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Table 3 Primary and secondary outcomes at 1 year by acute kidney injury and renal replacement therapy status

From: Long-term outcomes in patients who received veno-venous extracorporeal membrane oxygenation and renal replacement therapy: a retrospective cohort study

Characteristica Overall
N = 300
AKI, RRT
N = 178
AKI, no RRT
N = 52
No AKI
N = 70
P-valueb (AKI, no RRT vs. no AKI) P-valueb (AKI, RRT vs. no AKI)
1-year mortality (%) 79 (26.3%)
95% CI 21.4–31.7%
57 (32.0%)
95% CI 25.2–39.4%
7 (13.5%)
95% CI 5.6–25.8%
15 (21.4%)
95% CI 12.5–32.9%
0.241 0.014
(Survivors) 221 121 45 55
30-day mortality (%) 54 (18.0%)
95% CI 13.8–22.8%
41 (23.0%)
95% CI 17.1–29.9%
6 (11.5%)
95% CI 4.4–23.4%
7 (10.0%)
95% CI 4.1–19.5%
0.974 0.003
End-stage kidney disease (% among survivors) 3 (1.4%)
95% CI 0.3–3.9%
3 (2.5%)
95% CI 0.5–7.1%
0 (0.0%)
95% CI 0.0–7.9%
0 (0.0%)
95% CI 0.0–6.5%
NA 0.561
Mean (SD) serum creatinine in µmol/Lc
 6 months 85.6 (40.9) 90.8 (49.3) 86.6 (16.9) 72.4 (19.9) 0.060 0.161
 1 year 89.4 (53.6) 99.4 (69.3) 81.0 (18.5) 74.7 (15.7) 0.368 0.123
 1 year, or 6 months if unavailable 89.7 (51.7) 98.4 (64.0) 85.3 (18.5) 71.8 (16.6) 0.033 0.026
Chronic kidney disease at 1 year (% among survivors with SCr available)d 19 (20.9%)
95% CI 13.1–30.7%
18 (33.3%)
95% CI 21.1–47.5%
0 (0.0%)
95% CI 0.0–23.2%
1 (4.3%)
95% CI 0.1–21.9%
> 0.999 0.004
  1. AKI acute kidney injury, ICU intensive care unit, RRT renal replacement therapy, SCr serum creatinine, NA not available
  2. aStatistics presented: n (%)
  3. bP-values are from a Cox proportional hazard model with AKI-RRT status as a time-dependent covariate for mortality outcomes, and Fisher’s exact test for ESKD and CKD outcomes
  4. cAvailable in 80 patients at 6 months, 65 patients at 12 months and 91 patients at either 6 or 12 months
  5. dAmong 91 patients with a 6 or 12 month SCr measurement