Skip to main content

Clinical spectrum and prognostic impact of cancer in critically ill patients with HIV: a multicentre cohort study



Both AIDS-defining and non-AIDS-defining cancers (ADC/NADC) predispose people living with HIV (PLHIV) to critical illnesses. The objective of this multicentre study was to investigate the prognostic impact of ADC and NADC in PLHIV admitted to the intensive care unit (ICU).


All PLHIV admitted over the 2015–2020 period in 12 university-affiliated ICUs in France were included in the study cohort. The effect of ADC and NADC on in-hospital mortality (primary study endpoint) was measured through logistic regression with augmented backward elimination of potential independent variables. The association between ADC/NADC and treatment limitation decision (TLD) during the ICU stay (secondary study endpoint) was analysed. One-year mortality in patients discharged alive from the index hospital admission (exploratory study endpoint) was compared between those with ADC, NADC or no cancer.


Amongst the 939 included PLHIV (median age, 52 [43–59] years; combination antiretroviral therapy, 74.4%), 97 (10.3%) and 106 (11.3%) presented with an active NADC (mostly lung and intestinal neoplasms) and an active ADC (predominantly AIDS-defining non-Hodgkin lymphoma), respectively. Inaugural admissions were common. Bacterial sepsis and non-infectious neoplasm-related complications accounted for most of admissions in these subgroups. Hospital mortality was 12.4% in patients without cancer, 30.2% in ADC patients and 45.4% in NADC patients (P < 0.0001). NADC (adjusted odds ratio [aOR], 7.00; 95% confidence interval [CI], 4.07–12.05) and ADC (aOR, 3.11; 95% CI 1.76–5.51) were independently associated with in-hospital death after adjustment on severity and frailty markers. The prevalence of TLD was 8.0% in patients without cancer, 17.9% in ADC patients and 33.0% in NADC patients (P < 0.0001)—organ failures and non-neoplastic comorbidities were less often considered in patients with cancer. One-year mortality in survivors of the index hospital admission was 7.8% in patients without cancer, 17.0% in ADC patients and 33.3% in NADC patients (P < 0.0001).


NADC and ADC are equally prevalent, stand as a leading argument for TLD, and strongly predict in-hospital death in the current population of PLHIV requiring ICU admission.


The epidemiology of cancer in people living with HIV (PLHIV) has markedly evolved over the past decades owing to augmented access to combination antiretroviral therapy (cART). The incidence and attributable mortality of AIDS-defining cancers (ADC) (namely, high-grade B-cell non-Hodgkin lymphoma [NHL], Kaposi sarcoma, and carcinoma of the cervix) have globally declined though PLHIV remain at higher hazard for these neoplasms than seronegative individuals, especially in case of undiagnosed HIV infection or social issues that jeopardise sustainable cART adherence [1,2,3,4]. Conversely, extended life expectancy, lifestyle risk factors, certain viral co-infections and chronic systemic inflammation ensuing from silent HIV replication may all contribute to the growing prevalence of non-AIDS-defining cancers (NADC) which nowadays prevail and stand as a leading cause of death in the overall population of cART-treated PLHIV [5,6,7,8].

Both ADC and NADC predispose PLHIV to life-threatening events resulting from sepsis, metabolic disorders, mechanical complications, or chemotherapy-related toxicity [9, 10]. Yet, granular data are lacking to appraise the current impact of cancers on the clinical features and outcomes of critical illnesses in these patients [11]. Next, palliative approaches now constitute an essential component of care for PLHIV ageing with severe comorbidities and altered performance status [12]; however, treatment limitation decisions (TLD) remain under-investigated in those admitted to the intensive care unit (ICU) and how cancers affect TLD in this setting is unknown [11]. These elements appear pivotal to improve the collaborative management of PLHIV by intensivists, infectious diseases specialists and oncologists, define the appropriate level of care, and help rationalising the utilisation of ICU resources in this changing patient population.

The primary objective of this multicentre cohort study was to measure the effect of NADC and ADC on hospital mortality in a contemporary population of PLHIV admitted to the ICU. The secondary objective was to appraise the impact of cancer on TLD in these patients. The association between cancer status and one-year mortality in patients alive at hospital discharge was investigated as an exploratory objective.

Patients and methods

Study design and patient inclusion

This study was conducted in 12 medical ICUs located in university-affiliated hospitals in France and contributing to the GRRROH (Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique, and CRICS-TRIGGERSEP (Clinical Research in Intensive Care and Sepsis—Trial Group for Global Evaluation and Research in Sepsis, networks for research in intensive care (see the Additional file 1 for details on centre recruitment and characteristics). All adult PLHIV admitted to these ICUs over a 5.5 year period (from January 2015 to June 2020) were retrospectively identified by local investigators through hospital coding databases using the International Classification of Diseases–10th revision items related to HIV infection (that is B20-24, Z21, and R75) and included in the study cohort provided that there was no missing information regarding cART use at ICU admission and the vital status at hospital discharge. Only the first ICU stay was analysed in patients with multiple admissions over the inclusion period. The study protocol was approved by the ethical committee of the French Intensive Care Society on August 3, 2020 (report n°CE-SRLF-20–70); the requirement for informed consent was waived owing to the observational design. Results are reported according to the STROBE guidelines [13].

Data collection and definitions

The patient medical records from the ICU and the downstream unit were anonymised by local investigators and centralised before data extraction with a standardised form. Vital status at last follow-up visit in the participating centre was also collected, when available.

cART was defined according to the current International Antiviral Society guidelines [14]. When available, CD4 cell count and HIV viral load were collected within the 6 months preceding ICU admission for patients with previously known HIV infection and at ICU admission for those with newly diagnosed seropositivity. Missing values are indicated in Additional file 1: Table S1.

AIDS-defining conditions were defined according to the Centers for Diseases Control and Prevention classification, with primary brain lymphoma, Burkitt lymphoma, other high-grade B-cell NHL, Kaposi sarcoma and cervix cancer being identified as ADC [15]. Other solid and haematological neoplasms were classified as NADC. NADC and ADC were considered active in patients with either inaugural admission, response to first-line therapy, relapse, or refractory disease. Neoplasms with proven remission after first-line therapy were classified as inactive.

The primary diagnoses of the ICU stay were ventilated as cancer-related non-infectious complications, non-infectious complications of chronic conditions other than cancer, bacterial sepsis, non-AIDS-defining non-bacterial infections, AIDS-defining opportunistic infections, cART-related toxicity, and others.

The primary study endpoint was in-hospital mortality. The secondary study endpoint was the existence of a TLD (either withholding or withdrawal of organ support) during the ICU stay, as stated in the medical record file. Written arguments for TLD were collected. One-year mortality in patients discharged alive from the index hospital admission was investigated as an exploratory endpoint.

Statistical analyses

Data are expressed as median (interquartile range) for continuous variables and number (percentage) for categorical variables, unless otherwise indicated. The analysis of variance test and the Kruskal–Wallis test were used to compare continuous variables with normal and non-normal distributions, respectively. The Fisher’s exact test or the χ2 test, as appropriate, was used to compare categorical variables.

To assess the patient characteristics that could have influenced the occurrence of the primary study endpoint, we used a logistic regression model with in-hospital death as the dependent variable. As independent variables, we first entered in a global starting model a number of patient characteristics that could have been linked to this endpoint. To reduce the number of potential independent variables per event, we then proceeded to augmented backward elimination (ABE) that combines the standardised change-in-estimate criterion with significance-based backward elimination, with liberal criteria to keep independent variables in the model (threshold values, P < 0.35 and change-in-estimate < 35%) as to minimise the risk of eliminating important explanatory variables [16, 17]. Passive variables that were considered systematically associated with in-hospital death (namely age, sex, and the SOFA score value at ICU admission) were kept in the models. Other active variables that could have been linked to in-hospital mortality or modified the influence of passive variables were also introduced in the starting model submitted to ABE. This procedure was repeated on 1000 bootstrap samples (with replacement) of the study population. Potentially explanatory variables (exposed with their adjusted odd ratio [aOR] and 95% confidence interval [CI]) were retained in the final model if they were selected in more than 50% of the bootstrap samples, with a root mean square difference ratio < 1.5 and an absolute relative conditional bias of less than 50%. Discriminative ability of the model was assessed through area under the receiver operating characteristics curve (AUROC).

The cumulative survival at one year in patients discharged alive from the hospital was compared between the three groups (active ADC, active NADC, and no active cancer) through Kaplan–Meier analyses and the log-rank test, with right-censoring at the date of last follow-up information.

All analyses were conducted using the R software version 3.5.1 ( Two-tailed P values < 0.05 were considered statistically significant.


Baseline characteristics of the study population

A total of 939 PLHIV were included (Table 1 and Additional file 1: Fig. S1, additional characteristics of the study population in Additional file 1: Table S1). Amongst them, 812 (86.5%) were known as HIV-infected prior to hospital admission (time from HIV diagnosis, 13.6 [2.8–21.2] years; CD4 cell count, 370 [180–600] per µL; HIV viral load, < 50 [< 50 – < 50] copies per µL), including 699 (74.4%) receiving cART. The diagnosis of HIV infection was made during the index hospitalisation for the remaining 127 patients (13.5%) (CD4 cell count, 51 [20–147] cells per µL; HIV viral load, 5.105 [105–106] copies per µL). Chronic obstructive pulmonary disease, coronary artery disease, liver cirrhosis and renal conditions were the most common comorbidities (Table 1). Twenty-four patients (2.6%) were solid organ transplant recipients, including 21 kidney transplant recipients. Of note, the 5.5-year inclusion period ended in June 2020, that is barely 3 months after the beginning of the first COVID-19 wave in France, with only 7 patients (0.7%) admitted for COVID-19-related respiratory failure.

Table 1 Characteristics of the study population according to the cancer status

Prevalence and spectrum of ADC and NADC

Overall, 106 (11.3%) and 97 (10.3%) patients presented with an active ADC and an active NADC, respectively. Solid cancers—mostly lung and intestinal neoplasms—accounted for 62 (63.9%) of NADC, with a metastatic stage in half of cases (Table 2). Hodgkin disease, non-AIDS-defining NHL and acute leukaemia were equally distributed amongst haematological NADC. Burkitt lymphoma and other AIDS-defining NHL represented 86 (81.1%) of ADC whilst only 19 cases of Kaposi sarcoma were identified (Table 2). The diagnosis of neoplasm was made during the index hospitalisation in 30 (48.3%), 21 (60.0%) and 65 (75.6%) of patients with solid NADC, haematological NADC and haematological ADC, respectively (P = 0.005). HIV infection and cancer were co-diagnosed during the index hospitalisation in 18 (17.0%) patients with ADC. Patients with NADC were older, received cART more frequently, had more non-neoplastic chronic conditions and presented with a worst performance status than those with ADC (Table 1). None of the solid organ transplant recipients had an active cancer at ICU admission.

Table 2 Features of active cancers and association with in-hospital mortality in the study population

Clinical presentation and organ support in patients with and without cancer

Acute respiratory failure, sepsis and non-toxic coma were the leading reasons for ICU admission, whatever the cancer status (Table 1). The extent of organ failures at admission, as reflected by the SOFA score, did not differ between patients with and without neoplasm. Bacterial sepsis and cancer-related non-infectious complications were the most common definite diagnoses of the ICU stay in patients with NADC and ADC. Notably, NHL-related tumour lysis syndrome accounted for one-fourth of admissions in patients with ADC.

Invasive mechanical ventilation was similarly implemented in patients with and without cancer. Patients with ADC were more often treated with vasopressors and renal replacement therapy than those with NADC or no cancer. Half of patients with ADC received anti-neoplastic chemotherapy in the ICU.

In-hospital mortality

A total of 167 patients (17.8%) died during their hospital stay (Additional file 1: Table S1). Overall hospital mortality was 12.4% in patients without cancer, 30.2% in patients with ADC and 45.4% in patients with NADC (P < 0.0001) (Fig. 1). Around half of deaths in patients with cancer occurred after ICU discharge, which is in the downstream ward, and were related to cancer in most of cases (Table 1). For admissions with bacterial sepsis as the main diagnosis, hospital mortality was 19.4% in patients without cancer, 28.0% in those with ADC and 43.8% in those with NADC (P = 0.008).

In the final model, NADC (aOR, 7.00; 95% CI 4.07–12.05; P < 0.0001), ADC (aOR, 3.11; 95% CI 1.76–5.51; P = 0.0001), liver cirrhosis (aOR, 2.40; 95% CI 1.25–4.60; P = 0.008), invasive mechanical ventilation (aOR, 3.45; 95% CI 2.12–5.62; P < 0.0001) and the SOFA score value at admission (aOR per point-increase, 1.18; 95% CI 1.12–1.25; P < 0.0001) were independently associated with in-hospital death (Table 3, results of the full model in Additional file 1: Table S3). The final model showed a good discriminative ability with an AUROC of 0.86 (95% CI 0.83–0.89) (2000 non-stratified bootstrap replicates).

Table 3 Independent predictors of in-hospital death: results of the final model

Treatment limitation decisions

A TLD was pronounced during the ICU stay in 110 patients (11.7%), including organ support withdrawal in 38 (4.0%) and withholding in 72 (7.7%) of them. The prevalence of TLD was 8.0% in patients without cancer, 17.9% in those with ADC and 33.0% in those with NADC (P < 0.0001). Death occurred in a context of TLD in 37/69 patients (53.6%) without cancer, 15/32 patients (46.9%) with ADC and 27/44 patients (61.4%) with NADC (P = 0.45).

Arguments for TLD are exposed in Table 4. Cancer impacted this decision in 47 patients (92.2%) with ADC or NADC, without significant variation according to the classification or the stage of the disease (Additional file 1: Table S4). Organ failures and non-neoplastic comorbidities were less often considered in patients with cancer than in those without. Only 10 patients (9.1%) in whom a TLD was made had advance directives at ICU admission, a proportion that was not higher in those with neoplasm (Table 4).

Table 4 Written arguments for treatment limitation decision in the intensive care unit
Fig. 1
figure 1

In-hospital mortality according to the cancer status and use of organ support in the ICU. Data are exposed as percentages. MV, mechanical ventilation; VP, vasopressors; RRT, renal replacement therapy; ADC, AIDS-defining cancer; NADC, non-AIDS-defining cancer. *P < 0.0001; **P = 0.005; ***P = 0.01

One-year mortality for patients alive at hospital discharge

At least one follow-up hospital visit was available for 643 (83.3%) out of the 772 patients alive at hospital discharge. Figure 2 shows the cumulative survival at one year in these patients according to the cancer status (right-censoring at the time of last available information), the lowest survival being observed in those with ADC (log-rank test, P < 0.0001). Vital status at one year was available for 577 (74.7%) out of these 772 survivors of the index hospital admission (Additional file 1: Table S5): 1 year mortality in these patients was 38/488 (7.8%) in those without cancer, 9/53 (17.0%) in those with ADC (including 5/9 cancer-related deaths) and 12/36 (33.3%) in those with NADC (including 10/12 cancer-related deaths) (P < 0.0001).

Fig. 2
figure 2

Cumulative survival at one-year according to the cancer status in patients discharged alive from the index hospital admission. Kaplan–Meier curves (with right-censoring at the date of last follow-up information) were compared using the log-rank test. ADC, AIDS-defining cancer; NADC, non-AIDS-defining cancer


One-fifth of the 939 critically ill PLHIV included in this multicentre study suffered from an active neoplasm, with a similar prevalence of NADC and ADC. Bacterial sepsis and non-infectious cancer-related events accounted for most of admissions in these patients. Cancer was a predominant argument for TLD and strongly predicted in-hospital death after adjustment on other frailty and severity markers.

The prevalence of NADC was high in our cohort, exceeding rates reported in critically ill PLHIV over the early cART era [9, 18,19,20,21,22]. This trend correlates with evidence that PLVIH, including those with sustained viral control under cART, are at increased hazard for certain infection-related NADC (e.g. EBV-promoted Hodgkin lymphoma) and infection-unrelated NADC (e.g. lung cancer) when compared to age- and sex-matched seronegative individuals [8, 23]. The volume of PLHIV with cancer referred for ICU admission could continue to rise through the coming decade as the burden of NADC is expected to amplify, notably amongst patients aged 65 years or older [4]. Besides, Burkitt lymphoma and diffuse large B cell lymphoma represented most of ADC cases. Those high-grade presentations, which generally prevail in PLHIV [24], are associated with a marked propensity for life-threatening complications entailing ICU admission in patients with NHL, regardless of their HIV status [25, 26]. This may have contributed to the over-representation of ADC in our cohort whilst NADC now distinctly predominate in the overall population of PLHIV [27, 28].

The deleterious effect of cancer on hospital survival has several potential explanations. Most of patients with solid NADC presented with indicators of advanced disease, such as altered performance status, metastatic stage, or admission for a complication directly related to the underlying tumour. The noteworthy prevalence of inaugural admissions may also reflect aggressive phenotypes or late diagnoses. This could be especially relevant for haematological malignancies, with a large subset of patients with tumour lysis syndrome requiring renal replacement therapy or treated with chemotherapy during their ICU stay, as observed in other cohorts [29]. Moreover, patients with cancer were mainly transferred from wards. Early admission from the emergency department, before the worsening of organ failures, has been shown to improve survival in critically ill individuals with neoplasm [30,31,32]. Next, the additional immune deficiency resulting from cancer and antineoplastic chemotherapies may intrinsically impair survival in PLHIV at the acute phase of critical illnesses. Indeed, amongst patients admitted for bacterial sepsis, in-hospital mortality was greater in those with cancer, as reported in studies not focussed on PLHIV [33, 34]. Lastly, in-hospital fatalities occurring after ICU discharge were far more common in patients with cancer —in this later subgroup, most of deaths occurring in the downstream ward were related to disease progression or new cancer-related complications.

A key question is whether HIV infection impairs per se the outcomes of patients with cancer requiring ICU admission. Data regarding the prognostic impact of HIV infection on the outcome of critically ill patients are conflicting. A large cohort study conducted in the early cART era and including both PLHIV and seronegative controls (matched on age, gender, and medical versus surgical reasons for ICU admission) reported higher unadjusted short-term mortality rates in PLHIV [35]. However, most of studies from the same period found no independent association between HIV infection and survival in patients admitted to the ICU for common conditions such as resuscitated cardiac arrest or the acute respiratory distress syndrome [36, 37]. Also, the severity of HIV-induced immune deficiency, as reflected by the CD4 cell count, does not correlate with short-term outcomes in PLHIV admitted for acute respiratory failure [38], neurological failure [39], or sepsis [40, 41]. Overall, recent case series of critically ill PLHIV showed similar outcomes that those currently reported in seronegative individuals with comparable demographics, comorbidities, and level of organ dysfunctions [11, 21]. Next, to the best of our knowledge, the prognosis of critically ill patients with a given cancer type as never been studied according to the HIV status. Nevertheless, the hospital mortality rates that we observed in our cohort for patients with the most common cancer presentations—namely NHL and lung cancer—were similar to those observed in critically ill seronegative patients with these neoplasms [25, 26, 29, 42, 43]. Altogether, these data suggest that HIV infection has no major impact on the prognosis of critically ill patients with cancer though further studies are warranted to confirm this assumption.

TLD during the ICU stay and in-hospital deaths preceded by such decisions were as frequent in our cohort as in the general population of critically ill patients [44, 45]. Presenting with an active cancer acted as a major determinant for TLD, along with poor baseline health status and the extent of organ failures. HIV infection was only rarely taken in account, contrasting with studies conducted in the early cART era [46, 47]. Overall, these results and the evidence discussed above suggest that, in a context of extended access to cART and improved life expectancy, TLD in PLHIV admitted to the ICU now rests upon a similar making-process than for seronegative individuals, with a substantial impact of cancer prognosis. Strikingly, advance directives were unavailable for most of patients with cancer. Though the frequency of inaugural admissions may partly explain this observation, advance directive completion appears essential for better defining the goals of care in an ageing population of PLHIV in whom the prevalence of malignancies is increasing [48,49,50].

This work has limitations. First, ADC and NADC were pooled for analyses due to the restricted number of patients with each cancer subtype. Dedicated studies are necessary to appraise the specific prognostic impact of common neoplasms such as lung cancer or AIDS-defining NHL in critically ill PLHIV. Second, owing to the retrospective design, some relevant predictors of outcome might have been omitted, notably the time elapsed from the first symptoms of critical illness to ICU admission. Transient stress in bed availability or reluctance for ICU admission of patients with cancer could have led to delayed referral and impaired prognosis. Along this line, policies for both admission and do-not-resuscitate decisions may differ from one ICU to another, which could affect the external validity of our results. Next, we did not collect information on the course of organ failures throughout the ICU stay. Nevertheless, life-sustaining therapies were entered as active variables in the model for mortality prediction and whether organ failures influenced TLD was extracted from the patient report files. Lastly, as follow-up ended at hospital discharge, we did not explore the effect of critical illness on disease progression, functional outcomes and long-term survival in PLHIV with cancer.


NADC and ADC are equally prevalent, stand as a leading argument for TLD, and strongly predict in-hospital death in the current population of PLHIV requiring critical care. Enhanced screening procedures for earlier cancer diagnosis, routine policy for prompt ICU admission and promotion of advance directive completion in case of documented neoplasm may constitute important axes for improving the quality of care in these patients.

Availability of data and materials

The dataset used and analysed in this study is available from the corresponding author on reasonable request.



Human immunodeficiency virus


People living with HIV


Combination antiretroviral therapy


Acquired immune deficiency syndrome


AIDS-defining cancer


Non-Hodgkin lymphoma


Non-AIDS-defining cancers


Treatment limitation decision


Intensive care unit


Strengthening the reporting of observational studies in epidemiology


Augmented backward elimination


Sepsis-related organ failure assessment


Simplified acute physiology score 2


Adjusted odd ratio


Confidence interval


Receiver operating characteristics curve


Epstein–Barr virus


  1. Hleyhel M, Belot A, Bouvier AM, Tattevin P, Pacanowski J, Genet P, et al. Risk of AIDS-defining cancers among HIV-1-infected patients in France between 1992 and 2009: results from the FHDH-ANRS CO4 cohort. Clin Infect Dis. 2013;57(11):1638–47.

    Article  CAS  PubMed  Google Scholar 

  2. Hernández-Ramírez RU, Shiels MS, Dubrow R, Engels EA. Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. Lancet HIV. 2017;4(11):e495-504.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Mahale P, Engels EA, Coghill AE, Kahn AR, Shiels MS. Cancer risk in older persons living with human immunodeficiency virus infection in the United States. Clin Infect Dis. 2018;67(1):50–7.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Shiels MS, Islam JY, Rosenberg PS, Hall HI, Jacobson E, Engels EA. Projected cancer incidence rates and burden of incident cancer cases in HIV-infected adults in the United States Through 2030. Ann Intern Med. 2018;168(12):866–73.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Smith CJ, Ryom L, Weber R, Morlat P, Pradier C, Reiss P, et al. Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. The Lancet. 2014;384(9939):241–8.

    Article  Google Scholar 

  6. Croxford S, Kitching A, Desai S, Kall M, Edelstein M, Skingsley A, et al. Mortality and causes of death in people diagnosed with HIV in the era of highly active antiretroviral therapy compared with the general population: an analysis of a national observational cohort. Lancet Public Health. 2017;2(1):e35-46.

    Article  PubMed  Google Scholar 

  7. Horner MJ, Shiels MS, Pfeiffer RM, Engels EA. Deaths attributable to cancer in the US human immunodeficiency virus population during 2001–2015. Clin Infect Dis. 2021;72(9):e224–31.

    Article  PubMed  Google Scholar 

  8. Chiao EY, Coghill A, Kizub D, Fink V, Ndlovu N, Mazul A, et al. The effect of non-AIDS-defining cancers on people living with HIV. Lancet Oncol. 2021;22(6):e240–53.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, et al. Risk factors for hospitalization and medical intensive care unit (MICU) admission among HIV-infected veterans. J Acquir Immune Defic Syndr. 2013;62(1):52–9.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Barbier F, Mer M, Szychowiak P, Miller RF, Mariotte É, Galicier L, et al. Management of HIV-infected patients in the intensive care unit. Intensive Care Med. 2020;46(2):329–42.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Azoulay É, de Castro N, Barbier F. Critically ill patients with HIV: 40 years later. Chest. 2019;157(2):293–309.

    Article  PubMed  Google Scholar 

  12. Harding R. Palliative care as an essential component of the HIV care continuum. Lancet HIV. 2018;5(9):e524–30.

    Article  PubMed  Google Scholar 

  13. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344–9.

    Article  Google Scholar 

  14. Gandhi RT, Bedimo R, Hoy JF, Landovitz RJ, Smith DM, Eaton EF, et al. Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the International Antiviral Society-USA Panel. JAMA. 2023;329(1):63–84.

    Article  CAS  PubMed  Google Scholar 

  15. Centers for Disease Control and Prevention. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Available at (Access 1 Aug 2022).

  16. Dunkler D, Plischke M, Leffondré K, Heinze G. Augmented backward elimination: a pragmatic and purposeful way to develop statistical models. PLoS ONE. 2014;9(11):e113677.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Heinze G, Wallisch C, Dunkler D. Variable selection–A review and recommendations for the practicing statistician. Biom J Biom Z. 2018;60(3):431–49.

    Article  Google Scholar 

  18. Powell K, Davis JL, Morris AM, Chi A, Bensley MR, Huang L. Survival for patients with HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy. Chest. 2009;135(1):11–7.

    Article  PubMed  Google Scholar 

  19. Croda J, Croda MG, Neves A, De Sousa dos Santos S. Benefit of antiretroviral therapy on survival of human immunodeficiency virus-infected patients admitted to an intensive care unit. Crit Care Med. 2009;37(5):1605–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Barbier F, Roux A, Canet E, Martel-Samb P, Aegerter P, Wolff M, et al. Temporal trends in critical events complicating HIV infection: 1999–2010 multicentre cohort study in France. Intensive Care Med. 2014;40(12):1906–15.

    Article  PubMed  Google Scholar 

  21. Gaillet A, Azoulay E, de Montmollin E, Garrouste-Orgeas M, Cohen Y, Dupuis C, et al. Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort. Crit Care. 2023;27(1):108.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Penagos Gaviria S, Zapata N, Villa P, Agudelo CA, Molina FJ, González MA, et al. HIV/AIDS infection in critical care: epidemiological profile and risk factors for mortality in a Colombian cohort. J Infect Dev Ctries. 2023;17(1):102–10.

    Article  PubMed  Google Scholar 

  23. Haas CB, Engels EA, Horner MJ, Freedman ND, Luo Q, Gershman S, et al. Trends and risk of lung cancer among people living with HIV in the USA: a population-based registry linkage study. Lancet HIV. 2022;9(10):e700–8.

    Article  CAS  PubMed  Google Scholar 

  24. Carbone A, Vaccher E, Gloghini A. Hematologic cancers in individuals infected by HIV. Blood. 2022;139(7):995–1012.

    Article  CAS  PubMed  Google Scholar 

  25. Wohlfarth P, Carlström A, Staudinger T, Clauss S, Hermann A, Rabitsch W, et al. Incidence of intensive care unit admission, outcome and post intensive care survival in patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2016;57(8):1831–8.

    Article  CAS  PubMed  Google Scholar 

  26. Zduniak A, Mihailescu SD, Lequesne J, Lenain P, Contentin N, Pepin LF, et al. Outcomes after intensive care unit admission in newly diagnosed diffuse large B-cell lymphoma patients: a real-life study. Eur J Haematol. 2021;106(6):788–99.

    Article  CAS  PubMed  Google Scholar 

  27. Poizot-Martin I, Lions C, Allavena C, Huleux T, Bani-Sadr F, Cheret A, et al. Spectrum and incidence trends of AIDS- and non-AIDS-defining cancers between 2010 and 2015 in the French Dat’AIDS cohort. Cancer Epidemiol Biomark. 2021;30(3):554–63.

    Article  CAS  Google Scholar 

  28. Nkwonta CA, Zhang J, Chen S, Weissman S, Olatosi B, Li X. Prevalence and trend of AIDS-defining cancers and non-AIDS-defining cancers and their association with antiretroviral therapy among people living with HIV in South Carolina: a population-based cohort study. AIDS Care. 2022;35:1–11.

    Google Scholar 

  29. Algrin C, Faguer S, Lemiale V, Lengliné E, Boutboul D, Amorim S, et al. Outcomes after intensive care unit admission of patients with newly diagnosed lymphoma. Leuk Lymphoma. 2015;56(5):1240–5.

    Article  CAS  PubMed  Google Scholar 

  30. Mokart D, Lambert J, Schnell D, Fouché L, Rabbat A, Kouatchet A, et al. Delayed intensive care unit admission is associated with increased mortality in patients with cancer with acute respiratory failure. Leuk Lymphoma. 2013;54(8):1724–9.

    Article  PubMed  Google Scholar 

  31. Peyrony O, Chevret S, Meert AP, Perez P, Kouatchet A, Pène F, et al. Direct admission to the intensive care unit from the emergency department and mortality in critically ill hematology patients. Ann Intensive Care. 2019;9(1):110.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Lucet A, Franchitti J, Legay L, Milacic H, Fontaine JP, Ellouze S, et al. Effect of a delayed admission to the intensive care unit on survival after emergency department visit in patients with cancer: a retrospective observational study. Eur J Emerg Med. 2022;29(3):221–6.

    Article  PubMed  Google Scholar 

  33. Hensley MK, Donnelly JP, Carlton EF, Prescott HC. Epidemiology and outcomes of cancer-related versus non-cancer-related sepsis hospitalizations. Crit Care Med. 2019;47(10):1310–6.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Cooper AJ, Keller SP, Chan C, Glotzbecker BE, Klompas M, Baron RM, et al. Improvements in sepsis-associated mortality in hospitalized patients with cancer versus those without cancer: a 12-year analysis using clinical data. Ann Am Thorac Soc. 2020;17(4):466–73.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Medrano J, Álvaro-Meca A, Boyer A, Jiménez-Sousa MA, Resino S. Mortality of patients infected with HIV in the intensive care unit (2005 through 2010): significant role of chronic hepatitis C and severe sepsis. Crit Care. 2014;18(4):475.

    PubMed  PubMed Central  Google Scholar 

  36. Mongardon N, Geri G, Deye N, Sonneville R, Boissier F, Perbet S, et al. Etiologies, clinical features and outcome of cardiac arrest in HIV-infected patients. Int J Cardiol. 2015;201:302–7.

    Article  PubMed  Google Scholar 

  37. Mendez-Tellez PA, Damluji A, Ammerman D, Colantuoni E, Fan E, Sevransky JE, et al. Human immunodeficiency virus infection and hospital mortality in acute lung injury patients. Crit Care Med. 2010;38(7):1530–5.

    Article  PubMed  Google Scholar 

  38. Barbier F, Coquet I, Legriel S, Pavie J, Darmon M, Mayaux J, et al. Etiologies and outcome of acute respiratory failure in HIV-infected patients. Intensive Care Med. 2009;35(10):1678–86.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Sonneville R, Ferrand H, Tubach F, Roy C, Bouadma L, Klein IF, et al. Neurological complications of HIV infection in critically ill patients: clinical features and outcomes. J Infect. 2011;62(4):301–8.

    Article  CAS  PubMed  Google Scholar 

  40. Japiassú AM, Amâncio RT, Mesquita EC, Medeiros DM, Bernal HB, Nunes EP, et al. Sepsis is a major determinant of outcome in critically ill HIV/AIDS patients. Crit Care. 2010;14(4):R152.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Huson MAM, Scicluna BP, van Vught LA, Wiewel MA, Hoogendijk AJ, Cremer OL, et al. The impact of HIV co-infection on the genomic response to sepsis. PLoS ONE. 2016;11(2):e0148955.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Vigneron C, Charpentier J, Wislez M, Mira JP, Lefebvre A, Fournel L, et al. Short-term and long-term outcomes of patients with lung cancer and life-threatening complications. Chest. 2021;160(4):1560–4.

    Article  PubMed  Google Scholar 

  43. Barth C, Soares M, Toffart AC, Timsit JF, Burghi G, Irrazabal C, et al. Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs). Ann Intensive Care. 2018;8(1):80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Prendergast TJ, Claessens MT, Luce JM. A national survey of end-of-life care for critically ill patients. Am J Respir Crit Care Med. 1998;158(4):1163–7.

    Article  CAS  PubMed  Google Scholar 

  45. Sprung CL, Ricou B, Hartog CS, Maia P, Mentzelopoulos SD, Weiss M, et al. Changes in end-of-life practices in European intensive care units from 1999 to 2016. JAMA. 2019;322(17):1692–704.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Sprung CL, Cohen SL, Sjokvist P, Baras M, Bulow HH, Hovilehto S, et al. End-of-life practices in European intensive care units: the Ethicus Study. JAMA. 2003;290(6):790–7.

    Article  PubMed  Google Scholar 

  47. Gregory AB, Turvey SL, Bagshaw SM, Sligl WI. What determines do-not-resuscitate status in critically ill HIV-infected patients admitted to ICU? J Crit Care. 2019;53:207–11.

    Article  PubMed  Google Scholar 

  48. Barocas JA, Erlandson KM, Belzer BK, Hess T, Sosman J. Advance directives among people living with HIV: room for improvement. AIDS Care. 2015;27(3):370–7.

    Article  PubMed  Google Scholar 

  49. Smit M, Brinkman K, Geerlings S, Smit C, Thyagarajan K, van Sighem A, et al. Future challenges for clinical care of an ageing population infected with HIV: a modelling study. Lancet Infect Dis. 2015;15(7):810–8.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Nguyen AL, Park BY, Thayer E, Bailey J, Christensen C, Taylor J. Comparing advance care planning between older adults with and without HIV. AIDS Care. 2022;35:1–3.

    Google Scholar 

Download references





Author information

Authors and Affiliations



PS and FB designed the study and collected the data; TB performed the statistical analyses; PS and FB interpreted the results and drafted the manuscript; all other authors contributed substantially to data collection and draft revision. FB had full access to all of the data and takes responsibility for the integrity of the data and the accuracy of data analyses. All authors read and approved the final manuscript.

Corresponding author

Correspondence to François Barbier.

Ethics declarations

Ethics approval and consent to participate

The study protocol was approved by the ethical committee of the French Intensive Care Society on August 3, 2020 (report n°CE-SRLF-20–70); the requirement for informed consent was waived owing to the observational design.

Consent for publication

Not applicable.

Competing interests

All authors declare that they have no potential conflict of interest related to the submitted work.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1.

Recruitment and characteristics of participating intensive care units. Table S1. Characteristics of the study population according to the vital status at hospital discharge. Table S2. Bacterial sepsis as the main diagnosis in the intensive care unit. Table S3. Independent predictors of in-hospital death: full results of the initial model. Table S4. Written arguments for treatment limitation decision in patients with cancer. Table S5. One-year mortality in patients discharged alive from the index hospital admission. Figure S1. Study flowchart.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Szychowiak, P., Boulain, T., Timsit, JF. et al. Clinical spectrum and prognostic impact of cancer in critically ill patients with HIV: a multicentre cohort study. Ann. Intensive Care 13, 74 (2023).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


  • Human immunodeficiency virus
  • Cancer
  • Intensive care unit
  • Treatment limitation decision
  • Outcome