Articles

Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study

Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase ...

Authors: Rene A. Posma, Trine Frøslev, Bente Jespersen, Iwan C. C. van der Horst, Daan J. Touw, Reimar W. Thomsen, Maarten W. Nijsten and Christian F. Christiansen

Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study

Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS). Although increased dead-space ventilation (V_D/V_T) has been described in ARDS, its mechanism is not clearly und...

Authors: Gustavo A. Ospina-Tascón, Diego F. Bautista, Humberto J. Madriñán, Juan D. Valencia, William F. Bermúdez, Edgardo Quiñones, Luis Eduardo Calderón-Tapia, Glenn Hernandez, Alejandro Bruhn and Daniel De Backer

Adjunctive corticosteroids may be associated with better outcome for non-HIV Pneumocystis pneumonia with respiratory failure: a systemic review and meta-analysis of observational studies

Evidence supporting corticosteroids adjunctive treatment (CAT) for Pneumocystis jirovecii pneumonia (PCP) in non-HIV patients is highly controversial. We aimed to systematically review the literature and perform ...

Authors: Lin Ding, Huixue Huang, Heyan Wang and Hangyong He

Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province

Authors: Qin Sun, Haibo Qiu, Mao Huang and Yi Yang

Prescription of CRRT: a pathway to optimize therapy

Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is associated with prolonged hospitalization, progression to chronic kidney disease (CKD), financial burden, and high mortalit...

Authors: Ayman Karkar and Claudio Ronco

Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method

High-frequency oscillatory ventilation (HFOV) may theoretically provide lung protective ventilation. The negative clinical results may be due to inadequate mean airway pressure (mPaw) settings in HFOV. Our obj...

Authors: Songqiao Liu, Zhanqi Zhao, Li Tan, Lihui Wang, Knut Möller, Inéz Frerichs, Tao Yu, Yingzi Huang, Chun Pan, Yi Yang and Haibo Qiu

Comparison between watchful waiting strategy and early initiation of renal replacement therapy in the critically ill acute kidney injury population: an updated systematic review and meta-analysis

The optimal timing of renal replacement therapy (RRT) initiation is debatable. Many articles in this field enrolled trials not based on acute kidney injury. The safety of the watchful waiting strategy has not ...

Authors: Jia-Jin Chen, Cheng-Chia Lee, George Kuo, Pei-Chun Fan, Chan-Yu Lin, Su-Wei Chang, Ya-Chung Tian, Yung-Chang Chen and Chih-Hsiang Chang

Correction to: Changes in the clinical presentation and outcomes of patients treated for severe malaria in a referral French university intensive care unit from 2004 to 2017

After publication of the original article [1], we were notified that family names have been exchanged with the first names for all authors. Below the name are tagged correctly:

Authors: Jordane Lebut, Bruno Mourvillier, Nicolas Argy, Claire Dupuis, Camille Vinclair, Aguila Radjou, Etienne de Montmollin, Fabrice Sinnah, Juliette Patrier, Clément Le Bihan, Eric Magalahes, Roland Smonig, Eric Kendjo, Marc Thellier, Stéphane Ruckly, Lila Bouadma…

Transpulmonary thermodilution detects rapid and reversible increases in lung water induced by positive end-expiratory pressure in acute respiratory distress syndrome

It has been suggested that, by recruiting lung regions and enlarging the distribution volume of the cold indicator, increasing the positive end-expiratory pressure (PEEP) may lead to an artefactual overestimat...

Authors: Francesco Gavelli, Jean-Louis Teboul, Danila Azzolina, Alexandra Beurton, Temistocle Taccheri, Imane Adda, Christopher Lai, Gian Carlo Avanzi and Xavier Monnet

Short- and long-term renal outcomes following severe rhabdomyolysis: a French multicenter retrospective study of 387 patients

Rhabdomyolysis is a life-threatening disease that can lead to severe hyperkalemia, acute kidney injury (AKI) and hypovolemic shock. The predictive factors of AKI and acute to chronic kidney disease (CKD) trans...

Authors: Nelly Candela, Stein Silva, Bernard Georges, Claire Cartery, Thomas Robert, Julie Moussi-Frances, Eric Rondeau, Jean-Michel Rebibou, Laurence Lavayssiere, Julie Belliere, Thierry Krummel, Céline Lebas, Olivier Cointault, Marion Sallee and Stanislas Faguer

Impact of corticosteroid treatment on clinical outcomes of influenza-associated ARDS: a nationwide multicenter study

Corticosteroid treatment has been widely used in the treatment of septic shock, influenza, and ARDS, although some previous studies discourage its use in severe influenza patients. This multicenter retrospecti...

Authors: Ming-Ju Tsai, Kuang-Yao Yang, Ming-Cheng Chan, Kuo-Chin Kao, Hao-Chien Wang, Wann-Cherng Perng, Chieh-Liang Wu, Shinn-Jye Liang, Wen-Feng Fang, Jong-Rung Tsai, Wei-An Chang, Ying-Chun Chien, Wei-Chih Chen, Han-Chung Hu, Chiung-Yu Lin, Wen-Cheng Chao…

Natural light exposure and delirium in ICU: does the dark side cloud everything?

Authors: Romain Sonneville, Roland Smonig, Claire Dupuis, Lila Bouadma, Etienne de Montmollin and Jean-François Timsit

Feasibility, reproducibility and diagnostic usefulness of right ventricular strain by 2-dimensional speckle-tracking echocardiography in ARDS patients: the ARD strain study

Right ventricular (RV) function evaluation by echocardiography is key in the management of ICU patients with acute respiratory distress syndrome (ARDS), however, it remains challenging. Quantification of RV de...

Authors: Jérémie Lemarié, Charles-Henri Maigrat, Antoine Kimmoun, Nathalie Dumont, Pierre-Edouard Bollaert, Christine Selton-Suty, Sébastien Gibot and Olivier Huttin

Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review

The primary aim of the present contribution is to find a literature-based agreement on dose adjustments of vitamin C in critically ill patients undergoing renal replacement therapy (RRT).

Authors: Patrick M. Honore, Herbert D. Spapen, Paul Marik, Willem Boer and Heleen Oudemans-van Straaten

Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery?

Authors: Mina Khorashadi, Michael P. Bokoch and Matthieu Legrand

Changes in the clinical presentation and outcomes of patients treated for severe malaria in a referral French university intensive care unit from 2004 to 2017

In France, the incidence of severe imported malaria cases increased since early 2000. Artesunate was available (temporarily use authorization) since mid-2011 in France and commonly used for severe malaria sinc...

Authors: Jordane Lebut, Bruno Mourvillier, Nicolas Argy, Claire Dupuis, Camille Vinclair, Aguila Radjou, Etienne de Montmollin, Fabrice Sinnah, Juliette Patrier, Clément Le Bihan, Eric Magalahes, Roland Smonig, Eric Kendjo, Marc Thellier, Stéphane Ruckly, Lila Bouadma…

Influence of deprivation on initial severity and prognosis of patients admitted to the ICU: the prospective, multicentre, observational IVOIRE cohort study

The influence of socioeconomic status on patient outcomes is unclear. We assessed the impact of socioeconomic deprivation on severity of illness at intensive care unit (ICU) admission, and on the risk of death...

Authors: Jean-Pierre Quenot, Julie Helms, Guylaine Labro, Auguste Dargent, Nicolas Meunier-Beillard, Elea Ksiazek, Pierre-Edouard Bollaert, Guillaume Louis, Audrey Large, Pascal Andreu, Christophe Bein, Jean-Philippe Rigaud, Pierre Perez, Raphaël Clere-Jehl, Hamid Merdji, Hervé Devilliers…

Ketoacidosis in type 1 diabetics: we should return to pediatric guidelines

Authors: Sébastien Redant, David De Bels, Jacques Massaut, Jacques Devriendt, Xavier Beretta-Piccoli, Rachid Attou and Patrick M. Honore

Proceedings of Réanimation 2020, the French Intensive Care Society International Congress

Authors:

Neurally adjusted ventilatory assist vs. pressure support to deliver protective mechanical ventilation in patients with acute respiratory distress syndrome: a randomized crossover trial

Protective mechanical ventilation is recommended for patients with acute respiratory distress syndrome (ARDS), but it usually requires controlled ventilation and sedation. Using neurally adjusted ventilatory a...

Authors: Fabia Diniz-Silva, Henrique T. Moriya, Adriano M. Alencar, Marcelo B. P. Amato, Carlos R. R. Carvalho and Juliana C. Ferreira

Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis

High glycemic variability (GV) is common in critically ill patients; however, the prevalence and mortality association with early GV in patients with sepsis remains unclear.

Authors: Wen-Cheng Chao, Chien-Hua Tseng, Chieh-Liang Wu, Sou-Jen Shih, Chi-Yuan Yi and Ming-Cheng Chan

Natural versus artificial light exposure on delirium incidence in ARDS patients

Authors: Amir Vahedian-Azimi, Farshid R. Bashar, Abbas M. Khan and Andrew C. Miller

External validity of Adult Sepsis Event’s simplified eSOFA criteria: a retrospective analysis of patients with confirmed infection in China

The US Centers for Disease Control and Prevention (CDC) recently released simplified eSOFA organ dysfunction criteria of Adult Sepsis Event for sepsis surveillance in the US. Our study aimed to compare the pre...

Authors: Run Dong, Hongcheng Tian, Jianfang Zhou, Li Weng, Xiaoyun Hu, Jinmin Peng, Chunyao Wang, Wei Jiang, Xueping Du, Xiuming Xi, Youzhong An, Meili Duan and Bin Du

Ventilatory support and mechanical properties of the fibrotic lung acting as a “squishy ball”

Protective ventilation is the cornerstone of treatment of patients with the acute respiratory distress syndrome (ARDS); however, no studies have yet established the best ventilatory strategy to adopt when pati...

Authors: Alessandro Marchioni, Roberto Tonelli, Giulio Rossi, Paolo Spagnolo, Fabrizio Luppi, Stefania Cerri, Elisabetta Cocconcelli, Maria Rosaria Pellegrino, Riccardo Fantini, Luca Tabbì, Ivana Castaniere, Lorenzo Ball, Manu L. N. G. Malbrain, Paolo Pelosi and Enrico Clini

Prone positioning monitored by electrical impedance tomography in patients with severe acute respiratory distress syndrome on veno-venous ECMO

Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), t...

Authors: Guillaume Franchineau, Nicolas Bréchot, Guillaume Hekimian, Guillaume Lebreton, Simon Bourcier, Pierre Demondion, Loïc Le Guennec, Ania Nieszkowska, Charles-Edouard Luyt, Alain Combes and Matthieu Schmidt

An ultrasound limited test initiating medical airborne transportation (ULTIMAT-protocol): its impact in other settings in medicine

Authors: Daniel A. Lichtenstein

Herpesviridae reactivation for poor outcome in ARDS patients with ECMO: criminal or witness?

Authors: Huixue Huang and Hangyong He

Vasopressin and its analogues in shock states: a review

Activation of arginine–vasopressin is one of the hormonal responses to face vasodilation-related hypotension. Released from the post-pituitary gland, vasopressin induces vasoconstriction through the activation...

Authors: Julien Demiselle, Nicolas Fage, Peter Radermacher and Pierre Asfar

Response to Huang et al. “Herpesviridae reactivation for poor outcome in ARDS patients with ECMO: criminal or witness?”

Authors: Sami Hraiech and Laurent Papazian

Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code

Few validated biomarker or clinical score combinations exist which can discriminate between cases of infection and other non-infectious conditions following activation of an in-hospital sepsis code, as well as...

Authors: Jaume Baldirà, Juan Carlos Ruiz-Rodríguez, Darius Cameron Wilson, Adolf Ruiz-Sanmartin, Alejandro Cortes, Luis Chiscano, Roser Ferrer-Costa, Inma Comas, Nieves Larrosa, Anna Fàbrega, Juan José González-López and Ricard Ferrer

Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections

The aim of this study was to investigate the concordance between ventilator-associated events (VAE) and ventilator-associated lower respiratory tract infections (VA-LRTI), and their impact on outcome.

Authors: Olivier Pouly, Sylvain Lecailtel, Sophie Six, Sébastien Préau, Frédéric Wallet, Saad Nseir and Anahita Rouzé

Surfactant protein D (SP-D) gene polymorphism rs721917 is an independent predictor of acute kidney injury development in sepsis patients: a prospective cohort study

Currently, there are no reliable predictors of risk of development and severity of acute kidney injury (AKI) in septic patients. The surfactant protein D (SP-D) polymorphism rs721917C/T is associated with a gr...

Authors: Jiao Liu, Jianying Yao, Lidi Zhang, Yizhu Chen, Hangxiang Du, Zhenliang Wen and Dechang Chen

Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT >...

Authors: Amol T. Kothekar, Jigeeshu Vasishtha Divatia, Sheila Nainan Myatra, Anand Patil, Manjunath Nookala Krishnamurthy, Harish Mallapura Maheshwarappa, Suhail Sarwar Siddiqui, Murari Gurjar, Sanjay Biswas and Vikram Gota

Prevention and treatment of acute lung injury with time-controlled adaptive ventilation: physiologically informed modification of airway pressure release ventilation

Mortality in acute respiratory distress syndrome (ARDS) remains unacceptably high at approximately 39%. One of the only treatments is supportive: mechanical ventilation. However, improperly set mechanical vent...

Authors: Gary F. Nieman, Louis A. Gatto, Penny Andrews, Joshua Satalin, Luigi Camporota, Benjamin Daxon, Sarah J. Blair, Hassan Al-khalisy, Maria Madden, Michaela Kollisch-Singule, Hani Aiash and Nader M. Habashi

Nationwide survey on training and device utilization during tracheal intubation in French intensive care units

Intubation is a lifesaving procedure that is often performed in intensive care unit (ICU) patients, but leads to serious adverse events in 20–40% of cases. Recent trials aimed to provide guidance about which m...

Authors: M. Martin, P. Decamps, A. Seguin, C. Garret, L. Crosby, O. Zambon, A. F. Miailhe, E. Canet, J. Reignier and J. B. Lascarrou

ICU-acquired weakness, diaphragm dysfunction and long-term outcomes of critically ill patients

Intensive care unit (ICU)-acquired weakness and diaphragm dysfunction are frequent conditions, both associated with poor prognosis in critically ill patients. While it is well established that ICU-acquired wea...

Authors: Clément Saccheri, Elise Morawiec, Julie Delemazure, Julien Mayaux, Bruno-Pierre Dubé, Thomas Similowski, Alexandre Demoule and Martin Dres

Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO

Herpesviridae reactivation among non-immunocompromised critically ill patients is associated with impaired prognosis, especially during acute respiratory distress syndrome (ARDS). However, little is known about h...

Authors: Sami Hraiech, Eline Bonnardel, Christophe Guervilly, Cyprien Fabre, Anderson Loundou, Jean-Marie Forel, Mélanie Adda, Gabriel Parzy, Guilhem Cavaille, Benjamin Coiffard, Antoine Roch and Laurent Papazian

Gastrointestinal colonization with multidrug-resistant Gram-negative bacteria during extracorporeal membrane oxygenation: effect on the risk of subsequent infections and impact on patient outcome

In ICU patients, digestive tract colonization by multidrug-resistant (MDR) Gram-negative (G−) bacteria is a significant risk factor for the development of infections. In patients undergoing extracorporeal memb...

Authors: Giacomo Grasselli, Vittorio Scaravilli, Laura Alagna, Michela Bombino, Stefano De Falco, Alessandra Bandera, Chiara Abbruzzese, Nicolò Patroniti, Andrea Gori and Antonio Pesenti

Response to “Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score”

Authors: Jun Duan and Linfu Bai

Letter on “Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score”

Authors: Emna Ennouri, Khaoula Meddeb, Radhouane Toumi and Mohamed Boussarsar

How to detect a positive response to a fluid bolus when cardiac output is not measured?

Volume expansion is aimed at increasing cardiac output (CO), but this variable is not always directly measured. We assessed the ability of changes in arterial pressure, pulse pressure variation (PPV) and heart...

Authors: Zakaria Ait-Hamou, Jean-Louis Teboul, Nadia Anguel and Xavier Monnet

Low-pressure support vs automatic tube compensation during spontaneous breathing trial for weaning

During spontaneous breathing trial, low-pressure support is thought to compensate for endotracheal tube resistance, but it actually should provide overassistance. Automatic tube compensation is an option avail...

Authors: Claude Guérin, Nicolas Terzi, Mehdi Mezidi, Loredana Baboi, Nader Chebib, Hodane Yonis, Laurent Argaud, Leo Heunks and Bruno Louis

Correction to: Serum sodium and intracranial pressure changes after desmopressin therapy in severe traumatic brain injury patients: a multi-centre cohort study

Following publication of the original article [1], we were notified that the collaborators’ names part of the “The TBI Collaborative” group has not been indexed in Pubmed. Below the collaborators names full list:

Authors: A. Harrois, J. R. Anstey, F. S. Taccone, A. A. Udy, G. Citerio, J. Duranteau, C. Ichai, R. Badenes, J. R. Prowle, A. Ercole, M. Oddo, A. Schneider, M. van der Jagt, S. Wolf, R. Helbok, D. W. Nelson…

IgM-enriched immunoglobulins (Pentaglobin) may improve the microcirculation in sepsis: a pilot randomized trial

Polyclonal or IgM-enriched immunoglobulins may be beneficial during sepsis as an adjuvant immunomodulatory therapy. We aimed to test whether the infusion of IgM-enriched immunoglobulins improves microvascular ...

Authors: Roberta Domizi, Erica Adrario, Elisa Damiani, Claudia Scorcella, Andrea Carsetti, Paolo Giaccaglia, Erika Casarotta, Vincenzo Gabbanelli, Simona Pantanetti, Elena Lamura, Silvia Ciucani and Abele Donati

“I had the feeling that I was trapped”: a bedside qualitative study of cognitive and affective attitudes toward noninvasive ventilation in patients with acute respiratory failure

Noninvasive ventilation (NIV) is the application of mechanical ventilation through a mask. It is used to treat certain forms of acute respiratory failure in intensive care units (ICU). NIV has clinical benefit...

Authors: Marina Iosifyan, Matthieu Schmidt, Amélie Hurbault, Julien Mayaux, Christian Delafosse, Marina Mishenko, Nathalie Nion, Alexandre Demoule and Thomas Similowski

Epidemiology, clinical features, and management of severe hypercalcemia in critically ill patients

Severe hypercalcemia (HCM) is a common reason for admission in intensive-care unit (ICU). This case series aims to describe the clinical and biological features, etiologies, treatments, and outcome associated ...

Authors: Cyril Mousseaux, Axelle Dupont, Cédric Rafat, Kenneth Ekpe, Etienne Ghrenassia, Lionel Kerhuel, Fanny Ardisson, Eric Mariotte, Virginie Lemiale, Benoît Schlemmer, Elie Azoulay and Lara Zafrani

Survey of non-resuscitation fluids administered during septic shock: a multicenter prospective observational study

The indication, composition and timing of administration of non-resuscitation fluid in septic shock have so far received little attention and accordingly the potential to reduce this source of fluid is unknown...

Authors: Anja Lindén-Søndersø, Mårten Jungner, Martin Spångfors, Mohammed Jan, Adam Oscarson, Sally Choi, Thomas Kander, Johan Undén, Donald Griesdale, John Boyd and Peter Bentzer

Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study

Pneumocystis jirovecii pneumonia (PJP) remains a severe disease associated with high rates of invasive mechanical ventilation (MV) and mortality. The objectives of this study were to assess early risk factors for...

Authors: Benjamin Jean Gaborit, Benoit Tessoulin, Rose-Anne Lavergne, Florent Morio, Christine Sagan, Emmanuel Canet, Raphael Lecomte, Paul Leturnier, Colin Deschanvres, Lydie Khatchatourian, Nathalie Asseray, Charlotte Garret, Michael Vourch, Delphine Marest, François Raffi, David Boutoille…

Intra-aortic balloon pump does not influence cerebral hemodynamics and neurological outcomes in high-risk cardiac patients undergoing cardiac surgery: an analysis of the IABCS trial

The intra-aortic balloon pump (IABP) is often used in high-risk patients undergoing cardiac surgery to improve coronary perfusion and decrease afterload. The effects of the IABP on cerebral hemodynamics are un...

Authors: Juliana R. Caldas, Ronney B. Panerai, Edson Bor-Seng-Shu, Graziela S. R. Ferreira, Ligia Camara, Rogério H. Passos, Angela M. Salinet, Daniel S. Azevedo, Marcelo de-Lima-Oliveira, Filomena R. B. G. Galas, Julia T. Fukushima, Ricardo Nogueira, Fabio S. Taccone, Giovanni Landoni, Juliano P. Almeida, Thompson G. Robinson…

Effect of nitric oxide on postoperative acute kidney injury in patients who underwent cardiopulmonary bypass: a systematic review and meta-analysis with trial sequential analysis

The effect of nitric oxide (NO) on renal function is controversial in critical illness. We performed a systematic meta-analysis and trial sequential analysis to determine the effect of NO gas on renal function...

Authors: Jie Hu, Stefano Spina, Francesco Zadek, Nikolay O. Kamenshchikov, Edward A. Bittner, Juan Pedemonte and Lorenzo Berra