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  1. Research

    Response to different furosemide doses predicts AKI progression in ICU patients with elevated plasma NGAL levels

    Furosemide responsiveness (FR) is determined by urine output after furosemide administration and has recently been evaluated as a furosemide stress test (FST) for predicting severe acute kidney injury (AKI) pr...

    Ryo Matsuura, Yohei Komaru, Yoshihisa Miyamoto, Teruhiko Yoshida, Kohei Yoshimoto, Rei Isshiki, Kengo Mayumi, Tetsushi Yamashita, Yoshifumi Hamasaki, Masaomi Nangaku, Eisei Noiri, Naoto Morimura and Kent Doi

    Annals of Intensive Care 2018 8:8

    Published on: 17 January 2018

  2. Research

    Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study

    There is no consensus on the management of anticoagulation during extracorporeal membrane oxygenation (ECMO). ECMO is currently burdened by a high rate of hemostatic complications, possibly associated with ina...

    Mauro Panigada, Giacomo E. Iapichino, Matteo Brioni, Giovanna Panarello, Alessandro Protti, Giacomo Grasselli, Giovanna Occhipinti, Cristina Novembrino, Dario Consonni, Antonio Arcadipane, Luciano Gattinoni and Antonio Pesenti

    Annals of Intensive Care 2018 8:7

    Published on: 16 January 2018

  3. Research

    Quality of inter-hospital transportation in 431 transport survivor patients suffering from acute respiratory distress syndrome referred to specialist centers

    The acute respiratory distress syndrome (ARDS) is a life-threatening condition. In special situations, these critically ill patients must be transferred to specialized centers for escalating treatment. The aim...

    Sebastian Blecha, Frank Dodoo-Schittko, Susanne Brandstetter, Magdalena Brandl, Michael Dittmar, Bernhard M. Graf, Christian Karagiannidis, Christian Apfelbacher and Thomas Bein

    Annals of Intensive Care 2018 8:5

    Published on: 15 January 2018

  4. Research

    Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus

    Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS‐CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients ...

    Mohammed S. Alshahrani, Anees Sindi, Fayez Alshamsi, Awad Al-Omari, Mohamed El Tahan, Bayan Alahmadi, Ahmed Zein, Naif Khatani, Fahad Al-Hameed, Sultan Alamri, Mohammed Abdelzaher, Amenah Alghamdi, Faisal Alfousan, Adel Tash, Wail Tashkandi, Rajaa Alraddadi…

    Annals of Intensive Care 2018 8:3

    Published on: 10 January 2018

  5. Research

    Nutrition delivery of a model-based ICU glycaemic control system

    Hyperglycaemia is commonplace in the adult intensive care unit (ICU), associated with increased morbidity and mortality. Effective glycaemic control (GC) can reduce morbidity and mortality, but has proven diff...

    Kent W. Stewart, J. Geoffrey Chase, Christopher G. Pretty and Geoffrey M. Shaw

    Annals of Intensive Care 2018 8:4

    Published on: 10 January 2018

  6. Research

    Cardiac function during weaning failure: the role of diastolic dysfunction

    Cardiac dysfunction is a common cause of weaning failure. Weaning shares some similarities with a cardiac stress test and may challenge active phases of the cardiac cycle-like ventricular contractility and rel...

    Ferran Roche-Campo, Alexandre Bedet, Emmanuel Vivier, Laurent Brochard and Armand Mekontso Dessap

    Annals of Intensive Care 2018 8:2

    Published on: 9 January 2018

  7. Research

    Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans

    The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic aci...

    Enrique de-Madaria, Xavier Molero, Laia Bonjoch, Josefina Casas, Karina Cárdenas-Jaén, Andrea Montenegro and Daniel Closa

    Annals of Intensive Care 2018 8:1

    Published on: 9 January 2018

  8. Research

    Patient–ventilator asynchrony during conventional mechanical ventilation in children

    We aimed (1) to describe the characteristics of patient–ventilator asynchrony in a population of critically ill children, (2) to describe the risk factors associated with patient–ventilator asynchrony, and (3)...

    Guillaume Mortamet, Alexandrine Larouche, Laurence Ducharme-Crevier, Olivier Fléchelles, Gabrielle Constantin, Sandrine Essouri, Amélie-Ann Pellerin-Leblanc, Jennifer Beck, Christer Sinderby, Philippe Jouvet and Guillaume Emeriaud

    Annals of Intensive Care 2017 7:122

    Published on: 20 December 2017

  9. Research

    Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome

    Among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS), apart from acute cor pulmonale (ACP), the frequency and prognostic impact of basic critical care echocardiography (BCCE...

    Kay Choong See, Jeffrey Ng, Wen Ting Siow, Venetia Ong and Jason Phua

    Annals of Intensive Care 2017 7:120

    Published on: 19 December 2017

  10. Research

    Application of updated guidelines on diastolic dysfunction in patients with severe sepsis and septic shock

    Left ventricular diastolic dysfunction is suggested to be associated with higher mortality in severe sepsis and septic shock, yet the methods of diagnosis described in the literature are often inconsistent. Th...

    David J. Clancy, Timothy Scully, Michel Slama, Stephen Huang, Anthony S. McLean and Sam R. Orde

    Annals of Intensive Care 2017 7:121

    Published on: 19 December 2017

  11. Research

    Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

    Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality. Immunothrombosis-induced coagulopathy may contribute to hypercoa...

    Julie Helms, Raphaël Clere-Jehl, Elsa Bianchini, Pierrick Le Borgne, Mélanie Burban, Fatiha Zobairi, Jean-Luc Diehl, Lelia Grunebaum, Florence Toti, Ferhat Meziani and Delphine Borgel

    Annals of Intensive Care 2017 7:118

    Published on: 8 December 2017

  12. Review

    Immunohaemostasis: a new view on haemostasis during sepsis

    Host infection by a micro-organism triggers systemic inflammation, innate immunity and complement pathways, but also haemostasis activation. The role of thrombin and fibrin generation in host defence is now re...

    Xavier Delabranche, Julie Helms and Ferhat Meziani

    Annals of Intensive Care 2017 7:117

    Published on: 2 December 2017

  13. Research

    Does metformin exposure before ICU stay have any impact on patients’ outcome? A retrospective cohort study of diabetic patients

    Impact of metformin exposure before ICU stay remains controversial. Metformin is thought to induce lactic acidosis and haemodynamic instability but may reduce ICU mortality. We evaluated its influence on outco...

    Sebastien Jochmans, Jean-Emmanuel Alphonsine, Jonathan Chelly, Ly Van Phach Vong, Oumar Sy, Nathalie Rolin, Olivier Ellrodt, Mehran Monchi and Christophe Vinsonneau

    Annals of Intensive Care 2017 7:116

    Published on: 2 December 2017

  14. Review

    Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

    Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened...

    Antoine Dewitte, Sébastien Lepreux, Julien Villeneuve, Claire Rigothier, Christian Combe, Alexandre Ouattara and Jean Ripoche

    Annals of Intensive Care 2017 7:115

    Published on: 1 December 2017

  15. Review

    Piperacillin–tazobactam as alternative to carbapenems for ICU patients

    Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteria...

    Benoit Pilmis, Vincent Jullien, Alexis Tabah, Jean-Ralph Zahar and Christian Brun-Buisson

    Annals of Intensive Care 2017 7:113

    Published on: 10 November 2017

  16. Research

    Venovenous extracorporeal membrane oxygenation devices-related colonisations and infections

    Nosocomial infections occurring during extracorporeal membrane oxygenation (ECMO) support have already been reported, but few studied infections directly related to ECMO devices. This study aims to evaluate t...

    Guillemette Thomas, Sami Hraiech, Nadim Cassir, Samuel Lehingue, Romain Rambaud, Sandrine Wiramus, Christophe Guervilly, Fanny Klasen, Mélanie Adda, Stéphanie Dizier, Antoine Roch, Laurent Papazian and Jean-Marie Forel

    Annals of Intensive Care 2017 7:111

    Published on: 7 November 2017

  17. Research

    Admission of tetanus patients to the ICU: a retrospective multicentre study

    An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a significant impact on short- and long-term survival. The subject is noteworthy and d...

    Rafael Mahieu, Thomas Reydel, Adel Maamar, Jean-Marc Tadié, Angeline Jamet, Arnaud W. Thille, Nicolas Chudeau, Julien Huntzinger, Steven Grangé, Gaetan Beduneau, Anne Courte, Stephane Ehrmann, Jérémie Lemarié, Sébastien Gibot, Michael Darmon, Christophe Guitton…

    Annals of Intensive Care 2017 7:112

    Published on: 7 November 2017

  18. Research

    Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation

    No single anticoagulant has been proven effective for sepsis-associated disseminated intravascular coagulation (DIC). Thus, the concomitant use of antithrombin concentrate and recombinant thrombomodulin has be...

    Toshiaki Iba, Akiyoshi Hagiwara, Daizoh Saitoh, Hideaki Anan, Yutaka Ueki, Koichi Sato and Satoshi Gando

    Annals of Intensive Care 2017 7:110

    Published on: 2 November 2017

  19. Research

    Incidence of airway complications in patients using endotracheal tubes with continuous aspiration of subglottic secretions

    Continuous aspiration of subglottic secretions is effective in preventing ventilator-associated pneumonia, but it involves a risk of mucosal damage. The main objective of our study was to determine the inciden...

    Jordi Vallés, Susana Millán, Emili Díaz, Eva Castanyer, Xavier Gallardo, Ignacio Martín-Loeches, Marta Andreu, Mario Prenafeta, Paula Saludes, Jorge Lema, Montse Batlle, Néstor Bacelar and Antoni Artigas

    Annals of Intensive Care 2017 7:109

    Published on: 2 November 2017

  20. Research

    Risk stratification using SpO2/FiO2 and PEEP at initial ARDS diagnosis and after 24 h in patients with moderate or severe ARDS

    We assessed the potential of risk stratification of ARDS patients using SpO2/FiO2 and positive end-expiratory pressure (PEEP) at ARDS onset and after 24 h.

    Luigi Pisani, Jan-Paul Roozeman, Fabienne D. Simonis, Antonio Giangregorio, Sophia M. van der Hoeven, Laura R. Schouten, Janneke Horn, Ary Serpa Neto, Emir Festic, Arjen M. Dondorp, Salvatore Grasso, Lieuwe D. Bos and Marcus J. Schultz

    Annals of Intensive Care 2017 7:108

    Published on: 25 October 2017

  21. Research

    Anemia at pediatric intensive care unit discharge: prevalence and risk markers

    Anemia is prevalent at pediatric intensive care unit (PICU) admission and incident during PICU stay, but little is known about anemia at PICU discharge . Anemia after critical illness is an important issue bec...

    Pierre Demaret, Oliver Karam, Marisa Tucci, Jacques Lacroix, Hélène Behal, Alain Duhamel, Frédéric Lebrun, André Mulder and Stéphane Leteurtre

    Annals of Intensive Care 2017 7:107

    Published on: 24 October 2017

  22. Research

    Protective effect of early low-dose hydrocortisone on ventilator-associated pneumonia in the cancer patients: a propensity score analysis

    Ventilator-associated pneumonia (VAP) is a care-related event that could be promoted by immune suppression caused by critical diseases, malignancies and cancer treatments. Low dose of hydrocortisone was propos...

    David Lagier, Laura Platon, Jérome Lambert, Laurent Chow-Chine, Antoine Sannini, Magali Bisbal, Jean-Paul Brun, Karim Asehnoune, Marc Leone, Marion Faucher and Djamel Mokart

    Annals of Intensive Care 2017 7:106

    Published on: 23 October 2017

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