scholar
Cuthbertson DP. Post-shock metabolic response. Lancet. 1942;239:433–7.
Article
Google Scholar
Stewart KW, Chase JG, Dickson J, Pretty C, Shaw G. Can we fix it? Yes we can! Simplifying nutrition in STAR Glycemic Control. 16th annual diabetes technology meet. 2016.
Fisk LM, Le Compte AJ, Shaw GM, Penning S, Desaive T, Chase JG. STAR development and protocol comparison. IEEE Trans Biomed Eng. 2012;59:3357–64.
Article
PubMed
Google Scholar
Patino JF, de Pimiento SE, Vergara A, Savino P, Rodriguez M, Escallon J. Hypocaloric support in the critically ill. World J Surg. 1999;23:553–9.
Article
CAS
PubMed
Google Scholar
Dickerson RN, Boschert KJ, Kudsk KA, Brown RO. Hypocaloric enteral tube feeding in critically ill obese patients. Nutrition. 2002;18:241–6.
Article
PubMed
Google Scholar
Arabi YM, Tamim HM, Dhar GS, Al-Dawood A, Al-Sultan M, Sakkijha MH, et al. Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial. Am J Clin Nutr. 2011;93:569–77.
Article
CAS
PubMed
Google Scholar