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Annals of Intensive Care
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  • Research
  • Open Access

Effects of positive end-expiratory pressure strategy in supine and prone position on lung and chest wall mechanics in acute respiratory distress syndrome

  • 1, 2,
  • 3,
  • 1,
  • 1,
  • 4,
  • 5, 6,
  • 1, 2,
  • 1,
  • 1,
  • 1,
  • 3 and
  • 1, 2, 7Email author
Annals of Intensive Care20188:86

https://doi.org/10.1186/s13613-018-0434-2

©  The Author(s) 2018

  • Received: 25 June 2018
  • Accepted: 1 September 2018
  • Published:

Abstract

Background

In acute respiratory distress syndrome (ARDS) patients, it has recently been proposed to set positive end-expiratory pressure (PEEP) by targeting end-expiratory transpulmonary pressure. This approach, which relies on the measurement of absolute esophageal pressure (Pes), has been used in supine position (SP) and has not been investigated in prone position (PP). Our purposes were to assess Pes-guided strategy to set PEEP in SP and in PP as compared with a PEEP/FIO2 table and to explore the early (1 h) and late (16 h) effects of PP on lung and chest wall mechanics.

Results

We performed a prospective, physiologic study in two ICUs in university hospitals on ARDS patients with PaO2/FIO2 < 150 mmHg. End-expiratory Pes (Pes,ee) was measured in static (zero flow) condition. Patients received PEEP set according to a PEEP/FIO2 table then according to the Pes-guided strategy targeting a positive (3 ± 2 cmH2O) static end-expiratory transpulmonary pressure in SP. Then, patients were turned to PP and received same amount of PEEP from PEEP/FIO2 table then Pes-guided strategy. Respiratory mechanics, oxygenation and end-expiratory lung volume (EELV) were measured after 1 h of each PEEP in each position. For the rest of the 16-h PP session, patients were randomly allocated to either PEEP strategy with measurements done at the end. Thirty-eight ARDS patients (27 male), mean ± SD age 63 ± 13 years, were included. There were 33 primary ARDS and 26 moderate ARDS. PaO2/FIO2 ratio was 120 ± 23 mmHg. At same PEEP/FIO2 table-related PEEP, Pes,ee averaged 9 ± 4 cmH2O in both SP and PP (P = 0.88). With PEEP/FIO2 table and Pes-guided strategy, PEEP was 10 ± 2 versus 12 ± 4 cmH2O in SP and 10 ± 2 versus 12 ± 5 cmH2O in PP (PEEP strategy effect P = 0.05, position effect P = 0.96, interaction P = 0.96). With the Pes-guided strategy, chest wall elastance increased regardless of position. Lung elastance and transpulmonary driving pressure decreased in PP, with no effect of PEEP strategy. Both PP and Pes-guided strategy improved oxygenation without interaction. EELV did not change with PEEP strategy. At the end of PP session, respiratory mechanics did not vary but EELV and PaO2/FIO2 increased while PaCO2 decreased.

Conclusions

There was no impact of PP on Pes measurements. PP had an immediate improvement effect on lung mechanics and a late lung recruitment effect independent of PEEP strategy.

Keywords

  • Acute respiratory distress syndrome
  • Prone position
  • Positive end-expiratory pressure
  • Esophageal pressure
  • Electrical impedance tomography
  • Transpulmonary pressure

Background

With the currently used ventilator supportive management, the mortality of acute respiratory distress syndrome (ARDS) is still 30–40% [1]. Setting lower tidal volumes (VT) has been shown to improve survival by preventing further lung damage from excessive stress and strain [2]. Setting positive end-expiratory pressure (PEEP) was suggested as early as ARDS was described [3]. Three large trials failed to demonstrate survival benefit of using higher versus lower PEEP [4–6], but meta-analysis suggested a small but statistically significant benefit favoring of higher PEEP in severe ARDS [7].

Talmor and colleagues proposed to set PEEP by using end-expiratory transpulmonary pressure obtained by subtracting absolute esophageal pressure (Pes), a surrogate of pleural pressure, from airway pressure (Paw) at end-expiration. They proposed to increase PEEP in order to make end-expiratory transpulmonary pressure positive, and found marked physiologic benefits from this strategy [8]. While these results are awaiting confirmation from a large multicenter trial just completed [9], Pes monitoring has experienced a growing interest for the recent years [10].

Delivering lung protective ventilation in prone position (PP) in ARDS patients has been shown to improve survival [11–13] and is recommended in severe cases [14, 15]. Given that proning relieves the weight of mediastinum from the spinal parts of the lungs [16], the accuracy of Pes to reflect pleural pressure would be improved in PP as compared to supine (SP), as suggested recently in healthy patients under general anesthesia [17]. Accordingly, the measurement of end-expiratory transpulmonary pressure could be more relevant, in PP than in SP.

With this reasoning in mind, we underwent the present study to test the hypothesis that the static end-expiratory absolute Pes value (Pes,ee) would be lower in PP than in SP in ARDS patients. If this was true, this lower PEEP should be set in PP than in SP for a given static end-expiratory transpulmonary pressure (PL,ee). Our secondary objective was to explore the early and late effects of a PP session on arterial blood gas, lung and chest wall mechanics and regional ventilation according to the PEEP strategy.

Methods

Study design and population

Adult ARDS patients with PaO2/FIO2 ≤ 150 mmHg under invasive mechanical ventilation including PEEP ≥ 5 cmH2O and VT = 6 mL/kg predicted body weight were included in two academic medical intensive care units (Additional file 1: Figure S1).

Mechanical ventilation

Patients were under continuous intravenous sedation-analgesia and muscle paralysis and ventilated with Carestation R860 ventilator (GE Health Care, US) in volume-controlled mode, and PEEP set according to the low PEEP arm of the PEEP/FIO2 table used in the ARMA trial [2].

Measurements

Paw, flow and EELV [18] were measured. Pes and gastric pressure (Pga) were recorded with Nutrivent device (Sidam, Italy) after verification of correct placement [19] and non-stress minimal volume implementation [20]. Electrical impedance tomography (EIT) was recorded with the Swisstom BB2 monitor (Swisstom AG, Switzerland). Paw, Pes, Pga and flow signals were recorded at 200 Hz with Biopac150 device and Acknowledge software (Biopac inc., US).

Protocol

Protocol consisted of the following steps (Additional file 1: Figure S2):
  1. 1.

    Supine head-up at 30° at baseline PEEP (PEEP/FIO2 table).

     
  2. 2.

    Supine head-up at 30° at Pes-guided PEEP. PEEP was titrated by 1 cmH2O-steps to reach PL,ee of 3 ± 2 cmH2O. This average value was selected because it falls in the middle of the range of PL,ee values used to set PEEP from the Pes-guided strategy in the Epvent 2 trial [9].

     
After measurements, baseline PEEP was resumed and patient turned to PP with bed inclination between 0° and 15°.
  1. 3.

    PP at baseline PEEP. Same PEEP and ventilator settings as in step 1 were applied.

     
  2. 4.

    PP at Pes-guided PEEP. PEEP was titrated in prone in same way as in step 2.

     
For steps 1–4, measurements were done 1 h after change in PEEP.
  1. 5.

    Late Prone. Patients remained in PP for a total of 16 h during which they were randomly allocated into baseline PEEP or Pes-guided strategy. Measurements were done at session end.

     

Measurements

At each step, arterial blood gas and EELV were determined. While Paw, Pes, Pga, flow and EIT signals were continuously recorded, a 3-s inspiratory hold followed by a 3-s expiratory hold was performed (Additional file 1: Figure S3).

Data analysis

PL,ee was equal to static end-expiratory pressure of respiratory system (Paw,ee) minus Pes,ee. Static end-inspiratory transpulmonary plateau pressure was computed in two ways [21]: first as PL,ei = Paw,ei − Pes,ei (static end-inspiratory plateau pressure of respiratory system minus static end-inspiratory absolute plateau Pes) and second as PL,ei_Elastance derived = Paw,ei times lung to respiratory system static elastance ratio (Est,L/Est,rs). Driving pressures of respiratory system (DPrs) and chest wall (DPcw) were equal to Paw,ei-Paw,ee and Pes,ei-Pes,ee, respectively. Transpulmonary driving pressure (DPL) was equal to DPrs-DPcw. Est,rs, Est,L and chest wall elastance (Est,cw) were computed as usual.

EIT-derived regional respiratory system compliance was determined [22].

Recruited lung volume elicited by the change in PEEP in the early stage of the study in SP and in PP was computed according to the method described by Dellamonica et al. [23].

Statistical analysis

Continuous variables were expressed as mean ± standard deviation unless otherwise stated, and categorical variables as count (percentage point). Sample size was computed to 28 based on primary endpoint (Pes,ee) [24]. To account for incomplete data, we planned to include 38 patients. Data were compared by repeated measures 2-factor ANOVA. Categorical variables were compared using chi-squared test. Correlations between continuous variables were performed with Pearson test. Statistical significance level was set to p value < 0.05.

Results

Patients

From January 1, 2016, to March 31, 2017, 38 patients (27 male) were enrolled (Additional file 1: Table S1 and Figure S1). Each PEEP strategy was applied to 19 patients for the rest of the PP session (Additional file 1: Table S1). Fourteen patients died during the ICU stay (37%). All the data were lacking for Pes-guided PEEP in SP in one patient, who required immediate PP, and in late prone in 2 patients (1 death and 1 patient returned in SP for urgent coronarography). EIT data were not available in 11 patients.

Effect of Pes-guided PEEP in supine position

At 10 ± 2 cmH2O PEEP set from PEEP/FIO2 table in SP (step 1), Pes,ee and PL,ee averaged 9 ± 4 cmH2O and 2 ± 3 cmH2O, respectively (Table 1 and Fig. 1). Pes,ee as well as Pga,ee (but not PL,ee) correlated to patient’s body mass index: R = 0.43 (95% confidence interval [CI] [0.12–0.66]) (P = 0.008) and 0.52 [0.25–0.75] (P = 0.002), respectively. Ten patients (26%) had negative PL,ee. Figure 1 displays the individual values of Pes,ee and PL,ee at PEEP set from PEEP/FIO2 table. PEEP level resulting from the Pes-guided strategy (step 2) averaged 12 ± 4 cmH2O (P = 0.05 for PEEP strategy). With this strategy, PEEP increased in 20 patients, decreased in 11 patients and did not change in 6 patients (Fig. 2). It was associated with increasing Pes,ei, Pes,ee, and Est,cw (Table 1) and no change in regional lung compliance (Additional file 1: Table S2). Change of PEEP from Pes-guided strategy and body mass index did not correlate.
Table 1

Respiratory mechanics in supine and prone position according to PEEP strategy

Variables

Supine position

Prone position

P values

N*

 

PEEP/FIO2 table

Pes-guided strategy

PEEP/FIO2 table

Pes-guided strategy

Position effect

PEEP strategy effect

Position and PEEP interaction

 

PEEP set on ventilator (cmH2O)

10 ± 2

12 ± 4

10 ± 2

12 ± 5

0.96

0.05

0.96

37

Paw,ee (cmH2O)

11 ± 3

13 ± 4

11 ± 3

13 ± 5

0.47

0.05

0.91

37

Paw,ei (cmH2O)

23 ± 4

24 ± 6

22 ± 4

24 ± 6

0.11

0.08

0.78

37

Pes,ee (cmH2O)

9 ± 4

10 ± 5

9 ± 4

10 ± 5

0.88

0.05

0.83

37

Pes,ei (cmH2O)

12 ± 4

14 ± 5

13 ± 4

14 ± 6

0.66

0.01

0.80

37

Pga,ee (cmH2O)

12 ± 6

12 ± 5

18 ± 6

18 ± 7

< 0.001

0.19

0.06

31

Pga,ei (cmH2O)

14 ± 6

14 ± 6

20 ± 6

21 ± 7

< 0.001

0.11

0.04

31

PL,ee (cmH2O)

2 ± 3

2 ± 2

2 ± 3

3 ± 2

0.78

0.15

0.96

37

PL,ei (cmH2O)

10 ± 5

11 ± 5

10 ± 5

10 ± 4

0.03

0.47

0.66

37

PL,ei_Elastance (cmH2O)

16 ± 5

17 ± 6

15 ± 5

15 ± 6

< 0.01

0.46

0.34

37

DPrs (cmH2O)

12 ± 4

12 ± 4

11 ± 3

11 ± 4

< 0.001

0.88

0.65

37

DPcw (cmH2O)

3 ± 1

3 ± 2

3 ± 1

4 ± 1

0.33

0.03

0.42

37

DPL (cmH2O)

9 ± 4

8 ± 4

8 ± 4

7 ± 4

< 0.001

0.34

0.38

37

Est,rs (cmH2O/L)

34 ± 14

35 ± 14

32 ± 14

33 ± 14

0.04

0.46

0.83

37

Est,cw (cmH2O/L)

9 ± 4

10 ± 5

10 ± 3

11 ± 4

0.22

0.01

0.30

37

Est,L (cmH2O/L)

25 ± 15

25 ± 15

22 ± 15

22 ± 15

0.01

0.71

0.64

37

PaCO2 (mmHg)

53 ± 16

55 ± 17

52 ± 14

52 ± 18

0.08

0.12

0.36

36

PaO2/FIO2 ratio (mmHg)

143 ± 28

149 ± 31

172 ± 51

187 ± 53

< 0.001

0.03

0.17

36

EELV (mL)

1359 ± 503

1427 ± 456

1266 ± 391

1328 ± 415

0.01

0.08

0.93

37

Values are mean ± SD

PEEP positive end-expiratory pressure, Paw,ee static end-expiratory pressure of the respiratory system, Paw,ei static end-inspiratory pressure of the respiratory system, Pes,ee static end-expiratory esophageal pressure, Pes,ei static end-inspiratory esophageal pressure, Pga,ee static end-expiratory gastric pressure, Pga,ei static end-inspiratory gastric pressure, PL,ee static end-expiratory transpulmonary pressure, PL,ei static end-inspiratory transpulmonary pressure, PL,ei _Elastance Paw,ei × Est,L/Est,rs, Est,rs, Est,cw, Est,L static elastance, of respiratory system, chest wall and lung, respectively, DPrs, DPcw, DPL driving pressure of respiratory system, chest wall and lung, respectively, EELV end-expiratory lung volume

*Due to incomplete data, some patients were excluded from the analysis

Fig. 1
Fig. 1

Individual values of static end-expiratory esophageal (Pes,ee) (upper panel) and transpulmonary (PL,ee) (lower panel) pressures in supine and prone positions

Fig. 2
Fig. 2

Variation of positive end-expiratory pressure (PEEP) with esophageal pressure (Pes)-guided strategy in supine and prone position

Effect of prone position and PEEP strategy

By study design, the first PEEP used in PP (step 3) was set from the PEEP/FIO2 table and, hence was the same as in step 1. At that PEEP applied for 1 h in PP, Pes,ee averaged 9 ± 4 cmH2O as in step 1 (p = 0.88). There was no effect of position on PEEP level (Table 1), and a trend toward higher PEEP with Pes-guided strategy by 2 cmH2O. There was a significant effect of position on lung mechanics at either PEEP (Table 1): PL,ei, PL,ei_Elastance derived, DPL and Est,L were significantly lower in PP than in SP with no significant interaction with the PEEP strategy (Table 1). On average, PL,ee was independent of either PEEP strategy and position. However, for the position, there were individual variations (Fig. 1). In addition, PL,ee in step 1 and 3 was correlated: R 0.57 [0.31–0.75] (P = 0.002). There was a significant effect of PEEP strategy on chest wall mechanics and oxygenation (Table 1). Pga was significantly higher in PP than in SP with no effect of PEEP, but a significant interaction between position and PEEP was observed for Pga,ei (Table 1). Spinal lung compliance, as assessed by EIT, was significantly affected by position at either PEEP with higher values in PP (Additional file 1: Table S2). There was no correlation between variation of Est,cw and variation of PaO2/FIO2 ratio between SP and PP at each PEEP applied.

The recruited lung volume averaged 40 ± 191 and 82 ± 255 ml (P = 0.665) in SP and PP, respectively.

Effect of time in prone position

Over time in PP, EELV and PaO2/FIO2 significantly increased and PaCO2 significantly decreased regardless of the PEEP strategy (Table 2). With the Pes-guided PEEP, Est,cw and DPcw were higher than in the PEEP/FIO2 table group, without effect of time. Over the time spent in PP, we found that sternal lung compliance was higher at the end of the PP session, with no effect of PEEP group (Table 3).
Table 2

Respiratory mechanics in early and late prone position according to PEEP strategy

Variables

Early prone position

Late prone position

P values

 

PEEP/FIO2 table group (n = 19)

Pes-guided group (n = 19)

PEEP/FIO2 table group (n = 19)

Pes-guided group (n = 17)

Time effect

PEEP strategy effect

Time and PEEP interaction

PEEP set on ventilator (cmH2O)

10 ± 2

12 ± 5

10 ± 2

12 ± 4

0.53

0.23

0.50

Paw,ee (cmH2O)

11 ± 3

13 ± 5

11 ± 3

13 ± 4

0.93

0.09

0.26

Paw,ei (cmH2O)

22 ± 4

23 ± 5

22 ± 4

24 ± 4

0.79

0.28

0.67

Pes,ee (cmH2O)

9 ± 4

10 ± 5

9 ± 4

10 ± 6

0.88

0.47

0.07

Pes,ei (cmH2O)

12 ± 5

14 ± 4

12 ± 5

14 ± 5

0.87

0.20

0.07

Pga,ee (cmH2O)

18 ± 5

17 ± 6

17 ± 4

17 ± 5

0.48

0.96

0.77

Pga,ei (cmH2O)

20 ± 5

20 ± 6

19 ± 4

19 ± 6

0.43

0.96

0.75

PL,ee (cmH2O)

2 ± 4

3 ± 1

2 ± 4

3 ± 2

0.82

0.22

0.38

PL,ei (cmH2O)

10 ± 6

9 ± 3

10 ± 5

10 ± 4

0.95

0.69

0.11

PL,ei_Elastance (cmH2O)

16 ± 5

14 ± 5

15 ± 4

14 ± 5

0.96

0.47

0.16

DPrs (cmH2O)

11 ± 4

10 ± 3

11 ± 4

11 ± 4

0.79

0.51

0.17

DPcw (cmH2O)

3 ± 1

4 ± 1

3 ± 1

4 ± 1

0.52

0.02

0.42

DPL (cmH2O)

8 ± 4

6 ± 3

8 ± 4

7 ± 3

0.82

0.19

0.14

Est,rs (cmH2O/L)

34 ± 18

29 ± 11

33 ± 16

30 ± 12

0.76

0.41

0.24

Est,cw (cmH2O/L)

9 ± 3

12 ± 4

9 ± 3

11 ± 5

0.59

0.04

0.37

Est,L (cmH2O/L)

26 ± 18

18 ± 11

24 ± 16

19 ± 10

0.56

0.18

0.12

PaCO2 (mmHg)

50 ± 13

55 ± 13

45 ± 14

48 ± 10

< 0.001

0.42

0.43

PaO2/FIO2 ratio (mmHg)

178 ± 55

193 ± 48

223 ± 85

218 ± 65

< 0.001

0.82

0.27

EELV (mL)

1341 ± 440

1342 ± 445

1504 ± 547

1691 ± 950

0.01

0.63

0.28

Values are mean ± SD

PEEP positive end-expiratory pressure, Paw,ee static end-expiratory pressure of the respiratory system, Paw,ei static end-inspiratory pressure of the respiratory system, Pes,ee static end-expiratory esophageal pressure, Pes,ei static end-inspiratory esophageal pressure, Pga,ee static end-expiratory gastric pressure, Pga,ei static end-inspiratory gastric pressure, PL,ee static end-expiratory transpulmonary pressure, PL,ei static end-inspiratory transpulmonary pressure, PL,ei _Elastance Paw,ei x Est,L/Est,rs, Est,rs, Est,cw, Est,L static elastance, of respiratory system, chest wall and lung, respectively, DPrs, DPcw, DPL driving pressure of respiratory system, chest wall and lung, respectively, EELV end-expiratory lung volume

Table 3

Regional compliance in early and late prone position according to PEEP strategy

Electrical impedance tomography-derived regional compliance

Early prone position

Late prone position

P values

 

PEEP/FIO2 table (n = 13)

Pes-guided strategy (n = 10)

PEEP/FIO2 table (n = 13)

Pes-guided strategy (n = 10)

Position effect

PEEP strategy effect

Position and PEEP interaction

Sternal lung regions (mL/cmH2O)

11 ± 4

13 ± 6

13 ± 6

15 ± 8

0.002

0.42

0.89

Spinal lung regions (mL/cmH2O)

22 ± 9

24 ± 9

21 ± 9

24 ± 12

0.99

0.57

0.51

Values are mean ± SD

PEEP positive end-expiratory pressure, Pes esophageal pressure

Discussion

The two main findings of the present study that systematically assessed the Pes-guided strategy in PP in ARDS patients were that: (1) PP had no impact on absolute Pes measurements, suggesting the accuracy of esophageal balloon manometry independent of the mass of the mediastinum if esophageal balloon was calibrated properly; (2) PP was effective to improve lung mechanics (immediate effect) and facilitate lung recruitment (slow effect) independent of PEEP levels.

Impact of PP on Pes measurements

The Pes-guided PEEP concept is primarily driven by Pes,ee. Contrary to our expectations, Pes,ee did not decrease in PP from SP at same PEEP. One explanation may be that in PP pericardial ligaments prevent compression of esophagus by the heart and mediastinum and, hence avoid any real compression onto the esophageal balloon. Another explanation may be that we compared SP30° to PP0°–15°. Pes,ee decreased by 2 cmH2O between SP0° and PP0° in ARDS patients [25], as in normal subjects experiencing spine surgery [26].

Since average Pes,ee did not change significantly between SP and PP, the PEEP level resulting from the Pes-guided strategy was the same in both positions and it was systematically 2 cmH2O above the amount of PEEP from the PEEP/FIO2 table. This small change can be due to the fact that PL,ee, set from PEEP/FIO2 table, was near our target.

Talmor et al. [8] reported an average 7 cmH2O rise of PEEP with an improvement in oxygenation and Est,rs [8], by using Pes-guided strategy in SP. Potential explanations for the discrepancy between Talmor’s [8] and the present study are: (1) our case mix included mostly primary ARDS; (2) we set a fixed PL,ee (3 ± 2 cmH2O) goal and did not use a PL,ee-FIO2-table; (3) the correct placement of the esophageal balloon was assessed by the Baydur maneuver, and minimal non-stress esophageal balloon volume was determined; (4) Pes,ee averaged 9 cmH2O in our study versus 17 cmH2O in Talmor et al’ study [8], for PEEP of 10 and 13 cmH2O, respectively.

Impact of PP on chest wall mechanics

Between SP and PP in our study, Est,cw did not change. This result differs from Mentzelopoulos et al. [24], who found an increase in Est,cw by about 5 cmH2O/L between SP60° and PP0°. This discrepancy may be explained by different angulations in SP, and higher VT and PEEP in their study, making the volume–pressure curve of the chest wall displaced upward. Indeed, between SP and PP, EELV increased from 1.0 to 1.5 L in Mentzelopoulos et al. study [24] and decreased from 1.4 to 1.1 L in our study. Since the abdominal content has a major influence on the position of the diaphragm, and hence lung volume, SP30° might pull it down while PP might push it upward, which could easily result in the average difference of 0.3 L in lung volume we observed. Pelosi et al. found that chest wall compliance significantly decreased in PP from SP [27]. In two previous studies, we also found an increase in Est,cw in PP [25, 28] at 0° inclination in both positions, as Pelosi et al. [27]. Therefore, the inclination in SP and PP should be taken into account for interpreting the effect of PP on Est,cw.

Early impact of prone position on lung mechanics

PP significantly improved lung mechanics in the present study independently of PEEP strategy. The decrease in Est,L in PP should indicate lung recruitment or overdistension reduction. Previous CT scan studies found that PP can promote lung recruitment and lessen overdistension [29]. In the present study, EELV did not increase in PP. The effect of PP on EELV did vary across studies from no change [27] to increase [24]. Recently, EELV was found increasing from 1.6 L ± 0.476 to 1.8 ± 0.7 L (P = 0.008) after 1 h in PP [18]. In our study, moving the patients from SP30° to SP0° before proning may have significantly decreased EELV so that PP could not improve EELV immediately. Indeed, it took almost 14 h in PP for EELV to surpass its value in SP. The reduction in Est,L in PP could result from an imbalance between recruitment and derecruitment at the regional level with lung recruitment in the spinal parts of the lung being greater than the decrease in aerated lung volume in sternal parts [11]. Our increase in spinal lung compliance in PP favors this hypothesis, even though whole EELV did not change.

DPL [30] should theoretically better reflect lung stress than DPrs [31]. DPL decreased significantly in PP with no effect of PEEP strategy. Therefore, this finding may contribute to the better outcome of patients treated in PP.

PL,ei_elastance method may reflect lung stress in the sternal non-dependent parts of the lung in SP [32]. Whether or not PL,ei_Elastance derived in PP still reflects non-dependent parts of the lung or explores the sternal lung region is unknown. We found a significant decrease in PL,ei_Elastance derived in PP irrespective of the PEEP strategy. The fact that the compliance of non-dependent lung as assessed with EIT increased in PP suggests that PL,ei_Elastance derived reflects lung stress in that lung region in PP. PL,ei was suggested to reflect lung stress in the spinal dependent parts of the lung in SP [32]. Interestingly, PL,ei_Elastance derived remained greater than PL,ei in both SP and PP.

Taken together, these findings suggest that PP can prevent ventilator-induced lung injury regardless of PEEP strategy. Present results are important because they contribute to explain why survival was significantly improved in the Proseva trial [12] even though low levels of PEEP were used.

Slow effect of prone position on facilitation of lung recruitment

Over time in PP gas exchange and EELV improved. Increase in EELV may or may not include lung recruitment, defined as a decrease in non-aerated amount of lung tissue, i.e., as lung tissue that regains air. Poorly aerated lung regions that become well aerated can also contribute to higher EELV. The fact that increase in EELV was associated with better gas exchange argues in favor of the recruitment of functional lung tissue over time in PP. The improvement in sternal lung compliance over time in PP suggests a net gain of lung volume in dependent parts of the lung.

Impact of Pes-guided PEEP strategy on chest wall mechanics

With Pes-guided strategy, lung mechanics did not change but Est,cw increased between PEEP 10 and 12 cmH2O, on average, regardless of position or PP duration (Tables 1 and 2). This finding was uncommon in ARDS patients between 10 and 15 cmH2O PEEP [27, 33–35] and could be explained by a shift of chest wall volume–pressure curve toward its upper (higher PEEP) or lower (lower PEEP) less compliant parts. Since we did not find a significant increase in EELV with the Pes-guided strategy, we have no clear explanation for this finding. Higher Est,cw makes that Paw dissipates into the chest wall, which could protect the lung from excessive stress and strain.

Clinical implications

First, in a patient receiving Pes-guided PEEP strategy, it is likely that PEEP in PP will be near that in SP.

Second, as EELV early went down from SP to PP, the PEEP should be increased at this step. On the other hand, if PP promotes lung recruitment over time, higher PEEP should be used after the resumption of proning, i.e., when turning the patient back to SP, to prevent derecruitment [36]. However, whether EELV would decrease after turning patient back to SP at same PEEP was not assessed in the present study.

Third, continuous improvement in oxygenation and EELV over time in PP supports the use of prolonged proning sessions [14].

Limitations and strengths

Our study is limited by the lack of CT scan or other markers of ventilator-induced lung injury, the lack of EIT data in 11 patients and the not randomized design in the early application of PEEP strategy, which might have resulted in a carry-over effect since each patient was own control. Strengths include proper calibration of esophageal balloon, non-stress balloon volume implementation and detailed description of lung and chest wall mechanics in SP and PP with updated methodology.

Conclusions

There was no impact of PP on Pes measurements. PP had an immediate improvement effect on lung mechanics and a late lung recruitment effect independent of PEEP strategy.

Abbreviations

ARDS: 

acute respiratory distress syndrome

DPcw: 

driving pressure of the chest wall

DPL: 

driving pressure of the lung

DPrs: 

driving pressure of the respiratory system

EELV: 

end-expiratory lung volume

EIT: 

electrical impedance tomography

Est,cw: 

static elastance of the chest wall

Est,L: 

static elastance of the lung

Est,rs: 

static elastance of the respiratory system

FIO2 : 

inspired oxygen fraction in air

Paw: 

airway pressure

Paw,ee: 

static end-expiratory airway pressure

Paw,ei: 

static end-inspiratory airway pressure

Pes: 

esophageal pressure

Pes,ee: 

static end-expiratory esophageal pressure

Pes,ei: 

static end-inspiratory esophageal pressure

PEEP: 

positive end-expiratory pressure

Pga: 

gastric pressure

Pga,ee: 

static end-expiratory gastric pressure

Pga,ei: 

static end-inspiratory airway pressure

PL,ee: 

static end-expiratory transpulmonary pressure

PL,ei: 

static end-inspiratory transpulmonary pressure

PP: 

supine position

SP: 

prone position

VT: 

tidal volume

Declarations

Authors’ contributions

MM was a major contributor contributed to acquire the data and to analyze the data. FJP contributed to acquire the data and to analyze the data. HY contributed to include the patients. ZR contributed to include the patients. SB analyzed the data. AW analyzed the data. JCR contributed in writing the manuscript. FL contributed to include the patients. RT contributed to include the patients. LB contributed to include the patients and to acquire the data. JM was a major contributor in designing the study and in the writing the manuscript. CG was a major contributor in designing the study, in acquiring the data and in the writing of the manuscript. All authors read and approved the final manuscript.

Acknowledgements

The authors would like to thank Gilles Stackowiak and Marc Wysocki MD, GE Healthcare, for providing the Carestation R860 ventilator; Julien Servignat, Maquet, for his support to manage the Swisstom BB2 EIT device; Barbara Moro, MD, for her help in performing measurements; and the physicians and nurses of the medical ICUs at Croix Rousse Hospital, Lyon, France, and San Pau Hospital, Barcelona, Spain, for taking care of the patients during the study; and the PLUG, which is a working group of the acute respiratory failure section of the European Society of Intensive Care Medicine, for having endorsed this work.

Competing interests

The authors declare that they have no competing interests.

Availability of data and materials

Datasets used and/or analyzed during the current study are included which are available from the corresponding author on reasonable request.

Consent for publication

Not applicable.

Ethics approval and consent to participate

The protocol (69HCL14_0333) was approved by the ethical committees (2014-A01714-43) on February 24, 2015, and by the national agency on drug regulation (150038B-32) on March 31, 2015, and it was registered onto clinicalTrials.gov (NCT02416037). Inform consent was obtained by the next of kin in every instance.

Funding

CG received the Bernhard-Dräger Grant 2014 from the European Society of Intensive Care Medicine. MM received grants from the University hospital of Montpellier, France, and the University Claude Bernard Lyon I, France, to support his 1-year research training period in the service de reanimation médicale, Hôpital de la Croix Rousse, Lyon, France. Engström R860 was provided by GE Health Care. EIT device was provided by Swisstom and Maquet.

Publisher’s Note

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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors’ Affiliations

(1)
Service de Réanimation Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
(2)
Université de Lyon, Lyon, France
(3)
Intensive Care Unit, Sant Pau Hospital, Barcelona, Spain
(4)
Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Center, Schillingallee 35, 18057 Rostock, Germany
(5)
Swisstom AG, Lanquart, Switzerland
(6)
Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, Kliniken der Stadt Koln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, 51109 Cologne, Germany
(7)
INSERM 955, Créteil, France

References

  1. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315:788–800.View ArticlePubMedGoogle Scholar
  2. ARDSnet. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The acute respiratory distress syndrome network. N Engl J Med. 2000;342:1301–8.View ArticleGoogle Scholar
  3. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet. 1967;2:319–23.View ArticlePubMedGoogle Scholar
  4. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004;351:327–36.View ArticlePubMedGoogle Scholar
  5. Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, et al. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008;299:637–45.View ArticlePubMedGoogle Scholar
  6. Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, et al. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008;299:646–55.View ArticlePubMedGoogle Scholar
  7. Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, et al. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA. 2010;303:865–73.View ArticlePubMedGoogle Scholar
  8. Talmor D, Sarge T, Malhotra A, O’Donnell CR, Ritz R, Lisbon A, et al. Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med. 2008;359:2095–104.View ArticlePubMedPubMed CentralGoogle Scholar
  9. Fish E, Novack V, Banner-Goodspeed VM, Sarge T, Loring S, Talmor D. The Esophageal Pressure-Guided Ventilation 2 (EPVent2) trial protocol: a multicentre, randomised clinical trial of mechanical ventilation guided by transpulmonary pressure. BMJ Open. 2014;4:e006356.View ArticlePubMedPubMed CentralGoogle Scholar
  10. Akoumianaki E, Maggiore SM, Valenza F, Bellani G, Jubran A, Loring SH, et al. The application of esophageal pressure measurement in patients with respiratory failure. Am J Respir Crit Care Med. 2014;189:520–31.View ArticlePubMedGoogle Scholar
  11. Gattinoni L, Carlesso E, Taccone P, Polli F, Guerin C, Mancebo J. Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis. Minerva Anestesiol. 2010;76:448–54.PubMedGoogle Scholar
  12. Guerin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013;368:2159–68.View ArticlePubMedGoogle Scholar
  13. Sud S, Friedrich JO, Adhikari NK, Taccone P, Mancebo J, Polli F, et al. Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis. CMAJ. 2014;186:E381–90.View ArticlePubMedPubMed CentralGoogle Scholar
  14. Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, et al. An official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine clinical practice guideline: mechanical ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2017;195:1253–63.View ArticlePubMedGoogle Scholar
  15. Chiumello D, Brochard L, Marini JJ, Slutsky AS, Mancebo J, Ranieri VM, et al. Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Crit Care. 2017;21:240.View ArticlePubMedPubMed CentralGoogle Scholar
  16. Albert RK, Hubmayr RD. The prone position eliminates compression of the lungs by the heart. Am J Respir Crit Care Med. 2000;161:1660–5.View ArticlePubMedGoogle Scholar
  17. Kumaresan A, Gerber R, Mueller A, Loring SH, Talmor D. Effects of prone positioning on transpulmonary pressures and end-expiratory volumes in patients without lung disease. Anesthesiology. 2018;128:1187–92.View ArticlePubMedGoogle Scholar
  18. Aguirre-Bermeo H, Turella M, Bitondo M, Grandjean J, Italiano S, Festa O, et al. Lung volumes and lung volume recruitment in ARDS: a comparison between supine and prone position. Ann Intensive Care. 2018;8:25.View ArticlePubMedPubMed CentralGoogle Scholar
  19. Baydur A, Behrakis PK, Zin WA, Jaeger M, Milic-Emili J. A simple method for assessing the validity of the esophageal balloon technique. Am Rev Respir Dis. 1982;126:788–91.PubMedGoogle Scholar
  20. Mojoli F, Iotti GA, Torriglia F, Pozzi M, Volta CA, Bianzina S, et al. In vivo calibration of esophageal pressure in the mechanically ventilated patient makes measurements reliable. Crit Care. 2016;20:98.View ArticlePubMedPubMed CentralGoogle Scholar
  21. Grasso S, Terragni P, Birocco A, Urbino R, Del Sorbo L, Filippini C, et al. ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure. Intensive Care Med. 2012;38:395–403.View ArticlePubMedGoogle Scholar
  22. Lowhagen K, Lundin S, Stenqvist O. Regional intratidal gas distribution in acute lung injury and acute respiratory distress syndrome–assessed by electric impedance tomography. Minerva Anestesiol. 2010;76:1024–35.PubMedGoogle Scholar
  23. Dellamonica J, Lerolle N, Sargentini C, Beduneau G, Di Marco F, Mercat A, et al. PEEP-induced changes in lung volume in acute respiratory distress syndrome. Two methods to estimate alveolar recruitment. Intensive Care Med. 2011;37:1595–604.View ArticlePubMedGoogle Scholar
  24. Mentzelopoulos SD, Roussos C, Zakynthinos SG. Prone position reduces lung stress and strain in severe acute respiratory distress syndrome. Eur Respir J. 2005;25:534–44.View ArticlePubMedGoogle Scholar
  25. Riad Z, Mezidi M, Subtil F, Louis B, Guerin C. Short-term effects of the prone positioning maneuver on lung and chest wall mechanics in ARDS patients. Am J Respir Crit Care Med. 2017;97(10):1355–8.View ArticleGoogle Scholar
  26. Kumaresan A, Robert Gerber R, Mueller A, Loring SH, Talmor D. Effects of prone positioning on transpulmonary pressures and end-expiratory volumes in patients without lung disease. Anesthesiology. 2018;128(6):1187–92.View ArticlePubMedGoogle Scholar
  27. Pelosi P, Tubiolo D, Mascheroni D, Vicardi P, Crotti S, Valenza F, et al. Effects of the prone position on respiratory mechanics and gas exchange during acute lung injury. Am J Respir Crit Care Med. 1998;157:387–93.View ArticlePubMedGoogle Scholar
  28. Guerin C, Badet M, Rosselli S, Heyer L, Sab JM, Langevin B, et al. Effects of prone position on alveolar recruitment and oxygenation in acute lung injury. Intensive Care Med. 1999;25:1222–30.View ArticlePubMedGoogle Scholar
  29. Cornejo RA, Diaz JC, Tobar EA, Bruhn AR, Ramos CA, Gonzalez RA, et al. Effects of prone positioning on lung protection in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2013;188:440–8.View ArticlePubMedGoogle Scholar
  30. Baedorf Kassis E, Loring SH, Talmor D. Mortality and pulmonary mechanics in relation to respiratory system and transpulmonary driving pressures in ARDS. Intensive Care Med. 2016;42:1206–13.View ArticlePubMedGoogle Scholar
  31. Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015;372:747–55.View ArticlePubMedGoogle Scholar
  32. Yoshida T, Amato MBP, Grieco DL, Chen L, Lima CAS, Roldan R, et al. Esophageal manometry and regional transpulmonary pressure in lung injury. Am J Respir Crit Care Med. 2018;197(8):1018–26.View ArticlePubMedGoogle Scholar
  33. Pelosi P, Cereda M, Foti G, Giacomini M, Pesenti A. Alterations of lung and chest wall mechanics in patients with acute lung injury: effects of positive end-expiratory pressure. Am J Respir Crit Care Med. 1995;152:531–7.View ArticlePubMedGoogle Scholar
  34. Mergoni M, Martelli A, Volpi A, Primavera S, Zuccoli P, Rossi A. Impact of positive end-expiratory pressure on chest wall and lung pressure–volume curve in acute respiratory failure. Am J Respir Crit Care Med. 1997;156:846–54.View ArticlePubMedGoogle Scholar
  35. Gattinoni L, Pelosi P, Suter PM, Pedoto A, Vercesi P, Lissoni A. Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes? Am J Respir Crit Care Med. 1998;158:3–11.View ArticlePubMedGoogle Scholar
  36. Lim CM, Jung H, Koh Y, Lee JS, Shim TS, Lee SD, et al. Effect of alveolar recruitment maneuver in early acute respiratory distress syndrome according to antiderecruitment strategy, etiological category of diffuse lung injury, and body position of the patient. Crit Care Med. 2003;31:411–8.View ArticlePubMedGoogle Scholar

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© The Author(s) 2018

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