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  1. A recent landmark randomized controlled trial (RCT) in septic patients demonstrated an increased risk of death and persistent organ dysfunction with intravenous Vitamin C (IVVC) monotherapy, which represents a...

    Authors: Zheng-Yii Lee, Luis Ortiz-Reyes, Charles Chin Han Lew, M. Shahnaz Hasan, Lu Ke, Jayshil J. Patel, Christian Stoppe and Daren K. Heyland
    Citation: Annals of Intensive Care 2023 13:14
  2. Unique blood culture (UBC) has been proposed to limit the number of venipuncture and to decrease the risk of BC contaminations (BCC) without affecting their yield. We hypothesized that a multi-faceted program ...

    Authors: Rafael Mahieu, Carole Lemarié, Delphine Douillet, Alain Mercat, Hélène Cormier, Matthieu Eveillard, Vincent Dubée, Jérémie Riou and Achille Kouatchet
    Citation: Annals of Intensive Care 2023 13:13
  3. Thromboembolism is more common in patients with critical COVID-19 than in other critically ill patients, and inflammation has been proposed as a possible mechanism. The aim of this study was to investigate if ...

    Authors: Sandra Jonmarker, Felix Alarcón, Jacob Litorell, Anders Granholm, Eva Joelsson Alm, Michelle Chew, Lene Russell, Sarah Weihe, Emilie Kabel Madsen, Nick Meier, Jens Wolfgang Leistner, Johan Mårtensson, Jacob Hollenberg, Anders Perner, Maj-Brit Nørregaard Kjær, Marie Warrer Munch…
    Citation: Annals of Intensive Care 2023 13:12
  4. Sepsis prognosis correlates with antibiotic adequacy at the early phase. This adequacy is dependent on antibacterial spectrum, bacterial resistance profile and antibiotic dosage. Optimal efficacy of beta-lacta...

    Authors: Damien Roux, Nicolas Benichou, David Hajage, Laurent Martin-Lefèvre, Nicolas de Prost, Nicolas Lerolle, Dimitri Titeca-Beauport, Eric Boulet, Julien Mayaux, Bruno Mégarbane, Khaoula Mahjoub, Dorothée Carpentier, Saad Nseir, Florence Tubach, Jean-Damien Ricard, Didier Dreyfuss…
    Citation: Annals of Intensive Care 2023 13:11
  5. Electroencephalography (EEG) is recommended for the practical approach to the diagnosis and prognosis of encephalitis. We aimed to investigate the prognostic value of standard EEG (stdEEG) in adult patients with ...

    Authors: Lina Jeantin, Claire Dupuis, Geoffroy Vellieux, Pierre Jaquet, Etienne de Montmollin, Jean-François Timsit and Romain Sonneville
    Citation: Annals of Intensive Care 2023 13:10
  6. Intensivists target different blood pressure component values to manage intensive care unit (ICU) patients with sepsis. We aimed to evaluate the relationship between individual blood pressure components and or...

    Authors: Ashish K. Khanna, Takahiro Kinoshita, Annamalai Natarajan, Emma Schwager, Dustin D. Linn, Junzi Dong, Erina Ghosh, Francesco Vicario and Kamal Maheshwari
    Citation: Annals of Intensive Care 2023 13:9
  7. The pivotal ASPECT-NP trial showed ceftolozane/tazobactam was non-inferior to meropenem for the treatment of ventilated hospital-acquired/ventilator-associated bacterial pneumonia (vHABP/VABP). Here, we evalua...

    Authors: Ignacio Martin-Loeches, Andrew F. Shorr, Richard G. Wunderink, Marin H. Kollef, Jean-François Timsit, Brian Yu, Jennifer A. Huntington, Erin Jensen and Christopher J. Bruno
    Citation: Annals of Intensive Care 2023 13:8
  8. The past years have witnessed dramatic changes in the population admitted to the intensive care unit (ICU). Older and sicker patients are now commonly treated in this setting due to the newly available sophist...

    Authors: João Gonçalves-Pereira, André Oliveira, Tatiana Vieira, Ana Rita Rodrigues, Maria João Pinto, Sara Pipa, Ana Martinho, Sofia Ribeiro and José-Artur Paiva
    Citation: Annals of Intensive Care 2023 13:7
  9. The aim of this study was to assess the usefulness of adding thoracic CT to abdominal CT in intensive care unit (ICU) patients with signs of infection after abdominopelvic surgery.

    Authors: Heiner Nebelung, Natalie Wotschel, Hanns-Christoph Held, Johanna Kirchberg, Jürgen Weitz, Christoph Georg Radosa, Michael Laniado, Ralf-Thorsten Hoffmann and Verena Plodeck
    Citation: Annals of Intensive Care 2023 13:6
  10. The anatomic site for central venous catheter insertion influences the risk of central venous catheter-related intravascular complications. We developed and validated a predictive score of required catheter dw...

    Authors: Jeanne Iachkine, Niccolò Buetti, Harm-Jan de Grooth, Anaïs R. Briant, Olivier Mimoz, Bruno Mégarbane, Jean-Paul Mira, Xavier Valette, Cédric Daubin, Damien du Cheyron, Leonard A. Mermel, Jean-François Timsit and Jean-Jacques Parienti
    Citation: Annals of Intensive Care 2023 13:5
  11. Sepsis and septic shock are frequently accompanied by coagulopathy. Since the sepsis-induced coagulopathy (SIC) score was first described, subsequent studies from Asia revealed a SIC prevalence of 40–60%. In E...

    Authors: Thomas Schmoch, Patrick Möhnle, Markus A. Weigand, Josef Briegel, Michael Bauer, Frank Bloos, Patrick Meybohm, Didier Keh, Markus Löffler, Gunnar Elke, Thorsten Brenner and Holger Bogatsch
    Citation: Annals of Intensive Care 2023 13:3
  12. Studies regarding coronavirus disease 2019 (COVID-19) were mainly performed in the initial wave, but some small-scale data points to prognostic differences for patients in successive waves. We therefore aimed ...

    Authors: Diane Naouri, Albert Vuagnat, Gaëtan Beduneau, Martin Dres, Tai Pham, Alain Mercat, Alain Combes, Alexandre Demoule, Antoine Kimmoun, Matthieu Schmidt and Matthieu Jamme
    Citation: Annals of Intensive Care 2023 13:2

    The Correction to this article has been published in Annals of Intensive Care 2023 13:20

  13. Adverse reactions, especially nephrotoxicity, are great concerns of intravenous colistin treatment. The role of substitutive nebulized colistin in treating nosocomial pneumonia caused by carbapenem-resistant G...

    Authors: Jia-Yih Feng, Jhong-Ru Huang, Chang-Ching Lee, Yen-Han Tseng, Sheng-Wei Pan, Yuh-Min Chen and Kuang-Yao Yang
    Citation: Annals of Intensive Care 2023 13:1
  14. Auto-antibodies (auto-Abs) neutralizing type I interferons (IFN) have been found in about 15% of critical cases COVID-19 pneumonia and less than 1% of mild or asymptomatic cases. Determining whether auto-Abs i...

    Authors: Romain Arrestier, Paul Bastard, Thibaut Belmondo, Guillaume Voiriot, Tomas Urbina, Charles-Edouard Luyt, Adrian Gervais, Lucy Bizien, Lauriane Segaux, Mariem Ben Ahmed, Raphaël Bellaïche, Taï Pham, Zakaria Ait-Hamou, Damien Roux, Raphael Clere-Jehl, Elie Azoulay…
    Citation: Annals of Intensive Care 2022 12:121
  15. While frailty is a known predictor of adverse outcomes in older patients, its effect in younger populations is unknown. This prospective observational study was conducted in a tertiary-level mixed ICU to asses...

    Authors: Lina De Geer, Mats Fredrikson and Michelle S. Chew
    Citation: Annals of Intensive Care 2022 12:120
  16. Neurological complications are associated with poor outcome in patients with infective endocarditis (IE). Although guidelines recommend systematic brain imaging in the evaluation of IE patients, the associatio...

    Authors: Thomas Rambaud, Etienne de Montmollin, Pierre Jaquet, Augustin Gaudemer, Eric Mariotte, Sonia Abid, Marylou Para, Claire Cimadevilla, Bernard Iung, Xavier Duval, Michel Wolff, Lila Bouadma, Jean-François Timsit and Romain Sonneville
    Citation: Annals of Intensive Care 2022 12:119
  17. Acute kidney injury (AKI) is common in critically ill patients with coronavirus disease-19 (COVID-19). We aimed to explore the changes in AKI epidemiology between the first and the second COVID wave in the Uni...

    Authors: Nuttha Lumlertgul, Eleanor Baker, Emma Pearson, Kathryn V. Dalrymple, Jacqueline Pan, Anup Jheeta, Kittisak Weerapolchai, Yanzhong Wang, Richard Leach, Nicholas A. Barrett and Marlies Ostermann
    Citation: Annals of Intensive Care 2022 12:118
  18. Although risk factors of occlusive acute mesenteric ischemia are well known, triggering factors of nonocclusive mesenteric ischemia (NOMI) remain unclear. Alongside to the known risk factors for NOMI, the role...

    Authors: Anhum Konan, Gael Piton, Maxime Ronot, Youness Hassoun, Hadrien Winiszewski, Guillaume Besch, Alexandre Doussot, Eric Delabrousse and Paul Calame
    Citation: Annals of Intensive Care 2022 12:117
  19. Acute hypoxemic respiratory failure (AHRF) is a leading concern in critically ill patients. Experimental and clinical data suggest that early sedation with volatile anesthestics may improve arterial oxygenatio...

    Authors: Tobias Becher, Andreas Meiser, Ulf Guenther, Martin Bellgardt, Jan Wallenborn, Klaus Kogelmann, Hendrik Bracht, Andreas Falthauser, Jonas Nilsson, Peter Sackey and Patrick Kellner
    Citation: Annals of Intensive Care 2022 12:116
  20. Necrotizing skin and soft tissue infections (NSTIs) are rare but serious and rapidly progressive infections characterized by necrosis of subcutaneous tissue, fascia and even muscle. The care pathway of patient...

    Authors: Camille Windsor, Camille Hua, Quentin De Roux, Anatole Harrois, Nadia Anguel, Philippe Montravers, Antoine Vieillard-Baron, Jean-Paul Mira, Tomas Urbina, Stéphane Gaudry, Matthieu Turpin, Charles Damoisel, Djillali Annane, Jean-Damien Ricard, Barbara Hersant, Armand Mekontso Dessap…
    Citation: Annals of Intensive Care 2022 12:115
  21. The literature is unresolved on whether female receive advanced cardiac life support less than do male and on whether female have a survival advantage over male after cardiopulmonary resuscitation.

    Authors: Ines Lakbar, Mariachiara Ippolito, Aviv Nassiri, Louis Delamarre, Philippe Tadger, Marc Leone and Sharon Einav
    Citation: Annals of Intensive Care 2022 12:114
  22. Non-occlusive mesenteric ischemia (NOMI) is a challenging diagnosis and is associated with extremely high mortality in critically ill patients, particularly due to delayed diagnosis and when complicated by int...

    Authors: Simon Bourcier, Guillaume Ulmann, Matthieu Jamme, Guillaume Savary, Marine Paul, Sarah Benghanem, Jean-Rémi Lavillegrand, Matthieu Schmidt, Charles-Edouard Luyt, Eric Maury, Alain Combes, Frédéric Pène, Nathalie Neveux and Alain Cariou
    Citation: Annals of Intensive Care 2022 12:113
  23. The implication of sepsis-induced cardiomyopathy (SIC) to prognosis is controversial, and its association with mortality at different stages remains unclear. We conducted a systematic review and meta-analysis ...

    Authors: Yu-Min Lin, Mei-Chuan Lee, Han Siong Toh, Wei-Ting Chang, Sih-Yao Chen, Fang-Hsiu Kuo, Hsin-Ju Tang, Yi-Ming Hua, Dongmei Wei, Jesus Melgarejo, Zhen-Yu Zhang and Chia-Te Liao
    Citation: Annals of Intensive Care 2022 12:112
  24. About 80% of patients resuscitated from CA are comatose at ICU admission and nearly 50% of survivors are still unawake at 72 h. Predicting neurological outcome of these patients is important to provide correct...

    Authors: Sarah Benghanem, Estelle Pruvost-Robieux, Eléonore Bouchereau, Martine Gavaret and Alain Cariou
    Citation: Annals of Intensive Care 2022 12:111
  25. The ratio of SpO2/FiO2 to respiratory rate (ROX) index is commonly used to predict the failure of high-flow nasal cannula. However, its predictive power for noninvasive ventilation (NIV) failure is unclear.

    Authors: Jun Duan, Juhua Yang, Lei Jiang, Linfu Bai, Wenhui Hu, Weiwei Shu, Ke Wang and Fuxun Yang
    Citation: Annals of Intensive Care 2022 12:110
  26. Prone positioning is currently applied in time-limited daily sessions up to 24 h which determines that most patients require several sessions. Although longer prone sessions have been reported, there is scarce...

    Authors: Rodrigo A. Cornejo, Jorge Montoya, Abraham I. J. Gajardo, Jerónimo Graf, Leyla Alegría, Romyna Baghetti, Anita Irarrázaval, César Santis, Nicolás Pavez, Sofía Leighton, Vinko Tomicic, Daniel Morales, Carolina Ruiz, Pablo Navarrete, Patricio Vargas, Roberto Gálvez…
    Citation: Annals of Intensive Care 2022 12:109
  27. Frailty and delirium are prevalent among older adults admitted to the intensive care unit (ICU) and associated with adverse outcomes; however, their relationships have not been extensively explored. This study...

    Authors: Berhe W. Sahle, David Pilcher, Edward Litton, Richard Ofori-Asenso, Karlheinz Peter, James McFadyen and Tracey Bucknall
    Citation: Annals of Intensive Care 2022 12:108
  28. β-lactams are the main antibiotics used against wild-type AmpC-producing Enterobacterales (wtAE). However, they may fail or select AmpC-overproducing mutants. Our aim was to assess factors associated with clin...

    Authors: Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi…
    Citation: Annals of Intensive Care 2022 12:107
  29. Since the response to lung recruitment varies greatly among patients receiving mechanical ventilation, lung recruitability should be assessed before recruitment maneuvers. The pressure–volume curve (PV curve) ...

    Authors: Ryuichi Nakayama, Naofumi Bunya, Shinshu Katayama, Yuya Goto, Yusuke Iwamoto, Kenshiro Wada, Keishi Ogura, Naoya Yama, Shintaro Takatsuka, Masumi Kishimoto, Kanako Takahashi, Ryuichiro Kakizaki, Keigo Sawamoto, Shuji Uemura, Keisuke Harada and Eichi Narimatsu
    Citation: Annals of Intensive Care 2022 12:106
  30. Extracorporeal blood purification (EBP) treatments may be used in patients with sepsis and related conditions to mitigate toxic systemic inflammation, prevent or reverse vital organ injury, and improve outcome...

    Authors: James Matson, Paul Lange, Patrick M. Honore and Kevin K. Chung
    Citation: Annals of Intensive Care 2022 12:105
  31. Right ventricular (RV) dysfunction has been commonly reported in patients with Coronavirus disease 2019 (COVID-19), and is associated with mortality in mixed cohorts of patients requiring and not requiring inv...

    Authors: James McErlane, Philip McCall, Jennifer Willder, Colin Berry and Ben Shelley
    Citation: Annals of Intensive Care 2022 12:104
  32. Clinicians monitor mechanical ventilatory support using airway pressures—primarily the plateau and driving pressure, which are considered by many to determine the safety of the applied tidal volume. These airw...

    Authors: John Selickman and John J. Marini
    Citation: Annals of Intensive Care 2022 12:103
  33. Dexamethasone is recommended for COVID-19 patients who require oxygen therapy. However, its effectiveness in reducing mortality and intubation, and its safety, remain debated. We aimed to investigate whether d...

    Authors: Matthieu Raymond, Aurélie Le Thuaut, Pierre Asfar, Cédric Darreau, Florian Reizine, Gwenhaël Colin, Charly Dano, Julien Lorber, Baptiste Hourmant, Agathe Delbove, Aurélien Frérou, Jean Morin, Pierre Yves Egreteau, Philippe Seguin, Jean Reignier, Jean-Baptiste Lascarrou…
    Citation: Annals of Intensive Care 2022 12:102
  34. Etoposide remains the cornerstone of symptomatic management of critically ill patients with secondary hemophagocytic syndrome (sHS). Risk of healthcare-associated infections (HAIs) in this setting with etoposi...

    Authors: Thibault Dupont, Michael Darmon, Eric Mariotte, Virginie Lemiale, Jehane Fadlallah, Adrien Mirouse, Lara Zafrani, Elie Azoulay and Sandrine Valade
    Citation: Annals of Intensive Care 2022 12:101
  35. Fluid creep, including fluids administered as drug diluents and for the maintenance of catheter patency, is the major source of fluid intake in critically ill patients. Although hypoxemia may lead to fluid res...

    Authors: Masaaki Sakuraya, Shodai Yoshihiro, Kazuto Onozuka, Akihiro Takaba, Hideto Yasuda, Nobuaki Shime, Yuki Kotani, Yuki Kishihara, Natsuki Kondo, Kosuke Sekine and Keita Morikane
    Citation: Annals of Intensive Care 2022 12:100
  36. For mechanically ventilated critically ill COVID-19 patients, prone positioning has quickly become an important treatment strategy, however, prone positioning is labor intensive and comes with potential advers...

    Authors: Tariq A. Dam, Luca F. Roggeveen, Fuda van Diggelen, Lucas M. Fleuren, Ameet R. Jagesar, Martijn Otten, Heder J. de Vries, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco A. A. Peters…
    Citation: Annals of Intensive Care 2022 12:99
  37. Patients with acute pancreatitis (AP) often require ICU admission, especially when signs of multiorgan failure are present, a condition that defines AP as severe. This disease is characterized by a massive pancre...

    Authors: Andrea Crosignani, Stefano Spina, Francesco Marrazzo, Stefania Cimbanassi, Manu L. N. G. Malbrain, Niels Van Regenmortel, Roberto Fumagalli and Thomas Langer
    Citation: Annals of Intensive Care 2022 12:98

    The Correction to this article has been published in Annals of Intensive Care 2023 13:51

  38. Outcomes of postresuscitation shock after cardiac arrest can be affected by targeted temperature management (TTM). A post hoc analysis of the “TTM1 trial” suggested higher mortality with hypothermia at 33 °C. ...

    Authors: Ines Ziriat, Aurélie Le Thuaut, Gwenhael Colin, Hamid Merdji, Guillaume Grillet, Patrick Girardie, Bertrand Souweine, Pierre-François Dequin, Thierry Boulain, Jean-Pierre Frat, Pierre Asfar, Bruno Francois, Mickael Landais, Gaëtan Plantefeve, Jean-Pierre Quenot, Jean-Charles Chakarian…
    Citation: Annals of Intensive Care 2022 12:96
  39. Identifying patients who will receive renal replacement therapy (RRT) during intensive care unit (ICU) stay is a major challenge for intensivists. The objective of this study was to evaluate the performance of...

    Authors: Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau…
    Citation: Annals of Intensive Care 2022 12:95
  40. Helmet noninvasive support may provide advantages over other noninvasive oxygenation strategies in the management of acute hypoxemic respiratory failure. In this narrative review based on a systematic search o...

    Authors: Melania Cesarano, Domenico Luca Grieco, Teresa Michi, Laveena Munshi, Luca S. Menga, Luca Delle Cese, Ersilia Ruggiero, Tommaso Rosà, Daniele Natalini, Michael C. Sklar, Salvatore L. Cutuli, Filippo Bongiovanni, Gennaro De Pascale, Bruno L. Ferreyro, Ewan C. Goligher and Massimo Antonelli
    Citation: Annals of Intensive Care 2022 12:94
  41. Venoarterial extracorporeal membrane oxygenation (va-ECMO) is an advanced life support for critically ill patients with refractory cardiogenic shock. This temporary support bridges time for recovery, permanent...

    Authors: Sasa Rajsic, Benedikt Treml, Dragana Jadzic, Robert Breitkopf, Christoph Oberleitner, Marina Popovic Krneta and Zoran Bukumiric
    Citation: Annals of Intensive Care 2022 12:93
  42. Right ventricular (RV) dysfunction is common in critically ill patients and is associated with poor outcomes. RV function is usually evaluated by Tricuspid Annular Plane Systolic Excursion (TAPSE) which can be...

    Authors: Madelon E. Vos, Eline G. M. Cox, Maaike R. Schagen, Bart Hiemstra, Adrian Wong, Jacqueline Koeze, Iwan C. C. van der Horst and Renske Wiersema
    Citation: Annals of Intensive Care 2022 12:92
  43. The aim of this study was to compare the effectiveness and safety of ultrasound-guided out-of-plane internal jugular vein (OOP-IJV) and in-plane supraclavicular subclavian vein (IP-SSCV) catheterization in adu...

    Authors: Becem Trabelsi, Zied Hajjej, Dhouha Drira, Azza Yedes, Iheb Labbene, Mustapha Ferjani and Mechaal Ben Ali
    Citation: Annals of Intensive Care 2022 12:91
  44. Cefoxitin is active against some extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE), but has not been evaluated so far in the intensive care unit (ICU) settings. Data upon its pharmacokinetics ...

    Authors: Paul Chabert, Judith Provoost, Sabine Cohen, Céline Dupieux-Chabert, Laurent Bitker, Tristan Ferry, Sylvain Goutelle and Jean-Christophe Richard
    Citation: Annals of Intensive Care 2022 12:90
  45. Bedside assessment of low levels of inspiratory effort, which are probably insufficient to prevent muscle atrophy, is challenging. The flow index, which is derived from the analysis of the inspiratory portion ...

    Authors: Ming-Yue Miao, Wei Chen, Yi-Min Zhou, Ran Gao, De-Jing Song, Shu-Peng Wang, Yan-Lin Yang, Linlin Zhang and Jian-Xin Zhou
    Citation: Annals of Intensive Care 2022 12:89
  46. Augmented renal clearance (ARC) remains poorly evaluated in ICU. The objective of this study is to provide a full description of ARC in ICU including prevalence, evolution profile, risk factors and outcomes.

    Authors: Alexandre Egea, Claire Dupuis, Etienne de Montmollin, Paul-Henry Wicky, Juliette Patrier, Pierre Jaquet, Lucie Lefèvre, Fabrice Sinnah, Mehdi Marzouk, Romain Sonneville, Lila Bouadma, Bertrand Souweine and Jean-François Timsit
    Citation: Annals of Intensive Care 2022 12:88
  47. Lung reactivations of Herpesviridae, herpes simplex virus (HSV) and cytomegalovirus (CMV) have been reported in COVID-19 patients. Whether or not those viral reactivations are more frequent than in other patients...

    Authors: Charles-Edouard Luyt, Sonia Burrel, David Mokrani, Marc Pineton de Chambrun, Domitille Luyt, Juliette Chommeloux, Vincent Guiraud, Nicolas Bréchot, Matthieu Schmidt, Guillaume Hekimian, Alain Combes and David Boutolleau
    Citation: Annals of Intensive Care 2022 12:87
  48. While antibiotic therapy is advocated to improve outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) whenever mechanical ventilation is required, the evidence relies on small studi...

    Authors: G. Deniel, M. Cour, L. Argaud, J. C. Richard and L. Bitker
    Citation: Annals of Intensive Care 2022 12:86

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