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  1. Bedside assessment of low levels of inspiratory effort, which are probably insufficient to prevent muscle atrophy, is challenging. The flow index, which is derived from the analysis of the inspiratory portion ...

    Authors: Ming-Yue Miao, Wei Chen, Yi-Min Zhou, Ran Gao, De-Jing Song, Shu-Peng Wang, Yan-Lin Yang, Linlin Zhang and Jian-Xin Zhou
    Citation: Annals of Intensive Care 2022 12:89
  2. Augmented renal clearance (ARC) remains poorly evaluated in ICU. The objective of this study is to provide a full description of ARC in ICU including prevalence, evolution profile, risk factors and outcomes.

    Authors: Alexandre Egea, Claire Dupuis, Etienne de Montmollin, Paul-Henry Wicky, Juliette Patrier, Pierre Jaquet, Lucie Lefèvre, Fabrice Sinnah, Mehdi Marzouk, Romain Sonneville, Lila Bouadma, Bertrand Souweine and Jean-François Timsit
    Citation: Annals of Intensive Care 2022 12:88
  3. Lung reactivations of Herpesviridae, herpes simplex virus (HSV) and cytomegalovirus (CMV) have been reported in COVID-19 patients. Whether or not those viral reactivations are more frequent than in other patients...

    Authors: Charles-Edouard Luyt, Sonia Burrel, David Mokrani, Marc Pineton de Chambrun, Domitille Luyt, Juliette Chommeloux, Vincent Guiraud, Nicolas Bréchot, Matthieu Schmidt, Guillaume Hekimian, Alain Combes and David Boutolleau
    Citation: Annals of Intensive Care 2022 12:87
  4. While antibiotic therapy is advocated to improve outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) whenever mechanical ventilation is required, the evidence relies on small studi...

    Authors: G. Deniel, M. Cour, L. Argaud, J. C. Richard and L. Bitker
    Citation: Annals of Intensive Care 2022 12:86
  5. Among strategies that aimed to prevent acquired infections (AIs), selective decontamination regimens have been poorly studied in the COVID-19 setting. We assessed the impact of a multiple-site decontamination ...

    Authors: Nicolas Massart, Florian Reizine, Pierre Fillatre, Philippe Seguin, Béatrice La Combe, Aurélien Frerou, Pierre-Yves Egreteau, Baptiste Hourmant, Pierre Kergoat, Julien Lorber, Jerome Souchard, Emmanuel Canet, Guillaume Rieul, Yannick Fedun, Agathe Delbove and Christophe Camus
    Citation: Annals of Intensive Care 2022 12:84
  6. Authors: Michelle S. Chew, Saga Jansson, Meriam Åström Aneq and Jan Engvall
    Citation: Annals of Intensive Care 2022 12:83

    The original article was published in Annals of Intensive Care 2022 12:82

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:82

    The Research to this article has been published in Annals of Intensive Care 2022 12:56

  7. Authors: Minesh Chotalia, Mansoor N. Bangash, Jaimin M. Patel and Dhruv Parekh
    Citation: Annals of Intensive Care 2022 12:82

    The original article was published in Annals of Intensive Care 2022 12:56

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:83

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:83

  8. Dexmedetomidine is widely used in patients with sepsis. However, its effect on septic patients remains controversial. The objective of this study was to summarize all randomized controlled trials (RCTs) examin...

    Authors: Ting Zhang, Qimin Mei, Shabai Dai, Yecheng Liu and Huadong Zhu
    Citation: Annals of Intensive Care 2022 12:81
  9. Acute fulminant myocarditis in children is associated with elevated mortality and morbidity with few advances in its medical management. Here we report a preliminary experience of children treated with IL-1 re...

    Authors: Louise Maunier, Ramy Charbel, Virginie Lambert and Pierre Tissières
    Citation: Annals of Intensive Care 2022 12:80
  10. Long-term pulmonary sequelae, including 1-year thoracic computed tomography (CT) sequelae of paediatric acute respiratory distress syndrome (ARDS) remain unknown. The purpose of the study was to determine pulm...

    Authors: Véronique Nève, Ahmed Sadik, Laurent Petyt, Stéphane Dauger, Ahmed Kheniche, André Denjean, Pierre-Louis Léger, François Chalard, Michèle Boulé, Etienne Javouhey, Philippe Reix, Isabelle Canterino, Valérie Deken, Régis Matran, Stéphane Leteurtre and Francis Leclerc
    Citation: Annals of Intensive Care 2022 12:79
  11. In patients with septic shock, the impact of the mean arterial pressure (MAP) target on the course of mottling remains uncertain. In this post hoc analysis of the SEPSISPAM trial, we investigated whether a low...

    Authors: Nicolas Fage, Julien Demiselle, Valérie Seegers, Hamid Merdji, Fabien Grelon, Bruno Mégarbane, Nadia Anguel, Jean-Paul Mira, Pierre-François Dequin, Soizic Gergaud, Nicolas Weiss, François Legay, Yves Le Tulzo, Marie Conrad, Remi Coudroy, Frédéric Gonzalez…
    Citation: Annals of Intensive Care 2022 12:78
  12. Several scoring systems have been used to predict short-term outcome in patients with out-of-hospital cardiac arrest (OHCA), including the disease-specific OHCA and CAHP (Cardiac Arrest Hospital Prognosis) sco...

    Authors: René Blatter, Simon A. Amacher, Chantal Bohren, Christoph Becker, Katharina Beck, Sebastian Gross, Kai Tisljar, Raoul Sutter, Stephan Marsch and Sabina Hunziker
    Citation: Annals of Intensive Care 2022 12:77
  13. Although multiple individual immune parameters have been demonstrated to predict the occurrence of secondary infection after critical illness, significant questions remain with regards to the selection, timing...

    Authors: Jan-Alexis Tremblay, Florian Peron, Louis Kreitmann, Julien Textoris, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurence Quemeneur, Christophe Vedrine, Lionel K. Tan, Fabienne Venet, Thomas Rimmele and Guillaume Monneret
    Citation: Annals of Intensive Care 2022 12:76
  14. CAR-T cell (chimeric antigen receptor T) therapy has emerged as an effective treatment of refractory hematological malignancies. Intensive care management is intrinsic to CAR-T cell therapy. We aim to describe...

    Authors: Sandrine Valade, Michael Darmon, Lara Zafrani, Eric Mariotte, Virginie Lemiale, Swann Bredin, Guillaume Dumas, Nicolas Boissel, Florence Rabian, André Baruchel, Isabelle Madelaine, Jérôme Larghero, Anne Brignier, Etienne Lengliné, Stéphanie Harel, Bertrand Arnulf…
    Citation: Annals of Intensive Care 2022 12:75
  15. Capillary refill time (CRT) is a valuable tool for triage and to guide resuscitation. However, little is known about CRT kinetics after fluid infusion.

    Authors: Lisa Raia, Paul Gabarre, Vincent Bonny, Tomas Urbina, Louai Missri, Pierre-Yves Boelle, Jean-Luc Baudel, Bertrand Guidet, Eric Maury, Jeremie Joffre and Hafid Ait-Oufella
    Citation: Annals of Intensive Care 2022 12:74
  16. Tracheostomy is often performed in the intensive care unit (ICU) when mechanical ventilation (MV) weaning is prolonged to facilitate daily care. Tracheostomized patients require important healthcare resources ...

    Authors: Davy Cabrio, Timothée Vesin, Ermes Lupieri, Hélène Messet, Kishore Sandu and Lise Piquilloud
    Citation: Annals of Intensive Care 2022 12:73
  17. The mortality of extensively drug-resistant Gram-negative (XDR GN) bacilli-induced ventilator-associated pneumonia (VAP) is extremely high. The purpose of this study was to compare the efficacy and safety of i...

    Authors: Jiao Liu, Min Shao, Qianghong Xu, Fen Liu, Xiaojun Pan, Jianfeng Wu, Lihong Xiong, Yueming Wu, Mi Tian, Jianying Yao, Sisi Huang, Lidi Zhang, Yizhu Chen, Sheng Zhang, Zhenliang Wen, Hangxiang Du…
    Citation: Annals of Intensive Care 2022 12:72
  18. Recent guidelines advocate a step-up approach for managing suspected infected pancreatic necrosis (IPN) during acute pancreatitis. Nearly half the patients require secondary necrosectomy after catheter drainag...

    Authors: Charlotte Garret, Marion Douillard, Arthur David, Morgane Péré, Lucille Quenehervé, Ludivine Legros, Isabelle Archambeaud, Frédéric Douane, Marc Lerhun, Nicolas Regenet, Jerome Gournay, Emmanuel Coron, Eric Frampas and Jean Reignier
    Citation: Annals of Intensive Care 2022 12:71
  19. Acute kidney injury (AKI) is a frequent complication in patients with severe respiratory failure receiving extracorporeal membrane oxygenation (ECMO). However, little is known of long-term kidney function in E...

    Authors: Nuttha Lumlertgul, Rebeka Wright, Gareth Hutson, Jovana Kusic Milicevic, Georgios Vlachopanos, Ken Cheah Hooi Lee, Leah Pirondini, John Gregson, Barnaby Sanderson, Richard Leach, Luigi Camporota, Nicholas A. Barrett and Marlies Ostermann
    Citation: Annals of Intensive Care 2022 12:70
  20. The optimal early mean arterial pressure (MAP) level in terms of renal function remains to be established in patients with out-of-hospital cardiac arrest (OHCA). We aimed to evaluate the association between ea...

    Authors: Vincent Dupont, Anne-Sophie Bonnet-Lebrun, Alice Boileve, Julien Charpentier, Jean-Paul Mira, Guillaume Geri, Alain Cariou and Mathieu Jozwiak
    Citation: Annals of Intensive Care 2022 12:69
  21. Tracheal intubation and invasive mechanical ventilation initiation is a procedure at high risk for arterial hypotension in intensive care unit. However, little is known about the relationship between pre-exist...

    Authors: Vincent Dubée, Geoffroy Hariri, Jérémie Joffre, Julien Hagry, Lisa Raia, Vincent Bonny, Paul Gabarre, Sebastien Ehrminger, Naike Bigé, Jean-Luc Baudel, Bertrand Guidet, Eric Maury, Guillaume Dumas and Hafid Ait-Oufella
    Citation: Annals of Intensive Care 2022 12:68
  22. Authors: Zujin Luo, Zhixin Cao and Chen Wang
    Citation: Annals of Intensive Care 2022 12:67

    The original article was published in Annals of Intensive Care 2022 12:66

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:66

    The Research to this article has been published in Annals of Intensive Care 2022 12:41

  23. Authors: Radhouane Toumi, Khaoula Meddeb and Mohamed Boussarsar
    Citation: Annals of Intensive Care 2022 12:66

    The original article was published in Annals of Intensive Care 2022 12:41

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:67

  24. Little is known about the impact of hospital trajectory on survival and functional decline of older critically ill patients. We evaluate 6-month outcomes after admission to: intensive care units (ICU), interme...

    Authors: Sara Thietart, Ariane Boumendil, Dominique Pateron, Bertrand Guidet and Hélène Vallet
    Citation: Annals of Intensive Care 2022 12:65
  25. The long-term clinical status of coronavirus disease 2019 (COVID-19) in recovered patients remains largely unknown. This prospective cohort study evaluated clinical status of COVID-19 and explored the associated ...

    Authors: Dapeng Li, Xuejiao Liao, Zhenghua Ma, Lina Zhang, Jingke Dong, Guoqin Zheng, Mei Zi, Wujian Peng, Lanlan Wei, Zhiyan Li, Yingjun Kong, Lifei Wang, Dongjing Liu, Fang Wang, Qing He, Guobao Li…
    Citation: Annals of Intensive Care 2022 12:64
  26. Authors: Fredric Parenmark and Sten M. Walther
    Citation: Annals of Intensive Care 2022 12:63

    The original article was published in Annals of Intensive Care 2022 12:60

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:60

    The Research to this article has been published in Annals of Intensive Care 2022 12:31

  27. Whether early fluid accumulation is a risk factor for adverse renal outcomes in septic intensive care unit (ICU) patients remains uncertain. We assessed the association between cumulative fluid balance and maj...

    Authors: Alessandro Mele, Emanuele Cerminara, Henrike Häbel, Borja Rodriguez-Galvez, Anders Oldner, David Nelson, Johannes Gårdh, Ragnar Thobaben, Sandra Jonmarker, Maria Cronhjort, Jacob Hollenberg and Johan Mårtensson
    Citation: Annals of Intensive Care 2022 12:62
  28. Excess exposure to norepinephrine can compromise microcirculation and organ function. We aimed to assess the association between norepinephrine exposure and acute kidney injury (AKI) and intensive care unit (I...

    Authors: Pierre Huette, Mouhamed Djahoum Moussa, Christophe Beyls, Pierre-Grégoire Guinot, Mathieu Guilbart, Patricia Besserve, Mehdi Bouhlal, Sarah Mounjid, Hervé Dupont, Yazine Mahjoub, Audrey Michaud and Osama Abou-Arab
    Citation: Annals of Intensive Care 2022 12:61
  29. Authors: Benoit Painvin, Stephan Ehrmann, Arnaud W. Thille and Jean-Marc Tadié
    Citation: Annals of Intensive Care 2022 12:60

    The original article was published in Annals of Intensive Care 2022 12:31

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:63

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:63

  30. In our recent survey, we aimed to collect information on perceived inequity as well as professional and personal fulfillment among women intensivists in France. For the 371 respondents out of the 732 persons w...

    Authors: Olfa Hamzaoui, Florence Boissier, Charlotte Salmon Gandonnière, Cécile Aubron, Laetitia Bodet-Contentin, Muriel Sarah Fartoukh, Mélanie Faure, Mercedes Jourdain, Julien Le Marec, Fabienne Tamion, Nicolas Terzi, Caroline Hauw-Berlemont and Nadia Aissaoui
    Citation: Annals of Intensive Care 2022 12:59
  31. Post‐intensive care syndrome (PICS) encompasses physical, cognition, and mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it significantly impacts the long‐term prognosis, bo...

    Authors: Guillaume Voiriot, Mehdi Oualha, Alexandre Pierre, Charlotte Salmon-Gandonnière, Alexandre Gaudet, Youenn Jouan, Hatem Kallel, Peter Radermacher, Dominique Vodovar, Benjamine Sarton, Laure Stiel, Nicolas Bréchot, Sébastien Préau and Jérémie Joffre
    Citation: Annals of Intensive Care 2022 12:58
  32. The high transmission and fatality rates of coronavirus disease 2019 (COVID-19) strain intensive care resources and affect the treatment and prognosis of critically ill patients without COVID-19. Therefore, th...

    Authors: Sua Kim, Hangseok Choi, Jae Kyeom Sim, Won Jai Jung, Young Seok Lee and Je Hyeong Kim
    Citation: Annals of Intensive Care 2022 12:57
  33. Previous studies have found an increase in cardiac troponins (cTns) and echocardiographic abnormalities in patients with COVID-19 and reported their association with poor clinical outcomes. Whether acute injur...

    Authors: Saga Jansson, Patrik Johansson Blixt, Helen Didriksson, Carina Jonsson, Henrik Andersson, Cassandra Hedström, Jan Engvall, Meriam Åstrom Aneq and Michelle S. Chew
    Citation: Annals of Intensive Care 2022 12:56

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:82

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:83

  34. Hyperammonaemia is frequent in Intensive Care Unit patients. Some drugs have been described as associated with this condition, but there are no large-scale studies investigating this topic and most description...

    Authors: Alexander Balcerac, Kevin Bihan, Bénédicte Lebrun-Vignes, Dominique Thabut, Joe-Elie Salem and Nicolas Weiss
    Citation: Annals of Intensive Care 2022 12:55
  35. Pressure injuries (PIs), especially in the sacral region are frequent, costly, and increase morbidity and mortality of patients in an intensive care unit (ICU). These injuries can occur as a result of prolonge...

    Authors: Miriam Viviane Baron, Paulo Eugênio Silva, Janine Koepp, Janete de Souza Urbanetto, Andres Felipe Mantilla Santamaria, Michele Paula dos Santos, Marcus Vinicius de Mello Pinto, Cristine Brandenburg, Isabel Cristina Reinheimer, Sonia Carvalho, Mário Bernardes Wagner, Thomas Miliou, Carlos Eduardo Poli-de-Figueiredo and Bartira Ercília Pinheiro da Costa
    Citation: Annals of Intensive Care 2022 12:53
  36. Fluid overload is a risk factor for organ dysfunction and death in intensive care unit (ICU) patients, but no guidelines exist for its management. We systematically reviewed benefits and harms of a single loop...

    Authors: Sine Wichmann, Marija Barbateskovic, Ning Liang, Theis Skovsgaard Itenov, Rasmus Ehrenfried Berthelsen, Jane Lindschou, Anders Perner, Christian Gluud and Morten Heiberg Bestle
    Citation: Annals of Intensive Care 2022 12:52
  37. Some clinical and histological studies have reported that SARS-CoV-2 infection may damage the endothelium. However, the impact of this virus on endothelial function in vivo remains poorly characterized. In thi...

    Authors: Lisa Raia, Tomas Urbina, Paul Gabarre, Vincent Bonny, Geoffroy Hariri, Sebastien Ehrminger, Naïke Bigé, Jean-Luc Baudel, Bertrand Guidet, Eric Maury, Jeremie Joffre and Hafid Ait-Oufella
    Citation: Annals of Intensive Care 2022 12:51
  38. Dyspnea, a key symptom of acute respiratory failure, is not among the criteria for spontaneous breathing trial (SBT) failure. Here, we sought (1) to determine whether dyspnea is a reliable failure criterion fo...

    Authors: Côme Bureau, Martin Dres, Elise Morawiec, Julien Mayaux, Julie Delemazure, Thomas Similowski and Alexandre Demoule
    Citation: Annals of Intensive Care 2022 12:50
  39. Intensive care unit (ICU) patients often endure discomfort and distress brought about by their medical environment and the subjective experience of their stay. Distress, pain, and loss of control are important...

    Authors: Irma Bourgeon-Ghittori, Maryline Couette, Sylvie Marini, Rachida Ouedraogo, Aline Alves, Keyvan Razazi, Damien Carras, Ann-Cecile Pallud, Nancy Kentish-Barnes and Armand Mekontso Dessap
    Citation: Annals of Intensive Care 2022 12:49
  40. Organ shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be a valuable source of organs. Here, our objective was to identify factors associated with...

    Authors: M. Renaudier, Y. Binois, F. Dumas, L. Lamhaut, F. Beganton, D. Jost, J. Charpentier, O. Lesieur, E. Marijon, X. Jouven, A. Cariou and W. Bougouin
    Citation: Annals of Intensive Care 2022 12:48
  41. Septic shock remains a health care concern associated with significant morbidity and mortality. The Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock recommend early fluid resuscit...

    Authors: Mahmoud A. Ammar, Abdalla A. Ammar, Patrick M. Wieruszewski, Brittany D. Bissell, Micah T. Long, Lauren Albert, Ashish K. Khanna and Gretchen L. Sacha
    Citation: Annals of Intensive Care 2022 12:47
  42. Although the administration of fluid is the first treatment considered in almost all cases of circulatory failure, this therapeutic option poses two essential problems: the increase in cardiac output induced b...

    Authors: Xavier Monnet, Rui Shi and Jean-Louis Teboul
    Citation: Annals of Intensive Care 2022 12:46
  43. Hemadsorption of cytokines is used in critically ill patients with sepsis or septic shock. Concerns have been raised that the cytokine adsorber CytoSorb® unintentionally adsorbs vancomycin. This study aimed to qu...

    Authors: Christina Scharf, Ferdinand Weinelt, Ines Schroeder, Michael Paal, Michael Weigand, Michael Zoller, Michael Irlbeck, Charlotte Kloft, Josef Briegel and Uwe Liebchen
    Citation: Annals of Intensive Care 2022 12:44
  44. Hospital-acquired pneumonia (HAP) is the most common and severe complication in patients treated with venoarterial extracorporeal membrane oxygenation (VA ECMO) and its diagnosis remains challenging. Nothing i...

    Authors: Jean Pasqueron, Pauline Dureau, Gauthier Arcile, Baptiste Duceau, Geoffroy Hariri, Victoria Lepère, Guillaume Lebreton, Jean-Jacques Rouby and Adrien Bouglé
    Citation: Annals of Intensive Care 2022 12:43
  45. The impact of underlying comorbidities on the clinical presentation, management and outcomes in patients with ARDS is poorly understood and deserves further investigation.

    Authors: Emanuele Rezoagli, Bairbre A. McNicholas, Fabiana Madotto, Tài Pham, Giacomo Bellani and John G. Laffey
    Citation: Annals of Intensive Care 2022 12:42
  46. High-intensity noninvasive positive pressure ventilation (NPPV) is a novel ventilatory approach to maximally decreasing elevated arterial carbon dioxide tension (PaCO2) toward normocapnia with stepwise up-titrati...

    Authors: Zujin Luo, Zhixin Cao, Yichong Li, Jiawei Jin, Wei Sun, Jian Zhu, Na Zhao, Jichen Liu, Bing Wei, Yue Hu, Ying Zhang, Yingmin Ma and Chen Wang
    Citation: Annals of Intensive Care 2022 12:41

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:66

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2022 12:67

  47. Hyperoxia is associated with increased morbidity and mortality in the intensive care unit. Classical noninvasive measurements of oxygen saturation with pulse oximeters are unable to detect hyperoxia. The Oxyge...

    Authors: Hugues de Courson, Thomas Julien-Laferrière, Delphine Georges, Philippe Boyer, Eric Verchère and Matthieu Biais
    Citation: Annals of Intensive Care 2022 12:40

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