Table 3 ICU management and outcome of patient with acute respiratory failure revealing anti-synthetase syndrome or dermato-pulmonary syndrome associated with anti-MDA-5 antibodies
Missing data | All patients N = 47 | aMDA-5 ARF N = 19 | AS ARF N = 28 | p | |
|---|---|---|---|---|---|
Treatment, n (%) or median [IQR] | |||||
Antibiotics therapy at ICU admission | 0 | 41 (89) | 15 (79) | 26 (96) | 0.14 |
Immunosuppressive treatment | 0 | 47 (100) | 19 (100) | 28 (100) | 1.00 |
Delay ICU-IS treatment (days) | 0 | 6 [3–12] | 4 [1.5–11] | 6 [4–16] | 0.25 |
Corticosteroids pulses | 0 | 47 (100) | 19 (100) | 28 (100) | 1.00 |
Cyclophosphamide | 0 | 34 (72) | 16 (84) | 18 (64) | 0.24 |
Rituximab | 0 | 7 (15) | 6 (32) | 1 (4) | 0.01 |
Cyclosporine | 0 | 2 (4) | 2 (10) | 0 (0) | 0.16 |
Tacrolimus | 0 | 2 (4) | 2 (11) | 0 (0) | 0.16 |
Basiliximab | 0 | 2 (4) | 2 (11) | 0 (0) | 0.16 |
Intravenous immunoglobulins | 0 | 10 (21) | 5 (26) | 5 (18) | 0.50 |
Plasma exchange | 0 | 8 (17) | 7 (37) | 1 (4) | 0.005 |
Number of immunosuppressive treatments | 0 | 2 [2, 3] | 3 [2–4] | 2 [1, 2] | < 0.001 |
Ventilatory support, n (%) | |||||
Noninvasive ventilation before intubation | 0 | 14 (30) | 4 (21) | 10 (36) | 0.45 |
High-flow nasal cannula oxygen before intubation | 0 | 21 (45) | 11 (58) | 10 (36) | 0.23 |
Tracheal intubation | 0 | 43 (92) | 18 (95) | 25 (89) | 0.64 |
ARDS | 0 | 42 (89) | 18 (95) | 24 (86) | 0.64 |
Mild (200 < PaO2/FiO2 ≤ 300 mmHg) | 0 | 1 (2) | 1 (6) | 0 (0) | 0.43 |
Moderate (100 < PaO2/FiO2 ≤ 200 mmHg) | 0 | 5 (12) | 0 (0) | 5 (21) | 0.06 |
Severe (PaO2/FiO2 ≤ 100 mmHg) | 0 | 36 (86) | 17 (94) | 19 (79) | 0.21 |
Nitric oxide inhalation | 0 | 23 (50) | 14 (74) | 9 (33) | 0.02 |
Neuromuscular blocking agents | 0 | 36 (78) | 17 (90) | 19 (70) | 0.16 |
Prone position | 0 | 26 (57) | 12 (63) | 14 (52) | 0.64 |
Veno-venous ECMO | 0 | 8 (17) | 6 (32) | 2 (7) | 0.05 |
Extra-ventilatory support, n (%) | |||||
Renal replacement therapy | 0 | 8 (17) | 4 (21) | 4 (14) | 0.70 |
Vasopressors | 0 | 37 (79) | 17 (90) | 20 (71) | 0.17 |
Outcome, n (%) or median [IQR] | |||||
Duration of invasive mechanical ventilation (days) | 0 | 21 [14–35] | 19 [9–26] | 23 [17–37] | 0.34 |
Length of ICU stay (days) | 0 | 26 [19–38] | 22 [17–36] | 28 [21–38] | 0.20 |
Length of hospital stay (days) | 0 | 38 [22–67] | 22 [19–44] | 44 [33–70] | 0.015 |
ICU mortality | 0 | 21 (45) | 16 (84) | 5 (18) | < 0.001 |
Hospital mortality | 0 | 24 (51) | 16 (84) | 8 (29) | 0.001 |