Table 1 Baseline characteristics of patients
Patients characteristics | All patients (n = 56) | Patients with | p | |
|---|---|---|---|---|
Favourable outcome | Complicated outcome | |||
(n = 42) | (n = 14) | |||
Demographic data, median [IQR] | ||||
Sex ratio (M/F) | 22/34 | 17/25 | 5/9 | 0.75 |
Age (years) | 26.4 [21.7–29.8] | 27.4 [22.3–31.5] | 22.1 [20.7–26.8] | 0.06 |
BMI (kg/m2) | 21.3 [19.8–23.6] | 21.7 [19.8–23.4] | 20.8 [20.2–24.7] | 0.78 |
Cause of hospital admission, % (n) | ||||
Vaso-occlusive crisis | 48% (27) | 52% (32) | 43% (6) | 0.34 |
Acute chest syndrome | 46% (26) | 45% (19) | 50% (7) | |
Others | 6% (3) | 2% (1) | 7% (1) | |
Type of hemoglobinopathy, % (n) | ||||
SS | 93% (52) | 90% (38) | 100% (14) | 0.23 |
SC | 7% (4) | 10% (4) | – | |
Baseline Hb (g/dL), median [IQR] | 8.5 [7.5–9.5] | 8.7 [7.8–9.5] | 7.5 [7–9] | 0.08 |
Number of vaso-occlusive crises/year, % (n) | ||||
0 | 7% (4) | 5% (2) | 14% (2) | 0.47 |
1–3 | 70% (39) | 74% (31) | 57% (8) | |
4–6 | 21% (12) | 19% (8) | 29% (4) | |
> 6 | 2% (1) | 2% (1) | 0% (0) | |
Sickle cell disease-related complication, % (n) | ||||
Previous acute chest syndrome | 73% (41) | 74% (31) | 71% (10) | 0.86 |
1–2 | 34% (19) | 31% (13) | 43% (6) | 0.55 |
3–4 | 25% (14) | 26% (11) | 21% (3) | |
> 4 | 14% (8) | 17% (7) | 7% (1) | |
Cholecystectomy | 35% (19) | 26% (11) | 57% (8) | 0.03 |
Non-septic osteonecrosis | 24% (14) | 24% (10) | 29% (4) | 0.72 |
Renal injury | 22% (12) | 26% (11) | 7% (1) | 0.13 |
Retinopathy | 20% (12) | 21% (9) | 21% (3) | 1.00 |
Priapism | 7% (4) | 10% (4) | 0% (0) | 0.23 |
Others | 15% (8) | 14% (6) | 14% (2) | 1.00 |
Clinical severity score of Hebbel, median [IQR] | 6 [3–9] | 6 [3–9] | 5.5 [3–8] | 0.97 |