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  1. Little is known about the effectiveness of surface cooling (SC) and endovascular cooling (EC) on the outcome of out-of-hospital cardiac arrest (OHCA) patients receiving target temperature management (TTM) acco...

    Authors: Makoto Watanabe, Tasuku Matsuyama, Hikaru Oe, Makoto Sasaki, Yuki Nakamura, Yuki Miyamoto, Nobunaga Okada, Tetsuhisa Kitamura and Bon Ohta
    Citation: Annals of Intensive Care 2021 11:163
  2. The death rate in intensive care units (ICUs) can reach 20%. More than half occurs after a decision of care withholding/withdrawal. We aimed at describing and evaluating the experience of ICU physicians and nu...

    Authors:
    Citation: Annals of Intensive Care 2021 11:162

    The Correction to this article has been published in Annals of Intensive Care 2021 11:186

  3. The role of intravenous immunoglobulins (IVIG) during sepsis is controversial, as different trials on IVIG have observed inconsistent survival benefits. We aimed to elucidate the possible association and clini...

    Authors: Laura Alagna, Jennifer M. T. A. Meessen, Giacomo Bellani, Daniela Albiero, Pietro Caironi, Irene Principale, Luigi Vivona, Giacomo Grasselli, Francesca Motta, Nicolò M. Agnelli, Vieri Parrini, Stefano Romagnoli, Roberto Keim, Francesca Di Marzo Capozzi, Fabio S. Taccone, Walter Taccone…
    Citation: Annals of Intensive Care 2021 11:161
  4. Some unanswered questions persist regarding the effectiveness of corticosteroids for severe coronavirus disease 2019 (COVID-19) patients. We aimed to assess the clinical effect of corticosteroids on intensive ...

    Authors: Gerard Moreno, Raquel Carbonell, Ignacio Martin-Loeches, Jordi Solé-Violán, Eudald Correig i Fraga, Josep Gómez, Manuel Ruiz-Botella, Sandra Trefler, María Bodí, Josefa Murcia Paya, Emili Díaz, Pablo Vidal-Cortes, Elisabeth Papiol, Antonio Albaya Moreno, Susana Sancho Chinesta, Lorenzo Socias Crespi…
    Citation: Annals of Intensive Care 2021 11:159
  5. Acute respiratory failure (ARF) in patients admitted to the intensive care unit (ICU) with known or de novo small-vessel vasculitis (Svv) may be secondary to the underlying immune disease or to other causes. E...

    Authors: Aude Gibelin, Guillaume Dumas, Sandrine Valade, Marc Pineton de Chambrun, François Bagate, Mathilde Neuville, Francis Schneider, Loredana Baboi, Matthieu Groh, Jean-Herlé Raphalen, Jean-Daniel Chiche, Nicolas De Prost, Charles-Edouard Luyt, Claude Guérin, Eric Maury, Etienne de Montmollin…
    Citation: Annals of Intensive Care 2021 11:158
  6. Since March 2020, health care systems were importantly affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, with some patients presenting severe acute respiratory distress syndrom...

    Authors: Florence Daviet, Philippe Guilloux, Sami Hraiech, David Tonon, Lionel Velly, Jeremy Bourenne, Alizée Porto, Inès Gragueb-Chatti, Mickael Bobot, Karine Baumstarck, Laurent Papazian, Frédéric Collart, Jean-Marie Forel and Christophe Guervilly
    Citation: Annals of Intensive Care 2021 11:157
  7. Few data are available about outcomes of patients screened for, but not enrolled in, randomised clinical trials.

    Authors: J. B. Lascarrou, Gregoire Muller, Jean-Pierre Quenot, Nicolas Massart, Mickael Landais, Pierre Asfar, Jean-Pierre Frat, Jean-Charles Chakarian, Michel Sirodot, Bruno Francois, Guillaume Grillet, Sylvie Vimeux, Arnaud Delahaye, Stéphane Legriel, Didier Thevenin, Jean Reignier…
    Citation: Annals of Intensive Care 2021 11:156
  8. Initial reports have described the poor outcome of unexpected cardiac arrest (CA) in intensive care unit (ICU) among COVID-19 patients in China and the USA. However, there are scarce data on characteristics an...

    Authors: Jonathan Chelly, Gaetan Plantefève, Toufik Kamel, Cédric Bruel, Saad Nseir, Christopher Lai, Giulia Cirillo, Elena Skripkina, Sébastien Ehrminger, Fernando-Daniel Berdaguer-Ferrari, Julien Le Marec, Marine Paul, Aurélie Autret and Nicolas Deye
    Citation: Annals of Intensive Care 2021 11:155
  9. Baseline characteristics and disease severity of patients with septic shock according to the new Sepsis-3 definition may differ from patients that only comply with the Sepsis-2 definition. We conducted a retro...

    Authors: Joris Vermassen, Johan Decruyenaere, Liesbet De Bus, Pieter Depuydt and Kirsten Colpaert
    Citation: Annals of Intensive Care 2021 11:154
  10. The potential relationship between intravascular catheter infections with their insertion during weekend or night-time (i.e., off-hours or not regular business hours) remains an open issue. Our primary aim was to...

    Authors: Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Arthur Mageau, Claire Dupuis, Bertrand Souweine, Olivier Mimoz and Jean-François Timsit
    Citation: Annals of Intensive Care 2021 11:153
  11. COVID-19 is characterized by dysregulated immune response, respiratory failure and a relevant mortality rate among hospitalized patients. Interleukin-6 (IL-6) is involved in COVID-19-associated cytokine storm,...

    Authors: Alessandro Belletti, Corrado Campochiaro, Marilena Marmiere, Valery Likhvantsev, Andrey Yavorovskiy, Lorenzo Dagna, Giovanni Landoni, Alberto Zangrillo and Ludhmila Abrahão Hajjar
    Citation: Annals of Intensive Care 2021 11:152
  12. The first wave of the COVID-19 pandemic confronted healthcare systems around the world with unprecedented organizational challenges, particularly regarding the availability of intensive care unit (ICU) beds. O...

    Authors: Marc-Antoine Sanchez, Albert Vuagnat, Olivier Grimaud, Emmanuelle Leray, Jean-Marc Philippe, François-Xavier Lescure, Mathieu Boutonnet, Hélène Coignard, Agnès Ricard Hibon, Stephane Sanchez and Julien Pottecher
    Citation: Annals of Intensive Care 2021 11:151
  13. Prolonged need for mechanical ventilation greatly impacts life expectancy of patients after spinal cord injury (SCI). Weaning outcomes have never been systematically assessed. In this systematic review and met...

    Authors: Annia F. Schreiber, Jacopo Garlasco, Fernando Vieira, Yie Hui Lau, Dekel Stavi, David Lightfoot, Andrea Rigamonti, Karen Burns, Jan O. Friedrich, Jeffrey M. Singh and Laurent J. Brochard
    Citation: Annals of Intensive Care 2021 11:149
  14. The presence of bacteraemia in pneumococcal pneumonia in critically ill patients does not appear to be a strong independent prognostic factor in the existing literature. However, there may be a specific patter...

    Authors: Hugo Bellut, Raphael Porcher, Emmanuelle Varon, Pierre Asfar, Yves Le Tulzo, Bruno Megarbane, Armelle Mathonnet, Anthony Dugard, Anne Veinstein, Kader Ouchenir, Shidasp Siami, Jean Reignier, Arnaud Galbois, Joël Cousson, Sébastien Preau, Olivier Baldesi…
    Citation: Annals of Intensive Care 2021 11:148
  15. Ineffective triggering is frequent during pressure support ventilation (PSV) and may persist despite ventilator adjustment, leading to refractory asynchrony. We aimed to assess the effect of proportional assis...

    Authors: Anne-Fleur Haudebourg, Tommaso Maraffi, Samuel Tuffet, François Perier, Nicolas de Prost, Keyvan Razazi, Armand Mekontso Dessap and Guillaume Carteaux
    Citation: Annals of Intensive Care 2021 11:147
  16. Echocardiographic parameters have been poorly investigated for estimating cardiovascular risk in patients with sepsis and new-onset atrial fibrillation. We aim to assess the prevalence of transesophageal echoc...

    Authors: Vincent Labbé, Stephane Ederhy, Nathanael Lapidus, Jérémie Joffre, Keyvan Razazi, Laurent Laine, Oumar Sy, Sebastian Voicu, Frank Chemouni, Nadia Aissaoui, Roland Smonig, Denis Doyen, Fabrice Carrat, Guillaume Voiriot, Armand Mekontso-Dessap, Ariel Cohen…
    Citation: Annals of Intensive Care 2021 11:146
  17. In comatose patients receiving oro-tracheal intubation for mechanical ventilation (MV), the risk of aspiration is increased. Aspiration can lead to chemical pneumonitis (inflammatory reaction to the gastric co...

    Authors: Guylaine Labro, François Aptel, Marc Puyraveau, Jonathan Paillot, Sébastien Pili Floury, Hamid Merdji, Julie Helms, Gaël Piton, Fiona Ecarnot, Khaldoun Kuteifan, Jean Pierre Quenot and Gilles Capellier
    Citation: Annals of Intensive Care 2021 11:145
  18. ICU-acquired weakness (ICUAW) has been shown to be associated with prolonged duration of mechanical ventilation and extubation failure. It is usually assessed through Medical Research Council (MRC) score, a ti...

    Authors: Guillaume Cottereau, Jonathan Messika, Bruno Megarbane, Laurent Guérin, Daniel da Silva, Caroline Bornstain, Matilde Santos, Jean-Damien Ricard and Benjamin Sztrymf
    Citation: Annals of Intensive Care 2021 11:144
  19. Information is lacking regarding long-term survival and predictive factors for mortality in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) and undergoing invasive ...

    Authors: Oscar Peñuelas, Laura del Campo-Albendea, Amanda Lesmes González de Aledo, José Manuel Añón, Carmen Rodríguez-Solís, Jordi Mancebo, Paula Vera, Daniel Ballesteros, Jorge Jiménez, Emilio Maseda, Juan Carlos Figueira, Nieves Franco, Ángela Algaba, Juan Pablo Avilés, Ricardo Díaz, Beatriz Abad…
    Citation: Annals of Intensive Care 2021 11:143
  20. A delay in admission to the intensive care unit (ICU) of patients with community-acquired pneumonia (CAP) has been associated with an increased mortality. Decisions regarding interventions and eligibility for ...

    Authors: Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna and Tom van der Poll
    Citation: Annals of Intensive Care 2021 11:142
  21. Polymyxin B hemoperfusion (PMX) aims to treat septic shock by removing endotoxin from the patient’s blood. However, the relationship between the severity of the patient's organ damage and the survival benefit ...

    Authors: Kenji Fujimori, Kunio Tarasawa and Kiyohide Fushimi
    Citation: Annals of Intensive Care 2021 11:141
  22. Myoglobin and creatine kinase (CK) are both established markers of muscle injury but their hospital admission values have never been compared to predict post-traumatic acute kidney injury (AKI).

    Authors: Virginie Tarazona, Samy Figueiredo, Sophie Hamada, Jonas Pochard, Ryan W. Haines, John R. Prowle, Jacques Duranteau, Bernard Vigué and Anatole Harrois
    Citation: Annals of Intensive Care 2021 11:140
  23. The optimal mean arterial pressure (MAP) in cases of septic shock is still a matter of debate in patients with prior hypertension. An MAP between 75 and 85 mmHg can improve glomerular filtration rate (GFR) but...

    Authors: Antoine Dewitte, Aurore Labat, Pierre-Antoine Duvignaud, Gauthier Bouche, Olivier Joannes-Boyau, Jean Ripoche, Gilles Hilbert, Didier Gruson, Sébastien Rubin, Alexandre Ouattara, Alexandre Boyer and Christian Combe
    Citation: Annals of Intensive Care 2021 11:139
  24. Invasive pulmonary aspergillosis (IPA) has always been a challenging diagnosis and risk factors an important guide to investigate specific population, especially in Intensive Care Unit. Traditionally recognize...

    Authors: G. Montrucchio, T. Lupia, D. Lombardo, G. Stroffolini, S. Corcione, F. G. De Rosa and L. Brazzi
    Citation: Annals of Intensive Care 2021 11:136
  25. High-flow nasal oxygen cannula (HFNC) and noninvasive mechanical ventilation (NIV) can prevent reintubation in critically ill patients. However, their efficacy in post-extubated sepsis patients remains unclear...

    Authors: Surat Tongyoo, Porntipa Tantibundit, Kiattichai Daorattanachai, Tanuwong Viarasilpa, Chairat Permpikul and Suthipol Udompanturak
    Citation: Annals of Intensive Care 2021 11:135

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2021 11:172

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2021 11:173

  26. The aim of this study was to validate whether regional ventilation and perfusion data measured by electrical impedance tomography (EIT) with saline bolus could discriminate three broad acute respiratory failur...

    Authors: Huaiwu He, Yi Chi, Yun Long, Siyi Yuan, Rui Zhang, Yingying Yang, Inéz Frerichs, Knut Möller, Feng Fu and Zhanqi Zhao
    Citation: Annals of Intensive Care 2021 11:134
  27. The end-expiratory occlusion (EEXPO) test detects preload responsiveness, but it is 15 s long and induces small changes in cardiac index (CI). It is doubtful whether the Starling bioreactance device, which ave...

    Authors: Francesco Gavelli, Alexandra Beurton, Jean-Louis Teboul, Nello De Vita, Danila Azzolina, Rui Shi, Arthur Pavot and Xavier Monnet
    Citation: Annals of Intensive Care 2021 11:133
  28. Cardiogenic pulmonary oedema (CPE) may contribute to ventilator-associated lung injury (VALI) in patients with cardiogenic shock. The appropriate ventilatory strategy remains unclear. We aimed to evaluate the ...

    Authors: Laura Amado-Rodríguez, Cecilia Del Busto, Inés López-Alonso, Diego Parra, Juan Mayordomo-Colunga, Miguel Arias-Guillén, Rodrigo Albillos-Almaraz, Paula Martín-Vicente, Cecilia López-Martínez, Covadonga Huidobro, Luigi Camporota, Arthur S. Slutsky and Guillermo M. Albaiceta
    Citation: Annals of Intensive Care 2021 11:132
  29. Severe infections and multidrug-resistant pathogens are common in critically ill patients. Antimicrobial stewardship (AMS) and therapeutic drug monitoring (TDM) are contemporary tools to optimize the use of an...

    Authors: Christian Lanckohr, Christian Boeing, Jan J. De Waele, Dylan W. de Lange, Jeroen Schouten, Menno Prins, Maarten Nijsten, Pedro Povoa, Andrew Conway Morris and Hendrik Bracht
    Citation: Annals of Intensive Care 2021 11:131
  30. Acute gastrointestinal bleeding (GIB) may be a severe condition in immunocompromised patients and may require intensive care unit (ICU) admission. We aimed to describe the clinical spectrum of critically ill i...

    Authors: Jennifer Catano, Sophie Caroline Sacleux, Jean-Marc Gornet, Marine Camus, Naike Bigé, Faouzi Saliba, Elie Azoulay, Guillaume Dumas and Lara Zafrani
    Citation: Annals of Intensive Care 2021 11:130
  31. Precision medicine risk stratification is desperately needed to both avoid systemic antifungals treatment delay and over prescription in the critically ill with risk factors. The aim of the present study was t...

    Authors: Boris Jung, Clément Le Bihan, Pierre Portales, Nathalie Bourgeois, Thierry Vincent, Laurence Lachaud, Gerald Chanques, Matthieu Conseil, Philippe Corne, Pablo Massanet, Jean François Timsit and Samir Jaber
    Citation: Annals of Intensive Care 2021 11:129
  32. Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who ha...

    Authors: Raphael Romano Bruno, Bernhard Wernly, Hans Flaatten, Jesper Fjølner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Stephan Binnebössel, Philipp Heinrich Baldia, Malte Kelm, Michael Beil, Sivri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis…
    Citation: Annals of Intensive Care 2021 11:128
  33. The COVID-19 sanitary crisis inflicted different challenges regarding the reorganization of the human and logistic resources, particularly in intensive care unit (ICU). Interdependence between regional pandemi...

    Authors: Antoine Guillon, Emeline Laurent, Antoine Duclos, Lucile Godillon, Pierre-François Dequin, Nelly Agrinier, Antoine Kimmoun and Leslie Grammatico-Guillon
    Citation: Annals of Intensive Care 2021 11:127
  34. Videolaryngoscopes with an operating channel may improve the intubation success rate in critically ill patients. We aimed to compare four channelled videolaryngoscopes to the Macintosh laryngoscope used for in...

    Authors: Paul Decamps, Nicolas Grillot, Aurelie Le Thuaut, Noelle Brule, Corinne Lejus-Bourdeau, Jean Reignier and Jean-Baptiste Lascarrou
    Citation: Annals of Intensive Care 2021 11:126
  35. Very few studies assessed the association between Intensive Care Unit (ICU) triage decisions and mortality. The aim of this study was to assess whether an association could be found between 30-day mortality, a...

    Authors: Esther N. van der Zee, Dominique D. Benoit, Marinus Hazenbroek, Jan Bakker, Erwin J. O. Kompanje, Nuray Kusadasi and Jelle L. Epker
    Citation: Annals of Intensive Care 2021 11:125
  36. The current Berlin definition of acute respiratory distress syndrome (ARDS) uses the PaO2/FiO2 (P/F) ratio to classify severity. However, for the same P/F ratio, a patient on a higher positive end-expiratory pres...

    Authors: Sunitha Palanidurai, Jason Phua, Yiong Huak Chan and Amartya Mukhopadhyay
    Citation: Annals of Intensive Care 2021 11:124

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2021 11:137

  37. There are limited data on acute kidney injury (AKI) progression and long-term outcomes in critically ill patients with coronavirus disease-19 (COVID-19). We aimed to describe the prevalence and risk factors fo...

    Authors: Nuttha Lumlertgul, Leah Pirondini, Enya Cooney, Waisun Kok, John Gregson, Luigi Camporota, Katie Lane, Richard Leach and Marlies Ostermann
    Citation: Annals of Intensive Care 2021 11:123
  38. Coronavirus disease has heterogeneous clinical features; however, the reasons for the heterogeneity are poorly understood. This study aimed to identify clinical phenotypes according to patients’ temperature tr...

    Authors: Yanfei Shen, Dechang Chen, Xinmei Huang, Guolong Cai, Qianghong Xu, Caibao Hu, Jing Yan and Jiao Liu
    Citation: Annals of Intensive Care 2021 11:121
  39. Whether Intensive Care Unit (ICU) clinicians display unconscious bias towards cancer patients is unknown. The aim of this study was to compare the outcomes of critically ill patients with and without perceptio...

    Authors: Dominique D. Benoit, Esther N. van der Zee, Michael Darmon, An K. L. Reyners, Victoria Metaxa, Djamel Mokart, Alexander Wilmer, Pieter Depuydt, Andreas Hvarfner, Katerina Rusinova, Jan G. Zijlstra, François Vincent, Dimitrios Lathyris, Anne-Pascale Meert, Jacques Devriendt, Emma Uyttersprot…
    Citation: Annals of Intensive Care 2021 11:120
  40. Dynamic arterial elastance (Eadyn) has been extensively considered as a functional parameter of arterial load. However, conflicting evidence has been obtained on the ability of Eadyn to predict mean arterial pres...

    Authors: Xiaoyang Zhou, Weihao Pan, Bixin Chen, Zhaojun Xu and Jianneng Pan
    Citation: Annals of Intensive Care 2021 11:119
  41. Many patients with coronavirus disease 2019 (COVID-19) required critical care. Mid-term outcomes of the survivors need to be assessed. The objective of this single-center cohort study was to describe their phy...

    Authors: Anne-Françoise Rousseau, Pauline Minguet, Camille Colson, Isabelle Kellens, Sourour Chaabane, Pierre Delanaye, Etienne Cavalier, J. Geoffrey Chase, Bernard Lambermont and Benoit Misset
    Citation: Annals of Intensive Care 2021 11:118
  42. At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation.

    Authors: Muriel Fartoukh, Guillaume Voiriot, Laurent Guérin, Jean Damien Ricard, Alain Combes, Morgane Faure, Sarah Benghanem, Etienne de Montmollin, Yacine Tandjaoui-Lambiotte, Antoine Vieillard-Baron, Eric Maury, Jean-Luc Diehl, Keyvan Razazi, Virginie Lemiale, Pierre Trouiller, Benjamin Planquette…
    Citation: Annals of Intensive Care 2021 11:117
  43. Percutaneous dilatational tracheotomy (PDT) has become an established procedure in intensive care units (ICU). However, the safety of this method has been under debate given the growing number of critically il...

    Authors: Enzo Lüsebrink, Alexander Krogmann, Franziska Tietz, Matthias Riebisch, Rainer Okrojek, Friedhelm Peltz, Carsten Skurk, Carsten Hullermann, Jan Sackarnd, Dietmar Wassilowsky, Karl Toischer, Clemens Scherer, Michael Preusch, Christoph Testori, Ulrike Flierl, Sven Peterss…
    Citation: Annals of Intensive Care 2021 11:116
  44. A cytokine storm is life threatening for critically ill patients and is mainly caused by sepsis or severe trauma. In combination with supportive therapy, the cytokine adsorber Cytosorb® (CS) is increasingly used ...

    Authors: Christina Scharf, Ines Schroeder, Michael Paal, Martin Winkels, Michael Irlbeck, Michael Zoller and Uwe Liebchen
    Citation: Annals of Intensive Care 2021 11:115
  45. Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as c...

    Authors: Maeva Rodriguez, Stéphanie Ragot, Rémi Coudroy, Jean-Pierre Quenot, Philippe Vignon, Jean-Marie Forel, Alexandre Demoule, Jean-Paul Mira, Jean-Damien Ricard, Saad Nseir, Gwenhael Colin, Bertrand Pons, Pierre-Eric Danin, Jérome Devaquet, Gwenael Prat, Hamid Merdji…
    Citation: Annals of Intensive Care 2021 11:114
  46. Microvascular, arterial and venous thrombotic events have been largely described during severe coronavirus disease 19 (COVID-19). However, mechanisms underlying hemostasis dysregulation remain unclear.

    Authors: Nader Yatim, Jeremy Boussier, Richard Chocron, Jérôme Hadjadj, Aurélien Philippe, Nicolas Gendron, Laura Barnabei, Bruno Charbit, Tali-Anne Szwebel, Nicolas Carlier, Frédéric Pène, Célia Azoulay, Lina Khider, Tristan Mirault, Jean-Luc Diehl, Coralie L. Guerin…
    Citation: Annals of Intensive Care 2021 11:113

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