Articles

Duration of invasive mechanical ventilation prior to extracorporeal membrane oxygenation is not associated with survival in acute respiratory distress syndrome caused by coronavirus disease 2019

Duration of invasive mechanical ventilation (IMV) prior to extracorporeal membrane oxygenation (ECMO) affects outcome in acute respiratory distress syndrome (ARDS). In coronavirus disease 2019 (COVID-19) relat...

Authors: Martina Hermann, Daniel Laxar, Christoph Krall, Christina Hafner, Oliver Herzog, Oliver Kimberger, Sebastian Koenig, Felix Kraft, Mathias Maleczek, Klaus Markstaller, Oliver Robak, Bernhard Rössler, Eva Schaden, Peter Schellongowski, Mathias Schneeweiss-Gleixner, Thomas Staudinger…

Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the first and the consecutive upsurges of the second wave of the COVID-19 pandemic in the Netherlands

To assess trends in the quality of care for COVID-19 patients at the ICU over the course of time in the Netherlands.

Authors: Dave A. Dongelmans, Fabian Termorshuizen, Sylvia Brinkman, Ferishta Bakhshi-Raiez, M. Sesmu Arbous, Dylan W. de Lange, Bas C. T. van Bussel and Nicolette F. de Keizer

Correction to: Characteristics and prognosis of bloodstream infection in patients with COVID‑19 admitted in the ICU: an ancillary study of the COVID‑ICU study

Authors: Nicolas Massart, Virginie Maxime, Pierre Fillatre, Keyvan Razazi, Alexis Ferré, Pierre Moine, Francois Legay, Guillaume Voiriot, Marlene Amara, Francesca Santi, Saad Nseir, Stephanie Marque-Juillet, Rania Bounab, Nicolas Barbarot, Fabrice Bruneel and Charles-Edouard Luyt

The role of the microbiota in the management of intensive care patients

The composition of the gut microbiota is highly dynamic and changes according to various conditions. The gut microbiota mainly includes difficult-to-cultivate anaerobic bacteria, hence knowledge about its comp...

Authors: Piotr Szychowiak, Khanh Villageois-Tran, Juliette Patrier, Jean-François Timsit and Étienne Ruppé

Pulse oximetry, racial bias and statistical bias

Authors: Martin J. Tobin and Amal Jubran

Prevention of ventilator-associated pneumonia by noble metal coating of endotracheal tubes: a multi-center, randomized, double-blind study

Ventilator-associated pneumonia (VAP) causes increased mortality, prolonged hospital stay and increased healthcare costs. Prevention of VAP in intensive care units (ICUs) is currently based on several measures...

Authors: Pierre Damas, Caroline Legrain, Bernard Lambermont, Nadia Dardenne, Julien Guntz, Grâce Kisoka, Pierre Demaret, Anne-Françoise Rousseau, Laurent Jadot, Sonia Piret, Didier Noirot, Axelle Bertrand, Anne-Françoise Donneau and Benoît Misset

Correction to: End of life in the critically ill patient: evaluation of experience of end of life by caregivers (EOLE study)

Authors:

Correction to: Energetic dysfunction in sepsis: a narrative review

Authors: Sebastien Preau, Dominique Vodovar, Boris Jung, Steve Lancel, Lara Zafrani, Aurelien Flatres, Mehdi Oualha, Guillaume Voiriot, Youenn Jouan, Jeremie Joffre, Fabrice Uhel, Nicolas De Prost, Stein Silva, Eric Azabou and Peter Radermacher

Gas conditioning during helmet noninvasive ventilation: effect on comfort, gas exchange, inspiratory effort, transpulmonary pressure and patient–ventilator interaction

There is growing interest towards the use of helmet noninvasive ventilation (NIV) for the management of acute hypoxemic respiratory failure. Gas conditioning through heat and moisture exchangers (HME) or heate...

Authors: Filippo Bongiovanni, Domenico Luca Grieco, Gian Marco Anzellotti, Luca Salvatore Menga, Teresa Michi, Melania Cesarano, Valeria Raggi, Cecilia De Bartolomeo, Benedetta Mura, Giovanna Mercurio, Sonia D’Arrigo, Giuseppe Bello, Riccardo Maviglia, Mariano Alberto Pennisi and Massimo Antonelli

Characteristics and prognosis of bloodstream infection in patients with COVID-19 admitted in the ICU: an ancillary study of the COVID-ICU study

Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring intensive care unit (ICU) have a high incidence of hospital-acquired infections; however, data regarding ho...

Authors: Nicolas Massart, Virginie Maxime, Pierre Fillatre, Keyvan Razazi, Alexis Ferré, Pierre Moine, Francois Legay, Guillaume Voiriot, Marlene Amara, Francesca Santi, Saad Nseir, Stephanie Marque-Juillet, Rania Bounab, Nicolas Barbarot, Fabrice Bruneel and Charles-Edouard Luyt

Patterns of ICU admissions and outcomes in patients with solid malignancies over the revolution of cancer treatment

Major therapeutic advances including immunotherapy and targeted therapies have been changing the face of oncology and resulted in improved prognosis as well as in new toxic complications. The aim of this study...

Authors: Clara Vigneron, Julien Charpentier, Sandrine Valade, Jérôme Alexandre, Samy Chelabi, Lola-Jade Palmieri, Nathalie Franck, Valérie Laurence, Jean-Paul Mira, Matthieu Jamme and Frédéric Pène

Long-term follow-up and quality of life in patients receiving extracorporeal membrane oxygenation for pulmonary embolism and cardiogenic shock

Since 2019, European guidelines recommend considering extracorporeal life support as salvage strategy for the treatment of acute high-risk pulmonary embolism (PE) with circulatory collapse or cardiac arrest. H...

Authors: Andrea Stadlbauer, Alois Philipp, Sebastian Blecha, Matthias Lubnow, Dirk Lunz, Jing Li, Armando Terrazas, Christof Schmid, Tobias J. Lange and Daniele Camboni

Prospective international validation of the predisposition, infection, response and organ dysfunction (PIRO) clinical staging system among intensive care and general ward patients

Stratifying patients with sepsis was the basis of the predisposition, infection, response and organ dysfunction (PIRO) concept, an attempt to resolve the heterogeneity in treatment response. The purpose of thi...

Authors: T. Cardoso, P. P. Rodrigues, C. Nunes, M. Almeida, J. Cancela, F. Rosa, N. Rocha-Pereira, I. Ferreira, F. Seabra-Pereira, P. Vaz, L. Carneiro, C. Andrade, J. Davis, A. Marçal and N. D. Friedman

Awake prone position reduces work of breathing in patients with COVID-19 ARDS supported by CPAP

The use of awake prone position concomitant to non-invasive mechanical ventilation in acute respiratory distress syndrome (ARDS) secondary to COVID-19 has shown to improve gas exchange, whereas its effect on t...

Authors: Davide Chiumello, Elena Chiodaroli, Silvia Coppola, Simone Cappio Borlino, Claudia Granata, Matteo Pitimada and Pedro David Wendel Garcia

The impact of relative hypotension on acute kidney injury progression after cardiac surgery: a multicenter retrospective cohort study

Cardiac surgery is performed worldwide, and acute kidney injury (AKI) following cardiac surgery is a risk factor for mortality. However, the optimal blood pressure target to prevent AKI after cardiac surgery r...

Authors: Yuki Kotani, Takuo Yoshida, Junji Kumasawa, Jun Kamei, Akihisa Taguchi, Koji Kido, Naoki Yamaguchi, Takayuki Kariya, Masato Nakasone, Noriko Mikami, Takahiro Koga, Izumi Nakayama, Mami Shibata, Tomonao Yoshida, Hiroshi Nashiki, Shinsuke Karatsu…

Proportional assist ventilation relieves clinically significant dyspnea in critically ill ventilated patients

Dyspnea is common and often severe symptom in mechanically ventilated patients. Proportional assist ventilation (PAV) is an assist ventilatory mode that adjusts the level of assistance to the activity of respi...

Authors: Côme Bureau, Maxens Decavèle, Sébastien Campion, Marie-Cécile Nierat, Julien Mayaux, Elise Morawiec, Mathieu Raux, Thomas Similowski and Alexandre Demoule

The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study

Fluid management in patients after subarachnoid hemorrhage (SAH) aims at the optimization of cerebral blood flow and brain oxygenation. In this study, we investigated the effects of hemodynamic management on b...

Authors: Verena Rass, Elisa Gouvea Bogossian, Bogdan-Andrei Ianosi, Lorenzo Peluso, Mario Kofler, Anna Lindner, Alois J. Schiefecker, Lauma Putnina, Max Gaasch, Werner O. Hackl, Ronny Beer, Bettina Pfausler, Fabio Silvio Taccone and Raimund Helbok

Diagnosing capillary leak in critically ill patients: development of an innovative scoring instrument for non-invasive detection

The concomitant occurrence of the symptoms intravascular hypovolemia, peripheral edema and hemodynamic instability is typically named Capillary Leak Syndrome (CLS) and often occurs in surgical critical ill pat...

Authors: Jakob Wollborn, Lars O. Hassenzahl, Daniel Reker, Hans Felix Staehle, Anne Marie Omlor, Wolfgang Baar, Kai B. Kaufmann, Felix Ulbrich, Christian Wunder, Stefan Utzolino, Hartmut Buerkle, Johannes Kalbhenn, Sebastian Heinrich and Ulrich Goebel

Intravenous albumin for the prevention of hemodynamic instability during sustained low-efficiency dialysis: a randomized controlled feasibility trial (The SAFER-SLED Study)

Hemodynamic instability is a frequent complication of sustained low-efficiency dialysis (SLED) treatments in the ICU. Intravenous hyperoncotic albumin may prevent hypotension and facilitate ultrafiltration. In...

Authors: Edward G. Clark, Lauralyn McIntyre, Irene Watpool, Jennifer W. Y. Kong, Tim Ramsay, Elham Sabri, Mark Canney, Gregory L. Hundemer, Pierre-Antoine Brown, Manish M. Sood and Swapnil Hiremath

Author reply in response to a letter on “High-flow nasal oxygen cannula vs. noninvasive mechanical ventilation to prevent reintubation in sepsis: a randomized controlled trial”

Authors: Surat Tongyoo, Porntipa Tantibundit, Kiattichai Daorattanachai, Tanuwong Viarasilpa, Chairat Permpikul and Suthipol Udompanturak

High-flow nasal oxygen cannula vs. noninvasive mechanical ventilation to prevent reintubation in sepsis: a randomized controlled trial

Authors: Radhouane Toumi, Khaoula Meddeb and Mohamed Boussarsar

Association between mortality and age among mechanically ventilated COVID-19 patients: a Japanese nationwide COVID-19 database study

Only a few studies have reported the association between age and mortality in COVID-19 patients who require invasive mechanical ventilation (IMV). We aimed to evaluate the effect of age on COVID-19-related mor...

Authors: Chie Tanaka, Takashi Tagami, Fumihiko Nakayama, Saori Kudo, Akiko Takehara, Reo Fukuda, Junya Kaneko, Yoshito Ishiki, Shin Sato, Ami Shibata, Masamune Kuno, Kyoko Unemoto, Masayuki Hojo, Tetsuya Mizoue, Yusuke Asai, Setsuko Suzuki…

Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores

Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays.

Authors: Matthieu Schmidt, Bertrand Guidet, Alexandre Demoule, Maharajah Ponnaiah, Muriel Fartoukh, Louis Puybasset, Alain Combes and David Hajage

Impact of the COVID-19 pandemic on the epidemiology of out-of-hospital cardiac arrest: a systematic review and meta-analysis

The coronavirus disease 2019 (COVID-19) pandemic has significantly influenced epidemiology, yet its impact on out-of-hospital cardiac arrest (OHCA) remains unclear. We aimed to evaluate the impact of the pande...

Authors: Seth En Teoh, Yoshio Masuda, Darren Jun Hao Tan, Nan Liu, Laurie J. Morrison, Marcus Eng Hock Ong, Audrey L. Blewer and Andrew Fu Wah Ho

Automated left atrial strain analysis for predicting atrial fibrillation in severe COVID-19 pneumonia: a prospective study

Atrial fibrillation (AF) is the most documented arrhythmia in COVID-19 pneumonia. Left atrial (LA) strain (LAS) analysis, a marker of LA contractility, have been associated with the development of AF in severa...

Authors: Christophe Beyls, Alexis Hermida, Yohann Bohbot, Nicolas Martin, Christophe Viart, Solenne Boisgard, Camille Daumin, Pierre Huette, Hervé Dupont, Osama Abou-Arab and Yazine Mahjoub

Three bedside techniques to quantify dynamic pulmonary hyperinflation in mechanically ventilated patients with chronic obstructive pulmonary disease

Dynamic pulmonary hyperinflation may develop in patients with chronic obstructive pulmonary disease (COPD) due to dynamic airway collapse and/or increased airway resistance, increasing the risk of volutrauma a...

Authors: L. H. Roesthuis, J. G. van der Hoeven, C. Guérin, J. Doorduin and L. M. A. Heunks

Long-term cardiovascular complications following sepsis: is senescence the missing link?

Among the long-term consequences of sepsis (also termed “post-sepsis syndrome”) the increased risk of unexplained cardiovascular complications, such as myocardial infarction, acute heart failure or stroke, is ...

Authors: Hamid Merdji, Valérie Schini-Kerth, Ferhat Meziani and Florence Toti

A multivariate model for successful publication of intensive care medicine randomized controlled trials in the highest impact factor journals: the SCOTI score

Critical care randomized controlled trials (RCTs) are often published in high-impact journals, whether general journals [the New England Journal of Medicine (NEJM), The Lancet, the Journal of the American Medi...

Authors: Joris Pensier, Audrey De Jong, Gerald Chanques, Emmanuel Futier, Elie Azoulay, Nicolas Molinari and Samir Jaber

Optimizing high-flow nasal cannula flow settings in adult hypoxemic patients based on peak inspiratory flow during tidal breathing

Optimal flow settings during high-flow nasal cannula (HFNC) therapy are unknown. We investigated the optimal flow settings during HFNC therapy based on breathing pattern and tidal inspiratory flows in patients...

Authors: Jie Li, J. Brady Scott, James B. Fink, Brooke Reed, Oriol Roca and Rajiv Dhand

Impact of cooling method on the outcome of initial shockable or non-shockable out of hospital cardiac arrest patients receiving target temperature management: a nationwide multicentre cohort study

Little is known about the effectiveness of surface cooling (SC) and endovascular cooling (EC) on the outcome of out-of-hospital cardiac arrest (OHCA) patients receiving target temperature management (TTM) acco...

Authors: Makoto Watanabe, Tasuku Matsuyama, Hikaru Oe, Makoto Sasaki, Yuki Nakamura, Yuki Miyamoto, Nobunaga Okada, Tetsuhisa Kitamura and Bon Ohta

End of life in the critically ill patient: evaluation of experience of end of life by caregivers (EOLE study)

The death rate in intensive care units (ICUs) can reach 20%. More than half occurs after a decision of care withholding/withdrawal. We aimed at describing and evaluating the experience of ICU physicians and nu...

Authors:

Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial

The role of intravenous immunoglobulins (IVIG) during sepsis is controversial, as different trials on IVIG have observed inconsistent survival benefits. We aimed to elucidate the possible association and clini...

Authors: Laura Alagna, Jennifer M. T. A. Meessen, Giacomo Bellani, Daniela Albiero, Pietro Caironi, Irene Principale, Luigi Vivona, Giacomo Grasselli, Francesca Motta, Nicolò M. Agnelli, Vieri Parrini, Stefano Romagnoli, Roberto Keim, Francesca Di Marzo Capozzi, Fabio S. Taccone, Walter Taccone…

Effect of antibiotic therapy on the prognosis of ventilator-associated pneumonia caused by Stenotrophomonas maltophilia

Ventilator-associated pneumonia (VAP) caused by Stenotrophomonas maltophilia is poorly described in the literature. However, it has been shown to be associated with increased morbidity and mortality. Probabilisti...

Authors: Bérénice Puech, Clémence Canivet, Laura Teysseyre, Guillaume Miltgen, Thomas Aujoulat, Margot Caron, Chloé Combe, Julien Jabot, Olivier Martinet, Jerome Allyn, Cyril Ferdynus and Nicolas Allou

Corticosteroid treatment and mortality in mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients: a multicentre cohort study

Some unanswered questions persist regarding the effectiveness of corticosteroids for severe coronavirus disease 2019 (COVID-19) patients. We aimed to assess the clinical effect of corticosteroids on intensive ...

Authors: Gerard Moreno, Raquel Carbonell, Ignacio Martin-Loeches, Jordi Solé-Violán, Eudald Correig i Fraga, Josep Gómez, Manuel Ruiz-Botella, Sandra Trefler, María Bodí, Josefa Murcia Paya, Emili Díaz, Pablo Vidal-Cortes, Elisabeth Papiol, Antonio Albaya Moreno, Susana Sancho Chinesta, Lorenzo Socias Crespi…

Causes of acute respiratory failure in patients with small-vessel vasculitis admitted to intensive care units: a multicenter retrospective study

Acute respiratory failure (ARF) in patients admitted to the intensive care unit (ICU) with known or de novo small-vessel vasculitis (Svv) may be secondary to the underlying immune disease or to other causes. E...

Authors: Aude Gibelin, Guillaume Dumas, Sandrine Valade, Marc Pineton de Chambrun, François Bagate, Mathilde Neuville, Francis Schneider, Loredana Baboi, Matthieu Groh, Jean-Herlé Raphalen, Jean-Daniel Chiche, Nicolas De Prost, Charles-Edouard Luyt, Claude Guérin, Eric Maury, Etienne de Montmollin…

Impact of obesity on survival in COVID-19 ARDS patients receiving ECMO: results from an ambispective observational cohort

Since March 2020, health care systems were importantly affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, with some patients presenting severe acute respiratory distress syndrom...

Authors: Florence Daviet, Philippe Guilloux, Sami Hraiech, David Tonon, Lionel Velly, Jeremy Bourenne, Alizée Porto, Inès Gragueb-Chatti, Mickael Bobot, Karine Baumstarck, Laurent Papazian, Frédéric Collart, Jean-Marie Forel and Christophe Guervilly

Insights from patients screened but not randomised in the HYPERION trial

Few data are available about outcomes of patients screened for, but not enrolled in, randomised clinical trials.

Authors: J. B. Lascarrou, Gregoire Muller, Jean-Pierre Quenot, Nicolas Massart, Mickael Landais, Pierre Asfar, Jean-Pierre Frat, Jean-Charles Chakarian, Michel Sirodot, Bruno Francois, Guillaume Grillet, Sylvie Vimeux, Arnaud Delahaye, Stéphane Legriel, Didier Thevenin, Jean Reignier…

Incidence, clinical characteristics, and outcome after unexpected cardiac arrest among critically ill adults with COVID-19: insight from the multicenter prospective ACICOVID-19 registry

Initial reports have described the poor outcome of unexpected cardiac arrest (CA) in intensive care unit (ICU) among COVID-19 patients in China and the USA. However, there are scarce data on characteristics an...

Authors: Jonathan Chelly, Gaetan Plantefève, Toufik Kamel, Cédric Bruel, Saad Nseir, Christopher Lai, Giulia Cirillo, Elena Skripkina, Sébastien Ehrminger, Fernando-Daniel Berdaguer-Ferrari, Julien Le Marec, Marine Paul, Aurélie Autret and Nicolas Deye

Characteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition: an analysis of real-time collected data

Baseline characteristics and disease severity of patients with septic shock according to the new Sepsis-3 definition may differ from patients that only comply with the Sepsis-2 definition. We conducted a retro...

Authors: Joris Vermassen, Johan Decruyenaere, Liesbet De Bus, Pieter Depuydt and Kirsten Colpaert

Practices and intravascular catheter infection during on- and off-hours in critically ill patients

The potential relationship between intravascular catheter infections with their insertion during weekend or night-time (i.e., off-hours or not regular business hours) remains an open issue. Our primary aim was to...

Authors: Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Arthur Mageau, Claire Dupuis, Bertrand Souweine, Olivier Mimoz and Jean-François Timsit

Efficacy and safety of IL-6 inhibitors in patients with COVID-19 pneumonia: a systematic review and meta-analysis of multicentre, randomized trials

COVID-19 is characterized by dysregulated immune response, respiratory failure and a relevant mortality rate among hospitalized patients. Interleukin-6 (IL-6) is involved in COVID-19-associated cytokine storm,...

Authors: Alessandro Belletti, Corrado Campochiaro, Marilena Marmiere, Valery Likhvantsev, Andrey Yavorovskiy, Lorenzo Dagna, Giovanni Landoni, Alberto Zangrillo and Ludhmila Abrahão Hajjar

Impact of ICU transfers on the mortality rate of patients with COVID-19: insights from comprehensive national database in France

The first wave of the COVID-19 pandemic confronted healthcare systems around the world with unprecedented organizational challenges, particularly regarding the availability of intensive care unit (ICU) beds. O...

Authors: Marc-Antoine Sanchez, Albert Vuagnat, Olivier Grimaud, Emmanuelle Leray, Jean-Marc Philippe, François-Xavier Lescure, Mathieu Boutonnet, Hélène Coignard, Agnès Ricard Hibon, Stephane Sanchez and Julien Pottecher

Health-related quality of life in critically ill survivors: specific impact of cardiac arrest in non-shockable rhythm

Intensive care has a strong impact on health-related quality of life (HRQOL). The specific impact of cardiac arrest in non-shockable rhythm is poorly known.

Authors: Guillaume Geri, Nadia Aissaoui, Gwenhael Colin, Alain Cariou and Jean-Baptiste Lascarrou

Separation from mechanical ventilation and survival after spinal cord injury: a systematic review and meta-analysis

Prolonged need for mechanical ventilation greatly impacts life expectancy of patients after spinal cord injury (SCI). Weaning outcomes have never been systematically assessed. In this systematic review and met...

Authors: Annia F. Schreiber, Jacopo Garlasco, Fernando Vieira, Yie Hui Lau, Dekel Stavi, David Lightfoot, Andrea Rigamonti, Karen Burns, Jan O. Friedrich, Jeffrey M. Singh and Laurent J. Brochard

Comparison of prognostic factors between bacteraemic and non-bacteraemic critically ill immunocompetent patients in community-acquired severe pneumococcal pneumonia: a STREPTOGENE sub-study

The presence of bacteraemia in pneumococcal pneumonia in critically ill patients does not appear to be a strong independent prognostic factor in the existing literature. However, there may be a specific patter...

Authors: Hugo Bellut, Raphael Porcher, Emmanuelle Varon, Pierre Asfar, Yves Le Tulzo, Bruno Megarbane, Armelle Mathonnet, Anthony Dugard, Anne Veinstein, Kader Ouchenir, Shidasp Siami, Jean Reignier, Arnaud Galbois, Joël Cousson, Sébastien Preau, Olivier Baldesi…

Refractory ineffective triggering during pressure support ventilation: effect of proportional assist ventilation with load-adjustable gain factors

Ineffective triggering is frequent during pressure support ventilation (PSV) and may persist despite ventilator adjustment, leading to refractory asynchrony. We aimed to assess the effect of proportional assis...

Authors: Anne-Fleur Haudebourg, Tommaso Maraffi, Samuel Tuffet, François Perier, Nicolas de Prost, Keyvan Razazi, Armand Mekontso Dessap and Guillaume Carteaux

Transesophageal echocardiography for cardiovascular risk estimation in patients with sepsis and new-onset atrial fibrillation: a multicenter prospective pilot study

Echocardiographic parameters have been poorly investigated for estimating cardiovascular risk in patients with sepsis and new-onset atrial fibrillation. We aim to assess the prevalence of transesophageal echoc...

Authors: Vincent Labbé, Stephane Ederhy, Nathanael Lapidus, Jérémie Joffre, Keyvan Razazi, Laurent Laine, Oumar Sy, Sebastian Voicu, Frank Chemouni, Nadia Aissaoui, Roland Smonig, Denis Doyen, Fabrice Carrat, Guillaume Voiriot, Armand Mekontso-Dessap, Ariel Cohen…

Impact on antimicrobial consumption of procalcitonin-guided antibiotic therapy for pneumonia/pneumonitis associated with aspiration in comatose mechanically ventilated patients: a multicenter, randomized controlled study

In comatose patients receiving oro-tracheal intubation for mechanical ventilation (MV), the risk of aspiration is increased. Aspiration can lead to chemical pneumonitis (inflammatory reaction to the gastric co...

Authors: Guylaine Labro, François Aptel, Marc Puyraveau, Jonathan Paillot, Sébastien Pili Floury, Hamid Merdji, Julie Helms, Gaël Piton, Fiona Ecarnot, Khaldoun Kuteifan, Jean Pierre Quenot and Gilles Capellier

Handgrip strength to predict extubation outcome: a prospective multicenter trial

ICU-acquired weakness (ICUAW) has been shown to be associated with prolonged duration of mechanical ventilation and extubation failure. It is usually assessed through Medical Research Council (MRC) score, a ti...

Authors: Guillaume Cottereau, Jonathan Messika, Bruno Megarbane, Laurent Guérin, Daniel da Silva, Caroline Bornstain, Matilde Santos, Jean-Damien Ricard and Benjamin Sztrymf

Long-term survival of mechanically ventilated patients with severe COVID-19: an observational cohort study

Information is lacking regarding long-term survival and predictive factors for mortality in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) and undergoing invasive ...

Authors: Oscar Peñuelas, Laura del Campo-Albendea, Amanda Lesmes González de Aledo, José Manuel Añón, Carmen Rodríguez-Solís, Jordi Mancebo, Paula Vera, Daniel Ballesteros, Jorge Jiménez, Emilio Maseda, Juan Carlos Figueira, Nieves Franco, Ángela Algaba, Juan Pablo Avilés, Ricardo Díaz, Beatriz Abad…