Articles

Accuracy of P0.1 measurements performed by ICU ventilators: a bench study

Occlusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well cor...

Authors: François Beloncle, Lise Piquilloud, Pierre-Yves Olivier, Alice Vuillermoz, Elise Yvin, Alain Mercat and Jean-Christophe Richard

Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

Injury to endothelium and glycocalyx predisposes to vascular leak, which may subsequently lead to increased fluid requirements and worse outcomes. In this post hoc study of the prospective multicenter observat...

Authors: Nina Inkinen, Ville Pettilä, Päivi Lakkisto, Anne Kuitunen, Sakari Jukarainen, Stepani Bendel, Outi Inkinen, Tero Ala-Kokko and Suvi T. Vaara

Recruiting the microcirculation in septic shock

Authors: Matthieu Legrand, Daniel De Backer, François Dépret and Hafid Ait Oufella

Predictors of successful separation from high-flow nasal oxygen therapy in patients with acute respiratory failure: a retrospective monocenter study

High-flow nasal oxygen therapy (HFOT) is a promising first-line therapy for acute respiratory failure. However, its weaning has never been investigated and could lead to unnecessary prolonged intensive-care un...

Authors: Maeva Rodriguez, Arnaud W. Thille, Florence Boissier, Anne Veinstein, Delphine Chatellier, René Robert, Sylvain Le Pape, Jean-Pierre Frat and Remi Coudroy

Association between potassium concentrations, variability and supplementation, and in-hospital mortality in ICU patients: a retrospective analysis

Serum potassium concentrations are commonly between 3.5 and 5.0 mmol/l. Standardised protocols for potassium range and supplementation in the ICU are lacking. The purpose of this retrospective analysis of ICU ...

Authors: Lilian Jo Engelhardt, Felix Balzer, Michael C. Müller, Julius J. Grunow, Claudia D. Spies, Kenneth B. Christopher, Steffen Weber-Carstens and Tobias Wollersheim

Serum sodium and intracranial pressure changes after desmopressin therapy in severe traumatic brain injury patients: a multi-centre cohort study

In traumatic brain injury (TBI) patients desmopressin administration may induce rapid decreases in serum sodium and increase intracranial pressure (ICP).

Authors: A. Harrois, J. R. Anstey, F. S. Taccone, A. A. Udy, G. Citerio, J. Duranteau, C. Ichai, R. Badenes, J. R. Prowle, A. Ercole, M. Oddo, A. Schneider, M. van der Jagt, S. Wolf, R. Helbok, D. W. Nelson…

High-flow nasal cannula therapy: clinical practice in intensive care units

Despite the extensive use of high-flow nasal cannula (HFNC) therapy in intensive care units (ICU) for acute respiratory failure (ARF), its daily clinical practice has not been assessed. We designed a regional ...

Authors: Emmanuel Besnier, Sinad Hobeika, Saad NSeir, Fabien Lambiotte, Damien Du Cheyron, Bertrand Sauneuf, Benoit Misset, Fabienne Tamion, Guillaume Schnell, Jack Richecoeur, Julien Maizel and Christophe Girault

Impact of increased mean arterial pressure on skin microcirculatory oxygenation in vasopressor-requiring septic patients: an interventional study

Heterogeneity of microvascular blood flow leading to tissue hypoxia is a common finding in patients with septic shock. It may be related to suboptimal systemic perfusion pressure and lead to organ failure. Map...

Authors: Sigita Kazune, Anastasija Caica, Einars Luksevics, Karina Volceka and Andris Grabovskis

Acute respiratory failure and mechanical ventilation in cardiogenic shock complicating acute myocardial infarction in the USA, 2000–2014

There are limited epidemiological data on acute respiratory failure (ARF) in cardiogenic shock complicating acute myocardial infarction (AMI-CS). This study sought to evaluate the prevalence and outcomes of AR...

Authors: Saraschandra Vallabhajosyula, Kianoush Kashani, Shannon M. Dunlay, Shashaank Vallabhajosyula, Saarwaani Vallabhajosyula, Pranathi R. Sundaragiri, Bernard J. Gersh, Allan S. Jaffe and Gregory W. Barsness

Hyperchloremia is not associated with AKI or death in septic shock patients: results of a post hoc analysis of the “HYPER2S” trial

Recent data suggest that hyperchloremia induced by fluid resuscitation is associated with acute kidney injury (AKI) and mortality, particularly in sepsis. Experimental studies showed that hyperchloremia could ...

Authors: Morgane Commereuc, Camille Nevoret, Peter Radermacher, Sandrine Katsahian, Pierre Asfar and Frédérique Schortgen

Incidence and impact of sepsis on long-term outcomes after subarachnoid hemorrhage: a prospective observational study

Aneurysmal subarachnoid hemorrhage (SAH) is an acute cerebrovascular disease associated with high mortality and long-term functional impairment among survivors. Systemic inflammatory responses after acute inju...

Authors: Bruno Gonçalves, Pedro Kurtz, Ricardo Turon, Thayana Santos, Marco Prazeres, Cassia Righy and Fernando Augusto Bozza

Animal ICU… Why not also use the existing veterinary ICUs?

Authors: Florent Baudin, Céline Pouzot-Nevoret, Vanessa Louzier, Isabelle Goy-Thollot, Anthony Barthélemy, Stéphane Junot, Jeanne-Marie Bonnet-Garin and Bernard Allaouchiche

Diagnosis and management of metabolic acidosis: guidelines from a French expert panel

Metabolic acidosis is a disorder frequently encountered in emergency medicine and intensive care medicine. As literature has been enriched with new data concerning the management of metabolic acidosis, the Fre...

Authors: Boris Jung, Mikaël Martinez, Yann-Erick Claessens, Michaël Darmon, Kada Klouche, Alexandre Lautrette, Jacques Levraut, Eric Maury, Mathieu Oberlin, Nicolas Terzi, Damien Viglino, Youri Yordanov, Pierre-Géraud Claret and Naïke Bigé

Initial management of diabetic ketoacidosis and prognosis according to diabetes type: a French multicentre observational retrospective study

Guidelines for the management of diabetic ketoacidosis (DKA) do not consider the type of underlying diabetes. We aimed to compare the occurrence of metabolic adverse events and the recovery time for DKA accord...

Authors: Adrien Balmier, Fadia Dib, Arnaud Serret-Larmande, Etienne De Montmollin, Victorine Pouyet, Benjamin Sztrymf, Bruno Megarbane, Abirami Thiagarajah, Didier Dreyfuss, Jean-Damien Ricard and Damien Roux

Is immunosuppression status a risk factor for noninvasive ventilation failure in patients with acute hypoxemic respiratory failure? A post hoc matched analysis

Recent European/American guidelines recommend noninvasive ventilation (NIV) as a first-line therapy to manage acute hypoxemic respiratory failure in immunocompromised patients. By contrast, NIV may have delete...

Authors: Rémi Coudroy, Tài Pham, Florence Boissier, René Robert, Jean-Pierre Frat and Arnaud W. Thille

Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study

The electrical activity of the crural diaphragm (Eadi), a surrogate of respiratory drive, can now be measured at the bedside in mechanically ventilated patients with a specific catheter. The expected range of ...

Authors: Lise Piquilloud, François Beloncle, Jean-Christophe M. Richard, Jordi Mancebo, Alain Mercat and Laurent Brochard

Electrical impedance tomography during spontaneous breathing trials and after extubation in critically ill patients at high risk for extubation failure: a multicenter observational study

This study aims to assess the changes in lung aeration and ventilation during the first spontaneous breathing trial (SBT) and after extubation in a population of patients at risk of extubation failure.

Authors: Federico Longhini, Jessica Maugeri, Cristina Andreoni, Chiara Ronco, Andrea Bruni, Eugenio Garofalo, Corrado Pelaia, Camilla Cavicchi, Sergio Pintaudi and Paolo Navalesi

Complete blood count in acute kidney injury prediction: a narrative review

Acute kidney injury (AKI) is a complex syndrome defined by a decrease in renal function. The incidence of AKI has raised in the past decades, and it is associated with negative impact in patient outcomes in th...

Authors: Joana Gameiro and José António Lopes

Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis

Information on the clinical, epidemiological and molecular characterization of human metapneumovirus in critically ill adult patients with severe community-acquired pneumonia (CAP) and the role of biomarkers i...

Authors: Loreto Vidaur, Izarne Totorika, Milagrosa Montes, Diego Vicente, Jordi Rello and Gustavo Cilla

Impact of furosemide on mortality and the requirement for renal replacement therapy in acute kidney injury: a systematic review and meta-analysis of randomised trials

To examine the impact of furosemide on mortality and the need for renal replacement therapy (RRT) in adult patients with acute kidney injury (AKI) based on current evidence.

Authors: Łukasz J. Krzych and Piotr F. Czempik

Correction to: Factors associated with acute kidney injury in acute respiratory distress syndrome

After publication of the original article [1], we were notified that an author’s name has been incorrectly spelled. Andrei Hasting should be replaced with Andrei Hastings.

Authors: Anupol Panitchote, Omar Mehkri, Andrei Hastings, Tarik Hanane, Sevag Demirjian, Heather Torbic, Eduardo Mireles-Cabodevila, Sudhir Krishnan and Abhijit Duggal

Noninvasive assessment of airflows by electrical impedance tomography in intubated hypoxemic patients: an exploratory study

Noninvasive monitoring of maximal inspiratory and expiratory flows (MIF and MEF, respectively) by electrical impedance tomography (EIT) might enable early recognition of changes in the mechanical properties of...

Authors: Tommaso Mauri, Elena Spinelli, Francesca Dalla Corte, Eleonora Scotti, Cecilia Turrini, Marta Lazzeri, Laura Alban, Marco Albanese, Donatella Tortolani, Yu-Mei Wang, Savino Spadaro, Jian-Xin Zhou, Antonio Pesenti and Giacomo Grasselli

Long-term neurocognitive outcome is not worsened by of the use of venovenous ECMO in severe ARDS patients

Venovenous extracorporeal membrane oxygenation (VV-ECMO) is associated with a significant morbidity. There is the need to investigate long-term cognitive outcome among ARDS survivors treated with VV-ECMO. We a...

Authors: Aude Sylvestre, Mélanie Adda, François Maltese, Ariane Lannelongue, Florence Daviet, Gabriel Parzy, Benjamin Coiffard, Antoine Roch, Anderson Loundou, Karine Baumstarck and Laurent Papazian

PEEP titration in moderate to severe ARDS: plateau versus transpulmonary pressure

Although lung protection with low tidal volume and limited plateau pressure (P_plat) improves survival in acute respiratory distress syndrome patients (ARDS), the best way to set positive end-expiratory pressure (...

Authors: Marie Bergez, Nicolas Fritsch, David Tran-Van, Tahar Saghi, Tan Bounkim, Ariane Gentile, Philippe Labadie, Bruno Fontaine, Alexandre Ouattara and Hadrien Rozé

Correction to: P-42 Distribution and antifungal susceptibility of Candida isolates in a Tunisian burn unit

Introduction: Burned patients are at high risk of yeast colonization and thus of invasive fungal infections, particularly to Candida (C.) spp., leading to an increase in morbidity and mortality. While pre-empt...

Authors: Trabelsi Sonia, Hanachi Majdi, Bouchekoua Meriam, Aloui Dorsaf, Cheikhrouhou Sarra, Khaled Samira, Messadi Amen Allah and Thabet Lamia

Extracorporeal carbon dioxide removal for acute hypercapnic respiratory failure

In the past, the only treatment of acute exacerbations of obstructive diseases with hypercapnic respiratory failure refractory to medical treatment was invasive mechanical ventilation (IMV). Considerable techn...

Authors: Luis Morales-Quinteros, Lorenzo Del Sorbo and Antonio Artigas

The effect of pressure support on imposed work of breathing during paediatric extubation readiness testing

Paediatric critical care practitioners often make use of pressure support (PS) to overcome the perceived imposed work of breathing (WOBimp) during an extubation readiness test (ERT). However, no paediatric dat...

Authors: Jefta van Dijk, Robert G. T. Blokpoel, Alette A. Koopman, Sandra Dijkstra, Johannes G. M. Burgerhof and Martin C. J. Kneyber

Improve short-term survival in postcardiotomy cardiogenic shock by simultaneous use of intra-aortic balloon pumping with veno-arterial extracorporeal membrane oxygenation: Beware of confounders!

Authors: Patrick M. Honore, David De Bels, Sebastien Redant and Kianoush Kashani

Serum biomarkers of delirium in the elderly: a narrative review

Delirium after surgery and in the intensive care unit (ICU) remains a challenge for patients, families, and caregivers. Over the years, many promising biomarkers have been investigated as potential instruments...

Authors: Katharina Toft, Janna Tontsch, Salim Abdelhamid, Luzius Steiner, Martin Siegemund and Alexa Hollinger

Trisodium citrate 4% versus heparin as a catheter lock for non-tunneled hemodialysis catheters in critically ill patients: a multicenter, randomized clinical trial

Non-tunneled hemodialysis catheters are currently used for critically ill patients with acute kidney injury requiring extracorporeal renal replacement therapy. Strategies to prevent catheter dysfunction and in...

Authors: Jean-Pierre Quenot, Julie Helms, Abderrahmane Bourredjem, Auguste Dargent, Ferhat Meziani, Julio Badie, Gilles Blasco, Gaël Piton, Gilles Capellier, Chaouki Mezher, Jean-Michel Rebibou, Abdelouaid Nadji, Thomas Crepin, Saber Davide Barbar, Camille Fleck, Amélie Cransac…

Factors associated with acute kidney injury in acute respiratory distress syndrome

Acute kidney injury (AKI) is the most frequent extra-pulmonary organ failure in acute respiratory distress syndrome (ARDS). The objective of this study was to assess the factors associated with the development...

Authors: Anupol Panitchote, Omar Mehkri, Andrei Hastings, Tarik Hanane, Sevag Demirjian, Heather Torbic, Eduardo Mireles-Cabodevila, Sudhir Krishnan and Abhijit Duggal

Translational gap in pediatric septic shock management: an ESPNIC perspective

The Surviving Sepsis Campaign and the American College of Critical Care Medicine guidelines have provided recommendations for the management of pediatric septic shock patients. We conducted a survey among the ...

Authors: Luc Morin, Martin Kneyber, Nicolaas J. G. Jansen, Mark J. Peters, Etienne Javouhey, Simon Nadel, Graeme Maclaren, Luregn Jan Schlapbach and Pierre Tissieres

Outcomes of mechanical ventilation according to WIND classification in pediatric patients

The outcomes of weaning processes are not well known in pediatric patients, and the International Conference Classification on weaning from mechanical ventilation showed limited application. We evaluate the re...

Authors: Ah Young Choi, Minji Kim, Esther Park, Meong Hi Son, Jeong-Am Ryu and Joongbum Cho

Heparin-binding protein in sepsis: player! predictor! positioning?

Authors: Patrick M. Honore, David De Bels, Leonel Barreto Gutierrez, Sebastien Redant and Herbert D. Spapen

Ambulatory and stationary healthcare use in survivors of ARDS during the first year after discharge from ICU: findings from the DACAPO cohort

For many survivors of acute respiratory distress syndrome (ARDS), the process from discharge from intensive care unit (ICU) to recovery is long and difficult. However, healthcare use after discharge from ICU h...

Authors: Susanne Brandstetter, Frank Dodoo-Schittko, Magdalena Brandl, Sebastian Blecha, Thomas Bein and Christian Apfelbacher

Formal guidelines: management of acute respiratory distress syndrome

Fifteen recommendations and a therapeutic algorithm regarding the management of acute respiratory distress syndrome (ARDS) at the early phase in adults are proposed. The Grade of Recommendation Assessment, Dev...

Authors: Laurent Papazian, Cécile Aubron, Laurent Brochard, Jean-Daniel Chiche, Alain Combes, Didier Dreyfuss, Jean-Marie Forel, Claude Guérin, Samir Jaber, Armand Mekontso-Dessap, Alain Mercat, Jean-Christophe Richard, Damien Roux, Antoine Vieillard-Baron and Henri Faure

High-density lipoprotein (HDL) particle size and concentration changes in septic shock patients

Sepsis is associated with systemic inflammation that may impact lipoprotein function. In particular, high-density lipoproteins (HDLs) that display pleiotropic protective roles may be dysfunctional in septic co...

Authors: Sébastien Tanaka, Dévy Diallo, Sandrine Delbosc, Claire Genève, Nathalie Zappella, Jennyfer Yong-Sang, Jessica Patche, Anatole Harrois, Sophie Hamada, Erick Denamur, Philippe Montravers, Jacques Duranteau and Olivier Meilhac

Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational study

Anemia is one of the most common complications of sepsis. Sepsis-related anemia is associated mainly with inflammation. We aimed to observe the changes in the inflammatory anemia-associated parameters of patie...

Authors: Yi Jiang, Feng-Quan Jiang, Fang Kong, Meng-Meng An, Bei-Bei Jin, Da Cao and Ping Gong

Preclinical septic shock research: why we need an animal ICU

Animal experiments are widely used in preclinical medical research with the goal of disease modeling and exploration of novel therapeutic approaches. In the context of sepsis and septic shock, the translation ...

Authors: Antoine Guillon, Sebastien Preau, Jérôme Aboab, Eric Azabou, Boris Jung, Stein Silva, Julien Textoris, Fabrice Uhel, Dominique Vodovar, Lara Zafrani, Nicolas de Prost and Peter Radermacher

Changes in acute kidney injury epidemiology in critically ill patients: a population-based cohort study in Korea

Although no specific treatment facilitates renal tubular regeneration in acute kidney injury (AKI), the rapid increase in aging populations with more comorbidities and advances in critical care management are ...

Authors: Subin Hwang, Hyejeong Park, Youngha Kim, Danbee Kang, Ho Suk Ku, Juhee Cho, Jung Eun Lee, Wooseong Huh, Eliseo Guallar, Gee Young Suh and Hye Ryoun Jang

A multiplex analysis of sepsis mediators during human septic shock: a preliminary study on myocardial depression and organ failures

The mechanisms of organ failure during sepsis are not fully understood. The hypothesis of circulating factors has been suggested to explain septic myocardial dysfunction. We explored the biological coherence o...

Authors: Keyvan Razazi, Florence Boissier, Mathieu Surenaud, Alexandre Bedet, Aurélien Seemann, Guillaume Carteaux, Nicolas de Prost, Christian Brun-Buisson, Sophie Hue and Armand Mekontso Dessap

Sensitivity to angiotensin II dose in patients with vasodilatory shock: a prespecified analysis of the ATHOS-3 trial

Early clinical data showed that some patients with vasodilatory shock are responsive to low doses of angiotensin II. The objective of this analysis was to compare clinical outcomes in patients requiring ≤ 5 ng kg

Authors: Kealy R. Ham, David W. Boldt, Michael T. McCurdy, Laurence W. Busse, Raphael Favory, Michelle N. Gong, Ashish K. Khanna, Stefan N. Chock, Feng Zeng, Lakhmir S. Chawla, George F. Tidmarsh and Marlies Ostermann

Candidemia in critically ill immunocompromised patients: report of a retrospective multicenter cohort study

Immunocompromised critically ill patients constitute a population with the high risk of candidemia. This retrospective study aimed to assess the outcome of immunocompromised critically ill patients with candid...

Authors: Etienne Ghrenassia, Djamel Mokart, Julien Mayaux, Alexandre Demoule, Imène Rezine, Lionel Kerhuel, Laure Calvet, Audrey De Jong, Elie Azoulay and Michael Darmon

Influence of changes in ventricular systolic function and loading conditions on pulse contour analysis-derived femoral dP/dt_max

Femoral dP/dt_max (maximum rate of the arterial pressure increase during systole) measured by pulse contour analysis has been proposed as a surrogate of left ventricular (LV) dP/dt_max and as an estimator of LV sys...

Authors: Sergi Vaquer, Denis Chemla, Jean-Louis Teboul, Umar Ahmad, Flora Cipriani, Joan Carles Oliva, Ana Ochagavia, Antonio Artigas, Francisco Baigorri and Xavier Monnet

Interest and limits of assessing acute kidney injury in administrative dataset

Authors: Michaël Darmon, Emmanuel Canet and Lara Zafrani

Association between post-procedural hyperoxia and poor functional outcome after mechanical thrombectomy for ischemic stroke: an observational study

The actual effects of oxygen therapy on patients who have suffered a stroke are still unknown, and its recommendation as a routine measure in emergency services remains controversial. The aim of this study is ...

Authors: Héctor Vargas López, Miguel Fernández Vivas, Rafael Núñez Ruiz, José Ros Martínez, Blanca García-Villalba Navaridas, Manuel García Villa, Cristina Llamas Lázaro, Rubén Jara Rubio, Ana Morales Ortiz, Laura Albert Lacal and Antonio Moreno Diéguez

Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis

Low levels of ascorbic acid (AA) have been detected in critically ill patients in which AA supplementation leads to promising outcomes. However, the ability of AA to reduce mortality in critically ill patients...

Authors: Ying Wang, Huan Lin, Bing-wen Lin and Jian-dong Lin

Clinical review: peripheral muscular ultrasound in the ICU

Muscular weakness developing from critical illness neuropathy, myopathy and muscle atrophy has been characterized as intensive care unit-acquired weakness (ICUAW). This entity occurs commonly during and after ...

Authors: Paolo Formenti, Michele Umbrello, Silvia Coppola, Sara Froio and Davide Chiumello

Cytokine removal in human septic shock: Where are we and where are we going?

Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to i...

Authors: Patrick M. Honore, Eric Hoste, Zsolt Molnár, Rita Jacobs, Olivier Joannes-Boyau, Manu L. N. G. Malbrain and Lui G. Forni

Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study

Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respir...

Authors: Laura R. Schouten, Anton H. van Kaam, Franziska Kohse, Floor Veltkamp, Lieuwe D. Bos, Friso M. de Beer, Roosmarijn T. van Hooijdonk, Janneke Horn, Marleen Straat, Esther Witteveen, Gerie J. Glas, Luuk Wieske, Lonneke A. van Vught, Maryse A. Wiewel, Sarah A. Ingelse, Bart Cortjens…