Articles

Lung volumes and lung volume recruitment in ARDS: a comparison between supine and prone position

The use of positive end-expiratory pressure (PEEP) and prone position (PP) is common in the management of severe acute respiratory distress syndrome patients (ARDS). We conducted this study to analyze the vari...

Authors: Hernan Aguirre-Bermeo, Marta Turella, Maddalena Bitondo, Juan Grandjean, Stefano Italiano, Olimpia Festa, Indalecio Morán and Jordi Mancebo

Plasma microRNAs levels are different between pulmonary and extrapulmonary ARDS patients: a clinical observational study

Mesenchymal stem cells (MSC) obviously alleviate the damage of the structure and function of pulmonary vascular endothelial cells (VEC). The therapeutic effects of MSC are significantly different between pulmo...

Authors: Yi Zheng, Song-qiao Liu, Qin Sun, Jian-feng Xie, Jing-yuan Xu, Qing Li, Chun Pan, Ling Liu and Ying-zi Huang

Assessment of fluid responsiveness in spontaneously breathing patients: a systematic review of literature

Patients who increase stoke volume or cardiac index more than 10 or 15% after a fluid challenge are usually considered fluid responders. Assessment of fluid responsiveness prior to volume expansion is critical...

Authors: Renato Carneiro de Freitas Chaves, Thiago Domingos Corrêa, Ary Serpa Neto, Bruno de Arruda Bravim, Ricardo Luiz Cordioli, Fabio Tanzillo Moreira, Karina Tavares Timenetsky and Murillo Santucci Cesar de Assunção

Acute kidney injury in major abdominal surgery: incidence, risk factors, pathogenesis and outcomes

Acute kidney injury (AKI) is a common complication in patients undergoing major abdominal surgery. Various recent studies using modern standardized classifications for AKI reported a variable incidence of AKI ...

Authors: Joana Gameiro, José Agapito Fonseca, Marta Neves, Sofia Jorge and José António Lopes

Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study

Delayed cerebral thrombosis (DCT) is a devastating cerebrovascular complication in patients with excellent initial recovery of pneumococcal meningitis. The aetiology is unknown, but direct bacterial invasion, ...

Authors: Joo-Yeon Engelen-Lee, Matthijs C. Brouwer, Eleonora Aronica and Diederik van de Beek

The effect of a medication reconciliation program in two intensive care units in the Netherlands: a prospective intervention study with a before and after design

Medication errors occur frequently in the intensive care unit (ICU) and during care transitions. Chronic medication is often temporarily stopped at the ICU. Unfortunately, when the patient improves, the restar...

Authors: Liesbeth B. E. Bosma, Nicole G. M. Hunfeld, Rogier A. M. Quax, Edmé Meuwese, Piet H. G. J. Melief, Jasper van Bommel, SiokSwan Tan, Maaike J. van Kranenburg and Patricia M. L. A. van den Bemt

Physiological predictors of respiratory and cough assistance needs after extubation

Identifying patients at high risk of post-extubation acute respiratory failure requiring respiratory or mechanical cough assistance remains challenging. Here, our primary aim was to evaluate the accuracy of ea...

Authors: Nicolas Terzi, Frédéric Lofaso, Romain Masson, Pascal Beuret, Hervé Normand, Edith Dumanowski, Line Falaize, Bertrand Sauneuf, Cédric Daubin, Jennifer Brunet, Djillali Annane, Jean-Jacques Parienti and David Orlikowski

Proceedings of Réanimation 2018, the French Intensive Care Society International Congress

Authors:

New perspectives to improve critical care benchmarking

Authors: Jorge I. F. Salluh, Jean Daniel Chiche, Carlos Eduardo Reis and Marcio Soares

Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis

To explore potential design for pharmacogenomics trials in sepsis, we investigate the interaction between pharmacogenomic biomarkers and response to drotrecogin alfa (activated) (DrotAA). This trial was desig...

Authors: Djillali Annane, Jean-Paul Mira, Lorraine B. Ware, Anthony C. Gordon, Charles J. Hinds, David C. Christiani, Jonathan Sevransky, Kathleen Barnes, Timothy G. Buchman, Patrick J. Heagerty, Robert Balshaw, Nadia Lesnikova, Karen de Nobrega, Hugh F. Wellman, Mauricio Neira, Alexandra D. J. Mancini…

Epidemiology, causes, evolution and outcome in a single-center cohort of 1116 critically ill patients with hypoxic hepatitis

Hypoxic hepatitis (HH) is a type of acute hepatic injury that is histologically characterized by centrilobular liver cell necrosis and that is caused by insufficient oxygen delivery to the hepatocytes. Typical...

Authors: Astrid Van den broecke, Laura Van Coile, Alexander Decruyenaere, Kirsten Colpaert, Dominique Benoit, Hans Van Vlierberghe and Johan Decruyenaere

Reliability of respiratory pressure measurements in ventilated and non-ventilated patients in ICU: an observational study

Assessment of maximum respiratory pressures is a common practice in intensive care because it can predict the success of weaning from ventilation. However, the reliability of measurements through an intubation...

Authors: Clément Medrinal, Guillaume Prieur, Yann Combret, Aurora Robledo Quesada, Tristan Bonnevie, Francis Edouard Gravier, Eric Frenoy, Olivier Contal and Bouchra Lamia

Transcutaneous electromyographic respiratory muscle recordings to quantify patient–ventilator interaction in mechanically ventilated children

To explore the feasibility of transcutaneous electromyographic respiratory muscle recordings to automatically quantify the synchronicity of patient–ventilator interaction in the pediatric intensive care unit.

Authors: Alette A. Koopman, Robert G. T. Blokpoel, Leo A. van Eykern, Frans H. C. de Jongh, Johannes G. M. Burgerhof and Martin C. J. Kneyber

Comparison between a nurse-led weaning protocol and weaning based on physician’s clinical judgment in tracheostomized critically ill patients: a pilot randomized controlled clinical trial

Weaning protocols expedite extubation in mechanically ventilated patients, yet the literature investigating the application in tracheostomized patients remains scarce. The primary objective of this parallel ra...

Authors: Nazzareno Fagoni, Simone Piva, Elena Peli, Fabio Turla, Elisabetta Pecci, Livio Gualdoni, Bertilla Fiorese, Frank Rasulo and Nicola Latronico

The host response in critically ill sepsis patients on statin therapy: a prospective observational study

Statins can exert pleiotropic anti-inflammatory, vascular protective and anticoagulant effects, which in theory could improve the dysregulated host response during sepsis. We aimed to determine the association...

Authors: Maryse A. Wiewel, Brendon P. Scicluna, Lonneke A. van Vught, Arie J. Hoogendijk, Aeilko H. Zwinderman, René Lutter, Janneke Horn, Olaf L. Cremer, Marc J. Bonten, Marcus J. Schultz and Tom van der Poll

Stool cultures at the ICU: get rid of it!

Stool cultures for Campylobacter, Salmonella and Shigella and/or Yersinia spp. are frequently ordered in critically ill patients with diarrhea. The aim of this study is to analyze the diagnostic yield in a large ...

Authors: Carolin F. Manthey, Darja Dranova, Martin Christner, Laura Berneking, Stefan Kluge, Ansgar W. Lohse and Valentin Fuhrmann

Response to different furosemide doses predicts AKI progression in ICU patients with elevated plasma NGAL levels

Furosemide responsiveness (FR) is determined by urine output after furosemide administration and has recently been evaluated as a furosemide stress test (FST) for predicting severe acute kidney injury (AKI) pr...

Authors: Ryo Matsuura, Yohei Komaru, Yoshihisa Miyamoto, Teruhiko Yoshida, Kohei Yoshimoto, Rei Isshiki, Kengo Mayumi, Tetsushi Yamashita, Yoshifumi Hamasaki, Masaomi Nangaku, Eisei Noiri, Naoto Morimura and Kent Doi

Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study

There is no consensus on the management of anticoagulation during extracorporeal membrane oxygenation (ECMO). ECMO is currently burdened by a high rate of hemostatic complications, possibly associated with ina...

Authors: Mauro Panigada, Giacomo E. Iapichino, Matteo Brioni, Giovanna Panarello, Alessandro Protti, Giacomo Grasselli, Giovanna Occhipinti, Cristina Novembrino, Dario Consonni, Antonio Arcadipane, Luciano Gattinoni and Antonio Pesenti

Internal jugular vein variability predicts fluid responsiveness in cardiac surgical patients with mechanical ventilation

To evaluate the efficacy of using internal jugular vein variability (IJVV) as an index of fluid responsiveness in mechanically ventilated patients after cardiac surgery.

Authors: Guo-guang Ma, Guang-wei Hao, Xiao-mei Yang, Du-ming Zhu, Lan Liu, Hua Liu, Guo-wei Tu and Zhe Luo

Quality of inter-hospital transportation in 431 transport survivor patients suffering from acute respiratory distress syndrome referred to specialist centers

The acute respiratory distress syndrome (ARDS) is a life-threatening condition. In special situations, these critically ill patients must be transferred to specialized centers for escalating treatment. The aim...

Authors: Sebastian Blecha, Frank Dodoo-Schittko, Susanne Brandstetter, Magdalena Brandl, Michael Dittmar, Bernhard M. Graf, Christian Karagiannidis, Christian Apfelbacher and Thomas Bein

Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus

Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS‐CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients ...

Authors: Mohammed S. Alshahrani, Anees Sindi, Fayez Alshamsi, Awad Al-Omari, Mohamed El Tahan, Bayan Alahmadi, Ahmed Zein, Naif Khatani, Fahad Al-Hameed, Sultan Alamri, Mohammed Abdelzaher, Amenah Alghamdi, Faisal Alfousan, Adel Tash, Wail Tashkandi, Rajaa Alraddadi…

Nutrition delivery of a model-based ICU glycaemic control system

Hyperglycaemia is commonplace in the adult intensive care unit (ICU), associated with increased morbidity and mortality. Effective glycaemic control (GC) can reduce morbidity and mortality, but has proven diff...

Authors: Kent W. Stewart, J. Geoffrey Chase, Christopher G. Pretty and Geoffrey M. Shaw

Cardiac function during weaning failure: the role of diastolic dysfunction

Cardiac dysfunction is a common cause of weaning failure. Weaning shares some similarities with a cardiac stress test and may challenge active phases of the cardiac cycle-like ventricular contractility and rel...

Authors: Ferran Roche-Campo, Alexandre Bedet, Emmanuel Vivier, Laurent Brochard and Armand Mekontso Dessap

Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans

The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic aci...

Authors: Enrique de-Madaria, Xavier Molero, Laia Bonjoch, Josefina Casas, Karina Cárdenas-Jaén, Andrea Montenegro and Daniel Closa

Patient–ventilator asynchrony during conventional mechanical ventilation in children

We aimed (1) to describe the characteristics of patient–ventilator asynchrony in a population of critically ill children, (2) to describe the risk factors associated with patient–ventilator asynchrony, and (3)...

Authors: Guillaume Mortamet, Alexandrine Larouche, Laurence Ducharme-Crevier, Olivier Fléchelles, Gabrielle Constantin, Sandrine Essouri, Amélie-Ann Pellerin-Leblanc, Jennifer Beck, Christer Sinderby, Philippe Jouvet and Guillaume Emeriaud

Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome

Among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS), apart from acute cor pulmonale (ACP), the frequency and prognostic impact of basic critical care echocardiography (BCCE...

Authors: Kay Choong See, Jeffrey Ng, Wen Ting Siow, Venetia Ong and Jason Phua

Application of updated guidelines on diastolic dysfunction in patients with severe sepsis and septic shock

Left ventricular diastolic dysfunction is suggested to be associated with higher mortality in severe sepsis and septic shock, yet the methods of diagnosis described in the literature are often inconsistent. Th...

Authors: David J. Clancy, Timothy Scully, Michel Slama, Stephen Huang, Anthony S. McLean and Sam R. Orde

Risks of bleeding and thrombosis in intensive care unit patients with haematological malignancies

Patients with malignant haematological disease and especially those who require intensive care have an increased risk of bleeding and thrombosis, but none of these data were obtained in ICU patients only. We a...

Authors: Lene Russell, Lars Broksø Holst, Lars Kjeldsen, Jakob Stensballe and Anders Perner

Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality. Immunothrombosis-induced coagulopathy may contribute to hypercoa...

Authors: Julie Helms, Raphaël Clere-Jehl, Elsa Bianchini, Pierrick Le Borgne, Mélanie Burban, Fatiha Zobairi, Jean-Luc Diehl, Lelia Grunebaum, Florence Toti, Ferhat Meziani and Delphine Borgel

Immunohaemostasis: a new view on haemostasis during sepsis

Host infection by a micro-organism triggers systemic inflammation, innate immunity and complement pathways, but also haemostasis activation. The role of thrombin and fibrin generation in host defence is now re...

Authors: Xavier Delabranche, Julie Helms and Ferhat Meziani

Does metformin exposure before ICU stay have any impact on patients’ outcome? A retrospective cohort study of diabetic patients

Impact of metformin exposure before ICU stay remains controversial. Metformin is thought to induce lactic acidosis and haemodynamic instability but may reduce ICU mortality. We evaluated its influence on outco...

Authors: Sebastien Jochmans, Jean-Emmanuel Alphonsine, Jonathan Chelly, Ly Van Phach Vong, Oumar Sy, Nathalie Rolin, Olivier Ellrodt, Mehran Monchi and Christophe Vinsonneau

Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened...

Authors: Antoine Dewitte, Sébastien Lepreux, Julien Villeneuve, Claire Rigothier, Christian Combe, Alexandre Ouattara and Jean Ripoche

Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis

Serum procalcitonin (PCT) concentration is used to guide antibiotic decisions in choice, timing, and duration of anti-infection therapy to avoid antibiotic overuse. Thus, we performed a systematic review and m...

Authors: Hui-Bin Huang, Jin-Min Peng, Li Weng, Chun-Yao Wang, Wei Jiang and Bin Du

Piperacillin–tazobactam as alternative to carbapenems for ICU patients

Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteria...

Authors: Benoit Pilmis, Vincent Jullien, Alexis Tabah, Jean-Ralph Zahar and Christian Brun-Buisson

Venovenous extracorporeal membrane oxygenation devices-related colonisations and infections

Nosocomial infections occurring during extracorporeal membrane oxygenation (ECMO) support have already been reported, but few studied infections directly related to ECMO devices. This study aims to evaluate t...

Authors: Guillemette Thomas, Sami Hraiech, Nadim Cassir, Samuel Lehingue, Romain Rambaud, Sandrine Wiramus, Christophe Guervilly, Fanny Klasen, Mélanie Adda, Stéphanie Dizier, Antoine Roch, Laurent Papazian and Jean-Marie Forel

Admission of tetanus patients to the ICU: a retrospective multicentre study

An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a significant impact on short- and long-term survival. The subject is noteworthy and d...

Authors: Rafael Mahieu, Thomas Reydel, Adel Maamar, Jean-Marc Tadié, Angeline Jamet, Arnaud W. Thille, Nicolas Chudeau, Julien Huntzinger, Steven Grangé, Gaetan Beduneau, Anne Courte, Stephane Ehrmann, Jérémie Lemarié, Sébastien Gibot, Michael Darmon, Christophe Guitton…

Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation

No single anticoagulant has been proven effective for sepsis-associated disseminated intravascular coagulation (DIC). Thus, the concomitant use of antithrombin concentrate and recombinant thrombomodulin has be...

Authors: Toshiaki Iba, Akiyoshi Hagiwara, Daizoh Saitoh, Hideaki Anan, Yutaka Ueki, Koichi Sato and Satoshi Gando

Incidence of airway complications in patients using endotracheal tubes with continuous aspiration of subglottic secretions

Continuous aspiration of subglottic secretions is effective in preventing ventilator-associated pneumonia, but it involves a risk of mucosal damage. The main objective of our study was to determine the inciden...

Authors: Jordi Vallés, Susana Millán, Emili Díaz, Eva Castanyer, Xavier Gallardo, Ignacio Martín-Loeches, Marta Andreu, Mario Prenafeta, Paula Saludes, Jorge Lema, Montse Batlle, Néstor Bacelar and Antoni Artigas

Risk stratification using SpO₂/FiO₂ and PEEP at initial ARDS diagnosis and after 24 h in patients with moderate or severe ARDS

We assessed the potential of risk stratification of ARDS patients using SpO₂/FiO₂ and positive end-expiratory pressure (PEEP) at ARDS onset and after 24 h.

Authors: Luigi Pisani, Jan-Paul Roozeman, Fabienne D. Simonis, Antonio Giangregorio, Sophia M. van der Hoeven, Laura R. Schouten, Janneke Horn, Ary Serpa Neto, Emir Festic, Arjen M. Dondorp, Salvatore Grasso, Lieuwe D. Bos and Marcus J. Schultz

Anemia at pediatric intensive care unit discharge: prevalence and risk markers

Anemia is prevalent at pediatric intensive care unit (PICU) admission and incident during PICU stay, but little is known about anemia at PICU discharge . Anemia after critical illness is an important issue bec...

Authors: Pierre Demaret, Oliver Karam, Marisa Tucci, Jacques Lacroix, Hélène Behal, Alain Duhamel, Frédéric Lebrun, André Mulder and Stéphane Leteurtre

Protective effect of early low-dose hydrocortisone on ventilator-associated pneumonia in the cancer patients: a propensity score analysis

Ventilator-associated pneumonia (VAP) is a care-related event that could be promoted by immune suppression caused by critical diseases, malignancies and cancer treatments. Low dose of hydrocortisone was propos...

Authors: David Lagier, Laura Platon, Jérome Lambert, Laurent Chow-Chine, Antoine Sannini, Magali Bisbal, Jean-Paul Brun, Karim Asehnoune, Marc Leone, Marion Faucher and Djamel Mokart

Heparin-binding protein (HBP) improves prediction of sepsis-related acute kidney injury

Sepsis-related acute kidney injury (AKI) accounts for major morbidity and mortality among the critically ill. Heparin-binding protein (HBP) is a promising biomarker in predicting development and prognosis of s...

Authors: Jonas Tverring, Suvi T. Vaara, Jane Fisher, Meri Poukkanen, Ville Pettilä and Adam Linder

Outcome of in- and out-of-hospital cardiac arrest survivors with liver cirrhosis

Organ failure increases mortality in patients with liver cirrhosis. Data about resuscitated cardiac arrest patients with liver cirrhosis are missing. This study aims to assess aetiology, survival and functiona...

Authors: Kevin Roedl, Christian Wallmüller, Andreas Drolz, Thomas Horvatits, Karoline Rutter, Alexander Spiel, Julia Ortbauer, Peter Stratil, Pia Hubner, Christoph Weiser, Jasmin Katrin Motaabbed, Dominik Jarczak, Harald Herkner, Fritz Sterz and Valentin Fuhrmann

Effect of inspiratory synchronization during pressure-controlled ventilation on lung distension and inspiratory effort

In pressure-controlled (PC) ventilation, tidal volume (V _T) and transpulmonary pressure (P _L ) result from the addition...

Authors: Nuttapol Rittayamai, François Beloncle, Ewan C. Goligher, Lu Chen, Jordi Mancebo, Jean-Christophe M. Richard and Laurent Brochard

Ultrasound assessment of rectus femoris and anterior tibialis muscles in young trauma patients

Quantitative and qualitative changes of skeletal muscle are typical and early findings in trauma patients, being possibly associated with functional impairment. Early assessment of muscle changes—as evaluated ...

Authors: Maria Giuseppina Annetta, Mauro Pittiruti, Davide Silvestri, Domenico Luca Grieco, Alessio Maccaglia, Michele Fabio La Torre, Nicola Magarelli, Giovanna Mercurio, Anselmo Caricato and Massimo Antonelli

Prognostic implications of blood lactate concentrations after cardiac arrest: a retrospective study

Elevated lactate concentration has been associated with increased mortality after out-of-hospital cardiac arrest (CA). We investigated the variables associated with high blood lactate concentrations and explor...

Authors: Antonio Maria Dell’Anna, Claudio Sandroni, Irene Lamanna, Ilaria Belloni, Katia Donadello, Jacques Creteur, Jean-Louis Vincent and Fabio Silvio Taccone

Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured pla...

Authors: Laura S. Murphy, Nancy Wickersham, J. Brennan McNeil, Ciara M. Shaver, Addison K. May, Julie A. Bastarache and Lorraine B. Ware

The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty ...

Authors: Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee and Christopher F. Rose

Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS?

Interstitial pneumonia with autoimmune features (IPAF) identifies a recently recognized autoimmune syndrome characterized by interstitial lung disease and autoantibodies positivity, but absence of a specific c...

Authors: Giacomo Grasselli, Beatrice Vergnano, Maria Rosa Pozzi, Vittoria Sala, Gabriele D’Andrea, Vittorio Scaravilli, Marco Mantero, Alberto Pesci and Antonio Pesenti

High level of venous thromboembolism in critically ill trauma patients despite early and well-driven thromboprophylaxis protocol

Venous thromboembolism (VTE) is one of the most common preventable causes of in-hospital death in trauma patients surviving their injuries. We assessed the prevalence, incidence and risk factors for deep venou...

Authors: S. R. Hamada, C. Espina, T. Guedj, R. Buaron, A. Harrois, S. Figueiredo and J. Duranteau