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Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study



Anti-synthetase (AS) and dermato-pulmonary associated with anti-MDA-5 antibodies (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies potentially responsible for severe acute interstitial lung disease. We undertook a 13-year retrospective multicenter study in 35 French ICUs in order to describe the clinical presentation and the outcome of patients admitted to the ICU for acute respiratory failure (ARF) revealing AS or aMDA-5 syndromes.


From 2005 to 2017, 47 patients (23 males; median age 60 [1st–3rd quartiles 52–69] years, no comorbidity 85%) were admitted to the ICU for ARF revealing AS (n = 28, 60%) or aMDA-5 (n = 19, 40%) syndromes. Muscular, articular and cutaneous manifestations occurred in 11 patients (23%), 14 (30%) and 20 (43%) patients, respectively. Seventeen of them (36%) had no extra-pulmonary manifestations. C-reactive protein was increased (139 [40–208] mg/L), whereas procalcitonine was not (0.30 [0.12–0.56] ng/mL). Proportion of patients with creatine kinase ≥ 2N was 20% (n = 9/47). Forty-two patients (89%) had ARDS, which was severe in 86%, with a rate of 17% (n = 8/47) of extra-corporeal membrane oxygenation requirement. Proportion of patients who received corticosteroids, cyclophosphamide, rituximab, intravenous immunoglobulins and plasma exchange were 100%, 72%, 15%, 21% and 17%, respectively. ICU and hospital mortality rates were 45% (n = 21/47) and 51% (n = 24/47), respectively. Patients with aMDA-5 dermato-pulmonary syndrome had a higher hospital mortality than those with AS syndrome (n = 16/19, 84% vs. n = 8/28, 29%; p = 0.001).


Intensivists should consider inflammatory myopathies as a cause of ARF of unknown origin. Extra-pulmonary manifestations are commonly lacking. Mortality is high, especially in aMDA-5 dermato-pulmonary syndrome.


Identifying the cause of acute respiratory distress syndrome (ARDS) is a crucial step for initiating a targeted treatment and improving prognosis [1, 2]. However, two recent studies [3, 4] showed that 8% of patients with ARDS according to the Berlin criteria [5] lacked exposure to “common” risk factors (e.g., pneumonia, acute pancreatitis, aspiration of gastric content or extra-pulmonary sepsis) with no etiology eventually retrieved in 80% of them [4]. For such atypical ARDS, a comprehensive diagnostic work-up, including specific immunologic tests, is recommended [6] so that to identify immune causes, typically amenable to specific therapeutic interventions (e.g., corticosteroids). Yet, an ancillary analysis [4] of an international, multicenter, prospective cohort study [7] reported that such immunological examinations were performed in only 5% of ARDS without common risk factors.

Anti-synthetase (AS) and anti-melanoma differentiation-associated gene 5 (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies [8] potentially responsible for rapidly progressive interstitial lung disease leading to acute respiratory failure and ARDS [9,10,11,12]. AS and aMDA-5 dermato-pulmonary syndromes may be clinically indistinguishable one from another, with almost three-quarter of patients with aMDA-5 dermato-pulmonary syndrome exhibiting the clinical attributes of the AS syndrome [8]. When ARF is the initial presentation of AS or aMDA-5 syndromes [9,10,11, 13,14,15,16,17] or when extra-respiratory manifestations, such as muscular, cutaneous or articular signs are lacking [9, 18,19,20,21,22], the diagnosis is challenging, especially in the intensive care unit (ICU) setting, where many other reasons of acute respiratory failure (ARF) can be discussed. To the best of knowledge, a number of case reports of ARF revealing autoimmune inflammatory myopathies have been previously reported, but an extended case series has not been published as yet.

Therefore, we undertook this retrospective study in order to: (1) describe the clinical features and the outcome of patients admitted to the ICU for ARF revealing either an AS or an aMDA-5 dermato-pulmonary syndrome, and; (2) identify predictive factors of hospital mortality.

Patients and methods


We conducted a 13-year multicenter retrospective non-interventional study in 35 ICUs in France from January 1, 2005, to December 31, 2017. All patients older than 18 years were included if they met the following criteria: (1) admitted to the ICU for ARF not related to cardiogenic pulmonary edema; (2) no common ARDS risk factor, among pneumonia, acute pancreatitis, aspiration of gastric content, extra-pulmonary sepsis, multiple transfusions, major trauma, pulmonary vasculitis, drowning, severe burns, identified according to the Berlin definition [5]; (3) immunologic test performed during ICU stay, which was positive for anti-synthetase (Jo-1, PL7, PL12, OJ, EJ, KS, Zo, YRS/Tyr/Ha) or anti-MDA-5 autoantibodies; and (4) no alternative diagnosis for ARF. It is worth notifying that in the present study the diagnosis of AS or aMDA-5 dermato-pulmonary syndromes had to be made during the ICU stay. Therefore, those who had a diagnosis of AS or aMDA-5 made before ICU admission were not included.

The investigator of each participating center was responsible for the identification of the patients, either from the hospital medical reports, using the function “research the files in which the key words MDA-5 or anti-synthetase or myositis occurs” of Microsoft Windows®, or through a search using the International Classification of Diseases (10th Revision) following codes: M608 (autoimmune myositis), M609 (myositis), M332 (polymyositis) and M331 (dermatomyositis). The clinical charts of all identified patients were anonymized before sending to the main investigators (DC and CV). Clinical charts were reviewed in order to check the inclusion criteria.

Data collection

The following data were collected on a standardized anonymized case record form: demographic characteristics (age, gender), severity scores upon ICU admission (Sequential Organ Failure Assessment [23] and Simplified Acute Physiology Score II [24]), main comorbidities, delay between first respiratory sign and ICU admission, clinical examination (respiratory and extra-respiratory manifestations) and laboratory findings at the time of ICU admission (blood leukocytes and platelets counts, serum procalcitonine, C-reactive protein, creatine kinase and creatinine levels, PaO2/FiO2 with FiO2 calculated according to the following formula [25, 26]: FiO2 = oxygen flow in liter per minute × 0.04 + 0.21 when standard oxygen was used), radiological findings on chest X-ray and CT scan, cytological and bacteriological analyses of broncho-alveolar lavage (BAL) fluid, type of positive autoantibodies (Jo-1, PL7, PL12, OJ, EJ, KS, Zo, YRS/Tyr/Ha or aMDA-5), immunosuppressive treatments received (corticosteroids, cyclophosphamide, rituximab, basiliximab, tacrolimus, cyclosporine, methotrexate, intravenous immunoglobulins or plasma exchange), organ supports in the ICU (invasive mechanical ventilation, extra-corporeal membrane oxygenation (ECMO), renal replacement therapy, vasopressors), ICU and hospital length of stay, ICU and hospital mortality.

Written reports of chest CT scan performed at the time of ICU admission were sent to the main investigators (DC and CV) in order to individualize elementary lesions (ground-glass attenuation, alveolar consolidation, septal thickening, pleural effusion, pneumothorax, pneumomediastinum and mediastinal lymphadenopathy) and their location (lower or upper lobe predominance). Signs of lung fibrosis (honeycombing, traction bronchiectasis and reticulations) were also collected. Cytological analyses of BAL fluid collected at the time of ICU admission were reported, as well as results of open lung, skin or muscle biopsies, if performed.

Statistical analysis

Continuous variables are reported as median [1st–3rd quartiles] and compared by the Mann–Whitney U test. Categorical variables are reported as counts and percentage points in groups and compared by using the Fisher’s exact test. Survival curves of patients with aMDA-5 and AS syndromes were drawn using the Kaplan–Meier method and compared using the log-rank test. All tests were two-sided, with p < 0.05 indicating statistical significance. The statistical analysis was performed by using the RStudio software version 0.99.441 (


Study population and clinical manifestations

From January 1, 2005, to December 31, 2017, 47 patients fulfilled the inclusion criteria, including 28 (60%) with AS syndrome (Jo-1 n = 13/28 (47%); PL7 n = 9/28 (32%); PL12 n = 4/28 (14%); EJ n = 2/28 (7%)) and 19 (40%) with aMDA-5 dermato-pulmonary syndrome. All the patients with aMDA-5 dermato-pulmonary syndrome were admitted after January 1, 2010. Demographical characteristics, main comorbidities and clinical manifestations are given in Table 1. Most of the patients had no comorbidity (n = 40/47, 85%). Median SAPSII and SOFA scores at the time of ICU admission were 35 [27–53] and 5 [3–8], respectively. The median delay between first respiratory sign and ICU admission was 21 [10–41] days. Most of the patients had central temperature > 38 °C (n = 27/47, 57%). Myalgia, arthralgia/arthritis and cutaneous manifestations occurred in 23% (n = 11/47), 30% (n = 14/47) and 43% (n = 20/47) of patients, respectively. About one-third of patients (n = 17/47, 36%) had no extra-pulmonary manifestation, in a similar proportion in aMDA-5 and AS groups.

Table 1 Demographical and clinical manifestations of patients with acute respiratory failure revealing anti-synthetase syndrome or dermato-pulmonary syndrome associated with anti-MDA-5 antibodies

Laboratory and radiological findings

Biological data at the time of ICU admission and radiological findings are reported in Table 2. C-reactive protein levels (N < 5 mg/L) were increased (139 [40–208] mg/L), while procalcitonine levels (N < 0.5 ng/mL) were not (0.30 [0.12–0.56] ng/mL). The rate of patients having creatine kinase plasma levels greater than 2 times the upper limit of normal laboratory range was 20% (n = 9/47) in the whole population, and only 31% (n = 8/28) in the AS group. The median PaO2/FiO2 ratio at ICU admission was 123 [83–147] mmHg.

Table 2 Biological, radiological and cytological findings in patients with acute respiratory failure revealing anti-synthetase syndrome or dermato-pulmonary syndrome associated with anti-MDA-5 antibodies

Most patients (n = 45/47, 96%) had bilateral condensations on chest X-ray, with a predominantly lower location (n = 46/47, 98%) (Table 2). All patients underwent a lung CT scan, which showed ground-glass attenuation in 78% (n = 37/47) and alveolar condensation in 75% (n = 35/47). Signs of lung fibrosis were observed in 36% (n = 17/47), while 38% (n = 18/47) had mediastinal lymphadenopathies.

Broncho-alveolar fluid analysis and histological data

BAL fluid analyses were available in 89% (n = 42/47) of patients and are summarized in Table 2. The cell count was 250 [140–330] × 103/mL, and percentages of lymphocytes, neutrophils and macrophages were 11% [4–30], 38% [13–65] and 40% [20–60], respectively. BAL was performed before antibiotic therapy in only 12/42 (29%) patients and was negative for lung infection in every patient. There was no correlation between BAL findings and elementary lesions observed on chest CT scan. In particular, the proportion of patients with > 40% BAL neutrophils did not differ between patients with or without elementary lesions of lung fibrosis on chest CT scan (n = 8/19, 42% vs. n = 11/19, 58%, p = 0.72). An open lung biopsy was performed in 4 (9%) patients and depicted findings consistent with organizing pneumonia (n = 2), usual interstitial pneumonitis (n = 1) and diffuse alveolar damage (n = 1) (Table 2). A total of 13 patients (28%) had a muscle (n = 7) or a skin (n = 6) biopsy performed during the ICU stay. All muscle biopsies revealed findings consistent with an inflammatory myositis, while skin biopsies were either normal (n = 1) or revealed findings consistent with lichenoid dermatitis (n = 3) or with dermatomyositis (n = 2) (Table 2).

ICU management and outcome

Most patients (n = 41/47, 89%) received an antimicrobial therapy upon ICU admission (Table 3). All patients received steroids, after a median delay of 6 [3–12] days following the ICU admission. Other immunosuppressive treatments administered are reported in Table 3.

Table 3 ICU management and outcome of patient with acute respiratory failure revealing anti-synthetase syndrome or dermato-pulmonary syndrome associated with anti-MDA-5 antibodies

Almost all patients (n = 42/47, 89%) had ARDS, categorized as severe (PaO2/FiO2 ≤ 100 mmHg with PEEP ≥ 5 mmH2O) in 86% (n = 36/47), with 17% (n = 8/47) of them requiring ECMO. ICU and hospital mortality rates were 45% (n = 21/47) and 51% (n = 24/47), respectively. Patients with aMDA-5 dermato-pulmonary syndrome had a higher ICU mortality than those with AS syndrome (n = 16/19, 84% vs. n = 5/28, 18%; p < 0.001). Among the 26 ICU survivors, 5 (19%) were diagnosed with a cancer (colorectal n = 3, pharyngeal n = 1, melanoma n = 1) during the 279 [158–500] days post-ICU stay follow-up.

Comparison between hospital survivors and non-survivors

Compared to patients who survived at the hospital discharge, those who died were more likely to have an aMDA-5 autoantibody (n = 16/24, 67% vs. n = 3/23, 13%; p = 0.001), had a higher rate of ground-glass attenuation (n = 22/24, 92% vs. 15/23, 65%; p = 0.04) and a lower rate of alveolar condensation (n = 14/24, 58% vs. 21/23, 91%; p = 0.02) on chest CT scan, and were given 3 [2, 3] versus 2 [1, 2] different immunosuppressive regimens during the ICU stay (p = 0.002) (Table 4). After adjustment on syndrome (anti-synthetase or aMDA-5 dermato-pulmonary syndrome), the presence of ground-glass attenuations on chest CT scan was no longer associated with in-hospital mortality (p = 0.24). The Kaplan–Meier graph showed a lower probability of survival 90 days after ICU admission in patients with aMDA-5 antibody than in patients with AS antibody (Fig. 1; p < 0.0001 log-rank test).

Table 4 Comparison between hospital survivors and non-survivors
Fig. 1
figure 1

Kaplan–Meier graph of the probability of survival from ICU admission to day 90 in patients with dermato-pulmonary syndrome associated with anti-MDA-5 antibodies (black curve) and patients with anti-synthetase syndrome (gray curve)


We are herein reporting the first large cohort of patients admitted to ICU for ARF revealing either AS or aMDA-5 dermato-pulmonary syndrome. The main findings are: (1) clinical manifestations may be nonspecific with the absence of extra-pulmonary manifestations of inflammatory myositis in one-third of patients; (2) hypoxemia is severe with a high rate of severe ARDS and rescue maneuvers; and (3) hospital mortality is high, especially in dermato-pulmonary syndrome associated with aMDA-5 autoantibodies.

AS and aMDA-5-associated dermato-pulmonary syndromes are two near each of the other inflammatory myopathies that may be responsible for severe acute interstitial lung diseases [9,10,11]. The diagnosis is easy to consider when extra-pulmonary manifestations are present. In AS syndrome, the main extra-pulmonary manifestations include myositis with elevated creatine kinase levels, non-erosive arthritis, Raynaud’s phenomenon and thick cracked skin over the tips and sides of the fingers called “mechanic’s hands” [27,28,29,30,31,32]. However, there is a wide heterogeneity in clinical manifestations depending on the causative AS autoantibody [33, 34]. In aMDA-5-associated dermato-pulmonary syndrome, the cutaneous manifestations (skin ulcerations or necrosis, facial erythema, mechanic’s hands, periungual telangiectasia, Gottron’s papules, Raynaud’s phenomenon) are in the forefront [10, 11, 35] and usually contrast with the absence of clinical signs of myositis (clinically “amyopathic myositis”). Demographical and clinical findings in our patients were in line with those recently reported in non-ICU patients with AS [22, 32, 34] or with aMDA-5 dermato-pulmonary syndromes [10].

Both in AS and aMDA-5 dermato-pulmonary syndromes, extra-pulmonary manifestations may be lacking [9, 10] rendering the diagnosis difficult to make. In our series, more than one-third of patients had no extra-pulmonary manifestations with a similar proportion in AS and aMDA-5 patients. This rate contrasts with the 10% rate recently reported [10] in patients with aMDA-5 dermato-pulmonary syndrome, reflecting the lack of training of intensivists for the clinical assessment of these patients and highlighting the need for a multidisciplinary approach. Considering the high proportion of patients lacking extra-pulmonary manifestations, the clinical presentation may mimic that of a “bilateral pneumonia without microbiological documentation.” Hence, 89% of our patients received antibiotic therapy at ICU admission. The presence of an intense inflammatory syndrome with increased C-reactive protein levels contrasting with the lack of elevation of serum procalcitonine could help intensivists appreciating the probability of an infectious process, this dissociation being highly suggestive of a non-infectious inflammatory process.

In our series, BAL was performed in 89% of patients. Unlike a recent work [3] showing that a lymphocytic BAL fluid was associated with better ICU survival in ARDS patients with no common risk factor, our study failed to identify any predictive role of BAL cytology on hospital survival. BAL fluid analysis does not seem a useful diagnostic tool for AS or aMDA-5 dermato-pulmonary syndromes, but should nevertheless be performed to rule out an alternative diagnosis, such as diffuse alveolar hemorrhage or active infection.

All included patients underwent chest CT scan. Interestingly, CT chest findings predominate in the lower lobes, which is consistent with a previous report [36]. CT scan signs of lung fibrosis have been recently shown to be associated with a poor outcome in patients with ARF related to interstitial lung diseases [37]. In our study, CT scan signs of lung fibrosis were not associated with hospital mortality, probably because of a lack of adequate power. While ground-glass opacities are usually considered as potentially reversible lung lesions during idiopathic pulmonary fibrosis [38, 39], these lesions were associated with in-hospital mortality in our study, probably because they were more frequently observed during aMDA-5 dermato-pulmonary syndromes. Indeed, this association was no longer observed after adjustment on the type of positive antibody (anti-synthetase or aMDA-5).

Our series underlines the severity of AS and aMDA-5 dermato-pulmonary syndrome, since 89% of patients fulfilled the Berlin criteria for ARDS [5], categorized as severe (PaO2/FiO2 ≤ 100 mmHg with PEEP ≥ 5 mmH2O) in 86% of cases. Anti-MDA-5 dermato-pulmonary syndromes exhibited a significantly higher mortality than AS syndromes, with almost all these patients dying in the ICU of refractory ARDS despite a high rate of ECMO (32%). Moreover, aMDA-5 patients had a much higher mortality than those with severe ARDS included in the lung safe study [7], highlighting the irreversibility of lung lesions despite immunosuppressive treatments. These results are in line with previous series, showing that refractory ARDS is the leading cause of mortality in aMDA-5 patients [10].

Whether our patients had a true ARDS (i.e., presence of diffuse alveolar damage (DAD), the histological hallmark of ARDS) or simply fulfilled the Berlin criteria while having a non-DAD histology is unknown. In fact, the Berlin definition of ARDS is not fully reliable for diagnosing DAD, and several non-DAD histological entities (such as lung fibrosis, organizing pneumonia, diffuse alveolar hemorrhage or lung tumoral infiltration) have been reported in patients fulfilling the clinical and radiological criteria for ARDS [1, 40,41,42]. Regarding the onset of lung injury, the Berlin definition of ARDS stipulates that “respiratory signs should occur (or worsen) within 7 days after an exposure to a common ARDS risk factor” (e.g., pneumonia, acute pancreatitis, aspiration of gastric content or extra-pulmonary sepsis). In our patients, the absence of a common risk factor for ARDS according to the Berlin definition together with delay between first respiratory sign and ICU admission exceeding 7 days (21 days) advocate more for an ARDS mimicker rather than for a real ARDS. However, a recent histological study revealed that 50% of patients with an acute decompensation of AS syndrome due to JO-1 autoantibody exhibited histological lesions of DAD [43].

In non-ICU patients, the prognosis of inflammatory myopathies depends on the severity of lung involvement [10, 22, 32, 44]. Treatment of interstitial lung disease associated with AS and aMDA-5 dermato-pulmonary syndromes is not standardized and based on case reports. Numerous immunosuppressive therapies are available (e.g., cyclophosphamide, methotrexate, azathioprine, mycophenolate mofetil, cyclosporine, tacrolimus, rituximab, basiliximab, intravenous immunoglobulins or plasma exchange) [9, 11, 14, 21, 45, 46], but high-dose corticosteroids remain the first-line therapy. Our study underlines the wide variations in the choice of immunosuppressive treatment even if the association corticosteroids–cyclophosphamide was administered in almost 3 over 4 patients. Patients with aMDA-5 received significantly more immunosuppressive drugs highlighting a higher severity.

Of note, 19% of ICU survivors developed cancer, in line with previous series of AS patients [47].


Our study suffers from several limitations. First, we included a limited number of patients, inherent to the rarity of the disease. However, this is the first series on ARF revealing AS or aMDA-5 syndromes in an ICU context and our findings are consistent with previous reports. This limited number of patients precluded performing multivariable analyses and thus did not allow for adjusting the observed association between some variables and mortality with potential confounders. Second, the relationship between positive AS or aMDA-5 autoantibody and ARF is not proven. We therefore cannot exclude that some patients had a fortuitously positive autoantibody and that inflammatory myopathy was not the cause of ARF. However, this hypothesis appears unlikely since an alternative diagnosis for ARF had to be excluded, and all patients were treated with immunosuppressive therapies underlining the high degree of clinician’s suspicion. Third, because the patients were recruited over a 13-year period in 35 centers, ICU procedures were inevitably heterogeneous. Fourth, the prevalence of aMDA-5 dermato-pulmonary syndromes may have been underestimated during the study period since detection of aMDA-5 autoantibody was first described in 2005 [48] and was therefore routinely available only from 2010 in most of participating centers. Last, several classical predictors of mortality related to ventilation (tidal volume or driving pressure [49]) were not available as a result of a long-term retrospective design.

Clinical implications

Considering the high proportion of patients lacking extra-pulmonary manifestations and the nonspecific presentation mimicking that of a bilateral community-acquired pneumonia, we believe that ARF related to autoimmune inflammatory myopathies may be underdiagnosed. Hence, de Prost et al. recently showed that the diagnostic work-up performed in ARDS patients with no common risk factor was not comprehensive, with only 5% of patients having immunological tests [4]. The lack of screening for AS or aMDA-5 autoantibodies is probably one of the reasons why these diseases are underestimated. Therefore, when the etiology of ARF appears unclear, we recommend a more aggressive diagnostic work-up [6], including immunological tests in order to identify patients amenable to specific therapies.

A careful assessment of extra-pulmonary manifestations, such as cutaneous or articular signs, is crucial. While the presence of extra-pulmonary manifestations is highly suggestive, the 3-week delay between first respiratory signs and ICU admission, the absence of an obvious etiology for ARF, the presence of bi-basal consolidations on chest X-ray with an intense inflammatory process, contrasting with a low procalcitonin level together with the lack of microbiological documentation are the main clues to consider the diagnosis of AS or aMDA-5 syndromes in a patient without extra-pulmonary manifestation. To better assess the relevance of these signs, further prospective studies aiming at systematically screen for autoantibodies in ARDS without risk factors are needed. Once the diagnosis is made, the management is difficult and requires a multidisciplinary approach involving intensivists, pulmonologists, internists and rheumatologists in order to decide the best-individualized therapeutic strategy.


Intensivists should consider inflammatory myopathies, such as anti-synthetase syndrome and dermato-pulmonary syndrome associated with anti-MDA-5 antibodies, as a cause of acute respiratory failure when the etiology appears unclear. Extra-pulmonary manifestations are commonly lacking and an isolated lung involvement may reveal the disease. Hospital mortality is high, especially in aMDA-5 dermato-pulmonary syndrome.



acute respiratory distress syndrome


acute respiratory failure




anti-MDA-5 autoantibody


broncho-alveolar lavage


diffuse alveolar damage


extra-corporeal membrane oxygenation


intensive care unit


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Authors’ contributions

DC had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. DC made substantial contribution to the study design, data collection and analysis and manuscript writing. CV contributed to data collection and interpretation, and drafting of the manuscript. MPC, NdP, AD, J-PQ, SP, GL, MN, GV, MF, RC, GD, EM, NT, YT-L, FS, MG, EG, RL, SR, RLM, GC, CG, LZ and EM contributed to patients identification in each center, data collection and manuscript writing. MD contributed to the data analysis, statistical analysis and manuscript revision. NdP, CG, OP, HM and GP contributed to the manuscript writing and revision, and provided important intellectual content. All authors read and approved the final manuscript.


We thank Jonathan Messika (Réanimation, Hôpital Louis Mourier, Colombes), Frédéric Pène (Réanimation médicale, Hôpital Cochin, Paris), Morgan Benaïs (Réanimation médico-chirurgicale, Saint Denis), Jérémy Rosman (Réanimation polyvalente, Charleville), David Schnell (Réanimation médico-chirurgicale, Angoulême), Sébastien Jochmans (Réanimation Polyvalente, Melun), Sami Hraiech and Jérémy Bourenne (Réanimations, Marseille), Guillaume Schnell (Réanimation médico-chirurgicale, Le Havre), Damien Du Cheyron (Réanimation médicale, Caen), Aude Gibelin (Réanimation médico-chirurgicale, Hôpital Tenon, Paris), Cédric Bruel (Réanimation Polyvalente, Hôpital Saint-Joseph, Paris), Kamel Toufik (Réanimation médico-chirurgicale, Orléans) and Jérémie Lemarié (Réanimation, Nancy) for having searched for eligible patients.

Competing interests

The authors declare that they have no competing interests.

Ethics approval and consent to participate

The study was approved by Institutional Review Board of the French Society for Respiratory Medicine in September 2017 (CEPRO 2017-32), which waived informed consent.


This study did not receive funding from external or internal sources.

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Correspondence to Damien Contou.

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Vuillard, C., Pineton de Chambrun, M., de Prost, N. et al. Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study. Ann. Intensive Care 8, 87 (2018).

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