Articles

Vasopressin and its analogues in shock states: a review

Activation of arginine–vasopressin is one of the hormonal responses to face vasodilation-related hypotension. Released from the post-pituitary gland, vasopressin induces vasoconstriction through the activation...

Authors: Julien Demiselle, Nicolas Fage, Peter Radermacher and Pierre Asfar

Response to Huang et al. “Herpesviridae reactivation for poor outcome in ARDS patients with ECMO: criminal or witness?”

Authors: Sami Hraiech and Laurent Papazian

Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code

Few validated biomarker or clinical score combinations exist which can discriminate between cases of infection and other non-infectious conditions following activation of an in-hospital sepsis code, as well as...

Authors: Jaume Baldirà, Juan Carlos Ruiz-Rodríguez, Darius Cameron Wilson, Adolf Ruiz-Sanmartin, Alejandro Cortes, Luis Chiscano, Roser Ferrer-Costa, Inma Comas, Nieves Larrosa, Anna Fàbrega, Juan José González-López and Ricard Ferrer

Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections

The aim of this study was to investigate the concordance between ventilator-associated events (VAE) and ventilator-associated lower respiratory tract infections (VA-LRTI), and their impact on outcome.

Authors: Olivier Pouly, Sylvain Lecailtel, Sophie Six, Sébastien Préau, Frédéric Wallet, Saad Nseir and Anahita Rouzé

Surfactant protein D (SP-D) gene polymorphism rs721917 is an independent predictor of acute kidney injury development in sepsis patients: a prospective cohort study

Currently, there are no reliable predictors of risk of development and severity of acute kidney injury (AKI) in septic patients. The surfactant protein D (SP-D) polymorphism rs721917C/T is associated with a gr...

Authors: Jiao Liu, Jianying Yao, Lidi Zhang, Yizhu Chen, Hangxiang Du, Zhenliang Wen and Dechang Chen

Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT >...

Authors: Amol T. Kothekar, Jigeeshu Vasishtha Divatia, Sheila Nainan Myatra, Anand Patil, Manjunath Nookala Krishnamurthy, Harish Mallapura Maheshwarappa, Suhail Sarwar Siddiqui, Murari Gurjar, Sanjay Biswas and Vikram Gota

Prevention and treatment of acute lung injury with time-controlled adaptive ventilation: physiologically informed modification of airway pressure release ventilation

Mortality in acute respiratory distress syndrome (ARDS) remains unacceptably high at approximately 39%. One of the only treatments is supportive: mechanical ventilation. However, improperly set mechanical vent...

Authors: Gary F. Nieman, Louis A. Gatto, Penny Andrews, Joshua Satalin, Luigi Camporota, Benjamin Daxon, Sarah J. Blair, Hassan Al-khalisy, Maria Madden, Michaela Kollisch-Singule, Hani Aiash and Nader M. Habashi

Nationwide survey on training and device utilization during tracheal intubation in French intensive care units

Intubation is a lifesaving procedure that is often performed in intensive care unit (ICU) patients, but leads to serious adverse events in 20–40% of cases. Recent trials aimed to provide guidance about which m...

Authors: M. Martin, P. Decamps, A. Seguin, C. Garret, L. Crosby, O. Zambon, A. F. Miailhe, E. Canet, J. Reignier and J. B. Lascarrou

ICU-acquired weakness, diaphragm dysfunction and long-term outcomes of critically ill patients

Intensive care unit (ICU)-acquired weakness and diaphragm dysfunction are frequent conditions, both associated with poor prognosis in critically ill patients. While it is well established that ICU-acquired wea...

Authors: Clément Saccheri, Elise Morawiec, Julie Delemazure, Julien Mayaux, Bruno-Pierre Dubé, Thomas Similowski, Alexandre Demoule and Martin Dres

Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO

Herpesviridae reactivation among non-immunocompromised critically ill patients is associated with impaired prognosis, especially during acute respiratory distress syndrome (ARDS). However, little is known about h...

Authors: Sami Hraiech, Eline Bonnardel, Christophe Guervilly, Cyprien Fabre, Anderson Loundou, Jean-Marie Forel, Mélanie Adda, Gabriel Parzy, Guilhem Cavaille, Benjamin Coiffard, Antoine Roch and Laurent Papazian

Gastrointestinal colonization with multidrug-resistant Gram-negative bacteria during extracorporeal membrane oxygenation: effect on the risk of subsequent infections and impact on patient outcome

In ICU patients, digestive tract colonization by multidrug-resistant (MDR) Gram-negative (G−) bacteria is a significant risk factor for the development of infections. In patients undergoing extracorporeal memb...

Authors: Giacomo Grasselli, Vittorio Scaravilli, Laura Alagna, Michela Bombino, Stefano De Falco, Alessandra Bandera, Chiara Abbruzzese, Nicolò Patroniti, Andrea Gori and Antonio Pesenti

Response to “Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score”

Authors: Jun Duan and Linfu Bai

Letter on “Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score”

Authors: Emna Ennouri, Khaoula Meddeb, Radhouane Toumi and Mohamed Boussarsar

How to detect a positive response to a fluid bolus when cardiac output is not measured?

Volume expansion is aimed at increasing cardiac output (CO), but this variable is not always directly measured. We assessed the ability of changes in arterial pressure, pulse pressure variation (PPV) and heart...

Authors: Zakaria Ait-Hamou, Jean-Louis Teboul, Nadia Anguel and Xavier Monnet

Low-pressure support vs automatic tube compensation during spontaneous breathing trial for weaning

During spontaneous breathing trial, low-pressure support is thought to compensate for endotracheal tube resistance, but it actually should provide overassistance. Automatic tube compensation is an option avail...

Authors: Claude Guérin, Nicolas Terzi, Mehdi Mezidi, Loredana Baboi, Nader Chebib, Hodane Yonis, Laurent Argaud, Leo Heunks and Bruno Louis

Correction to: Serum sodium and intracranial pressure changes after desmopressin therapy in severe traumatic brain injury patients: a multi-centre cohort study

Following publication of the original article [1], we were notified that the collaborators’ names part of the “The TBI Collaborative” group has not been indexed in Pubmed. Below the collaborators names full list:

Authors: A. Harrois, J. R. Anstey, F. S. Taccone, A. A. Udy, G. Citerio, J. Duranteau, C. Ichai, R. Badenes, J. R. Prowle, A. Ercole, M. Oddo, A. Schneider, M. van der Jagt, S. Wolf, R. Helbok, D. W. Nelson…

IgM-enriched immunoglobulins (Pentaglobin) may improve the microcirculation in sepsis: a pilot randomized trial

Polyclonal or IgM-enriched immunoglobulins may be beneficial during sepsis as an adjuvant immunomodulatory therapy. We aimed to test whether the infusion of IgM-enriched immunoglobulins improves microvascular ...

Authors: Roberta Domizi, Erica Adrario, Elisa Damiani, Claudia Scorcella, Andrea Carsetti, Paolo Giaccaglia, Erika Casarotta, Vincenzo Gabbanelli, Simona Pantanetti, Elena Lamura, Silvia Ciucani and Abele Donati

“I had the feeling that I was trapped”: a bedside qualitative study of cognitive and affective attitudes toward noninvasive ventilation in patients with acute respiratory failure

Noninvasive ventilation (NIV) is the application of mechanical ventilation through a mask. It is used to treat certain forms of acute respiratory failure in intensive care units (ICU). NIV has clinical benefit...

Authors: Marina Iosifyan, Matthieu Schmidt, Amélie Hurbault, Julien Mayaux, Christian Delafosse, Marina Mishenko, Nathalie Nion, Alexandre Demoule and Thomas Similowski

Epidemiology, clinical features, and management of severe hypercalcemia in critically ill patients

Severe hypercalcemia (HCM) is a common reason for admission in intensive-care unit (ICU). This case series aims to describe the clinical and biological features, etiologies, treatments, and outcome associated ...

Authors: Cyril Mousseaux, Axelle Dupont, Cédric Rafat, Kenneth Ekpe, Etienne Ghrenassia, Lionel Kerhuel, Fanny Ardisson, Eric Mariotte, Virginie Lemiale, Benoît Schlemmer, Elie Azoulay and Lara Zafrani

Survey of non-resuscitation fluids administered during septic shock: a multicenter prospective observational study

The indication, composition and timing of administration of non-resuscitation fluid in septic shock have so far received little attention and accordingly the potential to reduce this source of fluid is unknown...

Authors: Anja Lindén-Søndersø, Mårten Jungner, Martin Spångfors, Mohammed Jan, Adam Oscarson, Sally Choi, Thomas Kander, Johan Undén, Donald Griesdale, John Boyd and Peter Bentzer

Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study

Pneumocystis jirovecii pneumonia (PJP) remains a severe disease associated with high rates of invasive mechanical ventilation (MV) and mortality. The objectives of this study were to assess early risk factors for...

Authors: Benjamin Jean Gaborit, Benoit Tessoulin, Rose-Anne Lavergne, Florent Morio, Christine Sagan, Emmanuel Canet, Raphael Lecomte, Paul Leturnier, Colin Deschanvres, Lydie Khatchatourian, Nathalie Asseray, Charlotte Garret, Michael Vourch, Delphine Marest, François Raffi, David Boutoille…

Intra-aortic balloon pump does not influence cerebral hemodynamics and neurological outcomes in high-risk cardiac patients undergoing cardiac surgery: an analysis of the IABCS trial

The intra-aortic balloon pump (IABP) is often used in high-risk patients undergoing cardiac surgery to improve coronary perfusion and decrease afterload. The effects of the IABP on cerebral hemodynamics are un...

Authors: Juliana R. Caldas, Ronney B. Panerai, Edson Bor-Seng-Shu, Graziela S. R. Ferreira, Ligia Camara, Rogério H. Passos, Angela M. Salinet, Daniel S. Azevedo, Marcelo de-Lima-Oliveira, Filomena R. B. G. Galas, Julia T. Fukushima, Ricardo Nogueira, Fabio S. Taccone, Giovanni Landoni, Juliano P. Almeida, Thompson G. Robinson…

Effect of nitric oxide on postoperative acute kidney injury in patients who underwent cardiopulmonary bypass: a systematic review and meta-analysis with trial sequential analysis

The effect of nitric oxide (NO) on renal function is controversial in critical illness. We performed a systematic meta-analysis and trial sequential analysis to determine the effect of NO gas on renal function...

Authors: Jie Hu, Stefano Spina, Francesco Zadek, Nikolay O. Kamenshchikov, Edward A. Bittner, Juan Pedemonte and Lorenzo Berra

Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS

Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and the ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. Thi...

Authors: Luis Morales-Quinteros, Marcus J. Schultz, Josep Bringué, Carolyn S. Calfee, Marta Camprubí, Olaf L. Cremer, Janneke Horn, Tom van der Poll, Pratik Sinha, Antonio Artigas and Lieuwe D. Bos

Targeted temperature management guided by the severity of hyperlactatemia for out-of-hospital cardiac arrest patients: a post hoc analysis of a nationwide, multicenter prospective registry

The International Liaison Committee on Resuscitation guidelines recommend target temperature management (TTM) between 32 and 36 °C for patients after out-of-hospital cardiac arrest, but did not indicate patien...

Authors: Tomoya Okazaki, Toru Hifumi, Kenya Kawakita and Yasuhiro Kuroda

Healthcare trajectories before and after critical illness: population-based insight on diverse patients clusters

The post intensive care syndrome (PICS) gathers various disabilities, associated with a substantial healthcare use. However, patients’ comorbidities and active medical conditions prior to intensive care unit (...

Authors: Youenn Jouan, Leslie Grammatico-Guillon, Noémie Teixera, Claire Hassen-Khodja, Christophe Gaborit, Charlotte Salmon-Gandonnière, Antoine Guillon and Stephan Ehrmann

Prediction of mortality in adult patients with sepsis using six biomarkers: a systematic review and meta-analysis

Angiopoietin-1 (Ang-1) and 2 (Ang-2), high mobility group box 1 (HMGB1), soluble receptor for advanced glycation endproducts (sRAGE), soluble triggering receptor expressed on myeloid cells 1 (sTREM1), and solu...

Authors: Andreas Pregernig, Mattia Müller, Ulrike Held and Beatrice Beck-Schimmer

Use of ultrasound-measured internal jugular vein collapsibility index to determine static intracardiac pressures in patients with presumed pulmonary hypertension

Bedside ultrasound helps to estimate volume status in critically ill patients and has traditionally relied on diameter, respiratory variation, and collapsibility of the inferior vena cava (IVC) to reflect flui...

Authors: Raj Parikh, Matthew Spring, Janice Weinberg, Christine C. Reardon and Harrison W. Farber

Impact of a multidisciplinary care bundle for necrotizing skin and soft tissue infections: a retrospective cohort study

Necrotizing skin and soft tissue infections (NSTIs) require both prompt medical and surgical treatment. The coordination of multiple urgent interventions by care bundles has improved outcome in other settings....

Authors: Tomas Urbina, Camille Hua, Emilie Sbidian, Romain Bosc, Françoise Tomberli, Raphael Lepeule, Jean-Winoc Decousser, Armand Mekontso Dessap, Olivier Chosidow and Nicolas de Prost

Effects of high-flow nasal cannula and non-invasive ventilation on inspiratory effort in hypercapnic patients with chronic obstructive pulmonary disease: a preliminary study

Non-invasive ventilation (NIV) is preferred as the initial ventilatory support to treat acute hypercapnic respiratory failure in patients with chronic obstructive pulmonary disease (COPD). High-flow nasal cann...

Authors: Nuttapol Rittayamai, Prapinpa Phuangchoei, Jamsak Tscheikuna, Nattakarn Praphruetkit and Laurent Brochard

Urgent need for a randomized controlled trial with only septic patients!

Authors: Sébastien Redant, Matthieu Legrand, Yael Langman, Alejandra Garcia Aguilar, Keitiane Kaefer, David De Bels, Rachid Attou, Kianoush Kashani and Patrick M. Honore

Impact of natural light exposure on delirium burden in adult patients receiving invasive mechanical ventilation in the ICU: a prospective study

To determine whether potential exposure to natural light via windows is associated with reduced delirium burden in critically ill patients admitted to the ICU in a single room.

Authors: Roland Smonig, Eric Magalhaes, Lila Bouadma, Olivier Andremont, Etienne de Montmollin, Fatiah Essardy, Bruno Mourvillier, Jordane Lebut, Claire Dupuis, Mathilde Neuville, Mathilde Lermuzeaux, Jean-François Timsit and Romain Sonneville

Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest

Growth differentiation factor 15 (GDF-15) is an inflammatory cytokine released in response to tissue injury. It has prognostic value in cardiovascular diseases and other acute and chronic conditions. Here, we ...

Authors: Ferran Rueda, Germán Cediel, Cosme García-García, Júlia Aranyó, Marta González-Lopera, M. Cruz Aranda Nevado, Judith Serra Gregori, Teresa Oliveras, Carlos Labata, Marc Ferrer, Nabil El Ouaddi and Antoni Bayés-Genís

Use of MIRUS™ for MAC-driven application of isoflurane, sevoflurane, and desflurane in postoperative ICU patients: a randomized controlled trial

The MIRUS™ (TIM, Koblenz, Germany) is an electronical gas delivery system, which offers an automated MAC (minimal alveolar concentration)-driven application of isoflurane, sevoflurane, or desflurane, and can b...

Authors: Martin Bellgardt, Adrian Iustin Georgevici, Mitja Klutzny, Dominik Drees, Andreas Meiser, Philipp Gude, Heike Vogelsang, Thomas Peter Weber and Jennifer Herzog-Niescery

Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre study

Dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variations and stroke volume variations, has been proposed to assess functional arterial load. We evaluated the evolution of Eady...

Authors: Hugues de Courson, Philippe Boyer, Romain Grobost, Romain Lanchon, Musa Sesay, Karine Nouette-Gaulain, Emmanuel Futier and Matthieu Biais

Evaluation of least significant changes of pulse contour analysis-derived parameters

Many maneuvers assessing fluid responsiveness (minifluid challenge, lung recruitment maneuver, end-expiratory occlusion test, passive leg raising) are considered as positive when small variations in cardiac in...

Authors: Hugues de Courson, Loic Ferrer, Grégoire Cane, Eric Verchère, Musa Sesay, Karine Nouette-Gaulain and Matthieu Biais

Management of severe asthma exacerbation: guidelines from the Société Française de Médecine d’Urgence, the Société de Réanimation de Langue Française and the French Group for Pediatric Intensive Care and Emergencies

The French Emergency Medicine Society, the French Intensive Care Society and the Pediatric Intensive Care and Emergency Medicine French-Speaking Group edited guidelines on severe asthma exacerbation (SAE) in a...

Authors: Philippe Le Conte, Nicolas Terzi, Guillaume Mortamet, Fekri Abroug, Guillaume Carteaux, Céline Charasse, Anthony Chauvin, Xavier Combes, Stéphane Dauger, Alexandre Demoule, Thibaut Desmettre, Stephan Ehrmann, Bénédicte Gaillard-Le Roux, Valérie Hamel, Boris Jung, Sabrina Kepka…

Physiological effects of high-flow oxygen in tracheostomized patients

High-flow oxygen therapy via nasal cannula (HFOT_NASAL) increases airway pressure, ameliorates oxygenation and reduces work of breathing. High-flow oxygen can be delivered through tracheostomy (HFOT_TRACHEAL), but ...

Authors: Daniele Natalini, Domenico L. Grieco, Maria Teresa Santantonio, Lucrezia Mincione, Flavia Toni, Gian Marco Anzellotti, Davide Eleuteri, Pierluigi Di Giannatale, Massimo Antonelli and Salvatore Maurizio Maggiore

Respiratory variations of inferior vena cava fail to predict fluid responsiveness in mechanically ventilated patients with isolated left ventricular dysfunction

Respiratory variation of inferior vena cava is problematic in predicting fluid responsiveness in patients with right ventricular dysfunction. However, its effectiveness in patients with isolated left ventricul...

Authors: Hongmin Zhang, Qing Zhang, Xiukai Chen, Xiaoting Wang and Dawei Liu

When one cannot see the forest for the trees: femoral dP/dt_max, LVEF and pulse pressure in critically ill patients

Authors: S. Vaquer, D. Chemla and X. Monnet

Assessing left ventricular systolic function with ejection fraction: using a double-edged knife as a hammer

Authors: M. Ignacio Monge García, Maurizio Cecconi and Michael R. Pinsky

Direct admission to the intensive care unit from the emergency department and mortality in critically ill hematology patients

The aim of this study was to assess the benefit of direct ICU admission from the emergency department (ED) compared to admission from wards, in patients with hematological malignancies requiring critical care.

Authors: Olivier Peyrony, Sylvie Chevret, Anne-Pascale Meert, Pierre Perez, Achille Kouatchet, Frédéric Pène, Djamel Mokart, Virginie Lemiale, Alexandre Demoule, Martine Nyunga, Fabrice Bruneel, Christine Lebert, Dominique Benoit, Adrien Mirouse and Elie Azoulay

Morpho-functional evaluation of lung aeration as a marker of sickle-cell acute chest syndrome severity in the ICU: a prospective cohort study

Acute chest syndrome (ACS) is the main cause of morbi-mortality in patients with sickle-cell disease in the intensive care unit (ICU). ACS definition encompasses many types of lung damage, making early detecti...

Authors: Marc Garnier, El Mahdi Hafiani, Charlotte Arbelot, Clarisse Blayau, Vincent Labbe, Katia Stankovic-Stojanovic, François Lionnet, Francis Bonnet, Jean-Pierre Fulgencio, Muriel Fartoukh and Christophe Quesnel

Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score

Early identification of noninvasive ventilation (NIV) failure is a promising strategy for reducing mortality in chronic obstructive pulmonary disease (COPD) patients. However, a risk-scoring system is lacking.

Authors: Jun Duan, Shengyu Wang, Ping Liu, Xiaoli Han, Yao Tian, Fan Gao, Jing Zhou, Junhuan Mou, Qian Qin, Jingrong Yu, Linfu Bai, Lintong Zhou and Rui Zhang

Correction to: Recruiting the microcirculation in septic shock

After publication of the original article [1], we were notified that an author’s name has been incorrectly spelled. Author’s first name is Hafid and the family name is Ait-Oufella (with a hyphen between Ait an...

Authors: Matthieu Legrand, Daniel De Backer, François Dépret and Hafid Ait-Oufella

Nephrotoxic drug burden among 1001 critically ill patients: impact on acute kidney injury

Nephrotoxic drug prescription may contribute to acute kidney injury (AKI) occurrence and worsening among critically ill patients and thus to associated morbidity and mortality. The objectives of this study wer...

Authors: Stephan Ehrmann, Julie Helms, Aurélie Joret, Laurent Martin-Lefevre, Jean-Pierre Quenot, Jean-Etienne Herbrecht, Dalila Benzekri-Lefevre, René Robert, Arnaud Desachy, Fréderic Bellec, Gaëtan Plantefeve, Anne Bretagnol, Auguste Dargent, Jean-Claude Lacherade, Ferhat Meziani, Bruno Giraudeau…

Withholding and withdrawing life-support in adults in emergency care: joint position paper from the French Intensive Care Society and French Society of Emergency Medicine

For many patients, notably among elderly nursing home residents, no plans about end-of-life decisions and palliative care are made. Consequently, when these patients experience life-threatening events, decisio...

Authors: Jean Reignier, Anne-Laure Feral-Pierssens, Thierry Boulain, Françoise Carpentier, Pierrick Le Borgne, Denis Del Nista, Gilles Potel, Sandrine Dray, Delphine Hugenschmitt, Alexandra Laurent, Agnès Ricard-Hibon, Thierry Vanderlinden and Tahar Chouihed

Accuracy of P0.1 measurements performed by ICU ventilators: a bench study

Occlusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well cor...

Authors: François Beloncle, Lise Piquilloud, Pierre-Yves Olivier, Alice Vuillermoz, Elise Yvin, Alain Mercat and Jean-Christophe Richard

Recruiting the microcirculation in septic shock

Authors: Matthieu Legrand, Daniel De Backer, François Dépret and Hafid Ait-Oufella

Predictors of successful separation from high-flow nasal oxygen therapy in patients with acute respiratory failure: a retrospective monocenter study

High-flow nasal oxygen therapy (HFOT) is a promising first-line therapy for acute respiratory failure. However, its weaning has never been investigated and could lead to unnecessary prolonged intensive-care un...

Authors: Maeva Rodriguez, Arnaud W. Thille, Florence Boissier, Anne Veinstein, Delphine Chatellier, René Robert, Sylvain Le Pape, Jean-Pierre Frat and Remi Coudroy