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  1. Although prompt initiation of appropriate antifungal therapy is essential for the control of invasive Candida infections and an improvement of prognosis, early diagnosis of invasive candidiasis remains a challeng...

    Authors: Guillaume Leroy, Fabien Lambiotte, Didier Thévenin, Christian Lemaire, Erika Parmentier, Patrick Devos and Olivier Leroy
    Citation: Annals of Intensive Care 2011 1:50
  2. Hypoglycemia is associated with increased mortality in critically ill patients. The impact of hypoglycemia on resource utilization has not been investigated. The objective of this investigation was to evaluate...

    Authors: James Krinsley, Marcus J Schultz, Peter E Spronk, Floris van Braam Houckgeest, Johannes P van der Sluijs, Christian Mélot and Jean-Charles Preiser
    Citation: Annals of Intensive Care 2011 1:49
  3. Microcirculation plays a vital role in the development of multiple organ failure in severe sepsis. The effects of red blood cell (RBC) transfusions on these tissue oxygenation and microcirculation variables in...

    Authors: Farid Sadaka, Ravi Aggu-Sher, Katie Krause, Jacklyn O'Brien, Eric S Armbrecht and Robert W Taylor
    Citation: Annals of Intensive Care 2011 1:46
  4. The prognosis for postcardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "postcardiac arrest syndrome," a phenomenon often severe enoug...

    Authors: Nicolas Mongardon, Florence Dumas, Sylvie Ricome, David Grimaldi, Tarik Hissem, Frédéric Pène and Alain Cariou
    Citation: Annals of Intensive Care 2011 1:45
  5. This study was designed to investigate the effect of hypertonic fluid administration on inflammatory mediator gene expression in patients with septic shock.

    Authors: Frank MP van Haren, James Sleigh, Ray Cursons, Mary La Pine, Peter Pickkers and Johannes G van der Hoeven
    Citation: Annals of Intensive Care 2011 1:44
  6. Red blood cell (RBC) transfusion is a common intervention in intensive care unit (ICU) patients. Anemia is frequent in this population and is associated with poor outcomes, especially in patients with ischemic...

    Authors: Christophe Lelubre and Jean-Louis Vincent
    Citation: Annals of Intensive Care 2011 1:43
  7. Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent patient-ventilat...

    Authors: Stéphane Delisle, Paul Ouellet, Patrick Bellemare, Jean-Pierre Tétrault and Pierre Arsenault
    Citation: Annals of Intensive Care 2011 1:42
  8. Mitochondrial functions include production of energy, activation of programmed cell death, and a number of cell specific tasks, e.g., cell signaling, control of Ca2+ metabolism, and synthesis of a number of impor...

    Authors: Andrey V Kozlov, Soheyl Bahrami, Enrico Calzia, Peter Dungel, Lars Gille, Andrey V Kuznetsov and Jakob Troppmair
    Citation: Annals of Intensive Care 2011 1:41
  9. Erythropoietin (EPO) is the major hormone stimulating the production and differentiation of red blood cells. EPO is used widely for treating anemia of critical illness or anemia induced by chemotherapy. EPO at...

    Authors: Nimesh SA Patel, Massimo Collino, Muhammad M Yaqoob and Christoph Thiemermann
    Citation: Annals of Intensive Care 2011 1:40
  10. Stress-related cardiomyopathies can be observed in the four following situations: Takotsubo cardiomyopathy or apical ballooning syndrome; acute left ventricular dysfunction associated with subarachnoid hemorrh...

    Authors: Christian Richard
    Citation: Annals of Intensive Care 2011 1:39
  11. Tight glycemic control (TGC) has shown benefits but has been difficult to achieve consistently. STAR (Stochastic TARgeted) is a flexible, model-based TGC approach directly accounting for intra- and inter- pati...

    Authors: Alicia Evans, Geoffrey M Shaw, Aaron Le Compte, Chia-Siong Tan, Logan Ward, James Steel, Christopher G Pretty, Leesa Pfeifer, Sophie Penning, Fatanah Suhaimi, Matthew Signal, Thomas Desaive and J Geoffrey Chase
    Citation: Annals of Intensive Care 2011 1:38
  12. Invasive candidiasis ranges from 5 to 10 cases per 1,000 ICU admissions and represents 5% to 10% of all ICU-acquired infections, with an overall mortality comparable to that of severe sepsis/septic shock. A la...

    Authors: Philippe Eggimann, Jacques Bille and Oscar Marchetti
    Citation: Annals of Intensive Care 2011 1:37
  13. Echocardiography is useful for the diagnosis and management of hemodynamic failure in the intensive care unit so that competence in some elements of echocardiography is a core skill of the critical care specia...

    Authors: Paul H Mayo
    Citation: Annals of Intensive Care 2011 1:36
  14. Recent interest in functional hemodynamic monitoring for the bedside assessment of cardiovascular insufficiency has heightened. Functional hemodynamic monitoring is the assessment of the dynamic interactions o...

    Authors: Xaime García and Michael R Pinsky
    Citation: Annals of Intensive Care 2011 1:35
  15. Catheters are the leading source of bloodstream infections for patients in the intensive care unit (ICU). Comprehensive unit-based programs have proven to be effective in decreasing catheter-related bloodstrea...

    Authors: Jean-François Timsit, Yohann Dubois, Clémence Minet, Agnès Bonadona, Maxime Lugosi, Claire Ara-Somohano, Rebecca Hamidfar-Roy and Carole Schwebel
    Citation: Annals of Intensive Care 2011 1:34
  16. The diagnostic ability of computer-based methods for cardiovascular system (CVS) monitoring offers significant clinical potential. This research tests the clinical applicability of a newly improved computer-ba...

    Authors: James A Revie, David J Stevenson, J Geoffrey Chase, Christopher E Hann, Bernard C Lambermont, Alexandre Ghuysen, Philippe Kolh, Philippe Morimont, Geoffrey M Shaw and Thomas Desaive
    Citation: Annals of Intensive Care 2011 1:33
  17. Evidence is accumulating showing that septic acute kidney injury (AKI) is different from non-septic AKI. Specifically, a large body of research points to apoptotic processes underlying septic AKI. Unravelling ...

    Authors: Patrick M Honore, Rita Jacobs, Olivier Joannes-Boyau, Jouke De Regt, Willem Boer, Elisabeth De Waele, Vincent Collin and Herbert D Spapen
    Citation: Annals of Intensive Care 2011 1:32
  18. We hypothesized that bedside nurses perceive significant variability in the pediatric intensivist thresholds for approaching a family about withdrawal/limitation of life-sustaining therapy.

    Authors: Colleen S Gresiuk and Ari R Joffe
    Citation: Annals of Intensive Care 2011 1:31
  19. The aging of the population has increased the demand for healthcare resources. The number of patients aged 80 years and older admitted to the intensive care unit (ICU) increased during the past decade, as has ...

    Authors: Yên-Lan Nguyen, Derek C Angus, Ariane Boumendil and Bertrand Guidet
    Citation: Annals of Intensive Care 2011 1:29
  20. Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the characteristics of these alterations, the various mechanisms potential...

    Authors: Daniel De Backer, Katia Donadello, Fabio Silvio Taccone, Gustavo Ospina-Tascon, Diamantino Salgado and Jean-Louis Vincent
    Citation: Annals of Intensive Care 2011 1:27
  21. Continuous infusion of vancomycin is increasingly preferred as an alternative to intermittent administration in critically ill patients. Intermittent vancomycin treatment is associated with an increased occurr...

    Authors: Herbert D Spapen, Karin Janssen van Doorn, Marc Diltoer, Walter Verbrugghe, Rita Jacobs, Nadia Dobbeleir, Patrick M Honoré and Philippe G Jorens
    Citation: Annals of Intensive Care 2011 1:26
  22. Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, stand...

    Authors: Jan Wernerman
    Citation: Annals of Intensive Care 2011 1:25
  23. Helium is a low-density inert gas whose physical properties are very different from those of nitrogen and oxygen. Such properties could be clinically useful in the adult critical care setting, especially in pa...

    Authors: J-L Diehl, V Peigne, E Guérot, C Faisy, L Lecourt and A Mercat
    Citation: Annals of Intensive Care 2011 1:24
  24. Suspicion of sepsis in neutropenic patients requires immediate antimicrobial treatment. The initial regimen in critically ill patients should cover both Gram-positive and Gram-negative pathogens, including Pseudo...

    Authors: Matthieu Legrand, Adeline Max, Benoît Schlemmer, Elie Azoulay and Bertrand Gachot
    Citation: Annals of Intensive Care 2011 1:22
  25. Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has a...

    Authors: MaryAnn Zhang, Raymond Hsu, Chi-yuan Hsu, Kristina Kordesch, Erica Nicasio, Alfredo Cortez, Ian McAlpine, Sandra Brady, Hanjing Zhuo, Kirsten N Kangelaris, John Stein, Carolyn S Calfee and Kathleen D Liu
    Citation: Annals of Intensive Care 2011 1:21
  26. Given the persistent shortage of organs for transplantation, new donor management strategies to improve both organ utilization and quality of procured organs are needed. Current management protocols for the ca...

    Authors: Lorraine B Ware, Tatsuki Koyama, Dean Billheimer, Megan Landeck, Elizabeth Johnson, Sandra Brady, Gordon R Bernard and Michael A Matthay
    Citation: Annals of Intensive Care 2011 1:20
  27. Microbiologists have extensively worked during the past decade on a particular phase of the bacterial cell cycle known as biofilm, in which single-celled individuals gather together to form a sedentary but dyn...

    Authors: Christophe Bordi and Sophie de Bentzmann
    Citation: Annals of Intensive Care 2011 1:19
  28. The primary objective of this study was to examine levels of B-type natriuretic peptide (BNP) in mechanically ventilated patients with acute lung injury and to test whether the level of BNP would be higher in ...

    Authors: Magda Cepkova, Vineet Kapur, Xiushui Ren, Thomas Quinn, Hanjing Zhuo, Elyse Foster, Michael A Matthay and Kathleen D Liu
    Citation: Annals of Intensive Care 2011 1:18
  29. The Surviving Sepsis Campaign is a global effort to improve the care of patients with severe sepsis and septic shock. The first Surviving Sepsis Campaign Guidelines were published in 2004 with an updated versi...

    Authors: Paul E Marik
    Citation: Annals of Intensive Care 2011 1:17
  30. ARDS is particularly characterized by pulmonary edema caused by an increase in pulmonary capillary permeability. It is considered that limiting pulmonary edema or accelerating its resorption through the modula...

    Authors: Antoine Roch, Christophe Guervilly and Laurent Papazian
    Citation: Annals of Intensive Care 2011 1:16
  31. Urine output often is used as a marker of acute kidney injury but also to guide fluid resuscitation in critically ill patients. Although decrease of urine output may be associated to a decrease of glomerular f...

    Authors: Matthieu Legrand and Didier Payen
    Citation: Annals of Intensive Care 2011 1:13
  32. Critically ill patients are highly variable in their response to care and treatment. This variability and the search for improved outcomes have led to a significant increase in the use of protocolized care to ...

    Authors: J Geoffrey Chase, Aaron J Le Compte, J-C Preiser, Geoffrey M Shaw, Sophie Penning and Thomas Desaive
    Citation: Annals of Intensive Care 2011 1:11
  33. Recruitment maneuvers (RM) consist of a ventilatory strategy that increases the transpulmonary pressure transiently to reopen the recruitable lung units in acute respiratory distress syndrome (ARDS). The ratio...

    Authors: Claude Guerin, Sophie Debord, Véronique Leray, Bertrand Delannoy, Frédérique Bayle, Gael Bourdin and Jean-Christophe Richard
    Citation: Annals of Intensive Care 2011 1:9
  34. Depression of left ventricular (LV) intrinsic contractility is constant in patients with septic shock. Because most parameters of cardiac function are strongly dependent on afterload, especially in this contex...

    Authors: Antoine Vieillard-Baron
    Citation: Annals of Intensive Care 2011 1:6
  35. A few decades have passed since intensive care unit (ICU) beds have been available for critically ill patients with cancer. Although the initial reports showed dismal prognosis, recent data suggest that an inc...

    Authors: Elie Azoulay, Marcio Soares, Michael Darmon, Dominique Benoit, Stephen Pastores and Bekele Afessa
    Citation: Annals of Intensive Care 2011 1:5
  36. Chest x-rays (CXRs) are the main imaging tool in intensive care units (ICUs). CXRs also are associated with concerns inherent to their use, considering both healthcare organization and patient perspectives. In...

    Authors: Vincent Ioos, Arnaud Galbois, Ludivine Chalumeau-Lemoine, Bertrand Guidet, Eric Maury and Gilles Hejblum
    Citation: Annals of Intensive Care 2011 1:4
  37. Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow. Accumulating evidence...

    Authors: Elizabeth Moore and Rinaldo Bellomo
    Citation: Annals of Intensive Care 2011 1:3
  38. The clinical determination of the intravascular volume can be extremely difficult in critically ill and injured patients as well as those undergoing major surgery. This is problematic because fluid loading is ...

    Authors: Paul E Marik, Xavier Monnet and Jean-Louis Teboul
    Citation: Annals of Intensive Care 2011 1:1

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