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Table 3 Blood gas parameters prior to and immediately after the first ADVOS treatment

From: Advanced organ support (ADVOS) in the critically ill: first clinical experience in patients with multiple organ failure

  All (n = 34) ARDS (n = 10) Severe metabolic acidosis (n = 11)
Before After Before After Before After
Blood gas       
Blood pH 7.29 (7.19, 7.35) 7.40 (7.32, 7.46)** 7.21 (7.11, 7.29) 7.40 (7.33, 7.48)** 7.19 (7.09, 7.19) 7.40 (7.33, 7.45)**
HCO3 (mmol/l) 19.0 (17.5, 23.1) 22.8 (20.0, 27.4)** 24.1 (18.6, 26.7) 32.5 (28.1, 39.6)** 15.4 (13.8, 16.8) 20.4 (18.0, 24.3)**
PaCO2 (mmHg) 40.6 (32.9, 60.8) 36.8 (31.6, 43.6)** 68.8 (58.4, 73.2) 49.5 (42.3, 56.1)** 37.5 (31.0, 42.9) 36.8 (32.5, 40.6)
PaO2 (mmHg) 81.1 (65.9, 97.8) 78.6 (73.4, 93.2) 73.0 (65.0, 83.3) 84.7 (74.8, 96.9) 88.4 (61.5, 108.2) 77.6 (65.1, 84.2)
Base excess (mmol/l) − 6.7 (− 9.3, − 1.6) − 1.5 (− 6.6, 3.1)** − 0.4 (− 7.0, 2.8) 7.8 (1.6, 15.5)** − 12.4 (− 14.9, − 10.5) − 4.9 (− 8.5, 0.9)**
Lactate (mmol/l) 2.20 (1.15, 9.40) 2.50 (1.50, 8.15) 1.90 (0.85, 3.45) 1.95 (1.75, 2.55) 9.60 (5.85, 12.60) 7.40 (5.10, 10.15)
SID (mEq/l) 31.4 (27.2, 35.4) 32.8 (27.5, 39.0) 38.7 (31.2, 40.7) 41.5 (33.4, 47.2) 23.2 (21.3, 25.7) 28.2 (24.6, 34.3)**
  1. Apart from the summary of all treatment sessions, Table 3 illustrates the blood gas parameters of two subgroups (i.e., patients with ARDS and patients with severe metabolic acidosis immediately prior to ADVOS. Median (IQ25, IQ75). Non-parametric paired Wilcoxon test. *p < 0.05, **p < 0.01