Skip to main content

Commentary to “Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review”

Main text

We have read with interest the manuscript from Honore et al. in Annals of Intensive Care about the dose adjustments of vitamin C in critically patients undergoing renal replacement therapy [1]. After a detailed review, we would like to highlight an inaccurate literature review performed in this study that may raise uncertainty in the conclusions of Honore and colleagues.

The authors included in their study the Wu et al.’s case report of a patient with hemolytic jaundice induced by pharmacological dose of ascorbic acid in glucose-6-phosphate dehydrogenase (G6PD) deficiency [2]. This manuscript is used in Honore et al. narrative review discussion to support an important conclusion related to the dose of up to 6 g/day (vitamin C) is not contraindicated in patients with G6PD deficiency [2]. However, the study from Wu et al. was retracted from Medicine (Baltimore) journal in 2019 (online: 2019 November 27) [3], because the accuracy or validity of the results is questionable and does not support the hypothesis, making the Wu et al.’s manuscript factually incorrect and inadequate to support Honore et al.’s previous conclusion.

The authors searched for studies and used studies published in 2020, like Fujii et al.’s study [4], so the retraction note, published online in 2019 November [3], should be observed.

We conclude that the exclusion of Wu et al.’s study does not probably affect the overall conclusions of Honore et al.’s study, but it affects directly the particular conclusion exposed previously because Wu et al.’s study failed to provide valid scientific evidence.

We recommend to exclude it, but a good and accurate literature review is a key element in high-quality original studies.

Availability of data and materials

Not applicable.

Abbreviations

G6PD:

Glucose-6-phosphate dehydrogenase

References

  1. 1.

    Honore PM, Spapen HD, Marik P, Boer W, Oudemans-van Straaten H. Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review. Ann Intensive Care. 2020;10:23. https://doi.org/10.1186/s13613-020-0640-6.

    Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Wu S, Wu G, Wu H. Hemolytic jaundice induced by pharmacological dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency: a case report. Medicine (Baltimore). 2018;97(51):e13588. https://doi.org/10.1097/md.0000000000013588.

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Wu S, Wu G, Wu H. Hemolytic jaundice induced by pharmacological dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency: a case report: retraction. Medicine (Baltimore). 2019;98(48):e18261. https://doi.org/10.1097/MD.0000000000018261.

    Article  Google Scholar 

  4. 4.

    Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, et al. Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the vitamins randomized clinical trial. JAMA. 2020. https://doi.org/10.1001/jama.2019.22176.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

Not applicable.

Funding

This research received no external funding.

Author information

Affiliations

Authors

Contributions

JMM and IHP has equally contributed in study’s conceptualization, methodology, analysis and writing. Both authors read and approved the final manuscript.

Corresponding author

Correspondence to I. Herrera-Peco.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare no competing interest or any conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Morán, J.M., Herrera-Peco, I. Commentary to “Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review”. Ann. Intensive Care 10, 87 (2020). https://doi.org/10.1186/s13613-020-00710-7

Download citation