Articles

High-flow oxygen therapy in tracheostomized patients at high risk of weaning failure

High-flow oxygen therapy delivered through nasal cannulae improves oxygenation and decreases work of breathing in critically ill patients. Little is known of the physiological effects of high-flow oxygen thera...

Authors: Tania Stripoli, Savino Spadaro, Rosa Di mussi, Carlo Alberto Volta, Paolo Trerotoli, Francesca De Carlo, Rachele Iannuzziello, Fabio Sechi, Paola Pierucci, Francesco Staffieri, Francesco Bruno, Luigi Camporota and Salvatore Grasso

Low-flow CO₂ removal in combination with renal replacement therapy effectively reduces ventilation requirements in hypercapnic patients: a pilot study

Lung-protective strategies are the cornerstone of mechanical ventilation in critically ill patients with both ARDS and other disorders. Extracorporeal CO₂ removal (ECCO₂R) may enhance lung protection by allowing ...

Authors: Jens Nentwich, Dominic Wichmann, Stefan Kluge, Simone Lindau, Haitham Mutlak and Stefan John

Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study

Although outcomes of critically ill patients with haematological malignancies (HMs) have been fully investigated in terms of organ failure and mortality, data are scarce on health-related quality of life (HRQO...

Authors: Franck Ehooman, Lucie Biard, Virginie Lemiale, Damien Contou, Nicolas de Prost, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, Alexandre Demoule, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez…

Driving pressure during proportional assist ventilation: an observational study

During passive mechanical ventilation, the driving pressure of the respiratory system is an important mediator of ventilator-induced lung injury. Monitoring of driving pressure during assisted ventilation, sim...

Authors: Katerina Vaporidi, Charalambos Psarologakis, Athanasia Proklou, Emmanouil Pediaditis, Evangelia Akoumianaki, Elisavet Koutsiana, Achilleas Chytas, Ioanna Chouvarda, Eumorfia Kondili and Dimitris Georgopoulos

Ischemic and hemorrhagic brain injury during venoarterial-extracorporeal membrane oxygenation

Structural neurological complications (ischemic stroke and intracranial bleeding) and their risk factors in patients receiving venoarterial-extracorporeal membrane oxygenation (VA-ECMO) are poorly described. O...

Authors: Loïc Le Guennec, Clémentine Cholet, Florent Huang, Matthieu Schmidt, Nicolas Bréchot, Guillaume Hékimian, Sébastien Besset, Guillaume Lebreton, Ania Nieszkowska, Pascal Leprince, Alain Combes and Charles-Edouard Luyt

Nasal high-flow bronchodilator nebulization: a randomized cross-over study

There is an absence of controlled clinical data showing bronchodilation effectiveness after nebulization via nasal high-flow therapy circuits.

Authors: François Reminiac, Laurent Vecellio, Laetitia Bodet-Contentin, Valérie Gissot, Deborah Le Pennec, Charlotte Salmon Gandonnière, Maria Cabrera, Pierre-François Dequin, Laurent Plantier and Stephan Ehrmann

ICU survival and need of renal replacement therapy with respect to AKI duration in critically ill patients

Transient and persistent acute kidney injury (AKI) could share similar physiopathological mechanisms. The objective of our study was to assess prognostic impact of AKI duration on ICU mortality.

Authors: A. S. Truche, S. Perinel Ragey, B. Souweine, S. Bailly, L. Zafrani, L. Bouadma, C. Clec’h, M. Garrouste-Orgeas, G. Lacave, C. Schwebel, F. Guebre-Egziabher, C. Adrie, A. S. Dumenil, Ph. Zaoui, L. Argaud, S. Jamali…

Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study

The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact o...

Authors: Laurent Poiroux, Lise Piquilloud, Valérie Seegers, Cyril Le Roy, Karine Colonval, Carole Agasse, Vanessa Zinzoni, Vanessa Hodebert, Alexandre Cambonie, Josselin Saletes, Irma Bourgeon, François Beloncle and Alain Mercat

Lung ultrasound estimation of pleural effusion fluid and the importance of patient position

Authors: Luigi Vetrugno and Tiziana Bove

Impact of individualized target mean arterial pressure for septic shock resuscitation on the incidence of acute kidney injury: a retrospective cohort study

To examine the relationship between delta mean arterial pressure (ΔMAP; MAP change between pre-admission minus post-resuscitation) and acute kidney injury (AKI) among patients with septic shock. In this retros...

Authors: Rajat N. Moman, Stuart A. Ostby, Abbasali Akhoundi, Rahul Kashyap and Kianoush Kashani

Proportional modes versus pressure support ventilation: a systematic review and meta-analysis

Proportional modes (proportional assist ventilation, PAV, and neurally adjusted ventilatory assist, NAVA) could improve patient–ventilator interaction and consequently may be efficient as a weaning mode. The p...

Authors: Jun Kataoka, Akira Kuriyama, Yasuhiro Norisue and Shigeki Fujitani

Effects of the timing of administration of IgM- and IgA-enriched intravenous polyclonal immunoglobulins on the outcome of septic shock patients

The administration of endovenous immunoglobulins in patients with septic shock could be beneficial and preparations enriched with IgA and IgM (ivIgGAM) seem to be more effective than those containing only IgG....

Authors: Giorgio Berlot, Michele Claudio Vassallo, Nicola Busetto, Margarita Nieto Yabar, Tatiana Istrati, Silvia Baronio, Giada Quarantotto, Mattia Bixio, Giulia Barbati, Roberto Dattola, Irene Longo, Antonino Chillemi, Alice Scamperle, Fulvio Iscra and Ariella Tomasini

Impact of hemoperfusion with polymyxin B added to hemofiltration in patients with endotoxic shock: a case–control study

Septic shock is a leading cause of death in critical patients. In patients with gram-negative septic shock, hemoperfusion with polymyxin B aims to remove endotoxins from plasma. We analyzed the clinical and bi...

Authors: Ana Navas, Ricard Ferrer, Maria Luisa Martínez, Gemma Gomà, Gisela Gili, Jordi Masip, David Suárez and Antonio Artigas

Hemodynamic effects of extended prone position sessions in ARDS

Hemodynamic response to prone position (PP) has never been studied in a large series of patients with acute respiratory distress syndrome (ARDS). The primary aim of this study was to estimate the rate of PP se...

Authors: Martin Ruste, Laurent Bitker, Hodane Yonis, Zakaria Riad, Aurore Louf-Durier, Floriane Lissonde, Sophie Perinel-Ragey, Claude Guerin and Jean-Christophe Richard

Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) patients may present impaired in lung function and structure after hospital discharge that may be related to mechanical ventilation strategy. The aim of this study wa...

Authors: Carlos Toufen Junior, Roberta R. De Santis Santiago, Adriana S. Hirota, Alysson Roncally S. Carvalho, Susimeire Gomes, Marcelo Brito Passos Amato and Carlos Roberto Ribeiro Carvalho

Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study

Septic shock has been found to disrupt circadian rhythms. Moreover, timing of onset has been associated with different circadian profiles in experimental studies.

Authors: Eleni N. Sertaridou, Ioanna G. Chouvarda, Konstantinos I. Arvanitidis, Eirini K. Filidou, George C. Kolios, Ioannis N. Pnevmatikos and Vasilios E. Papaioannou

Evaluation of emotional excitation during standardized endotracheal intubation in simulated conditions

To assess how stressful conditions in endotracheal intubation could induct emotional excitation in a population of acute care physicians.

Authors: Nicolas S. Marjanovic, Christelle Teiten, Nicola Pallamin and Erwan L’Her

Defending a mean arterial pressure in the intensive care unit: Are we there yet?

Authors: Ashish K. Khanna

Validation of a new WIND classification compared to ICC classification for weaning outcome

Although the WIND (Weaning according to a New Definition) classification based on duration of ventilation after the first separation attempt has been proposed, this new classification has not been tested in cl...

Authors: Byeong-Ho Jeong, Kyeong Yoon Lee, Jimyoung Nam, Myeong Gyun Ko, Soo Jin Na, Gee Young Suh and Kyeongman Jeon

Caring for the critically ill patients over 80: a narrative review

There is currently no international recommendation for the admission or treatment of the critically ill older patients over 80 years of age in the intensive care unit (ICU), and there is no valid prognostic se...

Authors: Bertrand Guidet, Helene Vallet, Jacques Boddaert, Dylan W. de Lange, Alessandro Morandi, Guillaume Leblanc, Antonio Artigas and Hans Flaatten

Sustained low efficiency dialysis should not be interrupted for performing transpulmonary thermodilution measurements

Treatment of multiple organ failure frequently requires enhanced hemodynamic monitoring. When renal replacement is indicated, it remains unclear whether transpulmonary thermodilution (TPTD) measurements are in...

Authors: Stefanie Geith, Lynne Stecher, Christian Rabe, Stefan Sack and Florian Eyer

Development and performance of a novel vasopressor-driven mortality prediction model in septic shock

Vasoactive medications are essential in septic shock, but are not fully incorporated into current mortality prediction risk scores. We sought to develop a novel mortality prediction model for septic shock inco...

Authors: Saraschandra Vallabhajosyula, Jacob C. Jentzer, Aditya A. Kotecha, Dennis H. Murphree Jr., Erin F. Barreto, Ashish K. Khanna and Vivek N. Iyer

Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis

Sepsis is associated with a deflection of inflammatory and coagulative parameters, since some clotting factors are known to be involved in the host’s defense against infection and inflammation. These parameter...

Authors: Christian Niederwanger, Mirjam Bachler, Tobias Hell, Caroline Linhart, Andreas Entenmann, Agnes Balog, Katharina Auer and Petra Innerhofer

Lung aeration and ventilation after percutaneous tracheotomy measured by electrical impedance tomography in non-hypoxemic critically ill patients: a prospective observational study

Percutaneous dilatational tracheotomy (PDT) may lead to transient impairment of pulmonary function due to suboptimal ventilation, loss of positive end-expiratory pressure (PEEP) and repetitive suction maneuver...

Authors: Lars Eichler, Jakob Mueller, Jörn Grensemann, Inez Frerichs, Christian Zöllner and Stefan Kluge

Artificial liver support systems: what is new over the last decade?

The liver is a complex organ that performs vital functions of synthesis, heat production, detoxification and regulation; its failure carries a highly critical risk. At the end of the last century, some artific...

Authors: Juan José García Martínez and Karim Bendjelid

ICU physicians’ and internists’ survival predictions for patients evaluated for admission to the intensive care unit

A higher chance of survival is a key justification for admission to the intensive care unit (ICU). This implies that physicians should be able to accurately estimate a patient’s prognosis, whether cared for on...

Authors: Monica Escher, Bara Ricou, Mathieu Nendaz, Fabienne Scherer, Stéphane Cullati, Patricia Hudelson and Thomas Perneger

Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database

Maintenance of mean arterial pressure (MAP) at levels sufficient to avoid tissue hypoperfusion is a key tenet in the management of distributive shock. We hypothesized that patients with distributive shock some...

Authors: Jean-Louis Vincent, Nathan D. Nielsen, Nathan I. Shapiro, Margaret E. Gerbasi, Aaron Grossman, Robin Doroff, Feng Zeng, Paul J. Young and James A. Russell

Correction to: Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care

In the original article [1], the authors noticed a typographical error in Figure 2. The top left box should have included “E/A <0.8 and E <50 cm/s”. Please see below the corrected figure.

Authors: F. Sanfilippo, S. Scolletta, A. Morelli and A. Vieillard-Baron

A multinational survey on the infrastructural quality of paediatric intensive care units

The aim of the present study was to assess whether paediatric intensive care units (PICUs) in three central European countries comply with guidelines concerning infrastructure provided by the European Society ...

Authors: Gert Warncke, Florian Hoffmann, Michael Sasse, Georg Singer, Istvan Szilagyi, Holger Till and Christoph Castellani

Brief summary of French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU

The French Society of Anaesthesia and Intensive Care Medicine and the French Society of Intensive Care edited guidelines focused on hospital-acquired pneumonia (HAP) in intensive care unit. The goal of 16 Fren...

Authors: Marc Leone, Lila Bouadma, Bélaïd Bouhemad, Olivier Brissaud, Stéphane Dauger, Sébastien Gibot, Sami Hraiech, Boris Jung, Eric Kipnis, Yoann Launey, Charles-Edouard Luyt, Dimitri Margetis, Fabrice Michel, Djamel Mokart, Philippe Montravers, Antoine Monsel…

Pleural effusion during weaning from mechanical ventilation: a prospective observational multicenter study

Pleural effusion is common during invasive mechanical ventilation, but its role during weaning is unclear. We aimed at assessing the prevalence and risk factors for pleural effusion at initiation of weaning. W...

Authors: Keyvan Razazi, Florence Boissier, Mathilde Neuville, Sébastien Jochmans, Martial Tchir, Faten May, Nicolas de Prost, Christian Brun-Buisson, Guillaume Carteaux and Armand Mekontso Dessap

Hemodynamic support in the early phase of septic shock: a review of challenges and unanswered questions

Improving sepsis support is one of the three pillars of a 2017 resolution according to the World Health Organization (WHO). Septic shock is indeed a burden issue in the intensive care units. Hemodynamic stabil...

Authors: Olivier Lesur, Eugénie Delile, Pierre Asfar and Peter Radermacher

Fluoroscopy-guided simultaneous distal perfusion as a preventive strategy of limb ischemia in patients undergoing extracorporeal membrane oxygenation

Limited data are available regarding prevention of limb ischemia in femorally cannulated patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO). We investigated the association between strategy...

Authors: Woo Jin Jang, Yang Hyun Cho, Taek Kyu Park, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Eun-Seok Jeon, Woo Jung Chun, Ju Hyeon Oh and Jeong Hoon Yang

Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care

There is growing evidence both in the perioperative period and in the field of intensive care (ICU) on the association between left ventricular diastolic dysfunction (LVDD) and worse outcomes in patients. The ...

Authors: F. Sanfilippo, S. Scolletta, A. Morelli and A. Vieillard-Baron

Albumin infusion in spontaneous bacterial peritonitis: another brick off the wall?

Authors: Damien Roux, Richard Moreau and Didier Dreyfuss

When timing and dose of nutrition support were examined, the modified Nutrition Risk in Critically Ill (mNUTRIC) score did not differentiate high-risk patients who would derive the most benefit from nutrition support: a prospective cohort study

The timing and dose of exclusive nutrition support (ENS) have not been investigated in previous studies aimed at validating the modified Nutrition Risk in Critically Ill (mNUTRIC) score. We therefore evaluated...

Authors: Charles Chin Han Lew, Gabriel Jun Yung Wong, Ka Po Cheung, Robert J. L. Fraser, Ai Ping Chua, Mary Foong Fong Chong and Michelle Miller

Estimation of sodium and chloride storage in critically ill patients: a balance study

Nonosmotic sodium storage has been reported in animals, healthy individuals and patients with hypertension, hyperaldosteronism and end-stage kidney disease. Sodium storage has not been studied in ICU patients,...

Authors: Lara Hessels, Annemieke Oude Lansink-Hartgring, Miriam Zeillemaker-Hoekstra and Maarten W. Nijsten

Beneficial effects of antioxidant therapy in crush syndrome in a rodent model: enough evidences to be used in humans?

Authors: Patrick M. Honore, David De Bels and Herbert D. Spapen

Perioperative statin therapy in cardiac and non-cardiac surgery: a systematic review and meta-analysis of randomized controlled trials

The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association between perioperative statin therapy and postoperative...

Authors: Alessandro Putzu, Carolina Maria Pinto Domingues de Carvalho e Silva, Juliano Pinheiro de Almeida, Alessandro Belletti, Tiziano Cassina, Giovanni Landoni and Ludhmila Abrahao Hajjar

Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning

Patients with influenza complicated with pneumonia are at high risk of rapid progression to acute respiratory distress syndrome (ARDS). Prone positioning with longer duration and lung-protective strategies mig...

Authors: Kuo-Chin Kao, Ko-Wei Chang, Ming-Cheng Chan, Shinn-Jye Liang, Ying-Chun Chien, Han-Chung Hu, Li-Chung Chiu, Wei-Chih Chen, Wen-Feng Fang, Yu-Mu Chen, Chau-Chyun Sheu, Ming-Ju Tsai, Wann-Cherng Perng, Chung-Kan Peng, Chieh-Liang Wu, Hao-Chien Wang…

Impact of oversedation prevention in ventilated critically ill patients: a randomized trial—the AWARE study

Although oversedation has been associated with increased morbidity in ventilated critically ill patients, it is unclear whether prevention of oversedation improves mortality. We aimed to assess 90-day mortali...

Authors:

Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis

To determine the preventive and therapeutic effect of dexmedetomidine on intensive care unit (ICU) delirium.

Authors: Julian Flükiger, Alexa Hollinger, Benjamin Speich, Vera Meier, Janna Tontsch, Tatjana Zehnder and Martin Siegemund

Renal failure in critically ill patients, beware of applying (central venous) pressure on the kidney

The central venous pressure (CVP) is traditionally used as a surrogate of intravascular volume. CVP measurements therefore are often applied at the bedside to guide fluid administration in postoperative and cr...

Authors: Xiukai Chen, Xiaoting Wang, Patrick M. Honore, Herbert D. Spapen and Dawei Liu

Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial

Criteria for the Sepsis-3 definition of septic shock include vasopressor treatment to maintain a mean arterial pressure > 65 mmHg and a lactate concentration > 2 mmol/L. The impact of hyperoxia in patients wit...

Authors: Julien Demiselle, Martin Wepler, Clair Hartmann, Peter Radermacher, Frédérique Schortgen, Ferhat Meziani, Mervyn Singer, Valérie Seegers and Pierre Asfar

Performance of closed-loop resuscitation of haemorrhagic shock with fluid alone or in combination with norepinephrine: an experimental study

Closed-loop resuscitation can improve personalization of care, decrease workload and bring expert knowledge in isolated areas. We have developed a new device to control the administration of fluid or simultane...

Authors: Nicolas Libert, Guillaume Chenegros, Anatole Harrois, Nathalie Baudry, Gilles Cordurie, Ryad Benosman, Eric Vicaut and Jacques Duranteau

Streptococcal toxic shock syndrome in the intensive care unit

The streptococcal toxic shock syndrome is a severe complication associated with invasive infections by group A streptococci. In spite of medical progresses in the care of patients with septic shock during the ...

Authors: Marylin Schmitz, Xavier Roux, Benedikt Huttner and Jérôme Pugin

Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study

Anti-synthetase (AS) and dermato-pulmonary associated with anti-MDA-5 antibodies (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies potentially responsible for severe acute interst...

Authors: Constance Vuillard, Marc Pineton de Chambrun, Nicolas de Prost, Claude Guérin, Matthieu Schmidt, Auguste Dargent, Jean-Pierre Quenot, Sébastien Préau, Geoffrey Ledoux, Mathilde Neuville, Guillaume Voiriot, Muriel Fartoukh, Rémi Coudroy, Guillaume Dumas, Eric Maury, Nicolas Terzi…

Effects of positive end-expiratory pressure strategy in supine and prone position on lung and chest wall mechanics in acute respiratory distress syndrome

In acute respiratory distress syndrome (ARDS) patients, it has recently been proposed to set positive end-expiratory pressure (PEEP) by targeting end-expiratory transpulmonary pressure. This approach, which re...

Authors: Mehdi Mezidi, Francisco José Parrilla, Hodane Yonis, Zakaria Riad, Stephan H. Böhm, Andreas D. Waldmann, Jean-Christophe Richard, Floriane Lissonde, Romain Tapponnier, Loredana Baboi, Jordi Mancebo and Claude Guérin

High-flow nasal oxygen versus noninvasive ventilation in adult patients with cystic fibrosis: a randomized crossover physiological study

Noninvasive ventilation (NIV) is the first-line treatment of adult patients with exacerbations of cystic fibrosis (CF). High-flow nasal oxygen therapy (HFNT) might benefit patients with hypoxemia and can reduc...

Authors: Michael C. Sklar, Martin Dres, Nuttapol Rittayamai, Brent West, Domenico Luca Grieco, Irene Telias, Detajin Junhasavasdikul, Michela Rauseo, Tai Pham, Fabiana Madotto, Carolyn Campbell, Elizabeth Tullis and Laurent Brochard

Ten-year trends in intensive care admissions for respiratory infections in the elderly

The consequences of the ageing population concerning ICU hospitalisation need to be adequately described. We believe that this discussion should be disease specific. A focus on respiratory infections is of par...

Authors: Lucile Laporte, Coralie Hermetet, Youenn Jouan, Christophe Gaborit, Emmanuelle Rouve, Kimberly M. Shea, Mustapha Si-Tahar, Pierre-François Dequin, Leslie Grammatico-Guillon and Antoine Guillon