Long-term outcomes in patients who received veno-venous extracorporeal membrane oxygenation and renal replacement therapy: a retrospective cohort study

Annals of Intensive Care

Table 3 Primary and secondary outcomes at 1 year by acute kidney injury and renal replacement therapy status

Characteristic^a	Overall N = 300	AKI, RRT N = 178	AKI, no RRT N = 52	No AKI N = 70	P-value^b (AKI, no RRT vs. no AKI)	P-value^b (AKI, RRT vs. no AKI)
1-year mortality (%)	79 (26.3%) 95% CI 21.4–31.7%	57 (32.0%) 95% CI 25.2–39.4%	7 (13.5%) 95% CI 5.6–25.8%	15 (21.4%) 95% CI 12.5–32.9%	0.241	0.014
(Survivors)	221	121	45	55	–	–
30-day mortality (%)	54 (18.0%) 95% CI 13.8–22.8%	41 (23.0%) 95% CI 17.1–29.9%	6 (11.5%) 95% CI 4.4–23.4%	7 (10.0%) 95% CI 4.1–19.5%	0.974	0.003
End-stage kidney disease (% among survivors)	3 (1.4%) 95% CI 0.3–3.9%	3 (2.5%) 95% CI 0.5–7.1%	0 (0.0%) 95% CI 0.0–7.9%	0 (0.0%) 95% CI 0.0–6.5%	NA	0.561
Mean (SD) serum creatinine in µmol/L^c
6 months	85.6 (40.9)	90.8 (49.3)	86.6 (16.9)	72.4 (19.9)	0.060	0.161
1 year	89.4 (53.6)	99.4 (69.3)	81.0 (18.5)	74.7 (15.7)	0.368	0.123
1 year, or 6 months if unavailable	89.7 (51.7)	98.4 (64.0)	85.3 (18.5)	71.8 (16.6)	0.033	0.026
Chronic kidney disease at 1 year (% among survivors with SCr available)^d	19 (20.9%) 95% CI 13.1–30.7%	18 (33.3%) 95% CI 21.1–47.5%	0 (0.0%) 95% CI 0.0–23.2%	1 (4.3%) 95% CI 0.1–21.9%	> 0.999	0.004

AKI acute kidney injury, ICU intensive care unit, RRT renal replacement therapy, SCr serum creatinine, NA not available
^aStatistics presented: n (%)
^bP-values are from a Cox proportional hazard model with AKI-RRT status as a time-dependent covariate for mortality outcomes, and Fisher’s exact test for ESKD and CKD outcomes
^cAvailable in 80 patients at 6 months, 65 patients at 12 months and 91 patients at either 6 or 12 months
^dAmong 91 patients with a 6 or 12 month SCr measurement