Patients
|
387
|
143
| |
Demographics
|
Age, years, median [IQR]
|
62 [49, 72]
|
64 [51, 73]
|
.47
|
Gender male, n (%)
|
252 (65.1)
|
83 (58.0)
|
.26
|
White race, n (%)
|
344 (88.9)
|
123 (86.0)
|
.45
|
Readmissiona, n (%)
|
11 (2.8)
|
3 (2.1)
|
.87
|
Chronic comorbidity, n (%)
|
None
|
110 (28.4)
|
35 (24.5)
|
.43
|
Immunocompromised state
|
82 (21.2)
|
50 (35.0)
|
.002
|
Cardiovascular insufficiency
|
110 (28.4)
|
32 (22.4)
|
.20
|
Malignancy
|
52 (13.4)
|
33 (23.1)
|
.011
|
Renal insufficiency
|
41 (10.6)
|
19 (13.3)
|
.48
|
Respiratory insufficiency
|
114 (29.5)
|
35 (24.5)
|
.31
|
COPD
|
82 (21.2)
|
26 (18.2)
|
.52
|
Diabetes mellitus
|
86 (22.2)
|
24 (16.8)
|
.21
|
Charlson comorbidity index
|
4 [2, 6]
|
4 [3, 6]
|
.18
|
Vital signs on admission, median [IQR]
|
Temperature
|
38 [37, 38]
|
38 [37, 39]
|
.14
|
PaO2/FiO2 ratio
|
114 [57, 477]
|
102 [50, 351]
|
.21
|
PEEP during first 24 h, cm H2O
|
24 [7, 25]
|
24 [6, 24]
|
.47
|
Severity of disease on ICU admission
|
APACHE IV Score, median [IQR]
|
75 [59, 98]
|
75 [60, 92]
|
.75
|
SOFA total, median [IQR]
|
6 [4, 8]
|
6 [4, 8]
|
.69
|
Mechanical ventilation, n (%)
|
303 (78.3)
|
101 (70.6)
|
.08
|
Shock, n (%)
|
179 (46.6)
|
48 (33.6)
|
.010
|
Acute kidney injury, n (%)
|
121 (31.3)
|
36 (25.2)
|
.21
|
Acute respiratory distress syndrome, n (%)
|
95 (24.5)
|
36 (25.2)
|
.97
|
Acute myocardial infarction, n (%)
|
14 (3.6)
|
3 (2.1)
|
.55
|
Causative pathogens
| | |
.08
|
Gram-positive bacteria
|
68 (17.6)
|
17 (11.9)
| |
Gram-negative bacteria
|
57 (14.7)
|
24 (16.8)
| |
Atypical bacteria
|
1 (0.3)
|
1 (0.7)
| |
Virus
|
16 (4.1)
|
12 (8.4)
| |
Fungi
|
11 (2.8)
|
10 (7.0)
| |
Other pathogens
|
1 (0.3)
|
1 (0.7)
| |
Multiple pathogens
|
42 (10.9)
|
11 (7.7)
| |
Unknown
|
191 (49.4)
|
67 (46.9)
| |
Outcome
|
Length of ICU stay, days, median [IQR]
|
5 [3, 9]
|
5 [2, 9]
|
.79
|
Length of hospital stay, days, median [IQR]
|
12 [16, 24]
|
14 [7, 24]
|
.21
|
MV characteristics
|
Duration of initial MV, days, median [IQR]
|
2 [1, 6]
|
2 [1, 6]
|
.34
|
Recurrence of MV, n (%)
|
10 (2.6)
|
10 (7.0)
|
.035
|
MV-free daysb, median [IQR]
|
22 [5, 26]
|
21 [5, 25]
|
.39
|
ICU-acquired complications, n (%)
|
None
|
327 (84.5)
|
122 (85.3)
|
.92
|
Acute kidney injury
|
35 (9.0)
|
11 (7.7)
|
.75
|
Acute respiratory distress syndrome
|
22 (5.7)
|
7 (4.9)
|
.89
|
Infection
|
25 (6.5)
|
11 (7.7)
|
.76
|
Mortalityc, n (%)
|
ICU
|
71 (18.9)
|
27 (19.3)
|
> .99
|
Hospital
|
101 (26.9)
|
46 (32.9)
|
.22
|
30 days
|
107 (28.5)
|
44 (31.4)
|
.58
|
60 days
|
123 (32.7)
|
53 (37.9)
|
.32
|
90 days
|
129 (34.3)
|
61 (43.6)
|
.07
|
1 year
|
158 (42.0)
|
71 (50.7)
|
.10
|