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  1. Very few studies assessed the association between Intensive Care Unit (ICU) triage decisions and mortality. The aim of this study was to assess whether an association could be found between 30-day mortality, a...

    Authors: Esther N. van der Zee, Dominique D. Benoit, Marinus Hazenbroek, Jan Bakker, Erwin J. O. Kompanje, Nuray Kusadasi and Jelle L. Epker
    Citation: Annals of Intensive Care 2021 11:125
  2. The current Berlin definition of acute respiratory distress syndrome (ARDS) uses the PaO2/FiO2 (P/F) ratio to classify severity. However, for the same P/F ratio, a patient on a higher positive end-expiratory pres...

    Authors: Sunitha Palanidurai, Jason Phua, Yiong Huak Chan and Amartya Mukhopadhyay
    Citation: Annals of Intensive Care 2021 11:124

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2021 11:137

  3. There are limited data on acute kidney injury (AKI) progression and long-term outcomes in critically ill patients with coronavirus disease-19 (COVID-19). We aimed to describe the prevalence and risk factors fo...

    Authors: Nuttha Lumlertgul, Leah Pirondini, Enya Cooney, Waisun Kok, John Gregson, Luigi Camporota, Katie Lane, Richard Leach and Marlies Ostermann
    Citation: Annals of Intensive Care 2021 11:123
  4. Coronavirus disease has heterogeneous clinical features; however, the reasons for the heterogeneity are poorly understood. This study aimed to identify clinical phenotypes according to patients’ temperature tr...

    Authors: Yanfei Shen, Dechang Chen, Xinmei Huang, Guolong Cai, Qianghong Xu, Caibao Hu, Jing Yan and Jiao Liu
    Citation: Annals of Intensive Care 2021 11:121
  5. Whether Intensive Care Unit (ICU) clinicians display unconscious bias towards cancer patients is unknown. The aim of this study was to compare the outcomes of critically ill patients with and without perceptio...

    Authors: Dominique D. Benoit, Esther N. van der Zee, Michael Darmon, An K. L. Reyners, Victoria Metaxa, Djamel Mokart, Alexander Wilmer, Pieter Depuydt, Andreas Hvarfner, Katerina Rusinova, Jan G. Zijlstra, François Vincent, Dimitrios Lathyris, Anne-Pascale Meert, Jacques Devriendt, Emma Uyttersprot…
    Citation: Annals of Intensive Care 2021 11:120
  6. Dynamic arterial elastance (Eadyn) has been extensively considered as a functional parameter of arterial load. However, conflicting evidence has been obtained on the ability of Eadyn to predict mean arterial pres...

    Authors: Xiaoyang Zhou, Weihao Pan, Bixin Chen, Zhaojun Xu and Jianneng Pan
    Citation: Annals of Intensive Care 2021 11:119
  7. Many patients with coronavirus disease 2019 (COVID-19) required critical care. Mid-term outcomes of the survivors need to be assessed. The objective of this single-center cohort study was to describe their phy...

    Authors: Anne-Françoise Rousseau, Pauline Minguet, Camille Colson, Isabelle Kellens, Sourour Chaabane, Pierre Delanaye, Etienne Cavalier, J. Geoffrey Chase, Bernard Lambermont and Benoit Misset
    Citation: Annals of Intensive Care 2021 11:118
  8. At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation.

    Authors: Muriel Fartoukh, Guillaume Voiriot, Laurent Guérin, Jean Damien Ricard, Alain Combes, Morgane Faure, Sarah Benghanem, Etienne de Montmollin, Yacine Tandjaoui-Lambiotte, Antoine Vieillard-Baron, Eric Maury, Jean-Luc Diehl, Keyvan Razazi, Virginie Lemiale, Pierre Trouiller, Benjamin Planquette…
    Citation: Annals of Intensive Care 2021 11:117
  9. Percutaneous dilatational tracheotomy (PDT) has become an established procedure in intensive care units (ICU). However, the safety of this method has been under debate given the growing number of critically il...

    Authors: Enzo Lüsebrink, Alexander Krogmann, Franziska Tietz, Matthias Riebisch, Rainer Okrojek, Friedhelm Peltz, Carsten Skurk, Carsten Hullermann, Jan Sackarnd, Dietmar Wassilowsky, Karl Toischer, Clemens Scherer, Michael Preusch, Christoph Testori, Ulrike Flierl, Sven Peterss…
    Citation: Annals of Intensive Care 2021 11:116
  10. A cytokine storm is life threatening for critically ill patients and is mainly caused by sepsis or severe trauma. In combination with supportive therapy, the cytokine adsorber Cytosorb® (CS) is increasingly used ...

    Authors: Christina Scharf, Ines Schroeder, Michael Paal, Martin Winkels, Michael Irlbeck, Michael Zoller and Uwe Liebchen
    Citation: Annals of Intensive Care 2021 11:115
  11. Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as c...

    Authors: Maeva Rodriguez, Stéphanie Ragot, Rémi Coudroy, Jean-Pierre Quenot, Philippe Vignon, Jean-Marie Forel, Alexandre Demoule, Jean-Paul Mira, Jean-Damien Ricard, Saad Nseir, Gwenhael Colin, Bertrand Pons, Pierre-Eric Danin, Jérome Devaquet, Gwenael Prat, Hamid Merdji…
    Citation: Annals of Intensive Care 2021 11:114
  12. Microvascular, arterial and venous thrombotic events have been largely described during severe coronavirus disease 19 (COVID-19). However, mechanisms underlying hemostasis dysregulation remain unclear.

    Authors: Nader Yatim, Jeremy Boussier, Richard Chocron, Jérôme Hadjadj, Aurélien Philippe, Nicolas Gendron, Laura Barnabei, Bruno Charbit, Tali-Anne Szwebel, Nicolas Carlier, Frédéric Pène, Célia Azoulay, Lina Khider, Tristan Mirault, Jean-Luc Diehl, Coralie L. Guerin…
    Citation: Annals of Intensive Care 2021 11:113
  13. To evaluate the ability of the oxygen reserve index (ORI) to predict the occurrence of mild hypoxemia (defined as SpO2  <  97%) during endotracheal intubation (ETI) of patients in the intensive care unit (ICU).

    Authors: Hugo Hille, Aurelie Le Thuaut, Emmanuel Canet, Jeremie Lemarie, Laura Crosby, Gregoire Ottavy, Charlotte Garret, Maelle Martin, Amelie Seguin, Pauline Lamouche-Wilquin, Jean Morin, Olivier Zambon, Arnaud-Felix Miaihle, Jean Reignier and Jean-Baptiste Lascarrou
    Citation: Annals of Intensive Care 2021 11:112
  14. De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring to the concept of sepsis-associated immunological dysregulation, seems to be a strong signature of severe COVID-19. ...

    Authors: Clémence Marais, Caroline Claude, Nada Semaan, Ramy Charbel, Simon Barreault, Brendan Travert, Jean-Eudes Piloquet, Zoé Demailly, Luc Morin, Zied Merchaoui, Jean-Louis Teboul, Philippe Durand, Jordi Miatello and Pierre Tissières
    Citation: Annals of Intensive Care 2021 11:111
  15. The difficulty of early diagnosis of bloodstream infection in the elderly patients leads to high mortality. Therefore, it is essential to determine some new methods of early warning of bloodstream infection in...

    Authors: Tingting Liu, Jiang Wang, Yaping Yuan, Jionghe Wu, Chao Wang, Yueqin Gu and Hongxia Li
    Citation: Annals of Intensive Care 2021 11:110
  16. There is on-going controversy regarding the potential for increased respiratory effort to generate patient self-inflicted lung injury (P-SILI) in spontaneously breathing patients with COVID-19 acute hypoxaemic...

    Authors: Liam Weaver, Anup Das, Sina Saffaran, Nadir Yehya, Timothy E. Scott, Marc Chikhani, John G. Laffey, Jonathan G. Hardman, Luigi Camporota and Declan G. Bates
    Citation: Annals of Intensive Care 2021 11:109
  17. Right ventricle (RV) dilation in combination with elevated central venous pressure (CVP), which is a state of RV congestion, is seen as a sign of RV failure (RVF). On the other hand, RV systolic function is us...

    Authors: Hongmin Zhang, Wei Huang, Qing Zhang, Xiukai Chen, Xiaoting Wang and Dawei Liu
    Citation: Annals of Intensive Care 2021 11:108
  18. Veno-venous extracorporeal membrane oxygenation (ECMO) is a helpful intervention in patients with severe refractory hypoxemia either because mechanical ventilation cannot ensure adequate oxygenation or because...

    Authors: Evangelia Akoumianaki, Annemijn Jonkman, Michael C. Sklar, Dimitris Georgopoulos and Laurent Brochard
    Citation: Annals of Intensive Care 2021 11:107
  19. Intensive care workers are known for their stressful work environment and for a high prevalence of mental health outcomes. The aim of this study was to evaluate the mental health, well-being and changes in lif...

    Authors: Hannah Wozniak, Lamyae Benzakour, Grégory Moullec, Niccolò Buetti, Alice Nguyen, Sandrine Corbaz, Pauline Roos, Laure Vieux, Jean-Claude Suard, Rafaël Weissbrodt, Jérôme Pugin, Jacques A. Pralong and Sara Cereghetti
    Citation: Annals of Intensive Care 2021 11:106
  20. Authors: Virginie Lemiale, Guillaume Dumas, Alexandre Demoule, Frederic Pène, Achille Kouatchet, Magali Bisbal, Saad Nseir, Laurent Argaud, Loay Kontar, Kada Klouche, Francois Barbier, Amelie Seguin, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet…
    Citation: Annals of Intensive Care 2021 11:105

    The original article was published in Annals of Intensive Care 2021 11:17

  21. Growing evidence associates organ dysfunction(s) with impaired metabolism in sepsis. Recent research has increased our understanding of the role of substrate utilization and mitochondrial dysfunction in the pa...

    Authors: Sebastien Preau, Dominique Vodovar, Boris Jung, Steve Lancel, Lara Zafrani, Aurelien Flatres, Mehdi Oualha, Guillaume Voiriot, Youenn Jouan, Jeremie Joffre, Fabrice Uhel, Nicolas De Prost, Stein Silva, Eric Azabou and Peter Radermacher
    Citation: Annals of Intensive Care 2021 11:104

    The Correction to this article has been published in Annals of Intensive Care 2021 11:185

  22. Bibliometric analyses show gender bias against women in scientific publications and citations. We hypothesized that a metric of an individual senior author’s inclusivity of women as first authors in critical c...

    Authors: Sowmya Chary, Karin Amrein, Djøra I. Soeteman, Sangeeta Mehta and Kenneth B. Christopher
    Citation: Annals of Intensive Care 2021 11:103
  23. Compared to other life-threatening infection survivors, long-term health-related quality of life (QOL) of patients surviving necrotizing soft-tissue infections (NSTI) and its determinants are little known.

    Authors: Tomas Urbina, Florence Canoui-Poitrine, Camille Hua, Richard Layese, Aline Alves, Rachida Ouedraogo, Romain Bosc, Emilie Sbidian, Olivier Chosidow, Armand Mekontso Dessap and Nicolas de Prost
    Citation: Annals of Intensive Care 2021 11:102
  24. We tested the effect of different blood flow levels in the extracorporeal circuit on the measurements of cardiac stroke volume (SV), global end-diastolic volume index (GEDVI) and extravascular lung water index...

    Authors: Gregor Loosen, Alice Marguerite Conrad, Michael Hagman, Nils Essert, Manfred Thiel, Thomas Luecke and Joerg Krebs
    Citation: Annals of Intensive Care 2021 11:101
  25. In early 2020, the Italian Society of Anesthesia Analgesia Resuscitation and Intensive Care (SIAARTI) published clinical ethics recommendations for the allocation of intensive care during COVID-19 pandemic eme...

    Authors: Luigi Riccioni, Francesca Ingravallo, Giacomo Grasselli, Davide Mazzon, Emiliano Cingolani, Gabrio Forti, Vladimiro Zagrebelsky, Riccardo Zoja and Flavia Petrini
    Citation: Annals of Intensive Care 2021 11:100
  26. Diaphragm dysfunction and weaning-induced pulmonary oedema are commonly involved during weaning failure, but their physiological interactions have been poorly reported. Our hypothesis was that diaphragm dysfun...

    Authors: Martin Dres, Emmanuel Rozenberg, Elise Morawiec, Julien Mayaux, Julie Delemazure, Thomas Similowski and Alexandre Demoule
    Citation: Annals of Intensive Care 2021 11:99
  27. Following endotracheal intubation, clearing secretions above the endotracheal tube cuff decreases the incidence of ventilator-associated pneumonia (VAP); therefore, subglottic secretion drainage (SSD) is widel...

    Authors: Ying Li, Xue Yuan, Bing Sun, Hai-chao Li, Hui-wen Chu, Li Wang, Yu Zhao, Xiao Tang, Rui Wang, Xu-yan Li, Zhao-hui Tong and Chen Wang
    Citation: Annals of Intensive Care 2021 11:98
  28. Transition from continuous renal replacement therapy (CRRT) to intermittent renal replacement therapy (IRRT) can be associated with intra-dialytic hypotension (IDH) although data to inform the definition of ID...

    Authors: William Beaubien-Souligny, Yifan Yang, Karen E. A. Burns, Jan O. Friedrich, Alejandro Meraz-Muñoz, Edward G. Clark, Neill K. Adhikari, Sean M. Bagshaw and Ron Wald
    Citation: Annals of Intensive Care 2021 11:96
  29. Hemodynamic instability is a frequent complication of continuous renal replacement therapy (CRRT). Postural tests (i.e., passive leg raising in the supine position or Trendelenburg maneuver in the prone positi...

    Authors: Guillaume Chazot, Laurent Bitker, Mehdi Mezidi, Nader Chebib, Paul Chabert, Louis Chauvelot, Laure Folliet, Guillaume David, Judith Provoost, Hodane Yonis and Jean-Christophe Richard
    Citation: Annals of Intensive Care 2021 11:95
  30. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jean-Rémi Lavillegrand, Marc Garnier, Agathe Spaeth, Nathalie Mario, Geofroy Hariri, Antoine Pilon, Enora Berti, Fabienne Fieux, Sara Thietart, Tomas Urbina, Matthieu Turpin, Lucie Darrivere, Muriel Fartoukh, Franck Verdonk, Guillaume Dumas, Alain Tedgui…
    Citation: Annals of Intensive Care 2021 11:93

    The original article was published in Annals of Intensive Care 2021 11:9

  31. Approximately 5% of COVID-19 patients develop respiratory failure and need ventilatory support, yet little is known about the impact of mechanical ventilation strategy in COVID-19. Our objective was to describ...

    Authors: Juliana C. Ferreira, Yeh-Li Ho, Bruno Adler Maccagnan Pinheiro Besen, Luiz Marcelo Sa Malbouisson, Leandro Utino Taniguchi, Pedro Vitale Mendes, Eduardo Leite Vieira Costa, Marcelo Park, Renato Daltro-Oliveira, Roberta M. L. Roepke, Joao M. Silva-Jr, Maria Jose Carvalho Carmona and Carlos R. R. Carvalho
    Citation: Annals of Intensive Care 2021 11:92
  32. Survivors of severe COVID-19 are at risk of impaired health-related quality of life (HRQoL) and persistent physical and psychological disability after ICU and hospital discharge. The subsequent social burden i...

    Authors: Luca Carenzo, Alessandro Protti, Francesca Dalla Corte, Romina Aceto, Giacomo Iapichino, Angelo Milani, Alessandro Santini, Chiara Chiurazzi, Michele Ferrari, Enrico Heffler, Claudio Angelini, Alessio Aghemo, Michele Ciccarelli, Arturo Chiti, Theodore J. Iwashyna, Margaret S. Herridge…
    Citation: Annals of Intensive Care 2021 11:91
  33. We investigated the impact of the COVID-19 crisis on mental health of professionals working in the intensive care unit (ICU) according to the intensity of the epidemic in France.

    Authors: Alexandra Laurent, Alicia Fournier, Florent Lheureux, Guillaume Louis, Saad Nseir, Gwenaelle Jacq, Cyril Goulenok, Grégoire Muller, Julio Badie, Bélaïd Bouhemad, Marjolaine Georges, Paul-Michel Mertes, Hamid Merdji, Vincent Castelain, Caroline Abdulmalak, Olivier Lesieur…
    Citation: Annals of Intensive Care 2021 11:90
  34. In mechanically ventilated patients with acute respiratory distress syndrome (ARDS), electrical impedance tomography (EIT) provides information on alveolar cycling and overdistension as well as assessment of r...

    Authors: Tobias Becher, Valerie Buchholz, Daniel Hassel, Timo Meinel, Dirk Schädler, Inéz Frerichs and Norbert Weiler
    Citation: Annals of Intensive Care 2021 11:89
  35. There is an ongoing discussion whether hyperoxia, i.e. ventilation with high inspiratory O2 concentrations (FIO2), and the consecutive hyperoxaemia, i.e. supraphysiological arterial O2 tensions (PaO2), have a pla...

    Authors: Julien Demiselle, Enrico Calzia, Clair Hartmann, David Alexander Christian Messerer, Pierre Asfar, Peter Radermacher and Thomas Datzmann
    Citation: Annals of Intensive Care 2021 11:88
  36. Dexamethasone decreases mortality in patients with severe coronavirus disease 2019 (COVID-19) and has become the standard of care during the second wave of pandemic. Dexamethasone is an immunosuppressive treat...

    Authors: Ines Gragueb-Chatti, Alexandre Lopez, Dany Hamidi, Christophe Guervilly, Anderson Loundou, Florence Daviet, Nadim Cassir, Laurent Papazian, Jean-Marie Forel, Marc Leone, Jean Dellamonica and Sami Hraiech
    Citation: Annals of Intensive Care 2021 11:87
  37. While acute kidney injury (AKI) is frequent in severe SARS-CoV2-related pneumonia ICU patients, few data are still available about its risk factors.

    Authors: Guillaume Geri, Michael Darmon, Lara Zafrani, Muriel Fartoukh, Guillaume Voiriot, Julien Le Marec, Saafa Nemlaghi, Antoine Vieillard-Baron and Elie Azoulay
    Citation: Annals of Intensive Care 2021 11:86
  38. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Elsa Manquat, Matthieu Le Dorze, Gauthier Pean De Ponflly, Hanaa Benmansour, Rishma Amarsy, Emmanuelle Cambau, Benjamin Soyer, Benjamin Glenn Chousterman and Hervé Jacquier
    Citation: Annals of Intensive Care 2021 11:84

    The original article was published in Annals of Intensive Care 2020 10:149

  39. Empirical antibiotic has been considered in severe COVID-19 although little data are available regarding concomitant infections. This study aims to assess the frequency of infections, community and hospital-ac...

    Authors: Anastasia Saade, Giulia Moratelli, Guillaume Dumas, Asma Mabrouki, Jean-Jacques Tudesq, Lara Zafrani, Elie Azoulay and Michael Darmon
    Citation: Annals of Intensive Care 2021 11:83
  40. Sepsis is a life-threatening, dysregulated response to infection. Lipid biomarkers including cholesterol are dynamically regulated during sepsis and predict short-term outcomes. In this study, we investigated ...

    Authors: Faheem W. Guirgis, Christiaan Leeuwenburgh, Lyle Moldawer, Gabriela Ghita, Lauren Page Black, Morgan Henson, Elizabeth DeVos, David Holden, Phil Efron, Srinivasa T. Reddy and Frederick A. Moore
    Citation: Annals of Intensive Care 2021 11:82
  41. The administration of epinephrine in the management of non-traumatic cardiac arrest remains recommended despite controversial effects on neurologic outcome. The use of resuscitative endovascular balloon occlus...

    Authors: Alice Hutin, Yaël Levy, Fanny Lidouren, Matthias Kohlhauer, Pierre Carli, Bijan Ghaleh, Lionel Lamhaut and Renaud Tissier
    Citation: Annals of Intensive Care 2021 11:81
  42. The autonomic nervous system (ANS) regulates the cardiovascular system. A growing body of experimental and clinical evidence confirms significant dysfunction of this regulation during sepsis and septic shock. ...

    Authors: Marta Carrara, Manuela Ferrario, Bernardo Bollen Pinto and Antoine Herpain
    Citation: Annals of Intensive Care 2021 11:80
  43. Iatrogenic fluid overload is a potential side effect of intravenous fluid therapy in the hospital. Little attention has been paid to sodium administration as a separate cause of harm. With this narrative revie...

    Authors: Niels Van Regenmortel, Lynn Moers, Thomas Langer, Ella Roelant, Tim De Weerdt, Pietro Caironi, Manu L. N. G. Malbrain, Paul Elbers, Tim Van den Wyngaert and Philippe G. Jorens
    Citation: Annals of Intensive Care 2021 11:79
  44. The ARDS is characterized by different degrees of impairment in oxygenation and distribution of the lung disease. Two radiological patterns have been described: a focal and a diffuse one. These two patterns co...

    Authors: Silvia Coppola, Tommaso Pozzi, Martina Gurgitano, Alessandro Liguori, Ejona Duka, Francesca Bichi, Arianna Ciabattoni and Davide Chiumello
    Citation: Annals of Intensive Care 2021 11:78
  45. The COVID-19 pandemic is a heavy burden in terms of health care resources. Future decision-making policies require consistent data on the management and prognosis of the older patients (> 70 years old) with CO...

    Authors: Martin Dres, David Hajage, Said Lebbah, Antoine Kimmoun, Tai Pham, Gaëtan Béduneau, Alain Combes, Alain Mercat, Bertrand Guidet, Alexandre Demoule and Matthieu Schmidt
    Citation: Annals of Intensive Care 2021 11:77
  46. EEG-based prognostication studies in intensive care units often rely on a standard 21-electrode montage (stdEEG) requiring substantial human, technical, and financial resources. We here evaluate whether a simplif...

    Authors: Cyril Touchard, Jérôme Cartailler, Geoffroy Vellieux, Etienne de Montmollin, Pierre Jaquet, Ruben Wanono, Jean Reuter, Marylou Para, Lila Bouadma, Jean-François Timsit, Marie-Pia d’Ortho, Nathalie Kubis, Anny Rouvel Tallec and Romain Sonneville
    Citation: Annals of Intensive Care 2021 11:76

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