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  1. Ventilator-associated pneumonia (VAP) is the leading nosocomial infection in critical care and is associated with adverse outcomes. When VAP is suspected, starting antibiotic therapy (AT) immediately after pul...

    Authors: Maëlle Martin, Solène Forveille, Jean-Baptiste Lascarrou, Amélie Seguin, Emmanuel Canet, Jérémie Lemarié, Maïté Agbakou, Luc Desmedt, Gauthier Blonz, Olivier Zambon, Stéphane Corvec, Aurélie Le Thuaut and Jean Reignier
    Citation: Annals of Intensive Care 2024 14:33
  2. Characterizing patient–ventilator interaction in critically ill patients is time-consuming and requires trained staff to evaluate the behavior of the ventilated patient.

    Authors: Julia Sauer, Jan Graßhoff, Niklas M. Carbon, Willi M. Koch, Steffen Weber-Carstens and Philipp Rostalski
    Citation: Annals of Intensive Care 2024 14:32
  3. Prolonged intensive care unit (ICU) stay is associated with physical, cognitive, and psychological disabilities. The impact of baseline frailty on long-stay ICU patients remains uncertain. This study aims to i...

    Authors: Hannah Wozniak, Tal Sarah Beckmann, Andre Dos Santos Rocha, Jérôme Pugin, Claudia-Paula Heidegger and Sara Cereghetti
    Citation: Annals of Intensive Care 2024 14:31
  4. The two latest studies on prolonged versus intermittent use of β-lactam antibiotics in patients with sepsis did not reach consistent conclusions, further contributing to the controversy surrounding the effecti...

    Authors: Yang Zhao, Bin Zang and Qian Wang
    Citation: Annals of Intensive Care 2024 14:30
  5. Muscle mass evaluation in ICU is crucial since its loss is related with long term complications, including physical impairment. However, quantifying muscle wasting with available bedside tools (ultrasound and ...

    Authors: Cristian Deana, Jan Gunst, Silvia De Rosa, Michele Umbrello, Matteo Danielis, Daniele Guerino Biasucci, Tommaso Piani, Antonella Cotoia, Alessio Molfino and Luigi Vetrugno
    Citation: Annals of Intensive Care 2024 14:29
  6. Suspected upper gastrointestinal bleeding (SUGIB) is a common issue during ICU stay. In the absence of specific guidelines on the indication and timing of esophagogastroduodenoscopy (EGD), there is substantial...

    Authors: Victor Penaud, Thibault Vieille, Tomas Urbina, Vincent Bonny, Paul Gabarre, Louai Missri, Maxime Gasperment, Jean-Luc Baudel, Nicolas Carbonell, Alexandra Beurton, Sayma Chaibi, Aurélia Retbi, Muriel Fartoukh, Gaël Piton, Bertrand Guidet, Eric Maury…
    Citation: Annals of Intensive Care 2024 14:28
  7. Authors: Piotr Szychowiak, Thierry Boulain, Jean-François Timsit, Alexandre Elabbadi, Laurent Argaud, Stephan Ehrmann, Nahema Issa, Emmanuel Canet, Frédéric Martino, Fabrice Bruneel, Jean-Pierre Quenot, Florent Wallet, Élie Azoulay and François Barbier
    Citation: Annals of Intensive Care 2024 14:27

    The original article was published in Annals of Intensive Care 2023 13:74

  8. Acute kidney injury (AKI) in intensive care unit (ICU) patients with severe COVID-19 is common (> 50%). A specific inflammatory process has been suggested in the pathogenesis of AKI, which could be improved by...

    Authors: Sébastien Rubin, Arthur Orieux, Mathilde Prezelin-Reydit, Antoine Garric, Yoann Picard, Nouchan Mellati, Lisa Le Gall, Antoine Dewitte, Renaud Prevel, Didier Gruson, Guillaume Louis and Alexandre Boyer
    Citation: Annals of Intensive Care 2024 14:26
  9. Cardiac injury is frequently reported in COVID-19 patients, the right ventricle (RV) is mostly affected. We systematically evaluated the cardiac function and longitudinal changes in severe COVID-19 acute respi...

    Authors: Vasiliki Tsolaki, George E. Zakynthinos, Nikitas Karavidas, Vasileios Vazgiourakis, John Papanikolaou, Kyriaki Parisi, Paris Zygoulis, Demosthenes Makris and Epaminondas Zakynthinos
    Citation: Annals of Intensive Care 2024 14:25
  10. Vaccination helped in reducing mortality and disease severity due to COVID-19. Some patients can develop breakthrough infections. The effect of vaccination in critically ill patients admitted with breakthrough...

    Authors: Amarja Ashok Havaldar and Sumithra Selvam
    Citation: Annals of Intensive Care 2024 14:24
  11. Acetaminophen (ACT) has been studied in septic patients with detectable plasmatic levels of cell-free hemoglobin (Hb), where it demonstrated to inhibit the hemoprotein-mediated lipid peroxidation and oxidative...

    Authors: R. Domizi, E. Damiani, A. Carsetti, L. Graciotti, A. D. Procopio, C. Scorcella, E. Casarotta, P. Giaccaglia, A. Donati and E. Adrario
    Citation: Annals of Intensive Care 2024 14:23
  12. The prevalence of hyperdynamic left ventricular (LV) systolic function in septic patients and its impact on mortality remain controversial. In this systematic review and meta-analysis, we investigated the prev...

    Authors: Ryota Sato, Filippo Sanfilippo, Daisuke Hasegawa, Narut Prasitlumkum, Abhijit Duggal and Siddharth Dugar
    Citation: Annals of Intensive Care 2024 14:22
  13. The benefit–risk balance and optimal timing of surgery for severe infective endocarditis (IE) with ischemic or hemorrhagic strokes is unknown. The study aim was to compare the neurological outcome between pati...

    Authors: Alexandre Gros, Benjamin Seguy, Guillaume Bonnet, Yves-Olivier Guettard, Xavier Pillois, Renaud Prevel, Arthur Orieux, Julien Ternacle, Sebastien Préau, Yoan Lavie-Badie, Elisabeth Coupez, Rémi Coudroy, Delphine Marest, Raphaël P. Martins, Didier Gruson, Thomas Tourdias…
    Citation: Annals of Intensive Care 2024 14:21
  14. Chimeric antigen receptor T-cell (CAR-T) therapy is increasingly used in patients with refractory haematological malignancies but can induce severe adverse events. We aimed to describe the clinical features an...

    Authors: Corentin Le Cacheux, Audrey Couturier, Clara Sortais, Roch Houot, Morgane Péré, Thomas Gastinne, Amélie Seguin, Jean Reignier, Jean-Baptiste Lascarrou, Jean-Marc Tadié, Quentin Quelven and Emmanuel Canet
    Citation: Annals of Intensive Care 2024 14:20
  15. Recent alerts have highlighted an increase in group A streptococcal (GAS) infections since 2022 in Europe and the United States. Streptococcus pyogenes can cause limited skin or mucosal disease, but can also pres...

    Authors: Marijke Peetermans, Veerle Matheeussen, Cedric Moerman, Fréderic De Rydt, Sabine Thieren, Emily Pollet, Michael Casaer, Benjamin De Backer, Rudi De Paep, Yves Debaveye, Lars Desmet, Stefanie Desmet, Els I. M. Duval, Vincent Fraipont, Dieter Geysels, Greet Hermans…
    Citation: Annals of Intensive Care 2024 14:19
  16. Inhaled sedation during invasive mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) has received increasing attention. However, inhaled sedation devices increase dead-space vent...

    Authors: Pierre-Louis Pellet, Neven Stevic, Florian Degivry, Bruno Louis, Laurent Argaud, Claude Guérin and Martin Cour
    Citation: Annals of Intensive Care 2024 14:18
  17. Recent studies identified coronavirus disease 2019 (COVID-19) as a risk factor for invasive pulmonary aspergillosis (IPA) but produced conflicting data on IPA incidence and impact on patient outcomes. We aimed...

    Authors: Luc Desmedt, Matthieu Raymond, Aurélie Le Thuaut, Pierre Asfar, Cédric Darreau, Florian Reizine, Gwenhaël Colin, Johann Auchabie, Julien Lorber, Béatrice La Combe, Pierre Kergoat, Baptiste Hourmant, Agathe Delbove, Aurélien Frérou, Jean Morin, Pierre Yves Ergreteau…
    Citation: Annals of Intensive Care 2024 14:17
  18. Bleeding is the most common complication in out-of-hospital cardiac arrest (OHCA) patients receiving extracorporeal cardiopulmonary resuscitation (ECPR). No studies comprehensively described the incidence rate...

    Authors: Shutaro Isokawa, Toru Hifumi, Keita Hirano, Yu Watanabe, Katsuhiro Horie, Kijong Shin, Kasumi Shirasaki, Masahiro Goto, Akihiko Inoue, Tetsuya Sakamoto, Yasuhiro Kuroda, Shiori Tomita, Norio Otani and The SAVE-J II study group
    Citation: Annals of Intensive Care 2024 14:16
  19. Current guidelines for adult patients with pneumococcal meningitis (PM) recommend initial management in intermediate or intensive care units (ICU), but evidence to support these recommendations is limited. We ...

    Authors: Michael Thy, Claire Dupuis, Arthur Mageau, Bruno Mourvillier, Lila Bouadma, Stéphane Ruckly, Anne Perozziello, Andrey Strukov, Damien Van-Gysel, Etienne de Montmollin, Romain Sonneville and Jean-François Timsit
    Citation: Annals of Intensive Care 2024 14:15
  20. Patients with COVID-19 admitted to intensive care unit (ICU) may have right ventricular (RV) injury. The main goal of this study was to investigate the incidence of RV injury and to describe the patient trajec...

    Authors: Mathieu Jozwiak, Claire Dupuis, Pierre Denormandie, Didac Aurenche Mateu, Jean Louchet, Nathan Heme, Jean-Paul Mira, Denis Doyen and Jean Dellamonica
    Citation: Annals of Intensive Care 2024 14:14
  21. Given the pathophysiology of hypoxemia in patients with Covid-19 acute respiratory failure (ARF), it seemed necessary to evaluate whether ROX index (ratio SpO2/FiO2 to respiratory rate) could accurately predict i...

    Authors: Christophe Girault, Michael Bubenheim, Déborah Boyer, Pierre-Louis Declercq, Guillaume Schnell, Philippe Gouin, Jean-Baptiste Michot, Dorothée Carpentier, Steven Grangé, Gaëtan Béduneau and Fabienne Tamion
    Citation: Annals of Intensive Care 2024 14:13
  22. Left ventricular ejection fraction (LVEF) is inconsistently associated with poor outcomes in patients with sepsis. Newer parameters such as LV longitudinal strain (LVLS), mitral annular plane systolic excursio...

    Authors: Patrik Johansson Blixt, Maxime Nguyen, Bernard Cholley, Fredrik Hammarskjöld, Alois Toiron, Belaid Bouhemad, Shaun Lee, Lina De Geer, Henrik Andersson, Meriam Åström Aneq, Jan Engvall and Michelle S. Chew
    Citation: Annals of Intensive Care 2024 14:12
  23. Previously, we reported a decreased mortality rate among patients with COVID-19 who were admitted at the ICU during the final upsurge of the second wave (February–June 2021) in the Netherlands. We examined whe...

    Authors: Fabian Termorshuizen, Dave A. Dongelmans, Sylvia Brinkman, Ferishta Bakhshi-Raiez, M. Sesmu Arbous, Dylan W. de Lange, Bas C. T. van Bussel and Nicolette F. de Keizer
    Citation: Annals of Intensive Care 2024 14:11
  24. Right ventricular (RV) function is tightly coupled to afterload, yet echocardiographic indices of RV function are frequently assessed in isolation. Normalizing RV function for afterload (RV-PA coupling) using ...

    Authors: Emma Bowcock, Stephen Huang, Rachel Yeo, Deshani Walisundara, Chris F. Duncan, Faraz Pathan, Geoffrey Strange, David Playford and Sam Orde
    Citation: Annals of Intensive Care 2024 14:10
  25. Healthcare expenses are increasing, as is the utilization of laboratory resources. Despite this, between 20% and 40% of requested tests are deemed inappropriate. Improper use of laboratory resources leads to u...

    Authors: Luigi Devis, Emilie Catry, Patrick M. Honore, Alexandre Mansour, Giuseppe Lippi, François Mullier and Mélanie Closset
    Citation: Annals of Intensive Care 2024 14:9
  26. Sepsis is a significant public health concern, particularly affecting individuals above 70 years in developed countries. This is a crucial fact due to the increasing aging population, their heightened vulnerab...

    Authors: Mercedes Ibarz, Lenneke E. M. Haas, Adrián Ceccato and Antonio Artigas
    Citation: Annals of Intensive Care 2024 14:6
  27. Authors: A. S. Giordani, A. Baritussio, R. Marcolongo and A. L. P. Caforio
    Citation: Annals of Intensive Care 2024 14:5

    The original article was published in Annals of Intensive Care 2023 13:78

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2024 14:3

  28. Aquaporin-4 immunoglobulin G Neuro Myelitis Optica spectrum disorders attacks (NMOSD-AQP4-IgG+ attacks) can cause respiratory failure requiring orotracheal intubation (OTI), but the risk factors and outcomes o...

    Authors: Edouard Januel, Vincent Brochard, Loïc Le Guennec, Elisabeth Maillart, Céline Louapre, Catherine Lubetzki, Nicolas Weiss, Sophie Demeret and Caroline Papeix
    Citation: Annals of Intensive Care 2024 14:4
  29. Authors: Marc Pineton de Chambrun, Yann Marquet, Mathieu Kerneis, Matthieu Schmidt, Charles-Edouard Luyt, Alain Combes and Guillaume Hekimian
    Citation: Annals of Intensive Care 2024 14:3

    The original article was published in Annals of Intensive Care 2024 14:5

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2024 14:5

  30. Whereas aging is a whole-organism process, senescence is a cell mechanism that can be triggered by several stimuli. There is increasing evidence that critical conditions activate cell senescence programs irres...

    Authors: Paula Martín-Vicente, Cecilia López-Martínez, Beatriz Rioseras and Guillermo M. Albaiceta
    Citation: Annals of Intensive Care 2024 14:2
  31. Various Positive End-Expiratory Pressure (PEEP) titration strategies have been proposed to optimize ventilation in patients with acute respiratory distress syndrome (ARDS). We aimed to compare PEEP titration s...

    Authors: Bertrand Pavlovsky, Christophe Desprez, Jean-Christophe Richard, Nicolas Fage, Arnaud Lesimple, Dara Chean, Antonin Courtais, Tommaso Mauri, Alain Mercat and François Beloncle
    Citation: Annals of Intensive Care 2024 14:1
  32. During Pressure Support Ventilation (PSV) an inspiratory hold allows to measure plateau pressure (Pplat), driving pressure (∆P), respiratory system compliance (Crs) and pressure-muscle-index (PMI), an index of...

    Authors: Mattia Docci, Emanuele Rezoagli, Maddalena Teggia-Droghi, Andrea Coppadoro, Matteo Pozzi, Alice Grassi, Isabella Bianchi, Giuseppe Foti and Giacomo Bellani
    Citation: Annals of Intensive Care 2023 13:132
  33. Internal redistribution of gas, referred to as pendelluft, is a new potential mechanism of effort-dependent lung injury. Neurally-adjusted ventilatory assist (NAVA) and proportional assist ventilation (PAV +) ...

    Authors: Daniel H. Arellano, Roberto Brito, Caio C. A. Morais, Pablo Ruiz-Rudolph, Abraham I. J. Gajardo, Dannette V. Guiñez, Marioli T. Lazo, Ivan Ramirez, Verónica A. Rojas, María A. Cerda, Juan N. Medel, Victor Illanes, Nivia R. Estuardo, Alejandro R. Bruhn, Laurent J. Brochard, Marcelo B. P. Amato…
    Citation: Annals of Intensive Care 2023 13:131
  34. Little attention has been paid to potential differences in prognosis between mechanically ventilated males and females in intensive care units (ICUs). We hypothesized that a sex gap in the risk of extubation f...

    Authors: Arnaud W. Thille, Florence Boissier, Rémi Coudroy, Sylvain Le Pape, François Arrivé, Laura Marchasson, Jean-Pierre Frat and Stéphanie Ragot
    Citation: Annals of Intensive Care 2023 13:130
  35. Although it has been reported that patients with pneumococcal pneumonia may develop meningitis, lumbar puncture is not systematically recommended in these patients, even in patients with associated bacteremia ...

    Authors: Paul Jaubert, Julien Charpentier, Sarah Benghanem, Alain Cariou, Frédéric Pène, Jean-Paul Mira and Mathieu Jozwiak
    Citation: Annals of Intensive Care 2023 13:129
  36. The physiological effects of renin-angiotensin system modulation in acute respiratory distress syndrome (ARDS) remain controversial and have not been investigated in randomized trials. We sought to determine w...

    Authors: Daniel E. Leisman, Damian R. Handisides, Lakhmir S. Chawla, Timothy E. Albertson, Laurence W. Busse, David W. Boldt, Adam M. Deane, Michelle N. Gong, Kealy R. Ham, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, B. Taylor Thompson, James S. Tumlin, Christopher D. Adams, Tony N. Hodges…
    Citation: Annals of Intensive Care 2023 13:128
  37. Endotoxin adsorption is a promising but controversial therapy in severe, refractory septic shock and conflicting results exist on the effective capacity of available devices to reduce circulating endotoxin and...

    Authors: Pedro David Wendel-Garcia, Barbara Eberle, Eva-Maria Kleinert, Matthias Peter Hilty, Stephan Blumenthal, Katharina Spanaus, Patricia Fodor and Marco Maggiorini
    Citation: Annals of Intensive Care 2023 13:127
  38. Frailty is widely acknowledged as influencing health outcomes among critically ill old patients. Yet, the traditional understanding of its impact has predominantly been through frequentist statistics. We endea...

    Authors: Bernhard Wernly, Raphael Romano Bruno, Michael Beil, Hans Flaatten, Malte Kelm, Sviri Sigal, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Andreas Koköfer, Sandra Oeyen, Brian Marsh, Rui Moreno, Sarah Wernly, Susannah Leaver, Dylan W. De Lange…
    Citation: Annals of Intensive Care 2023 13:126
  39. The administration technique for inhaled drug delivery during invasive ventilation remains debated. This study aimed to compare in vivo and in vitro the deposition of a radiolabeled aerosol generated through f...

    Authors: Jonathan Dugernier, Déborah Le Pennec, Guillaume Maerckx, Laurine Allimonnier, Michel Hesse, Diego Castanares-Zapatero, Virginie Depoortere, Laurent Vecellio, Gregory Reychler, Jean-Bernard Michotte, Pierre Goffette, Marie-Agnes Docquier, Christian Raftopoulos, François Jamar, Pierre-François Laterre, Stephan Ehrmann…
    Citation: Annals of Intensive Care 2023 13:125
  40. Patients with bacterial meningitis can be severely ill necessitating intensive care unit (ICU) treatment. Here, we describe clinical features and prognostic factors of adults with bacterial meningitis admitted...

    Authors: Nora Chekrouni, Merel Kroon, Evelien H. G. M. Drost, Thijs M. van Soest, Merijn. W. Bijlsma, Matthijs C. Brouwer and Diederik van de Beek
    Citation: Annals of Intensive Care 2023 13:124
  41. In the last decade, Ibrutinib has become the standard of care in the treatment of several lymphoproliferative diseases such as chronic lymphocytic leukemia (CLL) and several non-Hodgkin lymphoma. Beyond Bruton...

    Authors: Louise Baucher, Virginie Lemiale, Adrien Joseph, Florent Wallet, Marc Pineton de Chambrun, Alexis Ferré, Romain Lombardi, Laura Platon, Adrien Contejean, Charline Fuseau, Laure Calvet, Frédéric Pène, Achille Kouatchet, Djamel Mokart, Elie Azoulay and Antoine Lafarge
    Citation: Annals of Intensive Care 2023 13:123
  42. The unsuccessful extubation in patients with traumatic cervical spinal cord injuries (CSCI) may result from impairment diaphragm function and monitoring of diaphragm electrical activity (EAdi) can be informati...

    Authors: Rui Zhang, Xiaoting Xu, Hui Chen, Jennifer Beck, Christer Sinderby, Haibo Qiu, Yi Yang and Ling Liu
    Citation: Annals of Intensive Care 2023 13:122
  43. The prolonged β-lactam antibiotics infusion has been an attractive strategy in severe infections, because it provides a more stable free drug concentration and a longer duration of free drug concentration abov...

    Authors: Xiaoming Li, Yi Long, Guixin Wu, Rui Li, Mingming Zhou, Aiting He and Zhengying Jiang
    Citation: Annals of Intensive Care 2023 13:121
  44. Authors: Roberto Roncon-Albuquerque Jr, Sérgio Gaião, Francisco Vasques-Nóvoa, Carla Basílio, Ana Rita Ferreira, Alberto Touceda-Bravo, Rodrigo Pimentel, Ana Vaz, Sofia Silva, Guiomar Castro, Tiago Veiga, Hélio Martins, Francisco Dias, Catarina Pereira, Gonçalo Marto, Isabel Coimbra…
    Citation: Annals of Intensive Care 2023 13:120

    The original article was published in Annals of Intensive Care 2023 13:118

    The Research to this article has been published in Annals of Intensive Care 2023 13:86

  45. Disseminated intravascular coagulation (DIC) worsens the prognosis of septic shock and contributes to multiple organ failure. To date, no data linking DIC and acute kidney injury (AKI) occurrence, severity, an...

    Authors: Julie Helms, Hamid Merdji, Sébastien Loewert, François Severac, Alexandra Monnier, Julian Kaurin, Anaïs Curtiaud, Ferhat Meziani and Julien Demiselle
    Citation: Annals of Intensive Care 2023 13:119
  46. Authors: Alessandro Belletti, Jacopo D’Andria Ursoleo, Anna Mara Scandroglio, Giovanni Landoni and Alberto Zangrillo
    Citation: Annals of Intensive Care 2023 13:118

    The original article was published in Annals of Intensive Care 2023 13:86

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2023 13:120

  47. Multiple devices are available for noninvasive oxygenation support, including non-rebreather oxygen mask (O2-mask), high-flow oxygen through nasal cannula (HFNC), continuous positive airway pressure (CPAP), mask ...

    Authors: Anne-Fleur Haudebourg, Tommaso Maraffi, Samuel Tuffet, Philippe Le Corvoisier, Armand Mekontso Dessap and Guillaume Carteaux
    Citation: Annals of Intensive Care 2023 13:116

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