Articles

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortality

COVID-19 pneumonia and subsequent respiratory failure is causing an immense strain on intensive care units globally. Early prediction of severe disease enables clinicians to avoid acute respiratory distress sy...

Authors: Adeline Lim, Aleksandar Radujkovic, Markus A. Weigand and Uta Merle

An international survey on aminoglycoside practices in critically ill patients: the AMINO III study

While aminoglycosides (AG) have been used for decades, debate remains on their optimal dosing strategy. We investigated the international practices of AG usage specifically regarding dosing and therapeutic dru...

Authors: Claire Roger, Benjamin Louart, Loubna Elotmani, Greg Barton, Leslie Escobar, Despoina Koulenti, Jeffrey Lipman, Marc Leone, Laurent Muller, Caroline Boutin, Julien Amour, Iouri Banakh, Joel Cousson, Jeremy Bourenne, Jean-Michel Constantin, Jacques Albanese…

Pain and dyspnea control during awake fiberoptic bronchoscopy in critically ill patients: safety and efficacy of remifentanil target-controlled infusion

Flexible fiberoptic bronchoscopy is frequently used in intensive care unit, but is a source of discomfort, dyspnea and anxiety for patients. Our objective was to assess the feasibility and tolerance of a sedat...

Authors: Margot Caron, Antoine Parrot, Alexandre Elabbadi, Sophie Dupeyrat, Matthieu Turpin, Thomas Baury, Sacha Rozencwajg, Clarisse Blayau, Jean-Pierre Fulgencio, Aude Gibelin, Pierre-Yves Blanchard, Séverine Rodriguez, Daisy Daigné, Marie-Cécile Allain, Muriel Fartoukh and Tài Pham

Cerebrovascular autoregulation and arterial carbon dioxide in patients with acute respiratory distress syndrome: a prospective observational cohort study

Early hypercapnia is common in patients with acute respiratory distress syndrome (ARDS) and is associated with increased mortality. Fluctuations of carbon dioxide have been associated with adverse neurological...

Authors: Ursula Kahl, Yuanyuan Yu, Axel Nierhaus, Daniel Frings, Barbara Sensen, Anne Daubmann, Stefan Kluge and Marlene Fischer

Reply to: High levels of plasma biomarkers at 24 h were found to be strong predictors of 90-day mortality: beware of some potential confounders!

Authors: Toni Jäntti, Veli-Pekka Harjola, Mikko Haapio and Johan Lassus

High levels of plasma biomarkers at 24 h were found to be strong predictors of 90-day mortality: beware of some potential confounders!

Authors: Patrick M. Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani and David De Bels

Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunctio...

Authors: Kevin Roedl, Dominik Jarczak, Andreas Drolz, Dominic Wichmann, Olaf Boenisch, Geraldine de Heer, Christoph Burdelski, Daniel Frings, Barbara Sensen, Axel Nierhaus, Marc Lütgehetmann, Stefan Kluge and Valentin Fuhrmann

The use of extracorporeal CO₂ removal in acute respiratory failure

Chronic obstructive pulmonary disease (COPD) exacerbation and protective mechanical ventilation of acute respiratory distress syndrome (ARDS) patients induce hypercapnic respiratory acidosis.

Authors: Raphaël Giraud, Carlo Banfi, Benjamin Assouline, Amandine De Charrière, Maurizio Cecconi and Karim Bendjelid

Early combination of albumin with crystalloids administration might be beneficial for the survival of septic patients: a retrospective analysis from MIMIC-IV database

Fluid therapy is a cornerstone in the treatment of sepsis. Recently, the guidelines have recommended the combined administration that using crystalloids plus albumin for septic patients, but the optimal timing fo...

Authors: Shiyu Zhou, Zhenhua Zeng, Hongxia Wei, Tong Sha and Shengli An

New clinical algorithm including fungal biomarkers to better diagnose probable invasive pulmonary aspergillosis in ICU

The classification of invasive pulmonary aspergillosis (IPA) issued by the European Organization for the Research and Treatment of Cancer/Mycoses Study Group Education and Research Consortium (EORTC/MSGERC) is...

Authors: Joffrey Hamam, Jean-Christophe Navellou, Anne-Pauline Bellanger, Stéphane Bretagne, Hadrien Winiszewski, Emeline Scherer, Gael Piton and Laurence Millon

Serum melatonin concentration in critically ill patients randomized to sedation or non-sedation

Abolished circadian rhythm is associated with altered cognitive function, delirium, and as a result increased mortality in critically ill patients, especially in those who are mechanically ventilated. The caus...

Authors: Jakob Oxlund, Torben Knudsen, Thomas Strøm, Jørgen T. Lauridsen, Poul J. Jennum and Palle Toft

Ability of procalcitonin to distinguish between bacterial and nonbacterial infection in severe acute exacerbation of chronic obstructive pulmonary syndrome in the ICU

To assess the ability of procalcitonin (PCT) to distinguish between bacterial and nonbacterial causes of patients with severe acute exacerbation of COPD (AECOPD) admitted to the ICU, we conducted a retrospecti...

Authors: Cédric Daubin, François Fournel, Fabrice Thiollière, Fabrice Daviaud, Michel Ramakers, Andréa Polito, Bernard Flocard, Xavier Valette, Damien Du Cheyron, Nicolas Terzi, Muriel Fartoukh, Stephane Allouche and Jean-Jacques Parienti

Continuous positive airway pressure for respiratory support during COVID-19 pandemic: a frugal approach from bench to bedside

We describe a frugal approach (focusing on needs, performance, and costs) to manage a massive influx of COVID-19 patients with acute hypoxemic respiratory failure (AHRF) using the Boussignac valve protected by...

Authors: Guillaume Carteaux, Manuella Pons, François Morin, Samuel Tuffet, Arnaud Lesimple, Bilal Badat, Anne-Fleur Haudebourg, François Perier, Yvon Deplante, Constance Guillaud, Frédéric Schlemmer, Elena Fois, Nicolas Mongardon, Mehdi Khellaf, Karim Jaffal, Camille Deguillard…

High flow nasal oxygen therapy to avoid invasive mechanical ventilation in SARS-CoV-2 pneumonia: a retrospective study

The efficacy of high flow nasal canula oxygen therapy (HFNO) to prevent invasive mechanical ventilation (IMV) is not well established in severe coronavirus disease 2019 (COVID-19). The aim of this study was to...

Authors: Nicolas Bonnet, Olivier Martin, Marouane Boubaya, Vincent Levy, Nathan Ebstein, Philippe Karoubi, Yacine Tandjaoui-Lambiotte, Guillaume Van Der Meersch, Johanna Oziel, Marie Soulie, Mohamed Ghalayini, Anais Winchenne, Jean Ralph Zahar, Passem Ahmed, Stéphane Gaudry and Yves Cohen

Intensive care management of patients with COVID-19: a practical approach

SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the early twentieth century. Since there is no ...

Authors: Ludhmila Abrahão Hajjar, Isabela Bispo Santos da Silva Costa, Stephanie Itala Rizk, Bruno Biselli, Brenno Rizerio Gomes, Cristina Salvadori Bittar, Gisele Queiroz de Oliveira, Juliano Pinheiro de Almeida, Mariana Vieira de Oliveira Bello, Cibele Garzillo, Alcino Costa Leme, Moizo Elena, Fernando Val, Marcela de Almeida Lopes, Marcus Vinícius Guimarães Lacerda, José Antonio Franchini Ramires…

Determinants of hospital and one-year mortality among older patients admitted to intensive care units: results from the multicentric SENIOREA cohort

Improving outcomes of older patients admitted into intensive care units (ICU) is a raising concern. This study aimed at determining which geriatric and ICU parameters were associated with in-hospital and long-...

Authors: Julien Demiselle, Guillaume Duval, Jean-François Hamel, Anne Renault, Laetitia Bodet-Contentin, Laurent Martin-Lefèvre, Dominique Vivier, Daniel Villers, Montaine Lefèvre, René Robert, Philippe Markowicz, Sylvain Lavoué, Anne Courte, Eddy Lebas, Stéphanie Chevalier, Cédric Annweiler…

Predicting fluid responsiveness in non-intubated COVID-19 patients: two methods are better than one

Authors: Morgan Caplan, Michael Howsam, Raphael Favory and Sebastien Preau

Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation

The effect of cytomegalovirus (CMV) reactivation on the length of mechanical ventilation and mortality in immunocompetent ICU patients requiring invasive mechanical ventilation remains controversial. The main ...

Authors: Laurent Papazian, Samir Jaber, Sami Hraiech, Karine Baumstarck, Sophie Cayot-Constantin, Nadia Aissaoui, Boris Jung, Marc Leone, Bertrand Souweine, Carole Schwebel, Jérémy Bourenne, Jérôme Allardet-Servent, Toufik Kamel, Qin Lu, Christine Zandotti, Anderson Loundou…

Validation of the pediatric refractory septic shock definition: post hoc analysis of a controlled trial

The European Society of Pediatric and Neonatal Intensive Care (ESPNIC) developed and validated a definition of pediatric refractory septic shock (RSS), based on two septic shock scores (SSS). Both bedside SSS ...

Authors: Luc Morin, Karthik Narayanan Ramaswamy, Muralidharan Jayashree, Arun Bansal, Karthi Nallasamy, Pierre Tissieres and Sunit Singhi

Poor outcome associated with mucormycosis in critically ill hematological patients: results of a multicenter study

Mucormycosis is an emerging fungal infection that may lead to multi-organ failure, especially in patients with hematological malignancies (HM). We performed a retrospective, cohort study, in five intensive car...

Authors: Matthieu Jestin, Elie Azoulay, Frédéric Pène, Fabrice Bruneel, Julien Mayaux, Martin Murgier, Michael Darmon and Sandrine Valade

Non-invasive ventilation alternating with high-flow nasal oxygen versus high-flow nasal oxygen alone after extubation in COPD patients: a post hoc analysis of a randomized controlled trial

Several randomized clinical trials have shown that non-invasive ventilation (NIV) applied immediately after extubation may prevent reintubation in patients at high-risk of extubation failure. However, most of ...

Authors: Arnaud W. Thille, Rémi Coudroy, Mai-Anh Nay, Arnaud Gacouin, Maxens Decavèle, Romain Sonneville, François Beloncle, Christophe Girault, Laurence Dangers, Alexandre Lautrette, Quentin Levrat, Anahita Rouzé, Emmanuel Vivier, Jean-Baptiste Lascarrou, Jean-Damien Ricard, Keyvan Razazi…

Outcomes of severe systemic rheumatic disease patients requiring extracorporeal membrane oxygenation

Systemic rheumatic diseases (SRDs) are a group of inflammatory disorders that can require intensive care unit (ICU) admission because of multiorgan involvement with end-organ failure(s). Critically ill SRD pat...

Authors: Pierre Bay, Guillaume Lebreton, Alexis Mathian, Pierre Demondion, Cyrielle Desnos, Juliette Chommeloux, Guillaume Hékimian, Nicolas Bréchot, Ania Nieszkowska, Matthieu Schmidt, Fleur Cohen-Aubart, Pascal Leprince, Charles-Edouard Luyt, Zahir Amoura, Alain Combes and Marc Pineton de Chambrun

Predictors of fluid responsiveness in critically ill patients mechanically ventilated at low tidal volumes: systematic review and meta-analysis

Dynamic predictors of fluid responsiveness have shown good performance in mechanically ventilated patients at tidal volumes (Vt) > 8 mL kg⁻¹. Nevertheless, most critically ill conditions demand lower Vt. We sough...

Authors: Jorge Iván Alvarado Sánchez, Juan Daniel Caicedo Ruiz, Juan José Diaztagle Fernández, William Fernando Amaya Zuñiga, Gustavo Adolfo Ospina-Tascón and Luis Eduardo Cruz Martínez

Levosimendan use in patients with acute heart failure and reduced ejection fraction with or without severe renal dysfunction in critical cardiac care units: a multi-institution database study

Acute heart failure is a life-threatening clinical condition. Levosimendan is an effective inotropic agent used to maintain cardiac output, but its usage is limited by the lack of evidence in patients with sev...

Authors: Cze-Ci Chan, Kuang-Tso Lee, Wan-Jing Ho, Yi-Hsin Chan and Pao-Hsien Chu

Non-invasive method to detect high respiratory effort and transpulmonary driving pressures in COVID-19 patients during mechanical ventilation

High respiratory drive in mechanically ventilated patients with spontaneous breathing effort may cause excessive lung stress and strain and muscle loading. Therefore, it is important to have a reliable estimat...

Authors: Lisanne Roesthuis, Maarten van den Berg and Hans van der Hoeven

Predictive value of plasma proenkephalin and neutrophil gelatinase-associated lipocalin in acute kidney injury and mortality in cardiogenic shock

Acute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. However, data on AKI markers such as plasma proenkephalin (P-PENK) and neutrophil gelatinase-associated lipocalin (P-NGAL) in ...

Authors: Toni Jäntti, Tuukka Tarvasmäki, Veli-Pekka Harjola, Kari Pulkki, Heidi Turkia, Tuija Sabell, Heli Tolppanen, Raija Jurkko, Mari Hongisto, Anu Kataja, Alessandro Sionis, Jose Silva-Cardoso, Marek Banaszewski, Salvatore DiSomma, Alexandre Mebazaa, Mikko Haapio…

Sympathetic stimulation increases serum lactate concentrations in patients admitted with sepsis: implications for resuscitation strategies

Diametrically opposed positions exist regarding the deleterious effects of elevated lactate. There are data suggesting that it is a detrimental proxy for tissue hypoperfusion and anaerobic metabolism in sepsis...

Authors: Nikhil Jagan, Lee E. Morrow, Ryan W. Walters, Robert W. Plambeck, Tej M. Patel, Douglas R. Moore and Mark A. Malesker

Integrity at end of life in the intensive care unit: a qualitative study of nurses’ views

Integrity is a core value for delivering ethical health care. However, there is a lack of precision in defining what integrity is and how nurses understand it. In the setting of nurses caring for critically il...

Authors: Lena Palmryd, Åsa Rejnö and Tove E. Godskesen

Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study

Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments deve...

Authors: Hans Flaatten, Bertrand Guidet, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Ariane Boumendil, Muhammed Elhadi, Jesper Fjølner, Michael Joannidis, Christian Jung, Susannah Leaver, Brian Marsh, Rui Moreno, Sandra Oeyen, Yuriy Nalapko, Joerg C. Schefold…

Current use of inotropes in circulatory shock

Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope thera...

Authors: Thomas W. L. Scheeren, Jan Bakker, Thomas Kaufmann, Djillali Annane, Pierre Asfar, E. Christiaan Boerma, Maurizio Cecconi, Michelle S. Chew, Bernard Cholley, Maria Cronhjort, Daniel De Backer, Arnaldo Dubin, Martin W. Dünser, Jacques Duranteau, Anthony C. Gordon, Ludhmila A. Hajjar…

Increased susceptibility to intensive care unit-acquired pneumonia in severe COVID-19 patients: a multicentre retrospective cohort study

The aim of this study is to determine whether severe COVID-19 patients harbour a higher risk of ICU-acquired pneumonia.

Authors: Jean-François Llitjos, Swann Bredin, Jean-Baptiste Lascarrou, Thibaud Soumagne, Mariana Cojocaru, Maxime Leclerc, Arnaud Lepetit, Albin Gouhier, Julien Charpentier, Gaël Piton, Matthieu Faron, Annabelle Stoclin and Frédéric Pène

Predicting fluid responsiveness in non-intubated COVID-19 patients

Authors: Frederic Michard

Triage policy of severe Covid-19 patients: what to do now?

Authors: Pieter Depuydt and Bertrand Guidet

Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure

Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict ...

Authors: Virginie Lemiale, Guillaume Dumas, Alexandre Demoule, Frederic Pène, Achille Kouatchet, Magali Bisbal, Saad Nseir, Laurent Argaud, Loay Kontar, Kada Klouche, Francois Barbier, Amelie Seguin, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet…

Trendelenburg maneuver predicts fluid responsiveness in patients on veno-arterial extracorporeal membrane oxygenation

Evaluation of fluid responsiveness during veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support is crucial. The aim of this study was to investigate whether changes in left ventricular outflow tr...

Authors: Jing-chao Luo, Ying Su, Li-li Dong, Jun-yi Hou, Xin Li, Ying Zhang, Guo-guang Ma, Ji-li Zheng, Guang-wei Hao, Huan Wang, Yi-jie Zhang, Zhe Luo and Guo-wei Tu

Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial

The detrimental effects of inotropes are well-known, and in many fields they are only used within a goal-directed therapy approach. Nevertheless, standard management in many centers includes administering inot...

Authors: Rafael Alves Franco, Juliano Pinheiro de Almeida, Giovanni Landoni, Thomas W. L. Scheeren, Filomena Regina Barbosa Gomes Galas, Julia Tizue Fukushima, Suely Zefferino, Pasquale Nardelli, Marilde de Albuquerque Piccioni, Elisandra Cristina Trevisan Calvo Arita, Clarice Hyesuk Lee Park, Ligia Cristina Camara Cunha, Gisele Queiroz de Oliveira, Isabela Bispo Santos da Silva Costa, Roberto Kalil Filho, Fabio Biscegli Jatene…

Higher anticoagulation targets and risk of thrombotic events in severe COVID-19 patients: bi-center cohort study

Thromboprophylaxis of COVID-19 patients is a highly debated issue. We aimed to compare the occurrence of thrombotic/ischemic events in COVID-19 patients with acute respiratory distress syndrome (ARDS) treated ...

Authors: Julie Helms, François Severac, Hamid Merdji, Maleka Schenck, Raphaël Clere-Jehl, Mathieu Baldacini, Mickaël Ohana, Lélia Grunebaum, Vincent Castelain, Eduardo Anglés-Cano, Laurent Sattler and Ferhat Meziani

Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study

Regional citrate anticoagulation (RCA) is the gold standard of anticoagulation for continuous renal replacement therapy but is rarely used for intermittent hemodialysis (IHD) in ICU. Few studies assessed the s...

Authors: Christophe Leroy, Bruno Pereira, Edouard Soum, Claire Bachelier, Elisabeth Coupez, Laure Calvet, Konstantinos Bachoumas, Claire Dupuis, Bertrand Souweine and Alexandre Lautrette

Insulin sensitivity in critically ill patients: are women more insulin resistant?

Glycaemic control (GC) in intensive care unit is challenging due to significant inter- and intra-patient variability, leading to increased risk of hypoglycaemia. Recent work showed higher insulin resistance in...

Authors: Vincent Uyttendaele, J. Geoffrey Chase, Jennifer L. Knopp, Rebecca Gottlieb, Geoffrey M. Shaw and Thomas Desaive

Relationship between lipoprotein concentrations and short-term and 1-year mortality in intensive care unit septic patients: results from the HIGHSEPS study

High-density lipoproteins (HDLs), particles characterized by their reverse cholesterol transport function, display pleiotropic properties, including anti-inflammatory and antioxidant functions. Moreover, all l...

Authors: Sébastien Tanaka, Jules Stern, Donia Bouzid, Tiphaine Robert, Monique Dehoux, Aurélie Snauwaert, Nathalie Zappella, Maxime Cournot, Brice Lortat-Jacob, Pascal Augustin, Enora Atchade, Alexy Tran-Dinh, Olivier Meilhac and Philippe Montravers

Uncertainty in the impact of liver support systems in acute-on-chronic liver failure: a systematic review and network meta-analysis

The role of artificial and bioartificial liver support systems in acute-on-chronic liver failure (ACLF) is still controversial. We aimed to perform the first network meta-analysis comparing and ranking differe...

Authors: Klementina Ocskay, Anna Kanjo, Noémi Gede, Zsolt Szakács, Gabriella Pár, Bálint Erőss, Jan Stange, Steffen Mitzner, Péter Hegyi and Zsolt Molnár

Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients

SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known abou...

Authors: Jean-Rémi Lavillegrand, Marc Garnier, Agathe Spaeth, Nathalie Mario, Geoffroy Hariri, Antoine Pilon, Enora Berti, Fabienne Fieux, Sara Thietart, Tomas Urbina, Matthieu Turpin, Lucie Darrivere, Muriel Fartoukh, Franck Verdonk, Guillaume Dumas, Alain Tedgui…

The relationship between maximal expiratory pressure values and critical outcomes in mechanically ventilated patients: a post hoc analysis of an observational study

Little interest has been paid to expiratory muscle strength, and the impact of expiratory muscle weakness on critical outcomes is not known. Very few studies assessed the relationship between maximal expirator...

Authors: Yann Combret, Guillaume Prieur, Roger Hilfiker, Francis-Edouard Gravier, Pauline Smondack, Olivier Contal, Bouchra Lamia, Tristan Bonnevie and Clément Medrinal

Is COPD associated with increased risk for microaspiration in intubated critically ill patients?

Although COPD patients are at higher risk for aspiration when breathing spontaneously, no information is available on the risk for microaspiration in invasively ventilated COPD patients. The aim of our study w...

Authors: Thècle Degroote, Emmanuelle Jaillette, Jean Reignier, Farid Zerimech, Christophe Girault, Guillaume Brunin, Arnaud Chiche, Jean-Claude Lacherade, Jean-Paul MIRA, Patrice Maboudou, Malika Balduyck and Saad Nseir

Lung ultrasound score predicts outcomes in COVID-19 patients admitted to the emergency department

During the COVID-19 pandemic, creating tools to assess disease severity is one of the most important aspects of reducing the burden on emergency departments. Lung ultrasound has a high accuracy for the diagnos...

Authors: Julio Cesar Garcia de Alencar, Julio Flavio Meirelles Marchini, Lucas Oliveira Marino, Sabrina Correa da Costa Ribeiro, Cauê Gasparotto Bueno, Victor Paro da Cunha, Felippe Lazar Neto, Rodrigo Antonio Brandão Neto and Heraldo Possolo Souza

Pilot trial of high-dose vitamin C in critically ill COVID-19 patients

Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was effective for severe ...

Authors: Jing Zhang, Xin Rao, Yiming Li, Yuan Zhu, Fang Liu, Guangling Guo, Guoshi Luo, Zhongji Meng, Daniel De Backer, Hui Xiang and Zhiyong Peng

Preoperative endothelial dysfunction in cutaneous microcirculation is associated with postoperative organ injury after cardiac surgery using extracorporeal circulation: a prospective cohort study

Cardiac surgery is known to induce acute endothelial dysfunction, which may be central to the pathophysiology of postoperative complications. Preoperative endothelial dysfunction could also be implicated in th...

Authors: Stanislas Abrard, Olivier Fouquet, Jérémie Riou, Emmanuel Rineau, Pierre Abraham, Cyril Sargentini, Yannick Bigou, Christophe Baufreton, Sigismond Lasocki and Samir Henni

Ultraprotective ventilation allowed by extracorporeal CO₂ removal improves the right ventricular function in acute respiratory distress syndrome patients: a quasi-experimental pilot study

Right ventricular (RV) failure is a common complication in moderate-to-severe acute respiratory distress syndrome (ARDS). RV failure is exacerbated by hypercapnic acidosis and overdistension induced by mechani...

Authors: Suzanne Goursaud, Xavier Valette, Julien Dupeyrat, Cédric Daubin and Damien du Cheyron

Management of late onset urea cycle disorders—a remaining challenge for the intensivist?

Hyperammonemia caused by a disorder of the urea cycle is a rare cause of metabolic encephalopathy that may be underdiagnosed by the adult intensivists because of its rarity. Urea cycle disorders are autosomal ...

Authors: S. Redant, A. Empain, A. Mugisha, P. Kamgang, R. Attou, P. M. Honoré and D. De Bels

Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers?

Authors: Jérémie Joffre and Matthieu Legrand