Intensive care of the cancer patient: recent achievements and remaining challenges
Annals of Intensive Care volume 1, Article number: 5 (2011)
A few decades have passed since intensive care unit (ICU) beds have been available for critically ill patients with cancer. Although the initial reports showed dismal prognosis, recent data suggest that an increased number of patients with solid and hematological malignancies benefit from intensive care support, with dramatically decreased mortality rates. Advances in the management of the underlying malignancies and support of organ dysfunctions have led to survival gains in patients with life-threatening complications from the malignancy itself, as well as infectious and toxic adverse effects related to the oncological treatments. In this review, we will appraise the prognostic factors and discuss the overall perspective related to the management of critically ill patients with cancer. The prognostic significance of certain factors has changed over time. For example, neutropenia or autologous bone marrow transplantation (BMT) have less adverse prognostic implications than two decades ago. Similarly, because hematologists and oncologists select patients for ICU admission based on the characteristics of the malignancy, the underlying malignancy rarely influences short-term survival after ICU admission. Since the recent data do not clearly support the benefit of ICU support to unselected critically ill allogeneic BMT recipients, more outcome research is needed in this subgroup. Because of the overall increased survival that has been reported in critically ill patients with cancer, we outline an easy-to-use and evidence-based ICU admission triage criteria that may help avoid depriving life support to patients with cancer who can benefit. Lastly, we propose a research agenda to address unanswered questions.
The number of patients living with cancer has been increasing steadily [1–3]. The ageing population, improved diagnostic tools for cancer, and decrease in cancer-related mortality have contributed to this increase. The age-adjusted invasive cancer incidence rate (95% confidence interval) in the United States is 533.8 (532.6-535.1) per 100,000 population . More than 1.4 million people were projected to be diagnosed with cancer in the United States in 2009 . In Europe, there were an estimated 3,191,600 cancer cases diagnosed and 1,703,000 deaths from cancer in 2006 . In 2005, more than 100,000 cases of hematological malignancies were diagnosed in the United States and approximately 230,000 in Europe [4, 6]. Intensive chemotherapy regimens  and the use of new and more targeted therapeutic drugs have resulted in high cancer cure rates. However, the treatment often leads to drug-related organ toxicities and increased susceptibility to infection [8, 9]. As a consequence, intensivists are increasingly managing patients with cancer who are admitted to the intensive care unit (ICU) for organ dysfunction--chiefly respiratory failure, originating from infectious, malignant, or toxic complications [10, 11]. Timely recognition and early ICU admission offer opportunities to prevent and manage life-threatening complications that are cancer-related, including tumor lysis syndrome , leukostasis , and macrophage activation syndrome . Managing organ dysfunction in critically ill cancer patients requires specialized skills by the intensivist and close collaboration between the intensivist and oncologist.
Critically ill cancer patients have lower survival rates compared with patients without comorbidities. However, their in-hospital mortality rates are not higher compared with critically ill patients with other comorbidities, such as heart failure, liver cirrhosis, or other serious chronic diseases . Recent studies have shown that a substantial survival rate can be achieved even in severely ill patients with cancer [16–18]. Healthcare providers and patients often discuss the merits of providing mechanical ventilation, vasoactive agents, renal replacement therapy, or other life-sustaining treatments in patients with cancer . There also are unresolved questions about whether part or all of these supportive therapies can be simultaneously administered with cancer-specific treatments, including chemotherapy [20–22]. More recently, the lack of survival benefit in cancer patients admitted to the ICU with multiple organ failure [10, 17] has raised concerns about the timing of ICU admission .
This is not a systematic review but a consensus opinion from experts who care for critically ill patients with cancer. We plea for the development and implementation of broader ICU admission policies. Future observational research will be required to assess the validity of our conclusions.
Short-term survival after critical care illness improved
Several studies comparing two time periods in subgroups of cancer patients have reported improvement in hospital survival during the past decade [10, 11, 23–28] (Figure 1). Recent prospective and retrospective cohort studies have documented lower mortality rates compared with the mortality rates previously reported [16, 23, 29–33]. Improved survival rates have been reported in cancer patients who require mechanical ventilation [23, 30, 34–36], renal replacement therapy [37–39], and vasopressors [26, 27], as well as those with neurological complications . The impact of the Surviving Sepsis Campaign may have played a part in the reduction in mortality seen during the past few years in patients with septic shock [26, 27]. Although these studies include large cohorts of patients, most of them are retrospective and single-centered and do not provide adequate reasons for the improved survival. Only two prospective, multicenter, ICU outcome studies that involve cancer patients have been published to date . Another limitation of these studies is the huge heterogeneity in patient case mix: medical and surgical patients; solid and hematologic cancer patients; allogeneic and autologous blood; and bone marrow transplant (BMT) recipients. Moreover, it is difficult to compare the results between the published studies because of the variations in ICU admission and discharge criteria as well as the settings and timing for the implementation of end-of-life decisions .
Although there may have been a general improvement in ICU mortality of cancer patients over time, five hypotheses have been proposed to account for the decreased mortality rate in these patients : 1) an overall improved survival in cancer patients [42, 43] related to the use of more intensive chemotherapeutic regimens , the development of more potent and targeted therapies [8, 9, 44, 45], as well as advances in the supportive care and prevention of organ dysfunction ; 2) improved ICU management with the development of noninvasive diagnostic [40, 47] and therapeutic strategies [23, 48, 49]; 3) ability to obtain the etiological diagnosis in patients with acute respiratory failure [40, 49–51], e.g., bacterial infection [21, 22, 52]. In this regard, it is worth noting that patients admitted to ICUs with a large volume of hematological patients with acute respiratory failure experience a lower mortality ; 4) new strategies avoiding early chemotherapy during the course of chronic malignancies (such as watch-and-wait policies or immunotherapy) assist in managing patients with improved performance status with less organ-related toxicity and epithelial and endothelial dysfunction with its increased propensity for cardiovascular, renal, and pulmonary dysfunctions ; and 5) changes in triage patterns may have occurred that facilitate the ICU admission of cancer patients with the best chances for survival.
Overall, the medical literature has documented improvement in survival of critically ill patients with cancer. However, most of the studies have evaluated short-term outcomes, such as ICU, hospital, 28-day, and, rarely, 3- or 6-month survival. To our knowledge, no study has used long-term or meaningful outcomes, such as disease-free survival and quality of life after ICU admission.
Classic predictors of mortality are no longer relevant
Current studies still report that the need for mechanical ventilation, presence of invasive fungal infection, development of multiorgan failure, and high severity of illness scores are additional prognostic factors for mortality among cancer patients. Although these prognostic factors are important, they often are unreliable and mostly derived from inconsistent results. For example, a British multicenter study of patients with hematologic malignancy admitted to the ICU showed that BMT was a risk factor for increased hospital death . However, among patients with cancer admitted to the ICU, those who underwent autologous BMT had the same prognosis as those who did not [19, 23]. Benoit and colleagues reported neutropenia to be an independent risk factor for increased mortality in patients with hematologic malignancy admitted to the ICU . However, a subsequent study at the same institution proved this to be no longer valid , and based on another large multicenter study in Brazil, Soares et al. recently reported the lack of association between mortality and the presence of neutropenia in patients with cancer . These differences are likely to reflect differences of selection biases by oncologists in providing treatment. The reported prognostic importance of other classic mortality predictors, such as age or characteristics of the malignancy, vary among studies and may mainly depend on ICU admission criteria [18, 41]. We recommend not denying ICU admission to elderly patients based on age alone, or to those with advanced malignancies at the earliest phase of the disease, a time when response to therapy is not known.
Improved understanding of organ dysfunction
There has been an improved understanding of organ dysfunction, mainly as a result of a close collaboration between hematologists/oncologists and intensivists  (Table 2). Clinical experience in managing patients with cancer has led to better understanding of the pathophysiology of acute tumor lysis syndrome [12, 46, 58, 59] and macrophage activation syndrome  and to a comprehensive diagnostic strategy of acute respiratory failure . Although the cause-effect relationship cannot be proven, we strongly believe that the improved understanding of organ dysfunction in patients with cancer has translated into better survival.
Some groups of patients remain with high and unchanged mortality
In addition to bedridden patients and those with no lifespan expanding therapy (see point 5 following), there are three groups of patients in whom survival rates remain marginally low. These include allogeneic BMT recipients with severe graft-versus-host disease (GVHD) who are unresponsive to immunosuppressive therapy [27, 61], patients with multiple organ failure related to delayed ICU admission , and specific clinical vignettes in patients with solid tumors, such as pulmonary carcinomatous lymphangitis with acute respiratory failure , carcinomatous meningitis with coma , or bone involvement by extra-hematopoietic cancerous cells and medullar insufficiency .
Several studies have assessed the outcomes of allogeneic BMT recipients admitted to the ICU during the past three decades . Despite careful selection for ICU admission and advances in critical care, the prognosis remains grim, with an overall 1-yr survival rate of less than 10% in patients who receive mechanical ventilation [27, 34, 65–67]. Outcomes are not related to the source of stem cells (bone marrow vs. peripheral blood vs. cord blood donors), the underlying malignancy for which BMT was performed, and patient-related characteristics, such as age or comorbidities [27, 61, 67]. Ten factors have been identified to be associated with mortality after a critical care illness--most are surrogate markers of GVHD: 1) BMT from unrelated donor, because of increased risks for GVHD and associated complications; 2) GVHD itself, with epithelial injury and subsequent organ dysfunction (liver, gastrointestinal tract and skin,), and with toxic and infectious complications from immunosuppression (aspergillosis and other severe opportunistic infections); 3) the need for mechanical ventilation (associated with approximately 20% survival); 4) acute respiratory failure and the need for mechanical ventilation 4-6 weeks after BMT (GVHD period, 10% survival); 5) the association of severe sepsis and resistant GVHD; 6) thrombotic microangiopathy due to endothelial activation triggered by GVHD, total body irradiation, toxicity of immunosuppressive regimen, and infectious diseases; 7) multiple organ failure in the setting of severe hepatic veno-occlusive disease; 8) acute respiratory failure from pulmonary aspergillosis; 9) late noninfectious pulmonary complications, including diffuse alveolar hemorrhage [68, 69], bronchiolitis obliterans , and other new onset obstructive ventilatory disorders; and 10) relapse of the underlying malignancy after BMT. We recommend unrestricted intensive care support of allogeneic BMT recipients in three situations: patients at the earliest phase of transplantation (before GVHD develops) and BMT recipients proposed for ICU admission after 1 year of transplant and without GVHD or with controlled GVHD, and patients who require mechanical ventilation for status epilepticus related to posterior reversible encephalopathy syndrome (PRES). In all other situations, ICU admission and goals of therapy should be decided on an individual basis. Because survival remains exceptional, it seems reasonable to discourage ICU admission and mechanical ventilation in patients with severe sepsis or acute respiratory failure and uncontrolled GVHD.
Patients who develop multiple organ failure are at higher risk for death if their ICU admission is delayed. Khassawneh et al. reported only one survivor in patients admitted with three organ dysfunctions . In patients with multiple myeloma, delayed ICU admission was associated with increased mortality . The nature and the extent of organ dysfunctions, at ICU admission or more significantly after day 3, are good predictors of mortality [17, 26, 71].
Triage criteria that are usually used are unreliable
Marginal survival has been reported in severely impaired or bedridden patients [18, 24, 30], as well as in patients with no lifespan prolonging anticancer therapy . In these patients, care must be maintained but with transition from cure to comfort. Restricted admission policies based on these two criteria translates into improved survival [23, 24]. However, triage criteria for ICU admission remain unreliable. In a prospective study that evaluated the outcomes of patients proposed for ICU admission, 20% of patients who were not admitted because they were considered "too well" died before hospital discharge (mainly after a delayed ICU admission), and 25% of the patients who were not admitted because they were too sick survived . Importantly, this study highlighted the inadequacy of the triage criteria and the need for the development and implementation of new ICU admission policies.
At least 3 days of ICU management before making end-of-life decisions (ICU trial)
The use of life-sustaining therapies in most patients with cancer is no longer futile. However, recent data suggest that duration of mechanical ventilation, use of vasopressors, and dialysis are strong predictors of death. For example, marginal survival have been reported in patients who require invasive mechanical ventilation for 3 days or more [17, 50]. Studies of patients with neutropenia or septic shock have reported that outcomes were not easily predictable at the time of ICU admission . Identifying patients who remain severely ill, with no improvement (or with worsening condition) after 3 days of full ICU support, may be easier and more effective to appraise outcomes [17, 19].
There may be "golden hours or days" of resuscitation associated with improved outcome, for the ICU management of critically ill cancer patients. During this time, everything should be done. Subsequently, the continuation or introduction of life-sustaining therapies in patients whose conditions are worsening may not be beneficial. Further observational studies are needed to confirm the optimal time for the "ICU Trial."
Finding a balance between noninvasive treatments and avoiding delays in optimal therapies
Early ICU admission offers the opportunity to use noninvasive diagnostic tests (i.e., sputum analyses instead of bronchoalveolar lavage (BAL) in acute respiratory failure) and noninvasive ventilation (NIV) [48, 49]. This noninvasive approach is supported by the lower diagnostic yield of BAL in cancer patients with acute respiratory failure and the easy availability of noninvasive diagnostic tests [40, 60]. Although bronchoscopy and BAL can be avoided in a large proportion of patients, those who may benefit should be identified early after admission to the ICU.
Close relationship and collaboration need to be developed with hematologists and oncologists to increase the skills of both sides in the overall management of patients with cancer
Undoubtedly, some of the improvement in the outcome of critically ill cancer patients can be attributed to formal and informal free exchange of ideas between intensivists and hemato-oncologists. The hemato-oncologists are able to appraise outcomes and to update the intensivists about therapeutic options and potentials for cure of the underlying malignancies. Hemato-oncologists may teach the key pathophysiological aspects of malignant diseases as well as specific complications. Also, ICU admission decisions should be undertaken by both parties based on the acute medical disease, as well as the underlying disease prognosis and patients' preferences and values. ICU clinicians may be more knowledgeable and experienced in setting goals of life-sustaining therapies based on the reversibility of single organ dysfunction and on the presence of multiple organ failure. Decisions to withhold or withdraw life-sustaining therapies are best undertaken by both parties. Information given to patients' relatives and shared decision-making should be presented by both parties together.
Early admission to the ICU for patients with cancer
We are not aware of any study designed to assess the impact of early ICU admission. The following four observations suggest that early admission may improve outcome: a) during the past decade, decreased mortality was observed in association with earlier ICU admission ; b) receiving oxygen at a flow higher than 1 liter/min is significantly associated with subsequent need for mechanical ventilation and death ; c) performing high-risk procedures in severely ill patients (i.e., bronchoscopy and BAL in hypoxemic patients) may be less harmful if performed in the ICU (sometimes under NIV) [40, 51, 74, 75]; and d) there is a linear relationship between the number of organ dysfunctions and patients' survival, suggesting that patients should best be admitted as early as possible rather than at a time of multiple organ failure where survival remains marginal.
Doing everything that can be done, including cancer chemotherapy
When ICU admission is warranted, patients should be treated with a full code status, or according to an ICU trial. In both situations, patients receive everything they need during the first few ICU days and then have their situation reappraised after 3 to 5 days of full ICU support. This full-code status includes the administration of cancer chemotherapy along with ventilatory support, vasoactive agents, renal replacement therapy, and other life-sustaining therapies. Indeed, patients with tumor lysis syndrome, pulmonary or renal infiltration by the malignancy, sepsis related to obstructive pneumonia, or ureteral compression may require life-sustaining therapies until the cancer chemotherapy becomes effective. Studies have shown the feasibility of administering chemotherapy in the ICU, with acceptable short- and long-term outcomes [20, 21]. They also have demonstrated that when patients present with severe sepsis or septic shock after recent chemotherapy, outcomes may be better than in those who did not receive recent cancer chemotherapy [21, 22].
Broadening ICU admission policies and clarifying patient's code status at the time of admission
▶ Full code status
Most critically ill cancer patients are admitted to the ICU during the early management period of aggressive malignancies, i.e., during the first course of chemotherapy (induction or consolidation; Figure 2). Some patients with low-grade hematological malignancies (chronic lymphocytic or myeloid leukemia or low-grade lymphoma) may be admitted at any time of their disease course, mainly for infectious or toxic life-threatening complications. Patients with partial remission (myeloma) or high-risk solid tumors (metastatic breast or ovarian cancer) can be admitted at a later course of their disease, even after several courses of chemotherapy, which provides significant and sustained response with improved long-term survival . All of these patients are admitted to the ICU with a full-code status. The decision-making process is similar to that of other ICU patients without malignancy (Figure 2; Table 3). Also, the need to document patient preferences for resuscitation and end-of-life issues at the time of ICU admission is crucial.
▶ ICU trial
In some patients with cancer, the usual ICU admission triage criteria may be unreliable. Nevertheless, establishing the goals of therapy at the time of ICU admission is crucial to optimize their management. The ICU trial is an alternative to ICU refusal in cancer patients . It consists of an unlimited ICU support for a limited time period. Everything is done for at least 3 to 5 days . In a study performed at the Saint-Louis hospital in Paris, France, patients who were non-bedridden and who had a survival prolonging therapy were included . Allogeneic BMT recipients were excluded. Clinicians made clear to patients and families that the ICU trial was an alternative to ICU refusal and that as soon as the situation was considered irreversible with no hope for survival, the level of care was transitioned from cure to comfort. The major result from this ICU trial was that none of the variables available at ICU admission was significantly different between ICU survivors and nonsurvivors. Only after day 3, nonsurvivors had significantly more organ dysfunction than ICU survivors. More recently, we have advocated the use of the ICU trial in patients with newly diagnosed malignancies, but with life expectancy less than 1 year . This study was an attempt to broaden ICU admission policies and to suggest other types of ICU admission to avoid depriving ICU management to patients who may potentially benefit. Indeed, in the evaluation of the ICU trial , survival was 20% overall but 40% in patients who were alive and in the ICU after day 3.
▶ Exceptional ICU admission
The first status of admission is the "exceptional ICU" (Figure 2; Table 3). We propose this admission status for patients in whom severe limitation of the performance status are attributable to the malignancy itself and may improve in response to chemotherapy. Another scenario for this status is when evidence emerges from new trials that a new effective therapy is available for a patient without lifespan-prolonging therapy. This does not include results from in vitro studies or from phase I/II trials. For example, admission to the ICU for patients with intractable malignancy is not recommended. If the results from a new trial report that using a newly developed drug/protocol allows substantial survival, the question that can be raised is about the benefits from this drug when patients become critically ill. In this case, intensivists and hematologists or oncologists should decide to perform a careful evaluation in five to ten patients. In this circumstance, exceptional ICU admission includes formal discussions between hemato-oncologists and intensivists and must address the nature of ICU management and the time with which a response to therapy can be expected. As for the ICU trial, patients and relatives must agree with ICU admission and fully grasp its objectives.
▶ Heroic ICU admission
A second new status of ICU admission that we sometimes adopt is the "heroic ICU." This ICU management is used to resolve conflicts between ICU clinicians and hemato-oncologists, or between clinicians and patients/relatives about the actual prognosis and the appropriate level of care. The philosophy of this type of ICU admission is that 1 or 2 days of ICU management will make the prognosis more evident to appraise and create mutual trust. Although intensivists are aware that death is the most likely outcome, discussions among the stakeholders may help to resolve the conflicts and mistrust. The use of heroic ICU to resolve conflicts and to develop time for mutual trust between clinicians, intensivists, patients, and relatives may create false hope, raise unrealistic expectations, and can be perceived as highly controversial. We must emphasize that if this status of ICU admission is used more than 2 to 3 times per year, conflict resolution strategies or an attempt to increase the understanding and knowledge about the underlying condition (of the actual prognoses of malignancies or of the outcomes of organ dysfunction in cancer patients) are in order.
▶Other admission policies
The common characteristic of all the previous statuses of ICU admission is that patients receive full-code management for an unlimited or a limited time period. Other admission policies need to be evaluated before specific recommendations are made. Such policies include early ICU admission, prophylactic ICU admission, palliative ICU admission, ICU admission for non-ICU care, and terminal ICU admission (Figure 2; Table 3). The terminal admission policy is based on a controversial assumption that the ICU is the best place to die in the hospital and ICU clinicians are skilled to perform adequate palliative care to dying patients. Details on code status and clinical vignettes are reported in Table 3. Figure 3 summarizes our suggestions for ICU admission according to the factors that have been presented above.
Unanswered questions and research agenda
Many unanswered questions deserve future observational and interventional studies (Table 4). As experts in the management of critically ill cancer patients, we suggest a research agenda to address the following ten burning issues:
The first and most intriguing issue is the lack of studies on long-term outcomes in cancer patients who survive their ICU stay. We do not know whether the increase in the number of survival days is only a prolongation of the dying process or if it is an actual increase in survival with good quality of life. Beside ICU and hospital survival, very few studies have addressed survivors' quality of life. For example, in a study of noncancer patients with acute respiratory distress syndrome, survivors lost 18% of their baseline body weight during the ICU stay, experienced severe muscle weakness and fatigue, and had persistent functional disability 1 year after ICU discharge [77–79]. These findings are extremely relevant, because treatment decisions are substantially influenced by the clinical condition of the patient. In critically ill cancer patients, poor performance status has been associated with mortality [18, 30]. Moreover, poor performance status may prevent the use of optimally aggressive chemo- and radiation therapy regimens and/or decrease the ability to achieve radical surgical resection, thereby shortening long-term survival. We need studies evaluating outcomes up to 2 years after critical illness. These studies need to investigate survival, treatments that have been implemented, and remission from the malignancy.
In addition to physical outcomes, mental health and quality of life outcomes must be assessed in ICU survivors. At this time, no study has specifically evaluated health-related quality of life and post-ICU burden in critically ill cancer patients who survived the ICU. Nelson et al. investigated self-reported symptom experience of cancer patients at the time that they were receiving intensive care support . Most patients reported experiencing pain, discomfort, anxiety, sleep disturbance, or unsatisfied hunger or thirst. Approximately one third reported depression and dyspnea. Significant pain and discomfort were associated with common ICU procedures. Inability to communicate, sleep disruption, and limitations on visiting were particularly stressful among ICU conditions studied. However, no study has assessed the prevalence of these symptoms 6 months or 1 year after ICU discharge. Yet, such assessment is a key issue when addressing the question of ICU admission policies for cancer patients.
Studies in relatives of critically ill cancer patients should be developed to seek specific needs and communication strategies. Also, determinants of ICU and post-ICU burden on relatives of ICU survivors should be evaluated, because relatives of critically ill patients may become actual caregivers.
In this review, we describe provisional models of ICU admission with various code statuses that have not yet been evaluated. First, criteria for ICU admission need to be described and appraised. Second, new modalities of ICU admission should be evaluated and the balance between their strengths and weaknesses described. Controversial issues, such as palliative or terminal ICU admission, must be discussed at a global level. Indeed, it is possible, yet debatable, that death that occurs in the ICU is perceived as "good" by patients and relatives. However, broadening ICU admission criteria will be obviously associated with increased mortality and associated conflicts , clinician's burnout , demoralization , and further exhausting the limited available resources and ICU beds.
One of the most difficult issues in the ICU trial is determining the appropriate time for making end-of-life decisions . Transition from curative to palliative care is complex in cancer patients because of their young age, complex medical conditions, doubts on the actual therapeutic plans, and pressures from consultants and relatives. Implementing new ICU admission policies for cancer patients requires a critical evaluation of end-of-life care that occurs in up to 80% of these patients, i.e., when the irreversibility of the medical condition is deemed certain. Also, quality of dying and death must be specifically assessed in this context. Most importantly, the need to document patient preferences for resuscitation and end-of-life issues at the time of ICU admission is crucial.
The ICU benefits for overall long-term and disease-free survival are still unknown. We can hypothesize that patients with cancer who survive the initial complications without residual organ dysfunction will be able to receive full regimen chemotherapy and subsequently more available lifespan-prolonging therapies. However, no ICU study has evaluated the impact of the ICU support on long-term and disease-free survival.
Recent studies suggest survival benefits from early admission to the ICU . However, this has never been evaluated properly. Indeed, a randomized, clinical trial designed to admit selected patients with cancer at the earliest phase of the malignancy (before or within first few days of cancer chemotherapy) with only one organ dysfunction may be in order. Besides overall survival, if prevention of organ dysfunction translates into improved outcomes, practical guidelines will be easy to recommend.
An appraisal of classic prognostic factors is timely. There are data that suggest that neutropenia and autologous BMT may no longer have prognostic relevance . New determinants of outcome have emerged from recent studies. These new determinants include our ability to make the actual etiological diagnosis rather than treating empirically [40, 48, 50, 51, 85], delayed ICU admission , cytogenetic data in patients with aggressive malignancies , and, clearly, the number and the extent of organ dysfunctions [17, 26]. However, additional multicentre cohort studies are needed to identify predictors of death in cancer patients admitted to the ICU, controlling for the ASSESS criteria that we have recently proposed (Table 5) . These include triage criteria for ICU admission, code status implemented at ICU admission, the nature of life-sustaining therapies that are required, and the extent of organ dysfunction at admission, as well as long-term overall and disease-free survival and quality of life.
There is an emerging interest for adding NIV to routine supportive care provided in hematology/oncology wards [87–90]. This is partly due to shortage of ICU beds  and ICU physicians' reluctance to admit cancer patients with acute respiratory failure [92, 93], as well as the unconfirmed assumption that ICU admission may hamper patients' chances of receiving optimal hematology/oncology care and appropriate infection prevention. We advise caution when implementing NIV in hypoxemic patients with cancer . Unless NIV is the ceiling of therapy , we believe that NIV should be initiated only in an ICU or high-dependency unit setting, where endotracheal intubation and invasive mechanical ventilation can be safely and timely performed if NIV fails .
Mortality in patients who receive palliative NIV has been reported in various subgroups of patients [97–101]. Patients with cancer remain poor candidates for palliative NIV, even if some of them may receive some benefit . Additionally, the concept that the ICU is an appropriate setting to deliver palliative or terminal care is highly controversial. However, these studies report no qualitative outcomes, including quality of life, ICU-burden, and quality of dying for the majority of patients who die after NIV. We believe that qualitative studies are mandatory before establishing any recommendation on the use of NIV as the ceiling of therapy in patients with cancer.
In patients with cancer who require ICU admission, the survival rate has improved. Besides refinements in the selection criteria of patients for ICU admission, advances in hematology and oncology as well as enhancements in ICU management have contributed to this improved survival. In this changing context, clinicians' beliefs regarding the results of ICU management of patients with cancer must be appraised. Also, admission policies must be broadened and closely evaluated to avoid depriving patients who may benefit from life-sustaining therapies.
Coleman MP, Quaresma M, Berrino F, Lutz JM, De Angelis R, Capocaccia R, Baili P, Rachet B, Gatta G, Hakulinen T, Micheli A, Sant M, Weir HK, Elwood JM, Tsukuma H, Koifman S, Ga ES, Francisci S, Santaquilani M, Verdecchia A, Storm HH, Young JL: Cancer survival in five continents: a worldwide population-based study (CONCORD). Lancet Oncol 2008, 9: 730–756. Epub 2008 Jul 17 10.1016/S1470-2045(08)70179-7
Kinsey T, Jemal A, Liff J, Ward E, Thun M: Secular trends in mortality from common cancers in the United States by educational attainment, 1993–2001. J Natl Cancer Inst 2008, 100: 1003–1012. Epub 2008 Jul 8 10.1093/jnci/djn207
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ: Cancer statistics, 2008. CA Cancer J Clin 2008, 58: 71–96. Epub 2008 Feb 20 10.3322/CA.2007.0010
Atlanta U.S. Department of Health and Human Services Cfdcapanci: U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2005 Incidence and Mortality Web-based Report. [http://www.cdc.gov/uscs2009]
Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007, 18: 581–592. 10.1093/annonc/mdl498
Rodriguez-Abreu D, Bordoni A, Zucca E: Epidemiology of hematological malignancies. Ann Oncol 2007,18(Suppl 1):i3-i8. 10.1093/annonc/mdl443
Linker C, Damon L, Ries C, Navarro W: Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia. J Clin Oncol 2002, 20: 2464–2471. 10.1200/JCO.2002.07.116
Richardson PG, Sonneveld P, Schuster MW, Irwin D, Stadtmauer EA, Facon T, Harousseau JL, Ben-Yehuda D, Lonial S, Goldschmidt H, Reece D, San-Miguel JF, Blade J, Boccadoro M, Cavenagh J, Dalton WS, Boral AL, Esseltine DL, Porter JB, Schenkein D, Anderson KC: Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 2005, 352: 2487–2498. 10.1056/NEJMoa043445
Pfreundschuh M, Trumper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, Lopez-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M: CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 2006, 7: 379–391. 10.1016/S1470-2045(06)70664-7
Khassawneh BY, White P Jr, Anaissie EJ, Barlogie B, Hiller FC: Outcome from mechanical ventilation after autologous peripheral blood stem cell transplantation. Chest 2002, 121: 185–188. 10.1378/chest.121.1.185
Peigne V, Rusinova K, Karlin L, Darmon M, Fermand JP, Schlemmer B, Azoulay E: Continued survival gains in recent years among critically ill myeloma patients. Intensive Care Med 2009, 35: 512–518. 10.1007/s00134-008-1320-4
Darmon M, Guichard I, Vincent F, Schlemmer B, Azoulay E: Prognostic significance of acute renal injury in acute tumor lysis syndrome. Leuk Lymphoma 2010, 51: 221–227. 10.3109/10428190903456959
Azoulay E, Fieux F, Moreau D, Thiery G, Rousselot P, Parrot A, Le Gall Jr, Dombret H, Schlemmer B: Acute monocytic leukemia presenting as acute respiratory failure. Am J Respir Crit Care Med 2003, 167: 1329–1333. 10.1164/rccm.200206-554OC
Creput C, Galicier L, Buyse S, Azoulay E: Understanding organ dysfunction in hemophagocytic lymphohistiocytosis. Intensive Care Med 2008, 34: 1177–1187. 10.1007/s00134-008-1111-y
Tanvetyanon T, Leighton JC: Life-sustaining treatments in patients who died of chronic congestive heart failure compared with metastatic cancer. Crit Care Med 2003, 31: 60–64. 10.1097/00003246-200301000-00009
Benoit DD, Vandewoude KH, Decruyenaere JM, Hoste EA, Colardyn FA: Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med 2003, 31: 104–112. 10.1097/00003246-200301000-00017
Lecuyer L, Chevret S, Thiery G, Darmon M, Schlemmer B, Azoulay E: The ICU trial: a new admission policy for cancer patients requiring mechanical ventilation. Crit Care Med 2007, 35: 808–814. 10.1097/01.CCM.0000256846.27192.7A
Soares M, Azoulay E: Critical care management of lung cancer patients to prolong life without prolonging dying. Intensive Care Med 2009, 35: 2012–2014. 10.1007/s00134-009-1633-y
Azoulay E, Afessa B: The intensive care support of patients with malignancy: do everything that can be done. Intensive Care Med 2006, 32: 3–5. Epub 2005 Nov 25 10.1007/s00134-005-2835-6
Darmon M, Thiery G, Ciroldi M, De Miranda S, Galicier L, Raffoux E, Le Gall Jr, Schlemmer B, Azoulay E: Intensive care in patients with newly diagnosed malignancies and a need for cancer chemotherapy. Crit Care Med 2005, 33: 2488–2493. 10.1097/01.CCM.0000181728.13354.0A
Benoit DD, Depuydt PO, Vandewoude KH, Offner FC, Boterberg T, De Cock CA, Noens LA, Janssens AM, Decruyenaere JM: Outcome in severely ill patients with hematological malignancies who received intravenous chemotherapy in the intensive care unit. Intensive Care Med 2006, 32: 93–99. 10.1007/s00134-005-2836-5
Vandijck DM, Benoit DD, Depuydt PO, Offner FC, Blot SI, Van Tilborgh AK, Nollet J, Steel E, Noens LS, Decruyenaere JM: Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies. Intensive Care Med 2008, 34: 847–855. 10.1007/s00134-008-1002-2
Azoulay E, Alberti C, Bornstain C, Leleu G, Moreau D, Recher C, Chevret S, Le Gall Jr, Brochard L, Schlemmer B: Improved survival in cancer patients requiring mechanical ventilatory support: impact of noninvasive mechanical ventilatory support. Crit Care Med 2001, 29: 519–525. 10.1097/00003246-200103000-00009
Azoulay E, Recher C, Alberti C, Soufir L, Leleu G, Le Gall Jr, Fermand JP, Schlemmer B: Changing use of intensive care for hematological patients: the example of multiple myeloma. Intensive Care Med 1999, 25: 1395–1401. 10.1007/s001340051087
Kress JP, Christenson J, Pohlman AS, Linkin DR, Hall JB: Outcomes of critically ill cancer patients in a university hospital setting. Am J Respir Crit Care Med 1999, 160: 1957–1961.
Larche J, Azoulay E, Fieux F, Mesnard L, Moreau D, Thiery G, Darmon M, Le Gall Jr, Schlemmer B: Improved survival of critically ill cancer patients with septic shock. Intensive Care Med 2003, 29: 1688–1695. Epub 2003 Sep 12 10.1007/s00134-003-1957-y
Pene F, Aubron C, Azoulay E, Blot F, Thiery G, Raynard B, Schlemmer B, Nitenberg G, Buzyn A, Arnaud P, Socie G, Mira JP: Outcome of critically ill allogeneic hematopoietic stem-cell transplantation recipients: a reappraisal of indications for organ failure supports. J Clin Oncol 2006, 24: 643–649. Epub 2005 Dec 27 10.1200/JCO.2005.03.9073
Legriel S, Marijon H, Darmon M, Lemiale V, Bedos JP, Schlemmer B, Azoulay E: Central neurological complications in critically ill patients with malignancies. Intensive Care Med 36: 232–240. 10.1007/s00134-009-1709-8
Soares M, Salluh JI, Ferreira CG, Luiz RR, Spector N, Rocco Jr: Impact of two different comorbidity measures on the 6-month mortality of critically ill cancer patients. Intensive Care Med 2005, 31: 408–415. Epub 2005 Jan 28 10.1007/s00134-005-2554-z
Soares M, Salluh JI, Spector N, Rocco Jr: Characteristics and outcomes of cancer patients requiring mechanical ventilatory support for >24 hrs. Crit Care Med 2005, 33: 520–526. 10.1097/01.CCM.0000155783.46747.04
Staudinger T, Stoiser B, Mullner M, Locker GJ, Laczika K, Knapp S, Burgmann H, Wilfing A, Kofler J, Thalhammer F, Frass M: Outcome and prognostic factors in critically ill cancer patients admitted to the intensive care unit. Crit Care Med 2000, 28: 1322–1328. 10.1097/00003246-200005000-00011
Schellongowski P, Benesch M, Lang T, Traunmuller F, Zauner C, Laczika K, Locker GJ, Frass M, Staudinger T: Comparison of three severity scores for critically ill cancer patients. Intensive Care Med 2004, 30: 430–436. Epub 2003 Nov 4 10.1007/s00134-003-2043-1
Darmon M, Azoulay E, Alberti C, Fieux F, Moreau D, Gall Jr, Schlemmer B: Impact of neutropenia duration on short-term mortality in neutropenic critically ill cancer patients. Intensive Care Med 2002, 28: 1775–1780. 10.1007/s00134-002-1528-7
Groeger JS, White P Jr, Nierman Dm, Glassman J, Shi W, Horak D, Price K: Outcome for cancer patients requiring mechanical ventilation. J Clin Oncol 1999, 17: 991–997.
Depuydt PO, Benoit DD, Vandewoude KH, Decruyenaere JM, Colardyn FA: Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failure. Chest 2004, 126: 1299–1306. 10.1378/chest.126.4.1299
Soares M, Depuydt PO, Salluh JI: Mechanical ventilation in cancer patients: clinical characteristics and outcomes. Crit Care Clin 26: 41–58. 10.1016/j.ccc.2009.09.005
Benoit DD, Hoste EA, Depuydt PO, Offner FC, Lameire NH, Vandewoude KH, Dhondt AW, Noens LA, Decruyenaere JM: Outcome in critically ill medical patients treated with renal replacement therapy for acute renal failure: comparison between patients with and those without haematological malignancies. Nephrol Dial Transplant 2005, 20: 552–558. Epub 2005 Jan 25 10.1093/ndt/gfh637
Darmon M, Thiery G, Ciroldi M, Porcher R, Schlemmer B, Azoulay E: Should dialysis be offered to cancer patients with acute kidney injury? Intensive Care Med 2007, 33: 765–772. 10.1007/s00134-007-0579-1
Soares M, Salluh JI, Carvalho MS, Darmon M, Rocco Jr, Spector N: Prognosis of critically ill patients with cancer and acute renal dysfunction. J Clin Oncol 2006, 24: 4003–4010. 10.1200/JCO.2006.05.7869
Azoulay E, Mokart D, Rabbat A, Pene F, Kouatchet A, Bruneel F, Vincent F, Hamidfar R, Moreau D, Mohammedi I, Epinette G, Beduneau G, Castelain V, De Lassence A, Gruson D, Lemiale V, Renard B, Chevret S, Schlemmer B: Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter data. Crit Care Med 2008, 36: 100–107. 10.1097/01.CCM.0000295590.33145.C4
Massion PB, Dive AM, Doyen C, Bulpa P, Jamart J, Bosly A, Installe E: Prognosis of hematologic malignancies does not predict intensive care unit mortality. Crit Care Med 2002, 30: 2260–2270. 10.1097/00003246-200210000-00014
Brenner H: Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis. Lancet 2002, 360: 1131–1135. 10.1016/S0140-6736(02)11199-8
Brenner H, Gondos A, Arndt V: Recent major progress in long-term cancer patient survival disclosed by modeled period analysis. J Clin Oncol 2007, 25: 3274–3280. 10.1200/JCO.2007.11.3431
O'brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, Lechner K, Nielsen JL, Rousselot P, Reiffers J, Saglio G, Shepherd J, Simonsson B, Gratwohl A, Goldman JM, Kantarjian H, Taylor K, Verhoef G, Bolton AE, Capdeville R, Druker BJ: Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003, 348: 994–1004.
Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, Cortes J, O'Brien S, Nicaise C, Bleickardt E, Blackwood-Chirchir MA, Iyer V, Chen TT, Huang F, Decillis AP, Sawyers CL: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006, 354: 2531–2541. 10.1056/NEJMoa055229
Wossmann W, Schrappe M, Meyer U, Zimmermann M, Reiter A: Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/leukemia before and after introduction of prophylactic use of urate oxidase. Ann Hematol 2003, 82: 160–165.
Rano A, Agusti C, Jimenez P, Angrill J, Benito N, Danes C, Gonzalez J, Rovira M, Pumarola T, Moreno A, Torres A: Pulmonary infiltrates in non-HIV immunocompromised patients: a diagnostic approach using non-invasive and bronchoscopic procedures. Thorax 2001, 56: 379–387. 10.1136/thorax.56.5.379
Hilbert G, Gruson D, Vargas F, Valentino R, Chene G, Boiron JM, Pigneux A, Reiffers J, Gbikpi-Benissan G, Cardinaud JP: Noninvasive continuous positive airway pressure in neutropenic patients with acute respiratory failure requiring intensive care unit admission. Crit Care Med 2000, 28: 3185–3190. 10.1097/00003246-200009000-00012
Hilbert G, Gruson D, Vargas F, Valentino R, Gbikpi-Benissan G, Dupon M, Reiffers J, Cardinaud JP: Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 2001, 344: 481–487. 10.1056/NEJM200102153440703
Azoulay E, Thiery G, Chevret S, Moreau D, Darmon M, Bergeron A, Yang K, Meignin V, Ciroldi M, Le Gall Jr, Tazi A, Schlemmer B: The prognosis of acute respiratory failure in critically ill cancer patients. Medicine (Baltimore) 2004, 83: 360–370. 10.1097/01.md.0000145370.63676.fb
Hilbert G, Gruson D, Vargas F, Valentino R, Favier JC, Portel L, Gbikpi-Benissan G, Cardinaud JP: Bronchoscopy with bronchoalveolar lavage via the laryngeal mask airway in high-risk hypoxemic immunosuppressed patients. Crit Care Med 2001, 29: 249–255. 10.1097/00003246-200102000-00004
Benoit DD, Depuydt PO, Peleman RA, Offner FC, Vandewoude KH, Vogelaers DP, Blot SI, Noens LA, Colardyn FA, Decruyenaere JM: Documented and clinically suspected bacterial infection precipitating intensive care unit admission in patients with hematological malignancies: impact on outcome. Intensive Care Med 2005, 31: 934–942. 10.1007/s00134-005-2599-z
Lecuyer L, Chevret S, Guidet B, Aegerter P, Martel P, Schlemmer B, Azoulay E: Case volume and mortality in haematological patients with acute respiratory failure. Eur Respir J 2008, 32: 748–754. Epub 2008 Apr 30 10.1183/09031936.00142907
Ardeshna KM, Smith P, Norton A, Hancock BW, Hoskin PJ, Maclennan KA, Marcus RE, Jelliffe A, Vaughan G, Hudson , Linch DC: Long-term effect of a watch and wait policy versus immediate systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised controlled trial. Lancet 2003, 362: 516–522. 10.1016/S0140-6736(03)14110-4
Hampshire PA, Welch CA, Mccrossan LA, Francis K, Harrison DA: Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care 2009, 13: R137. 10.1186/cc8016
Meyer S, Gortner L, Gottschling S: Comment on "impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with haematological malignancies" by Vandijck et al. Intensive Care Med 2008, 34: 1929. author reply 1930–1931 10.1007/s00134-008-1222-5
Soares M, Caruso P, Silva E, Teles JM, Lobo SM, Friedman G, Dal Pizzol F, Mello PV, Bozza FA, Silva UV, Torelly AP, Knibel MF, Rezende E, Netto JJ, Piras C, Castro A, Ferreira BS, Rea-Neto A, Olmedo PB, Salluh JI: Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study. Crit Care Med 2010, 38: 9–15. 10.1097/CCM.0b013e3181c0349e
Coiffier B, Altman A, Pui CH, Younes A, Cairo MS: Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol 2008, 26: 2767–2778. 10.1200/JCO.2007.15.0177
Tosi P, Barosi G, Lazzaro C, Liso V, Marchetti M, Morra E, Pession A, Rosti G, Santoro A, Zinzani PL, Tura S: Consensus conference on the management of tumor lysis syndrome. Haematologica 2008, 93: 1877–1885. 10.3324/haematol.13290
Azoulay E, Schlemmer B: Diagnostic strategy in cancer patients with acute respiratory failure. Intensive Care Med 2006, 32: 808–822. Epub 2006 Apr 29 10.1007/s00134-006-0129-2
Afessa B, Azoulay E: Critical care of the hematopoietic stem cell transplant recipient. Crit Care Clin 2010, 26: 133–150. 10.1016/j.ccc.2009.09.001
Meert AP, Berghmans T, Hardy M, Markiewicz E, Sculier JP: Non-invasive ventilation for cancer patients with life-support techniques limitation. Support Care Cancer 2006, 14: 167–171. Epub 2005 Jun 10 10.1007/s00520-005-0845-0
Oh SY, Lee SJ, Lee J, Lee S, Kim SH, Kwon HC, Lee GW, Kang JH, Hwang IG, Jang JS, Lim HY, Park YS, Kang WK, Kim HJ: Gastric leptomeningeal carcinomatosis: multi-center retrospective analysis of 54 cases. World J Gastroenterol 2009, 15: 5086–5090. 10.3748/wjg.15.5086
Ruffato A, Mattioli S, Pileri S, Daddi N, D'ovidio F, Pilotti V, Tazzari P: Do bone marrow isolated tumor cells influence long-term survival of non-small cell lung cancer? Eur J Cardiothorac Surg 2009, 35: 463–468. 10.1016/j.ejcts.2008.11.017
Price KJ, Thall PF, Kish SK, Shannon VR, Andersson BS: Prognostic indicators for blood and marrow transplant patients admitted to an intensive care unit. Am J Respir Crit Care Med 1998, 158: 876–884.
Rubenfeld GD, Crawford SW: Withdrawing life support from mechanically ventilated recipients of bone marrow transplants: a case for evidence-based guidelines. Ann Intern Med 1996, 125: 625–633.
Afessa B, Tefferi A, Dunn WF, Litzow MR, Peters SG: Intensive care unit support and Acute Physiology and Chronic Health Evaluation III performance in hematopoietic stem cell transplant recipients. Crit Care Med 2003, 31: 1715–1721. 10.1097/01.CCM.0000065761.51367.2D
Afessa B, Tefferi A, Litzow MR, Krowka MJ, Wylam ME, Peters SG: Diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med 2002, 166: 641–645. 10.1164/rccm.200112-141CC
Afessa B, Tefferi A, Litzow MR, Peters SG: Outcome of diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med 2002, 166: 1364–1368. 10.1164/rccm.200208-792OC
Afessa B, Litzow MR, Tefferi A: Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation. Bone Marrow Transplant 2001, 28: 425–434. 10.1038/sj.bmt.1703142
Guiguet M, Blot F, Escudier B, Antoun S, Leclercq B, Nitenberg G: Severity-of-illness scores for neutropenic cancer patients in an intensive care unit: Which is the best predictor? Do multiple assessment times improve the predictive value? Crit Care Med 1998, 26: 488–493. 10.1097/00003246-199803000-00020
Thiery G, Azoulay E, Darmon M, Ciroldi M, De Miranda S, Levy V, Fieux F, Moreau D, Le Gall Jr, Schlemmer B: Outcome of cancer patients considered for intensive care unit admission: a hospital-wide prospective study. J Clin Oncol 2005, 23: 4406–4413. 10.1200/JCO.2005.01.487
Gruson D, Vargas F, Hilbert G, Bui N, Maillot T, Mayet T, Pillet O, Chene G, Gbikpi-Benissan G: Predictive factors of intensive care unit admission in patients with haematological malignancies and pneumonia. Intensive Care Med 2004, 30: 965–971. 10.1007/s00134-004-2237-1
Antonelli M, Conti G, Riccioni L, Meduri GU: Noninvasive positive-pressure ventilation via face mask during bronchoscopy with BAL in high-risk hypoxemic patients. Chest 1996, 110: 724–728. 10.1378/chest.110.3.724
Maitre B, Jaber S, Maggiore SM, Bergot E, Richard JC, Bakthiari H, Housset B, Boussignac G, Brochard L: Continuous positive airway pressure during fiberoptic bronchoscopy in hypoxemic patients. A randomized double-blind study using a new device. Am J Respir Crit Care Med 2000, 162: 1063–1067.
Darmon M, Azoulay E: Critical care management of cancer patients: cause for optimism and need for objectivity. Curr Opin Oncol 2009, 21: 318–326. 10.1097/CCO.0b013e32832b68b6
Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matte A, Barr A, Mehta S, Mazer CD, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook D, Slutsky AS, Herridge MS: Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 2006, 174: 538–544. 10.1164/rccm.200505-693OC
Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, Stewart TE, Barr A, Cook D, Slutsky AS: One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003, 348: 683–693. 10.1056/NEJMoa022450
Tansey CM, Louie M, Loeb M, Gold WL, Muller MP, De Jager J, Cameron JI, Tomlinson G, Mazzulli T, Walmsley SL, Rachlis AR, Mederski BD, Silverman M, Shainhouse Z, Ephtimios IE, Avendano M, Downey J, Styra R, Yamamura D, Gerson M, Stanbrook MB, Marras TK, Phillips EJ, Zamel N, Richardson SE, Slutsky AS, Herridge MS: One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome. Arch Intern Med 2007, 167: 1312–1320. 10.1001/archinte.167.12.1312
Nelson JE, Meier DE, Oei EJ, Nierman DM, Senzel RS, Manfredi PL, Davis SM, Morrison RS: Self-reported symptom experience of critically ill cancer patients receiving intensive care. Crit Care Med 2001, 29: 277–282. 10.1097/00003246-200102000-00010
Azoulay E, Timsit JF, Sprung CL, Soares M, Rusinova K, Lafabrie A, Abizanda R, Svantesson M, Rubulotta F, Ricou B, Benoit D, Heyland D, Joynt G, Francais A, Azeivedo-Maia P, Owczuk R, Benbenishty J, De Vita M, Valentin A, Ksomos A, Cohen S, Kompan L, Ho K, Abroug F, Kaarlola A, Gerlach H, Kyprianou T, Michalsen A, Chevret S, Schlemmer B: Prevalence and factors of intensive care unit conflicts: the conflicus study. Am J Respir Crit Care Med 2009, 180: 853–860. 10.1164/rccm.200810-1614OC
Poncet MC, Toullic P, Papazian L, Kentish-Barnes N, Timsit JF, Pochard F, Chevret S, Schlemmer B, Azoulay E: Burnout syndrome in critical care nursing staff. Am J Respir Crit Care Med 2007, 175: 698–704. 10.1164/rccm.200606-806OC
Hamric AB, Blackhall LJ: Nurse-physician perspectives on the care of dying patients in intensive care units: collaboration, moral distress, and ethical climate. Crit Care Med 2007, 35: 422–429. 10.1097/01.CCM.0000254722.50608.2D
Gaeta S, Price KJ: End-of-life issues in critically ill cancer patients. Crit Care Clin 26: 219–227. 10.1016/j.ccc.2009.10.002
Stover DE, Zaman MB, Hajdu SI, Lange M, Gold J, Armstrong D: Bronchoalveolar lavage in the diagnosis of diffuse pulmonary infiltrates in the immunosuppressed host. Ann Intern Med 1984, 101: 1–7.
Prebet T, Boissel N, Reutenauer S, Thomas X, Delaunay J, Cahn JY, Pigneux A, Quesnel B, Witz F, Thepot S, Ugo V, Terre C, Recher C, Tavernier E, Hunault M, Esterni B, Castaigne S, Guilhot F, Dombret H, Vey N: Acute myeloid leukemia with translocation (8;21) or inversion (16) in elderly patients treated with conventional chemotherapy: a collaborative study of the French CBF-AML intergroup. J Clin Oncol 2009, 27: 4747–4753. 10.1200/JCO.2008.21.0674
Walsh TJ: Advances and challenges in infectious diseases supportive care of patients with hematologic malignancies, hematopoietic stem cell transplantation, and severe aplastic anemia. Semin Hematol 2009, 46: 191–197. 10.1053/j.seminhematol.2009.05.001
L'her E: Noninvasive ventilation outside the intensive care unit: a new standard of care? Crit Care Med 2005, 33: 1642–1643.
Elliott MW, Confalonieri M, Nava S: Where to perform noninvasive ventilation? Eur Respir J 2002, 19: 1159–1166. 10.1183/09031936.02.00297202
Hill NS: Where should noninvasive ventilation be delivered? Respir Care 2009, 54: 62–70. 10.4187/002013209793800439
Sinuff T, Kahnamoui K, Cook DJ, Luce JM, Levy MM: Rationing critical care beds: a systematic review. Crit Care Med 2004, 32: 1588–1597. 10.1097/01.CCM.0000130175.38521.9F
Azoulay E, Pochard F, Chevret S, Vinsonneau C, Garrouste M, Cohen Y, Thuong M, Paugam C, Apperre C, De Cagny B, Brun F, Bornstain C, Parrot A, Thamion F, Lacherade JC, Bouffard Y, Le Gall Jr, Herve C, Grassin M, Zittoun R, Schlemmer B, Dhainaut JF: Compliance with triage to intensive care recommendations. Crit Care Med 2001, 29: 2132–2136. 10.1097/00003246-200111000-00014
Pastores SM, Voigt LP: Acute respiratory failure in the patient with cancer: diagnostic and management strategies. Crit Care Clin 26: 21–40. 10.1016/j.ccc.2009.10.001
Truwit JD, Bernard GR: Noninvasive ventilation--don't push too hard. N Engl J Med 2004, 350: 2512–2515. 10.1056/NEJMe048049
Tanvetyanon T: Which patient with a do-not-intubate order is a candidate for noninvasive ventilation? Crit Care Med 2004, 32: 2148–2150. 10.1097/01.CCM.0000142903.66336.E6
Adda M, Coquet I, Darmon M, Thiery G, Schlemmer B, Azoulay E: Predictors of noninvasive ventilation failure in patients with hematologic malignancy and acute respiratory failure. Crit Care Med 2008, 36: 2766–2772. 10.1097/CCM.0b013e31818699f6
Chu CM, Chan VL, Wong IW, Leung WS, Lin AW, Cheung KF: Noninvasive ventilation in patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease who refused endotracheal intubation. Crit Care Med 2004, 32: 372–377. 10.1097/01.CCM.0000108879.86838.4F
Cuomo A, Delmastro M, Ceriana P, Nava S, Conti G, Antonelli M, Iacobone E: Noninvasive mechanical ventilation as a palliative treatment of acute respiratory failure in patients with end-stage solid cancer. Palliat Med 2004, 18: 602–610. 10.1191/0269216304pm933oa
Curtis Jr, Cook DJ, Sinuff T, White DB, Hill N, Keenan SP, Benditt JO, Kacmarek R, Kirchhoff KT, Levy MM: Noninvasive positive pressure ventilation in critical and palliative care settings: understanding the goals of therapy. Crit Care Med 2007, 35: 932–939. 10.1097/01.CCM.0000256725.73993.74
Levy M, Tanios MA, Nelson D, Short K, Senechia A, Vespia J, Hill NS: Outcomes of patients with do-not-intubate orders treated with noninvasive ventilation. Crit Care Med 2004, 32: 2002–2007. 10.1097/01.CCM.0000142729.07050.C9
Nava S, Sturani C, Hartl S, Magni G, Ciontu M, Corrado A, Simonds A: End-of-life decision-making in respiratory intermediate care units: a European survey. Eur Respir J 2007, 30: 156–164. 10.1183/09031936.00128306
Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard Jr, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, De Pauw B: Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 2002, 347: 408–415. 10.1056/NEJMoa020191
Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999, 340: 409–417. 10.1056/NEJM199902113400601
Chagnon K, Boissel N, Raffoux E, Dombret H, Tazi A, Bergeron A: A new pattern of cytosine-arabinoside-induced lung toxicity. Br J Haematol 2009, 147: 771–774. 10.1111/j.1365-2141.2009.07895.x
Bergeron A, Rea D, Levy V, Picard C, Meignin V, Tamburini J, Bruzzoni-Giovanelli H, Calvo F, Tazi A, Rousselot P: Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series. Am J Respir Crit Care Med 2007, 176: 814–818. 10.1164/rccm.200705-715CR
Chagnon K, Boissel N, Raffoux E, Dombret H, Tazi A, Bergeron A: A new pattern of cytosine-arabinoside-induced lung toxicity. Br J Haematol 2009, 147: 771–774. 10.1111/j.1365-2141.2009.07895.x
Legriel S, Marijon H, Darmon M, Lemiale V, Bedos JP, Schlemmer B, Azoulay E: Central neurological complications in critically ill patients with malignancies. Intensive Care Med 36: 232–240. 10.1007/s00134-009-1709-8
Supported by a grant from the Assistance-Publique Hôpitaux de Paris (AOM 04139) and the French Society for Intensive Care Medicine. Dr. Soares is supported in part by individual research grant from CNPq.
The authors declare that they have no competing interests.
All authors contributed to the preparation of this manuscript and critical review of the material.
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Azoulay, E., Soares, M., Darmon, M. et al. Intensive care of the cancer patient: recent achievements and remaining challenges. Ann. Intensive Care 1, 5 (2011). https://doi.org/10.1186/2110-5820-1-5