Articles

Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review

Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).

Authors: Yasser Sakr, Manuela Giovini, Marc Leone, Giacinto Pizzilli, Andreas Kortgen, Michael Bauer, Tommaso Tonetti, Gary Duclos, Laurent Zieleskiewicz, Samuel Buschbeck, V. Marco Ranieri and Elio Antonucci

Respiratory virus-associated infections in HIV-infected adults admitted to the intensive care unit for acute respiratory failure: a 6-year bicenter retrospective study (HIV-VIR study)

Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the epidemiology of respiratory viruses in this population.

Authors: Alexandre Elabbadi, Jérémie Pichon, Benoit Visseaux, Aurélie Schnuriger, Lila Bouadma, Quentin Philippot, Juliette Patrier, Vincent Labbé, Stéphane Ruckly, Muriel Fartoukh, Jean-François Timsit and Guillaume Voiriot

A preliminary study of intensivist-performed DVT ultrasound screening in trauma ICU patients (APSIT Study)

Multiple screening Duplex ultrasound scans (DUS) are performed in trauma patients at high risk of deep vein thrombosis (DVT) in the intensive care unit (ICU). Intensive care physician performed compression ult...

Authors: Lloyd Roberts, Tom Rozen, Deirdre Murphy, Adam Lawler, Mark Fitzgerald, Harry Gibbs, Kyle Brooks, Joshua F. Ihle, Tim Leong, Judit Orosz, Eldho Paul and Vinodh Bhagyalakshmi Nanjayya

Potential risks in using midodrine for persistent hypotension after cardiac surgery: a comparative cohort study

Persistent hypotension is a frequent complication after cardiac surgery with cardiopulmonary bypass (CPB). Midodrine, an orally administered alpha agonist, could potentially reduce intravenous vasopressor use ...

Authors: Jan-Alexis Tremblay, Philippe Laramée, Yoan Lamarche, André Denault, William Beaubien-Souligny, Anne-Julie Frenette, Loay Kontar, Karim Serri and Emmanuel Charbonney

Ultrasonographic assessment of parasternal intercostal muscles during mechanical ventilation

Although mechanical ventilation is a lifesaving treatment, abundant evidence indicates that its prolonged use (1 week or more) promotes respiratory muscle weakness due to both contractile dysfunction and atrop...

Authors: Paolo Formenti, Michele Umbrello, Martin Dres and Davide Chiumello

Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU

Data on the prevalence of bacterial and viral co-infections among patients admitted to the ICU for acute respiratory failure related to SARS-CoV-2 pneumonia are lacking. We aimed to assess the rate of bacteria...

Authors: Damien Contou, Aurore Claudinon, Olivier Pajot, Maïté Micaëlo, Pascale Longuet Flandre, Marie Dubert, Radj Cally, Elsa Logre, Megan Fraissé, Hervé Mentec and Gaëtan Plantefève

Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit

The French Society of Intensive Care Medicine (SRLF), jointly with the French-Speaking Group of Paediatric Emergency Rooms and Intensive Care Units (GFRUP) and the French-Speaking Association of Paediatric Sur...

Authors: Jean-François Timsit, Julien Baleine, Louis Bernard, Silvia Calvino-Gunther, Michael Darmon, Jean Dellamonica, Eric Desruennes, Marc Leone, Alain Lepape, Olivier Leroy, Jean-Christophe Lucet, Zied Merchaoui, Olivier Mimoz, Benoit Misset, Jean-Jacques Parienti, Jean-Pierre Quenot…

Acute kidney injury in patients with SARS-CoV-2 infection

Acute Kidney Injury (AKI) is a frequent complication of severe SARS-CoV-2 infection. Multiple mechanisms are involved in COVID-19-associated AKI, from direct viral infection and secondary inflammation to compl...

Authors: Adrien Joseph, Lara Zafrani, Asma Mabrouki, Elie Azoulay and Michael Darmon

Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospective study of pain control and intubation requirements

Nonintubated chest trauma patients with fractured ribs admitted to the intensive care unit (ICU) are at risk for complications and may require invasive ventilation at some point. Effective pain control is esse...

Authors: Konstantinos Bachoumas, Albrice Levrat, Aurélie Le Thuaut, Stéphane Rouleau, Samuel Groyer, Hervé Dupont, Paul Rooze, Nathanael Eisenmann, Timothée Trampont, Julien Bohé, Benjamin Rieu, Jean-Charles Chakarian, Aurélie Godard, Laura Frederici, Stephanie Gélinotte, Aurélie Joret…

The impact of critical illness on the expiratory muscles and the diaphragm assessed by ultrasound in mechanical ventilated children

Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact...

Authors: Marloes M. IJland, Joris Lemson, Johannes G. van der Hoeven and Leo M. A. Heunks

A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study

Capillary refill time (CRT) may improve more rapidly than lactate in response to increments in systemic flow. Therefore, it can be assessed more frequently during septic shock (SS) resuscitation. Hyperlactatem...

Authors: Eduardo Kattan, Glenn Hernández, Gustavo Ospina-Tascón, Emilio Daniel Valenzuela, Jan Bakker and Ricardo Castro

Prognostic performance of endothelial biomarkers to early predict clinical deterioration of patients with suspected bacterial infection and sepsis admitted to the emergency department

The objective of this study was to evaluate the ability of endothelial biomarkers to early predict clinical deterioration of patients admitted to the emergency department (ED) with a suspected sepsis. This was...

Authors: Thomas Lafon, Marie-Angélique Cazalis, Christine Vallejo, Karim Tazarourte, Sophie Blein, Alexandre Pachot, Pierre-François Laterre, Said Laribi and Bruno François

Gasping during refractory out-of-hospital cardiac arrest is a prognostic marker for favourable neurological outcome following extracorporeal cardiopulmonary resuscitation: a retrospective study

Gasping during cardiac arrest is associated with favourable neurological outcomes for out-of-hospital cardiac arrest. Moreover, while extracorporeal cardiopulmonary resuscitation (ECPR) performed for refractor...

Authors: Naofumi Bunya, Hirofumi Ohnishi, Kenshiro Wada, Ryuichiro Kakizaki, Takehiko Kasai, Nobutaka Nagano, Nobuaki Kokubu, Kei Miyata, Shuji Uemura, Keisuke Harada and Eichi Narimatsu

Mortality and morbidity of low-grade red blood cell transfusions in septic patients: a propensity score-matched observational study of a liberal transfusion strategy

Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but...

Authors: Caroline Ulfsdotter Nilsson, Peter Bentzer, Linnéa E. Andersson, Sofia A. Björkman, Fredrik P. Hanssson and Thomas Kander

Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak

The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome among...

Authors: Elie Azoulay, Jan De Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J. Schaller, Manu Shankar Hari, Mariangela Pellegrini, Michael Darmon, Jozef Kesecioglu and Maurizio Cecconi

Diastolic shock index (DSI) works… and it could be a quite useful tool

Authors: Gustavo A. Ospina-Tascón, Glenn Hernández and Jan Bakker

Is hypoxemia explained by intracardiac or intrapulmonary shunt in COVID-19-related acute respiratory distress syndrome?

Hypoxemia is the main feature of COVID-19-related acute respiratory distress syndrome (C-ARDS), but its underlying mechanisms are debated, especially in patients with low respiratory system elastance (Ers). We...

Authors: Paul Masi, François Bagate, Thomas d’Humières, Lara Al-Assaad, Laure Abou Chakra, Genevieve Derumeaux and Armand Mekontso Dessap

Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation

Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs witho...

Authors: Daniel E. Hurtado, Benjamín Erranz, Felipe Lillo, Mauricio Sarabia-Vallejos, Pablo Iturrieta, Felipe Morales, Katherine Blaha, Tania Medina, Franco Diaz and Pablo Cruces

Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)

In critically ill patients, tigecycline (TGC) remains an important therapeutic option due to its efficacy against multiresistant Gram-positive and Gram-negative bacteria. TGC is metabolized and eliminated pred...

Authors: Rawan Alraish, Sebastian G. Wicha, Otto R. Frey, Anka C. Roehr, Johann Pratschke, Martin Stockmann, Tilo Wuensch and Magnus Kaffarnik

P-SILI is not justification for intubation of COVID-19 patients

Authors: Martin J. Tobin, Franco Laghi and Amal Jubran

Cognitive and psychosocial outcomes of mechanically ventilated intensive care patients with and without delirium

Delirium is common in intensive care patients and is associated with short- and long-term adverse outcomes. We investigated the long-term risk of cognitive impairment and post-traumatic stress disorder (PTSD) ...

Authors: Daniella Bulic, Michael Bennett, Ekavi N. Georgousopoulou, Yahya Shehabi, Tai Pham, Jeffrey C. L. Looi and Frank M. P. van Haren

The diastolic shock index works… but, what is it?

Authors: Rafael Dalmau

Electrical impedance tomography: the solution for lung morphology assessment?

Authors: Florian Blanchard, Adrien Picod and Jean-Michel Constantin

Accuracy of the clinical pulmonary infection score to differentiate ventilator-associated tracheobronchitis from ventilator-associated pneumonia

Differentiating Ventilator-Associated Tracheobronchitis (VAT) from Ventilator-Associated Pneumonia (VAP) may be challenging for clinicians, yet their management currently differs. In this study, we evaluated t...

Authors: Alexandre Gaudet, Ignacio Martin-Loeches, Pedro Povoa, Alejandro Rodriguez, Jorge Salluh, Alain Duhamel and Saad Nseir

Assessing transpulmonary pressure via direct pleural manometry

Authors: Christopher Rugg, Stefan Schmid, Janett Kreutziger and Mathias Ströhle

Clinical outcomes of COVID-19 in Wuhan, China: a large cohort study

Since December 2019, an outbreak of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) initially emerged in Wuhan, China, and has spread worldwide no...

Authors: Jiao Liu, Sheng Zhang, Zhixiong Wu, You Shang, Xuan Dong, Guang Li, Lidi Zhang, Yizhu Chen, Xiaofei Ye, Hangxiang Du, Yongan Liu, Tao Wang, SiSi Huang, Limin Chen, Zhenliang Wen, Jieming Qu…

SARS-CoV-2 post-infective myocarditis: the tip of COVID-19 immune complications?

Recent paediatric cases of acute myocarditis following a SARS-CoV-2 infection have raised the possibility of post-infective complications of COVID-19. This short editorial is reviewing current understanding of...

Authors: Pierre Tissières and Jean-Louis Teboul

Management and prevention of anemia (acute bleeding excluded) in adult critical care patients

Anemia is very common in critical care patients, on admission (affecting about two-thirds of patients), but also during and after their stay, due to repeated blood loss, the effects of inflammation on erythrop...

Authors: Sigismond Lasocki, Frédéric Pène, Hafid Ait-Oufella, Cécile Aubron, Sylvain Ausset, Pierre Buffet, Olivier Huet, Yoann Launey, Matthieu Legrand, Thomas Lescot, Armand Mekontso Dessap, Michael Piagnerelli, Hervé Quintard, Lionel Velly, Antoine Kimmoun and Gérald Chanques

Advanced organ support (ADVOS) in the critically ill: first clinical experience in patients with multiple organ failure

Prevalence of multiple organ failure (MOF) in critically ill patients is increasing and associated mortality remains high. Extracorporeal organ support is a cornerstone in the management of MOF. We report data...

Authors: Valentin Fuhrmann, Theresa Weber, Kevin Roedl, Jasmin Motaabbed, Adel Tariparast, Dominik Jarczak, Aritz Perez Ruiz de Garibay, Johannes Kluwe, Olaf Boenisch, Harald Herkner, John A. Kellum and Stefan Kluge

Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study

COVID-19 ARDS could differ from typical forms of the syndrome.

Authors: J.-L. Diehl, N. Peron, R. Chocron, B. Debuc, E. Guerot, C. Hauw-Berlemont, B. Hermann, J. L. Augy, R. Younan, A. Novara, J. Langlais, L. Khider, N. Gendron, G. Goudot, J.-F. Fagon, T. Mirault…

Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections

In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We designed a prospective ...

Authors: Gennaro De Pascale, Lucia Lisi, Gabriella Maria Pia Ciotti, Maria Sole Vallecoccia, Salvatore Lucio Cutuli, Laura Cascarano, Camilla Gelormini, Giuseppe Bello, Luca Montini, Simone Carelli, Valentina Di Gravio, Mario Tumbarello, Maurizio Sanguinetti, Pierluigi Navarra and Massimo Antonelli

Response to the letter of Morán et al. regarding our use of an inaccurate reference for the maximal dose of vitamin C in G6PD deficiency

Authors: Patrick M. Honore, Herbert D. Spapen, Paul Marik, Willem Boer and Heleen Oudemans-van Straaten

Performances of disseminated intravascular coagulation scoring systems in septic shock patients

There is no gold standard to diagnose septic shock-induced disseminated intravascular coagulation (DIC). The objective of our multicenter prospective study was to assess the performances of the different major...

Authors: Julie Helms, François Severac, Hamid Merdji, Raphaël Clere-Jehl, Bruno François, Emmanuelle Mercier, Jean-Pierre Quenot and Ferhat Meziani

Impact of the perioperative inotropic support in grown-up congenital heart patients undergoing cardiac surgery: a propensity score adjusted analysis

Grown-up congenital heart (GUCH) patients represent a growing population with a high morbidity risk when undergoing reparative surgery. A main preoperative feature is right ventricular failure, which represent...

Authors: Philippe Mauriat, Mirela Bojan, Sylvie Soulie, Hélène Foulgoc, Nadir Tafer and Alexandre Ouattara

Comparison of the proximal and distal approaches for axillary vein catheterization under ultrasound guidance (PANDA) in cardiac surgery patients susceptible to bleeding: a randomized controlled trial

The present study aimed at comparing the success rate and safety of proximal versus distal approach for ultrasound (US)-guided axillary vein catheterization (AVC) in cardiac surgery patients susceptible to ble...

Authors: Ying Su, Jun-yi Hou, Guo-guang Ma, Guang-wei Hao, Jing-chao Luo, Shen-ji Yu, Kai Liu, Ji-li Zheng, Yan Xue, Zhe Luo and Guo-wei Tu

Ultrasound guidance and risk for intravascular catheter-related infections among peripheral arterial catheters: a post-hoc analysis of two large randomized-controlled trials

The impact on infectious risk of ultrasound guidance at insertion remains controversial in short-term arterial catheters (ACs). The present study investigated the association between ultrasound guidance (US) d...

Authors: Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Lila Bouadma, Carole Schwebel, Olivier Mimoz and Jean-François Timsit

Spontaneous breathing, transpulmonary pressure and mathematical trickery

Authors: Luciano Gattinoni, John J. Marini, Mattia Busana, Davide Chiumello and Luigi Camporota

Commentary to “Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review”

Authors: J. M. Morán and I. Herrera-Peco

Clinical outcomes according to cannula configurations in patients with acute respiratory distress syndrome under veno-venous extracorporeal membrane oxygenation: a Korean multicenter study

Recirculation during veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a known drawback that limits sufficient oxygenation. This study aimed to compare the short-term oxygenation and long-term morta...

Authors: Sung Yoon Lim, Soyeon Ahn, Sang-Bum Hong, Chi Ryang Chung, Kyeongman Jeon, Sang-Min Lee, Woo Hyun Cho, Sunghoon Park and Young-Jae Cho

Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review

The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans, secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such as albumin and antithrombin associat...

Authors: Cesar Aldecoa, Juan V. Llau, Xavier Nuvials and Antonio Artigas

Ethical dilemmas due to the Covid-19 pandemic

The devastating pandemic that has stricken the worldwide population induced an unprecedented influx of patients in ICUs, raising ethical concerns not only surrounding triage and withdrawal of life support deci...

Authors: René Robert, Nancy Kentish-Barnes, Alexandre Boyer, Alexandra Laurent, Elie Azoulay and Jean Reignier

Multidisciplinary team approach in acute myocardial infarction patients undergoing veno-arterial extracorporeal membrane oxygenation

Limited data are available on the impact of a specialized extracorporeal membrane oxygenation (ECMO) team on clinical outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shoc...

Authors: David Hong, Ki Hong Choi, Yang Hyun Cho, Su Hyun Cho, So Jin Park, Darae Kim, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Kiick Sung, Hyeon-Cheol Gwon, Eun-Seok Jeon…

Impact of prior antibiotics on infected pancreatic necrosis microbiology in ICU patients: a retrospective cohort study

Recent guidelines advise against prophylactic antibiotics in patients with necrotizing pancreatitis, advocating instead a step-up drainage and necrosectomy strategy with antibiotics as dictated by microbiologi...

Authors: Charlotte Garret, Emmanuel Canet, Stéphane Corvec, David Boutoille, Matthieu Péron, Isabelle Archambeaud, Aurélie Le Thuaut, Jean-Baptiste Lascarrou, Frédéric Douane, Marc Lerhun, Nicolas Regenet, Emmanuel Coron and Jean Reignier

High-dose methotrexate in ICU patients: a retrospective study

High-dose methotrexate (HD-MTX) is commonly used in the treatment of solid tumors and hematological malignancies. Severe toxicities are frequent, leading to organ dysfunction and death. Risk–benefit ratio of u...

Authors: Sandrine Valade, Eric Mariotte, Elie Azoulay and Michael Darmon

Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial

Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sep...

Authors: Shih-Hong Chen, Wing-Sum Chan, Chih-Min Liu, Ching-Tang Chiu, Anne Chao, Vin-Cent Wu, Wang-Huei Sheng, Chien-Heng Lai, Ming-Jiuh Wang and Yu-Chang Yeh

A comparison of nasogastric tube insertion by SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) versus neck flexion lateral pressure in critically ill patients admitted to ICU: a prospective randomized clinical trial

Although many techniques have been introduced to facilitate nasogastric tube (NGT) insertion using anatomic landmarks and a group of devices, there is a lack of general consensus regarding a standard method. T...

Authors: Sarvin Sanaie, Negin Mirzalou, Kamran Shadvar, Samad E. J. Golzari, Hassan Soleimanpour, Ali Shamekh, Deepti Bettampadi, Saeid Safiri and Ata Mahmoodpoor

Caution about early intubation and mechanical ventilation in COVID-19

Authors: Martin J. Tobin, Franco Laghi and Amal Jubran

Response to the authors

Authors: Pauline de Jager and Martin C. J. Kneyber

Letter to the Editor: Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children

Authors: Arpita Chattopadhyay

Amikacin pharmacokinetic/pharmacodynamic in intensive care unit: a prospective database

Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C_max) reaches eight to tenfold the minimal inhibitory concentration (MIC). With an amikacin MIC of 8 mg/L, the C_max

Authors: Elsa Logre, Maya Enser, Sébastien Tanaka, Marie Dubert, Aurore Claudinon, Nathalie Grall, Hervé Mentec, Philippe Montravers and Olivier Pajot