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Table 4 Unadjusted and adjusted hazard ratios of the association between clinical characteristics and 1-year mortality

From: Long-term outcomes in patients who received veno-venous extracorporeal membrane oxygenation and renal replacement therapy: a retrospective cohort study

Characteristic Univariate analysis Multivariable modela
Hazard ratio 95% CI P-value Adjusted hazard ratio 95% CI P-value
AKI/RRT group
 No AKI 1 (reference) 1 (reference)
 AKI without RRT 0.57 0.22, 1.46 0.241
 AKI with RRT 2.01 1.15, 3.51 0.014 1.80 1.06, 3.06 0.029
Age (per 5 years) 1.10 1.01, 1.19 0.022 1.06 0.98, 1.15 0.171
Female sex 1.00 0.64, 1.56 0.988    
BMI (per kg/m2) 0.98 0.95, 1.02 0.335    
Chronic liver disease 3.71 1.61, 8.55 0.002 4.36 1.83, 10.4 < 0.001
Malignancy 5.98 3.15, 11.4 < 0.001 7.68 3.95, 14.9 < 0.001
SOFA score on admission 1.08 1.02, 1.14 0.009*    
Diabetes 1.41 0.78, 2.56 0.253    
Hypertension 1.28 0.74, 2.21 0.384    
Congestive heart failure 0.41 0.06, 2.92 0.371    
CKD 0.50 0.07, 3.56 0.485    
Coronary artery disease 1.42 0.45, 4.50 0.551    
Atrial fibrillation 1.90 0.47,7.73 0.371    
Cerebrovascular accidents 1.23 0.30, 5.02 0.770    
Chronic lung disease 0.71 0.40, 1.25 0.232    
Infectious vs. non-infectious aetiology 0.85 0.53, 1.37 0.503 0.62 0.38, 1.01 0.054
Baseline serum albumin on admission (per 10 g/L) 0.57 0.35, 0.91 0.018 0.55 0.32, 0.95 0.031
  1. RRT renal replacement therapy, BMI body mass index, SOFA Sequential Organ Failure Assessment, CKD chronic kidney disease, ECMO extracorporeal membrane oxygenation, HR hazard ratio, CI confidence interval
  2. *SOFA score not selected for multivariable analysis due to the collinearity with RRT status
  3. aMultivariable model includes RRT status (as a time-dependent covariate), age, chronic liver disease, malignancy, infectious vs. non-infectious aetiology and baseline serum albumin