Rodvold KA, George JM, Yoo L. Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antibacterial agents. Clin Pharmacokinet. 2011;50:637–64.
Article
CAS
PubMed
Google Scholar
de Montmollin E, Bouadma L, Gault N, Mourvillier B, Mariotte E, Chemam S, et al. Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen. Intensive Care Med. 2014;40:998–1005.
Article
PubMed
Google Scholar
Kollef MH, Chastre J, Clavel M, Restrepo MI, Michiels B, Kaniga K, et al. A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia. Crit Care. 2012;16:R218.
Article
PubMed
PubMed Central
Google Scholar
Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 Clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63:e61–111.
Article
PubMed
Google Scholar
Goldstein I, Wallet F, Nicolas-Robin A, Ferrari F, Marquette CH, Rouby JJ. Lung deposition and efficiency of nebulized amikacin during Escherichia coli pneumonia in ventilated piglets. Am J Respir Crit Care Med. 2002;166:1375–81.
Article
PubMed
Google Scholar
Lu Q, Luo R, Bodin L, Yang J, Zahr N, Aubry A, et al. Efficacy of high-dose nebulized colistin in ventilator-associated pneumonia caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. Anesthesiology. 2012;117:1335–47.
Article
CAS
PubMed
Google Scholar
Dalhoff A. Pharmacokinetics and pharmacodynamics of aerosolized antibacterial agents in chronically infected cystic fibrosis patients. Clin Microbiol Rev. 2014;27:753–82.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mogayzel PJ Jr, Naureckas ET, Robinson KA, Mueller G, Hadjiliadis D, Hoag JB, Lubsch L, Hazle L, Sabadosa K, Marshall B. Cystic fibrosis pulmonary guidelines. Chronic medications for maintenance of lung health. Am J Respir Crit Care Med. 2013;187:680–9.
Article
PubMed
Google Scholar
MacIntyre NR, Silver RM, Miller CW, Schuler F, Coleman RE. Aerosol delivery in intubated, mechanically ventilated patients. Crit Care Med. 1985;13:81–4.
Article
CAS
PubMed
Google Scholar
Brain JD, Valberg PA. Deposition of aerosol in the respiratory tract. Am Rev Respir Dis. 1979;120:1325–73.
CAS
PubMed
Google Scholar
Ari A, Atalay OT, Harwood R, Sheard MM, Aljamhan EA, Fink JB. Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care. 2010;55:845–51.
PubMed
Google Scholar
Harvey CJ, O’Doherty MJ, Page CJ, Thomas SH, Nunan TO, Treacher DF. Comparison of jet and ultrasonic nebulizer pulmonary aerosol deposition during mechanical ventilation. Eur Respir J. 1997;10:905–9.
CAS
PubMed
Google Scholar
Ferrari F, Liu ZH, Lu Q, Becquemin MH, Louchahi K, Aymard G, et al. Comparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers. Intensive Care Med. 2008;34:1718–23.
Article
PubMed
Google Scholar
O’Doherty MJ, Thomas SH, Page CJ, Treacher DF, Nunan TO. Delivery of a nebulized aerosol to a lung model during mechanical ventilation. Effect of ventilator settings and nebulizer type, position, and volume of fill. Am Rev Respir Dis. 1992;146:383–8.
Article
PubMed
Google Scholar
Wallace SJ, Li J, Rayner CR, Coulthard K, Nation RL. Stability of colistin methanesulfonate in pharmaceutical products and solutions for administration to patients. Antimicrob Agents Chemother. 2008;52:3047–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Boe J, Dennis JH, O’Driscoll BR, Bauer TT, Carone M, Dautzenberg B, et al. Adaptations of the European Respiratory Society guidelines by the Aerosol Therapy Group of the French Lung Society on the use of aerosol therapy through nebulization. Rev Mal Respir. 2004;21:1033–8.
Article
CAS
PubMed
Google Scholar
Dugernier J, Reychler G, Wittebole X, Roeseler J, Depoortere V, Sottiaux T, et al. Aerosol delivery with two ventilation modes during mechanical ventilation: a randomized study. Ann Intensive Care. 2016;6:73.
Article
PubMed
PubMed Central
Google Scholar
Miller DD, Amin MM, Palmer LB, Shah AR, Smaldone GC. Aerosol delivery and modern mechanical ventilation: in vitro/in vivo evaluation. Am J Respir Crit Care Med. 2003;168:1205–9.
Article
PubMed
Google Scholar
Ehrmann S, Lyazidi A, Louis B, Isabey D, Le Pennec D, Brochard L, et al. Ventilator-integrated jet nebulization systems: tidal volume control and efficiency of synchronization. Respir Care. 2014;59:1508–16.
Article
PubMed
Google Scholar
Rau JL, Ari A, Restrepo RD. Performance comparison of nebulizer designs: constant-output, breath-enhanced, and dosimetric. Respir Care. 2004;49:174–9.
PubMed
Google Scholar
Ari A, Areabi H, Fink JB. Evaluation of aerosol generator devices at 3 locations in humidified and non-humidified circuits during adult mechanical ventilation. Respir Care. 2010;55:837–44.
PubMed
Google Scholar
Boukhettala N, Poree T, Diot P, Vecellio L. In vitro performance of spacers for aerosol delivery during adult mechanical ventilation. J Aerosol Med Pulm Drug Deliv. 2015;28:130–6.
Article
CAS
PubMed
Google Scholar
Lin HL, Fink JB, Zhou Y, Cheng YS. Influence of moisture accumulation in inline spacer on delivery of aerosol using metered-dose inhaler during mechanical ventilation. Respir Care. 2009;54:1336–41.
PubMed
Google Scholar
Villafane MC, Cinnella G, Lofaso F, Isabey D, Harf A, Lemaire F, et al. Gradual reduction of endotracheal tube diameter during mechanical ventilation via different humidification devices. Anesthesiology. 1996;85:1341–9.
Article
CAS
PubMed
Google Scholar
Dhand R. Maximizing aerosol delivery during mechanical ventilation: go with the flow and go slow. Intensive Care Med. 2003;29:1041–2.
Article
PubMed
Google Scholar
Dhand R. Special problems in aerosol delivery: artificial airways. Respir Care. 2000;45:636–45.
CAS
PubMed
Google Scholar
Dugernier J, Wittebole X, Roeseler J, Michotte JB, Sottiaux T, Dugernier T, et al. Influence of inspiratory flow pattern and nebulizer position on aerosol delivery with a vibrating-mesh nebulizer during invasive mechanical ventilation: an in vitro analysis. J Aerosol Med Pulm Drug Deliv. 2015;28:229–36.
Article
CAS
PubMed
Google Scholar
Carcas AJ, Garcia-Satue JL, Zapater P, Frias-Iniesta J. Tobramycin penetration into epithelial lining fluid of patients with pneumonia. Clin Pharmacol Ther. 1999;65:245–50.
Article
CAS
PubMed
Google Scholar
Taccone FS, Laterre PF, Spapen H, Dugernier T, Delattre I, Layeux B, et al. Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock. Crit Care. 2010;14:R53.
Article
PubMed
PubMed Central
Google Scholar
Lu Q, Girardi C, Zhang M, Bouhemad B, Louchahi K, Petitjean O, et al. Nebulized and intravenous colistin in experimental pneumonia caused by Pseudomonas aeruginosa. Intensive Care Med. 2010;36:11471155.
Article
Google Scholar
Imberti R, Cusato M, Villani P, Carnevale L, Iotti GA, Langer M, et al. Steady-state pharmacokinetics and BAL concentration of colistin in critically ill patients after IV colistin methanesulfonate administration. Chest. 2010;138:1333–9.
Article
CAS
PubMed
Google Scholar
Markou N, Fousteri M, Markantonis SL, Boutzouka E, Tsigou E, Baltopoulo G. Colistin penetration in the alveolar lining fluid of critically ill patients treated with IV colistimethate sodium. Chest. 2011;139:232–4.
Article
PubMed
Google Scholar
Ferrari F, Lu Q, Girardi C, Petitjean O, Marquette CH, Wallet F, et al. Nebulized ceftazidime in experimental pneumonia caused by partially resistant Pseudomonas aeruginosa. Intensive Care Med. 2009;35:1792–800.
Article
CAS
PubMed
Google Scholar
Lu Q, Yang J, Liu Z, Gutierrez C, Aymard G, Rouby JJ. Nebulized ceftazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Am J Respir Crit Care Med. 2011;184:106–15.
Article
CAS
PubMed
Google Scholar
Paul M, Lador A, Grozinsky-Glasberg S, Leibovici L. Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis. Cochrane Database Syst Rev. 2014;1:CD003344.
Google Scholar
Badia JR, Soy D, Adrover M, Ferrer M, Sarasa M, Alarcon A, et al. Disposition of instilled versus nebulized tobramycine and imipenem in ventilated intensive care unit (ICU) patients. J Antimicrob Chemother. 2004;54:508–14.
Article
CAS
PubMed
Google Scholar
Petitcollin A, Dequin PF, Darrouzain F, Vecellio L, Boulain T, Garot D, et al. Pharmacokinetics of high-dose nebulized amikacin in ventilated critically ill patients. J Antimicrob Chemother. 2016;71:3482–6.
Article
CAS
PubMed
Google Scholar
Ferrari F, Goldstein I, Nieszkowszka A, Elman M, Marquette CH, Rouby JJ. Lack of lung tissue and systemic accumulation after consecutive daily aerosols of amikacin in ventilated piglets with healthy lungs. Anesthesiology. 2003;98:1016–9.
Article
PubMed
Google Scholar
Landersdorfer CB, Nguyen TH, Lieu LT, Nguyen G, Bischof RJ, Meeusen EN, et al. Substantial targeting advantage achieved by pulmonary administration of colistin methanesulfonate in a large-animal model. Antimicrob Agents Chemother. 2017;61:e01934-16.
Article
PubMed
Google Scholar
Luyt CE, Clavel M, Guntupalli K, Johannigman J, Kennedy JI, Wood C, et al. Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia. Crit Care. 2009;13:R200.
Article
PubMed
PubMed Central
Google Scholar
Niederman MS, Chastre J, Corkery K, Fink JB, Luyt CE, Garcia MS. BAY41-6551 achieves bactericidal tracheal aspirate amikacin concentrations in mechanically ventilated patients with Gram-negative pneumonia. Intensive Care Med. 2012;38:263–71.
Article
CAS
PubMed
Google Scholar
Dhand R, Sohal H. Pulmonary drug delivery system for inhalation therapy in mechanically ventilated patients. Expert Rev Med Devices. 2008;5:9–18.
Article
CAS
PubMed
Google Scholar
Montgomery AB, Vallance S, Abuan T, Tservistas M, Davies A. A randomized double-blind placebo-controlled dose-escalation phase 1 study of aerosolized amikacin and fosfomycin delivered via the PARI investigational eFlow(R) inline nebulizer system in mechanically ventilated patients. J Aerosol Med Pulm Drug Deliv. 2014;27:441–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Athanassa ZE, Markantonis SL, Fousteri MZ, Myrianthefs PM, Boutzouka EG, Tsakris A, et al. Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients. Intensive Care Med. 2012;38:1779–86.
Article
CAS
PubMed
Google Scholar
Boisson M, Jacobs M, Gregoire N, Gobin P, Marchand S, Couet W, et al. Comparison of intrapulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and colistin after aerosol delivery and intravenous administration of CMS in critically ill patients. Antimicrob Agents Chemother. 2014;58:7331–9.
Article
PubMed
PubMed Central
Google Scholar
Bihan K, Lu Q, Enjalbert M, Apparuit M, Langeron O, Rouby JJ, et al. Determination of colistin and colistimethate levels in human plasma and urine by high-performance liquid chromatography-tandem mass spectrometry. Ther Drug Monit. 2016;38:796–803.
Article
CAS
PubMed
Google Scholar
Sorli L, Luque S, Grau S, Berenguer N, Segura C, Montero MM, et al. Trough colistin plasma level is an independent risk factor for nephrotoxicity: a prospective observational cohort study. BMC Infect Dis. 2013;13:380.
Article
PubMed
PubMed Central
Google Scholar
Kiem S, Schentag JJ. Interpretation of epithelial lining fluid concentrations of antibiotics against methicillin resistant staphylococcus aureus. Infect Chemother. 2014;46:219–25.
Article
PubMed
PubMed Central
Google Scholar
Mukker JK, Singh RS, Derendorf H. Pharmacokinetic and pharmacodynamic implications in inhalable antimicrobial therapy. Adv Drug Deliv Rev. 2015;85:57–64.
Article
CAS
PubMed
Google Scholar
Palmer LB, Smaldone GC, Chen JJ, Baram D, Duan T, Monteforte M, et al. Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit. Crit Care Med. 2008;36:2008–13.
Article
CAS
PubMed
Google Scholar
Palmer LB, Smaldone GC. Reduction of bacterial resistance with inhaled antibiotics in the intensive care unit. Am J Respir Crit Care Med. 2014;189:1225–33.
Article
PubMed
Google Scholar
Kollef MH, Ricard JD, Roux D, Francois B, Ischaki E, Rozgonyi Z, et al. A randomized trial of the amikacin fosfomycin inhalation system for the adjunctive therapy of Gram-negative ventilator-associated pneumonia: IASIS Trial. Chest. 2016. doi:10.1016/j.chest.2016.11.026.
Google Scholar
Rattanaumpawan P, Lorsutthitham J, Ungprasert P, Angkasekwinai N, Thamlikitkul V. Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria. J Antimicrob Chemother. 2010;65:2645–9.
Article
CAS
PubMed
Google Scholar
Abdellatif S, Trifi A, Daly F, Mahjoub K, Nasri R, Ben Lakhal S. Efficacy and toxicity of aerosolised colistin in ventilator-associated pneumonia: a prospective, randomised trial. Ann Intensive Care. 2016;6:26.
Article
PubMed
PubMed Central
Google Scholar
Kofteridis DP, Alexopoulou C, Valachis A, Maraki S, Dimopoulou D, Georgopoulos D, et al. Aerosolized plus intravenous colistin versus intravenous colistin alone for the treatment of ventilator-associated pneumonia: a matched case-control study. Clin Infect Dis. 2010;51:1238–44.
Article
CAS
PubMed
Google Scholar
Korbila IP, Michalopoulos A, Rafailidis PI, Nikita D, Samonis G, Falagas ME. Inhaled colistin as adjunctive therapy to intravenous colistin for the treatment of microbiologically documented ventilator-associated pneumonia: a comparative cohort study. Clin Microbiol Infect. 2010;16:1230–6.
Article
CAS
PubMed
Google Scholar
Tumbarello M, De Pascale G, Trecarichi EM, De Martino S, Bello G, Maviglia R, et al. Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria. Chest. 2013;144:1768–75.
Article
CAS
PubMed
Google Scholar
Dalfino L, Puntillo F, Mosca A, Monno R, Spada ML, Coppolecchia S, et al. High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study. Clin Infect Dis. 2012;54:1720–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Poudyal A, Howden BP, Bell JM, Gao W, Owen RJ, Turnidge JD, et al. In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae. J Antimicrob Chemother. 2008;62:1311–8.
Article
CAS
PubMed
Google Scholar
Florescu DF, Qiu F, McCartan MA, Mindru C, Fey PD, Kalil AC. What is the efficacy and safety of colistin for the treatment of ventilator-associated pneumonia? A systematic review and meta-regression. Clin Infect Dis. 2012;54:670–80.
Article
CAS
PubMed
Google Scholar
Ioannidou E, Siempos II, Falagas ME. Administration of antimicrobials via the respiratory tract for the treatment of patients with nosocomial pneumonia: a meta-analysis. J Antimicrob Chemother. 2007;60:1216–26.
Article
CAS
PubMed
Google Scholar
Valachis A, Samonis G, Kofteridis DP. The role of aerosolized colistin in the treatment of ventilator-associated pneumonia: a systematic review and metaanalysis. Crit Care Med. 2015;43:527–33.
Article
CAS
PubMed
Google Scholar
Zampieri FG, Nassar AP Jr, Gusmao-Flores D, Taniguchi LU, Torres A, Ranzani OT. Nebulized antibiotics for ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care. 2015;19:150.
Article
PubMed
PubMed Central
Google Scholar
Russell CJ, Shiroishi MS, Siantz E, Wu BW, Patino CM. The use of inhaled antibiotic therapy in the treatment of ventilator-associated pneumonia and tracheobronchitis: a systematic review. BMC Pulm Med. 2016;16:40.
Article
PubMed
PubMed Central
Google Scholar
Sole-Lleonart C, Rouby JJ, Blot S, Poulakou G, Chastre J, Palmer LB, et al. Nebulization of antiinfective agents in invasively mechanically ventilated adults: a systematic review and meta-analysis. Anesthesiology. 2017;126:890–908.
Article
CAS
PubMed
Google Scholar
Karvouniaris M, Makris D, Zygoulis P, Triantaris A, Xitsas S, Mantzarlis K, et al. Nebulised colistin for ventilator-associated pneumonia prevention. Eur Respir J. 2015;46:1732–9.
Article
CAS
PubMed
Google Scholar
Wood GC, Boucher BA, Croce MA, Hanes SD, Herring VL, Fabian TC. Aerosolized ceftazidime for prevention of ventilator-associated pneumonia and drug effects on the proinflammatory response in critically ill trauma patients. Pharmacotherapy. 2002;22:972–82.
Article
CAS
PubMed
Google Scholar
Ehrmann S, Roche-Campo F, Sferrazza Papa GF, Isabey D, Brochard L, Apiou-Sbirlea G. Aerosol therapy during mechanical ventilation: an international survey. Intensive Care Med. 2013;39:1048–56.
Article
CAS
PubMed
Google Scholar
Ehrmann S, Roche-Campo F, Bodet-Contentin L, Razazi K, Dugernier J, Trenado-Alvarez J, et al. Aerosol therapy in intensive and intermediate care units: prospective observation of 2808 critically ill patients. Intensive Care Med. 2016;42:192–201.
Article
CAS
PubMed
Google Scholar
Sole-Lleonart C, Roberts JA, Chastre J, Poulakou G, Palmer LB, Blot S, et al. Global survey on nebulization of antimicrobial agents in mechanically ventilated patients: a call for international guidelines. Clin Microbiol Infect. 2016;22:359–64.
Article
CAS
PubMed
Google Scholar
Sole-Lleonart C, Rouby JJ, Chastre J, Poulakou G, Palmer LB, Blot S, et al. Intratracheal administration of antimicrobial agents in mechanically ventilated adults: an international survey on delivery practices and safety. Respir Care. 2016;61:1008–14.
Article
PubMed
Google Scholar
Rello J, Rouby JJ, Sole-Lleonart C, Chastre J, Blot S, Luyt CE, et al. Key conceptional considerations on nebulization of antimicrobial agents to mechanically ventilated patients. Clin Microbiol Infect. 2017. doi:10.1016/j.cmi.2017.03.018.
Google Scholar
Mostofi R, Wang B, Haghighat F, Bahloul A, Jaime L. Performance of mechanical filters and respirators for capturing nanoparticles—limitations and future direction. Ind Health. 2010;48:296–304.
Article
PubMed
Google Scholar
Rengasamy S, BerryAnn R, Szalajda J. Nanoparticle filtration performance of filtering facepiece respirators and canister/cartridge filters. J Occup Environ Hyg. 2013;10:519–25.
Article
CAS
PubMed
Google Scholar
Tonnelier A, Lellouche F, Bouchard PA, L’Her E. Impact of humidification and nebulization during expiratory limb protection: an experimental bench study. Respir Care. 2013;58:1315–22.
Article
PubMed
Google Scholar
Antoniu S, Azoicai D. Novel amikacin inhaled formulation for the treatment of lower respiratory tract infections. Drugs Today (Barc). 2013;49:683–92.
Article
CAS
Google Scholar
Rouby JJ, Bouhemad B, Monsel A, Brisson H, Arbelot C, Lu Q. Aerosolized antibiotics for ventilator-associated pneumonia: lessons from experimental studies. Anesthesiology. 2012;117:1364–80.
Article
CAS
PubMed
Google Scholar
Falagas ME, Siempos II, Bliziotis IA, Michalopoulos A. Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: a meta-analysis of comparative trials. Crit Care. 2006;10:R123.
Article
PubMed
PubMed Central
Google Scholar
Roquilly A, Marret E, Abraham E, Asehnoune K. Pneumonia prevention to decrease mortality in intensive care unit: a systematic review and meta-analysis. Clin Infect Dis. 2015;60:64–75.
Article
CAS
PubMed
Google Scholar
Rello J, Solé-Lleonart C, Rouby JJ, Chastre J, Blot S, Poulakou G, et al. Use of nebulized antimicrobials for the treatment of respiratory infections in invasively mechanically ventilated adults: a position paper from the european society of clinical microbiology and infectious diseases. Clin Microbiol Infect. 2017. doi:10.1016/j.cmi.2017.04.011.
Google Scholar
American Thoracic Society. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388–416.
Article
Google Scholar
Hurley JC. Topical antibiotics as a major contextual hazard toward bacteremia within selective digestive decontamination studies: a meta-analysis. BMC Infect Dis. 2014;14:714.
Article
PubMed
PubMed Central
Google Scholar
Nseir S, Di Pompeo C, Pronnier P, Beague S, Onimus T, Saulnier F, et al. Nosocomial tracheobronchitis in mechanically ventilated patients: incidence, aetiology and outcome. Eur Respir J. 2002;20:1483–9.
Article
CAS
PubMed
Google Scholar
Nseir S, Martin-Loeches I, Makris D, Jaillette E, Karvouniaris M, Valles J, et al. Impact of appropriate antimicrobial treatment on transition from ventilator-associated tracheobronchitis to ventilator-associated pneumonia. Crit Care. 2014;18:R129.
Article
PubMed
PubMed Central
Google Scholar
Vincent JL, Jacobs F. Effect of selective decontamination on antibiotic resistance. Lancet Infect Dis. 2011;11:337–8.
Article
PubMed
Google Scholar