Articles

Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial

Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sep...

Authors: Shih-Hong Chen, Wing-Sum Chan, Chih-Min Liu, Ching-Tang Chiu, Anne Chao, Vin-Cent Wu, Wang-Huei Sheng, Chien-Heng Lai, Ming-Jiuh Wang and Yu-Chang Yeh

A comparison of nasogastric tube insertion by SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) versus neck flexion lateral pressure in critically ill patients admitted to ICU: a prospective randomized clinical trial

Although many techniques have been introduced to facilitate nasogastric tube (NGT) insertion using anatomic landmarks and a group of devices, there is a lack of general consensus regarding a standard method. T...

Authors: Sarvin Sanaie, Negin Mirzalou, Kamran Shadvar, Samad E. J. Golzari, Hassan Soleimanpour, Ali Shamekh, Deepti Bettampadi, Saeid Safiri and Ata Mahmoodpoor

Caution about early intubation and mechanical ventilation in COVID-19

Authors: Martin J. Tobin, Franco Laghi and Amal Jubran

Response to the authors

Authors: Pauline de Jager and Martin C. J. Kneyber

Letter to the Editor: Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children

Authors: Arpita Chattopadhyay

Amikacin pharmacokinetic/pharmacodynamic in intensive care unit: a prospective database

Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C_max) reaches eight to tenfold the minimal inhibitory concentration (MIC). With an amikacin MIC of 8 mg/L, the C_max

Authors: Elsa Logre, Maya Enser, Sébastien Tanaka, Marie Dubert, Aurore Claudinon, Nathalie Grall, Hervé Mentec, Philippe Montravers and Olivier Pajot

Mucormycosis in intensive care unit: surgery is a major prognostic factor in patients with hematological malignancy

Mucormycosis is an invasive fungal infection, with an increasing incidence especially in patients with hematological malignancies. Its prognosis is poor because of its high invasive power and its intrinsic low...

Authors: Johanna Claustre, Romaric Larcher, Thomas Jouve, Anne-Sophie Truche, Saad Nseir, Julien Cadiet, Yoann Zerbib, Alexandre Lautrette, Jean-Michel Constantin, Pierre-Emmanuel Charles, Cedric Daubin, Remi Coudroy, Jean Dellamonica, Laurent Argaud, Pierre Phelouzat, Damien Contou…

Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China

The ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept all over the world, posing a great pressure on critical care resources due to large number of patients needing critical care. Statements fro...

Authors: You Shang, Chun Pan, Xianghong Yang, Ming Zhong, Xiuling Shang, Zhixiong Wu, Zhui Yu, Wei Zhang, Qiang Zhong, Xia Zheng, Ling Sang, Li Jiang, Jiancheng Zhang, Wei Xiong, Jiao Liu and Dechang Chen

Correction to: Early sepsis markers in patients admitted to intensive care unit with moderate‑to‑severe diabetic ketoacidosis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Florian Blanchard, Judith Charbit, Guillaume Van der Meersch, Benjamin Popoff, Adrien Picod, Regis Cohen, Frank Chemouni, Stephane Gaudry, Helene Bihan and Yves Cohen

COVID-19-associated invasive pulmonary aspergillosis

Authors: Lynn Rutsaert, Nicky Steinfort, Tine Van Hunsel, Peter Bomans, Reinout Naesens, Helena Mertes, Hilde Dits and Niels Van Regenmortel

Journal club in an ICU: rate and factors associated with practice-changing articles. Analysis of 1712 articles read over a 13-year period (2007–2019)

Authors: Damien Contou, Marina Thirion, Olivier Pajot, Gaëtan Plantefève and Hervé Mentec

Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children

A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. Th...

Authors: Marion Grimaud, Julie Starck, Michael Levy, Clémence Marais, Judith Chareyre, Diala Khraiche, Marianne Leruez-Ville, Pierre Quartier, Pierre Louis Léger, Guillaume Geslain, Nada Semaan, Florence Moulin, Matthieu Bendavid, Sandrine Jean, Géraldine Poncelet, Sylvain Renolleau…

Organizational factors associated with adherence to low tidal volume ventilation: a secondary analysis of the CHECKLIST-ICU database

Survival benefit from low tidal volume (V_T) ventilation (LTVV) has been demonstrated for patients with acute respiratory distress syndrome (ARDS), and patients not having ARDS could also benefit from this strateg...

Authors: Thais Dias Midega, Fernando A. Bozza, Flávia Ribeiro Machado, Helio Penna Guimarães, Jorge I. Salluh, Antonio Paulo Nassar Jr., Karina Normílio-Silva, Marcus J. Schultz, Alexandre Biasi Cavalcanti and Ary Serpa Neto

Recruitment pattern of the diaphragm and extradiaphragmatic inspiratory muscles in response to different levels of pressure support

Inappropriate ventilator assist plays an important role in the development of diaphragm dysfunction. Ventilator under-assist may lead to muscle injury, while over-assist may result in muscle atrophy. This prov...

Authors: L. H. Roesthuis, J. G. van der Hoeven, H. W. H. van Hees, W.-J. M. Schellekens, J. Doorduin and L. M. A. Heunks

Duration of prone position sessions: a prospective cohort study

Prone position (PP) is highly recommended in moderate-to-severe ARDS. However, the optimal duration of PP sessions remains unclear. We searched to evaluate the time required to obtain the maximum physiological...

Authors: Sebastien Jochmans, Sandie Mazerand, Jonathan Chelly, Franck Pourcine, Oumar Sy, Nathalie Thieulot-Rolin, Olivier Ellrodt, Emmanuelle Mercier Des Rochettes, Gaël Michaud, Jean Serbource-Goguel, Christophe Vinsonneau, Ly Van Phach Vong and Mehran Monchi

The end-expiratory occlusion test for detecting preload responsiveness: a systematic review and meta-analysis

We performed a systematic review and meta-analysis of studies assessing the end-expiratory occlusion test (EEXPO test)-induced changes in cardiac output (CO) measured by any haemodynamic monitoring device, as ...

Authors: Francesco Gavelli, Rui Shi, Jean-Louis Teboul, Danila Azzolina and Xavier Monnet

Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)

Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid adm...

Authors: Manu L. N. G. Malbrain, Thomas Langer, Djillali Annane, Luciano Gattinoni, Paul Elbers, Robert G. Hahn, Inneke De laet, Andrea Minini, Adrian Wong, Can Ince, David Muckart, Monty Mythen, Pietro Caironi and Niels Van Regenmortel

Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome

Authors: Sami Hraiech, Jérémy Bourenne, Khaldoun Kuteifan, Julie Helms, Julien Carvelli, Marc Gainnier, Ferhat Meziani and Laurent Papazian

Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study

No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock.

Authors: C. Darreau, F. Martino, M. Saint-Martin, S. Jacquier, J. F. Hamel, M. A. Nay, N. Terzi, G. Ledoux, F. Roche-Campo, L. Camous, F. Pene, T. Balzer, F. Bagate, J. Lorber, P. Bouju, C. Marois…

Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome

COVID-19 is an emerging disease of public health concern. While there is no specific recommended treatment for COVID-19, nitric oxide has the potential to be of therapeutic value for managing acute respiratory...

Authors: Jun Kobayashi and Isamu Murata

Microvascular alterations in patients with SARS-COV-2 severe pneumonia

Authors: Elisa Damiani, Andrea Carsetti, Erika Casarotta, Claudia Scorcella, Roberta Domizi, Erica Adrario and Abele Donati

The outbreak of COVID-19 in Mulhouse

Authors: Khaldoun Kuteifan, Pierre Pasquier, Christian Meyer, Jacques Escarment and Odile Theissen

Early sepsis markers in patients admitted to intensive care unit with moderate-to-severe diabetic ketoacidosis

Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicro...

Authors: Florian Blanchard, Judith Charbit, Guillaume Van der Meersch, Benjamin Popoff, Adrien Picod, Regis Cohen, Frank Chemouni, Stephane Gaudry, Helene Bihan and Yves Cohen

Beneficial effect modification on survival outcome of sepsis between ART-123 and polymyxin B‑immobilised haemoperfusion: a nationwide Japanese registry study

Although recently published randomised controlled trials did not confirm significant positive effect of ART-123 or polymyxin B‑immobilised haemoperfusion (PMX-HP) on survival outcome, previous studies using a ...

Authors: Katsunori Mochizuki, Kotaro Mori, Hiroshi Kamijo, Michitaro Ichikawa, Kenichi Nitta and Hiroshi Imamura

Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study

The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Se...

Authors: Mercedes Ibarz, Ariane Boumendil, Lenneke E. M. Haas, Marian Irazabal, Hans Flaatten, Dylan W. de Lange, Alessandro Morandi, Finn H. Andersen, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno…

Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome

A large proportion of patients with a SARS-Cov-2-associated respiratory failure develop an acute respiratory distress syndrome (ARDS). It has been recently suggested that SARS-Cov-2-associated ARDS may differ ...

Authors: François M. Beloncle, Bertrand Pavlovsky, Christophe Desprez, Nicolas Fage, Pierre-Yves Olivier, Pierre Asfar, Jean-Christophe Richard and Alain Mercat

Thenar oxygen saturation (StO₂) alterations during a spontaneous breathing trial predict extubation failure

Weaning from mechanical ventilation (MV) is a cardiovascular stress test. Monitoring the regional oxygenation status has shown promising results in predicting the tolerance to spontaneously breathe in the proc...

Authors: Jaume Mesquida, Guillem Gruartmoner, Cristina Espinal, Jordi Masip, Caroline Sabatier, Ana Villagrá, Hernando Gómez, Michael Pinsky, Francisco Baigorri and Antonio Artigas

One-year survival in acute stroke patients requiring mechanical ventilation: a multicenter cohort study

Most prognostic studies in acute stroke patients requiring invasive mechanical ventilation are outdated and have limitations such as single-center retrospective designs. We aimed to study the association of IC...

Authors: Etienne de Montmollin, Nicolas Terzi, Claire Dupuis, Maité Garrouste-Orgeas, Daniel da Silva, Michaël Darmon, Virginie Laurent, Guillaume Thiéry, Johana Oziel, Guillaume Marcotte, Marc Gainnier, Shidasp Siami, Benjamin Sztrymf, Christophe Adrie, Jean Reignier, Stephane Ruckly…

Tracheostomy in patients with acute respiratory distress syndrome is not related to quality of life, symptoms of psychiatric disorders or return-to-work: the prospective DACAPO cohort study

Acute respiratory distress syndrome (ARDS) is a life-threatening condition that often requires prolonged mechanical ventilation. Tracheostomy is a common procedure with some risks, on the other hand with poten...

Authors: Sebastian Blecha, Magdalena Brandl, Florian Zeman, Frank Dodoo-Schittko, Susanne Brandstetter, Christian Karagiannidis, Thomas Bein and Christian Apfelbacher

Urine NGAL as a biomarker for septic AKI: a critical appraisal of clinical utility—data from the observational FINNAKI study

Neutrophil gelatinase-associated lipocalin (NGAL) is released from kidney tubular cells under stress as well as from neutrophils during inflammation. It has been suggested as a biomarker for acute kidney injur...

Authors: Sanna Törnblom, Sara Nisula, Liisa Petäjä, Suvi T. Vaara, Mikko Haapio, Eero Pesonen and Ville Pettilä

Diagnosis and management of respiratory viruses in critically ill adult patients: an international survey of knowledge and practice among intensivists

In this survey endorsed by the European Society of Intensive Care Medicine (ESICM), we aimed to describe the practice patterns of intensivists worldwide, regarding their diagnosis and management of respiratory...

Authors: Quentin Philippot, Vincent Labbé, Jérémie Pichon, Michel Djibré, Muriel Fartoukh and Guillaume Voiriot

Systematic review and literature appraisal on methodology of conducting and reporting critical-care echocardiography studies: a report from the European Society of Intensive Care Medicine PRICES expert panel

The echocardiography working group of the European Society of Intensive Care Medicine recognized the need to provide structured guidance for future CCE research methodology and reporting based on a systematic ...

Authors: S. Huang, F. Sanfilippo, A. Herpain, M. Balik, M. Chew, F. Clau-Terré, C. Corredor, D. De Backer, N. Fletcher, G. Geri, A. Mekontso-Dessap, A. McLean, A. Morelli, S. Orde, T. Petrinic, M. Slama…

Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study

Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug con...

Authors: Jörn Grensemann, David Busse, Christina König, Kevin Roedl, Walter Jäger, Dominik Jarczak, Stefanie Iwersen-Bergmann, Carolin Manthey, Stefan Kluge, Charlotte Kloft and Valentin Fuhrmann

Bedside prediction of intradialytic hemodynamic instability in critically ill patients: the SOCRATE study

Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, ...

Authors: Naïke Bigé, Jean-Rémi Lavillegrand, Julien Dang, Philippe Attias, Stéphanie Deryckere, Jérémie Joffre, Vincent Dubée, Gabriel Preda, Guillaume Dumas, Geoffroy Hariri, Claire Pichereau, Jean-Luc Baudel, Bertrand Guidet, Eric Maury, Pierre-Yves Boelle and Hafid Ait-Oufella

Urinary [TIMP-2] × [IGFBP7] and serum procalcitonin to predict and assess the risk for short-term outcomes in septic and non-septic critically ill patients

Biomarkers can play a critical role by facilitating diagnosis and stratification of disease, as well as assessment or prediction of disease severity. Urinary tissue inhibitor of metalloproteinase-2 and insulin...

Authors: Ilaria Godi, Silvia De Rosa, Francesca Martino, Simona Bazzano, Marina Martin, Elisa Boni, Maria Rosa Carta, Claudia Tamayo Diaz, Gaia Mari, Anna Lorenzin, Massimo de Cal, Valentina Corradi, Carlotta Caprara, Davide Giavarina and Claudio Ronco

Therapeutic strategies for critically ill patients with COVID-19

Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. Among people ...

Authors: Lei Li, Ranran Li, Zhixiong Wu, Xianghong Yang, Mingyan Zhao, Jiao Liu and Dechang Chen

Factors associated with major adverse kidney events in patients who underwent veno-arterial extracorporeal membrane oxygenation

To describe acute kidney injury (AKI) natural history and to identify predictors of major adverse kidney events (MAKE) within 1 year in patients supported by veno-arterial extracorporeal membrane oxygenation (...

Authors: Camille Vinclair, Etienne De Montmollin, Romain Sonneville, Jean Reuter, Jordane Lebut, Radj Cally, Bruno Mourvillier, Mathilde Neuville, Stéphane Ruckly, Jean-François Timsit and Lila Bouadma

Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA

Authors: Marion Ferreira, Timothee Blin, Nived Collercandy, Piotr Szychowiak, Pierre-François Dequin, Youenn Jouan and Antoine Guillon

SEA-MAKE score as a tool for predicting major adverse kidney events in critically ill patients with acute kidney injury: results from the SEA-AKI study

Acute kidney injury (AKI) is a common problem in critically ill patients and associated with high rates of morbidity and mortality. Recently, Major Adverse Kidney Events (MAKE) were introduced as important kid...

Authors: Theerapon Sukmark, Nuttha Lumlertgul, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong and Nattachai Srisawat

Diastolic shock index and clinical outcomes in patients with septic shock

Loss of vascular tone is a key pathophysiological feature of septic shock. Combination of gradual diastolic hypotension and tachycardia could reflect more serious vasodilatory conditions. We sought to evaluate...

Authors: Gustavo A. Ospina-Tascón, Jean-Louis Teboul, Glenn Hernandez, Ingrid Alvarez, Alvaro I. Sánchez-Ortiz, Luis E. Calderón-Tapia, Ramiro Manzano-Nunez, Edgardo Quiñones, Humberto J. Madriñan-Navia, Juan E. Ruiz, José L. Aldana and Jan Bakker

Characteristics of resuscitation, and association between use of dynamic tests of fluid responsiveness and outcomes in septic patients: results of a multicenter prospective cohort study in Argentina

Resuscitation of septic patients regarding goals, monitoring aspects and therapy is highly variable. Our aim was to characterize cardiovascular and fluid management of sepsis in Argentina, a low and middle-inc...

Authors: Arnaldo Dubin, Cecilia Loudet, Vanina S. Kanoore Edul, Javier Osatnik, Fernando Ríos, Daniela Vásquez, Mario Pozo, Bernardo Lattanzio, Fernando Pálizas, Francisco Klein, Damián Piezny, Paolo N. Rubatto Birri, Graciela Tuhay, Analía García, Analía Santamaría, Graciela Zakalik…

Occurrence of pendelluft under pressure support ventilation in patients who failed a spontaneous breathing trial: an observational study

Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO₂ as compared to fres...

Authors: Andrea Coppadoro, Alice Grassi, Cecilia Giovannoni, Francesca Rabboni, Nilde Eronia, Alfio Bronco, Giuseppe Foti, Roberto Fumagalli and Giacomo Bellani

Ocular microvascular changes in patients with sepsis: a prospective observational study

The aim of the study was to detect differences in the conjunctival microcirculation between septic patients and healthy subjects and to evaluate the course of conjunctival and retinal microvasculature in survi...

Authors: Jurate Simkiene, Zivile Pranskuniene, Astra Vitkauskiene, Vidas Pilvinis, E. Christiaan Boerma and Andrius Pranskunas

The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China

The outbreak of a novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) is currently ongoing in China. Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. However, the...

Authors: Ke Wang, Wei Zhao, Ji Li, Weiwei Shu and Jun Duan

Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study

Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase ...

Authors: Rene A. Posma, Trine Frøslev, Bente Jespersen, Iwan C. C. van der Horst, Daan J. Touw, Reimar W. Thomsen, Maarten W. Nijsten and Christian F. Christiansen

Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study

Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS). Although increased dead-space ventilation (V_D/V_T) has been described in ARDS, its mechanism is not clearly und...

Authors: Gustavo A. Ospina-Tascón, Diego F. Bautista, Humberto J. Madriñán, Juan D. Valencia, William F. Bermúdez, Edgardo Quiñones, Luis Eduardo Calderón-Tapia, Glenn Hernandez, Alejandro Bruhn and Daniel De Backer

Adjunctive corticosteroids may be associated with better outcome for non-HIV Pneumocystis pneumonia with respiratory failure: a systemic review and meta-analysis of observational studies

Evidence supporting corticosteroids adjunctive treatment (CAT) for Pneumocystis jirovecii pneumonia (PCP) in non-HIV patients is highly controversial. We aimed to systematically review the literature and perform ...

Authors: Lin Ding, Huixue Huang, Heyan Wang and Hangyong He

Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province

Authors: Qin Sun, Haibo Qiu, Mao Huang and Yi Yang

Prescription of CRRT: a pathway to optimize therapy

Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is associated with prolonged hospitalization, progression to chronic kidney disease (CKD), financial burden, and high mortalit...

Authors: Ayman Karkar and Claudio Ronco

Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method

High-frequency oscillatory ventilation (HFOV) may theoretically provide lung protective ventilation. The negative clinical results may be due to inadequate mean airway pressure (mPaw) settings in HFOV. Our obj...

Authors: Songqiao Liu, Zhanqi Zhao, Li Tan, Lihui Wang, Knut Möller, Inéz Frerichs, Tao Yu, Yingzi Huang, Chun Pan, Yi Yang and Haibo Qiu