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  1. Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug con...

    Authors: Jörn Grensemann, David Busse, Christina König, Kevin Roedl, Walter Jäger, Dominik Jarczak, Stefanie Iwersen-Bergmann, Carolin Manthey, Stefan Kluge, Charlotte Kloft and Valentin Fuhrmann

    Citation: Annals of Intensive Care 2020 10:48

    Content type: Research

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  2. Biomarkers can play a critical role by facilitating diagnosis and stratification of disease, as well as assessment or prediction of disease severity. Urinary tissue inhibitor of metalloproteinase-2 and insulin...

    Authors: Ilaria Godi, Silvia De Rosa, Francesca Martino, Simona Bazzano, Marina Martin, Elisa Boni, Maria Rosa Carta, Claudia Tamayo Diaz, Gaia Mari, Anna Lorenzin, Massimo de Cal, Valentina Corradi, Carlotta Caprara, Davide Giavarina and Claudio Ronco

    Citation: Annals of Intensive Care 2020 10:46

    Content type: Research

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  3. Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. Among people ...

    Authors: Lei Li, Ranran Li, Zhixiong Wu, Xianghong Yang, Mingyan Zhao, Jiao Liu and Dechang Chen

    Citation: Annals of Intensive Care 2020 10:45

    Content type: Review

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  4. To describe acute kidney injury (AKI) natural history and to identify predictors of major adverse kidney events (MAKE) within 1 year in patients supported by veno-arterial extracorporeal membrane oxygenation (...

    Authors: Camille Vinclair, Etienne De Montmollin, Romain Sonneville, Jean Reuter, Jordane Lebut, Radj Cally, Bruno Mourvillier, Mathilde Neuville, Stéphane Ruckly, Jean-François Timsit and Lila Bouadma

    Citation: Annals of Intensive Care 2020 10:44

    Content type: Research

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  5. Acute kidney injury (AKI) is a common problem in critically ill patients and associated with high rates of morbidity and mortality. Recently, Major Adverse Kidney Events (MAKE) were introduced as important kid...

    Authors: Theerapon Sukmark, Nuttha Lumlertgul, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong and Nattachai Srisawat

    Citation: Annals of Intensive Care 2020 10:42

    Content type: Research

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  6. Loss of vascular tone is a key pathophysiological feature of septic shock. Combination of gradual diastolic hypotension and tachycardia could reflect more serious vasodilatory conditions. We sought to evaluate...

    Authors: Gustavo A. Ospina-Tascón, Jean-Louis Teboul, Glenn Hernandez, Ingrid Alvarez, Alvaro I. Sánchez-Ortiz, Luis E. Calderón-Tapia, Ramiro Manzano-Nunez, Edgardo Quiñones, Humberto J. Madriñan-Navia, Juan E. Ruiz, José L. Aldana and Jan Bakker

    Citation: Annals of Intensive Care 2020 10:41

    Content type: Research

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  7. Resuscitation of septic patients regarding goals, monitoring aspects and therapy is highly variable. Our aim was to characterize cardiovascular and fluid management of sepsis in Argentina, a low and middle-inc...

    Authors: Arnaldo Dubin, Cecilia Loudet, Vanina S. Kanoore Edul, Javier Osatnik, Fernando Ríos, Daniela Vásquez, Mario Pozo, Bernardo Lattanzio, Fernando Pálizas, Francisco Klein, Damián Piezny, Paolo N. Rubatto Birri, Graciela Tuhay, Analía García, Analía Santamaría, Graciela Zakalik…

    Citation: Annals of Intensive Care 2020 10:40

    Content type: Research

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  8. Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO2 as compared to fres...

    Authors: Andrea Coppadoro, Alice Grassi, Cecilia Giovannoni, Francesca Rabboni, Nilde Eronia, Alfio Bronco, Giuseppe Foti, Roberto Fumagalli and Giacomo Bellani

    Citation: Annals of Intensive Care 2020 10:39

    Content type: Research

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  9. The aim of the study was to detect differences in the conjunctival microcirculation between septic patients and healthy subjects and to evaluate the course of conjunctival and retinal microvasculature in survi...

    Authors: Jurate Simkiene, Zivile Pranskuniene, Astra Vitkauskiene, Vidas Pilvinis, E. Christiaan Boerma and Andrius Pranskunas

    Citation: Annals of Intensive Care 2020 10:38

    Content type: Research

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  10. The outbreak of a novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) is currently ongoing in China. Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. However, the...

    Authors: Ke Wang, Wei Zhao, Ji Li, Weiwei Shu and Jun Duan

    Citation: Annals of Intensive Care 2020 10:37

    Content type: Research

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  11. Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase ...

    Authors: Rene A. Posma, Trine Frøslev, Bente Jespersen, Iwan C. C. van der Horst, Daan J. Touw, Reimar W. Thomsen, Maarten W. Nijsten and Christian F. Christiansen

    Citation: Annals of Intensive Care 2020 10:36

    Content type: Research

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  12. Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS). Although increased dead-space ventilation (VD/VT) has been described in ARDS, its mechanism is not clearly und...

    Authors: Gustavo A. Ospina-Tascón, Diego F. Bautista, Humberto J. Madriñán, Juan D. Valencia, William F. Bermúdez, Edgardo Quiñones, Luis Eduardo Calderón-Tapia, Glenn Hernandez, Alejandro Bruhn and Daniel De Backer

    Citation: Annals of Intensive Care 2020 10:35

    Content type: Research

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  13. Evidence supporting corticosteroids adjunctive treatment (CAT) for Pneumocystis jirovecii pneumonia (PCP) in non-HIV patients is highly controversial. We aimed to systematically review the literature and perform ...

    Authors: Lin Ding, Huixue Huang, Heyan Wang and Hangyong He

    Citation: Annals of Intensive Care 2020 10:34

    Content type: Research

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  14. Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is associated with prolonged hospitalization, progression to chronic kidney disease (CKD), financial burden, and high mortalit...

    Authors: Ayman Karkar and Claudio Ronco

    Citation: Annals of Intensive Care 2020 10:32

    Content type: Review

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  15. High-frequency oscillatory ventilation (HFOV) may theoretically provide lung protective ventilation. The negative clinical results may be due to inadequate mean airway pressure (mPaw) settings in HFOV. Our obj...

    Authors: Songqiao Liu, Zhanqi Zhao, Li Tan, Lihui Wang, Knut Möller, Inéz Frerichs, Tao Yu, Yingzi Huang, Chun Pan, Yi Yang and Haibo Qiu

    Citation: Annals of Intensive Care 2020 10:31

    Content type: Research

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  16. The optimal timing of renal replacement therapy (RRT) initiation is debatable. Many articles in this field enrolled trials not based on acute kidney injury. The safety of the watchful waiting strategy has not ...

    Authors: Jia-Jin Chen, Cheng-Chia Lee, George Kuo, Pei-Chun Fan, Chan-Yu Lin, Su-Wei Chang, Ya-Chung Tian, Yung-Chang Chen and Chih-Hsiang Chang

    Citation: Annals of Intensive Care 2020 10:30

    Content type: Research

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  17. After publication of the original article [1], we were notified that family names have been exchanged with the first names for all authors. Below the name are tagged correctly:

    Authors: Jordane Lebut, Bruno Mourvillier, Nicolas Argy, Claire Dupuis, Camille Vinclair, Aguila Radjou, Etienne de Montmollin, Fabrice Sinnah, Juliette Patrier, Clément Le Bihan, Eric Magalahes, Roland Smonig, Eric Kendjo, Marc Thellier, Stéphane Ruckly, Lila Bouadma…

    Citation: Annals of Intensive Care 2020 10:29

    Content type: Correction

    Published on:

    The original article was published in Annals of Intensive Care 2020 10:21

  18. It has been suggested that, by recruiting lung regions and enlarging the distribution volume of the cold indicator, increasing the positive end-expiratory pressure (PEEP) may lead to an artefactual overestimat...

    Authors: Francesco Gavelli, Jean-Louis Teboul, Danila Azzolina, Alexandra Beurton, Temistocle Taccheri, Imane Adda, Christopher Lai, Gian Carlo Avanzi and Xavier Monnet

    Citation: Annals of Intensive Care 2020 10:28

    Content type: Research

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  19. Rhabdomyolysis is a life-threatening disease that can lead to severe hyperkalemia, acute kidney injury (AKI) and hypovolemic shock. The predictive factors of AKI and acute to chronic kidney disease (CKD) trans...

    Authors: Nelly Candela, Stein Silva, Bernard Georges, Claire Cartery, Thomas Robert, Julie Moussi-Frances, Eric Rondeau, Jean-Michel Rebibou, Laurence Lavayssiere, Julie Belliere, Thierry Krummel, Céline Lebas, Olivier Cointault, Marion Sallee and Stanislas Faguer

    Citation: Annals of Intensive Care 2020 10:27

    Content type: Research

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  20. Corticosteroid treatment has been widely used in the treatment of septic shock, influenza, and ARDS, although some previous studies discourage its use in severe influenza patients. This multicenter retrospecti...

    Authors: Ming-Ju Tsai, Kuang-Yao Yang, Ming-Cheng Chan, Kuo-Chin Kao, Hao-Chien Wang, Wann-Cherng Perng, Chieh-Liang Wu, Shinn-Jye Liang, Wen-Feng Fang, Jong-Rung Tsai, Wei-An Chang, Ying-Chun Chien, Wei-Chih Chen, Han-Chung Hu, Chiung-Yu Lin, Wen-Cheng Chao…

    Citation: Annals of Intensive Care 2020 10:26

    Content type: Research

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  21. Right ventricular (RV) function evaluation by echocardiography is key in the management of ICU patients with acute respiratory distress syndrome (ARDS), however, it remains challenging. Quantification of RV de...

    Authors: Jérémie Lemarié, Charles-Henri Maigrat, Antoine Kimmoun, Nathalie Dumont, Pierre-Edouard Bollaert, Christine Selton-Suty, Sébastien Gibot and Olivier Huttin

    Citation: Annals of Intensive Care 2020 10:24

    Content type: Research

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  22. The primary aim of the present contribution is to find a literature-based agreement on dose adjustments of vitamin C in critically ill patients undergoing renal replacement therapy (RRT).

    Authors: Patrick M. Honore, Herbert D. Spapen, Paul Marik, Willem Boer and Heleen Oudemans-van Straaten

    Citation: Annals of Intensive Care 2020 10:23

    Content type: Review

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  23. In France, the incidence of severe imported malaria cases increased since early 2000. Artesunate was available (temporarily use authorization) since mid-2011 in France and commonly used for severe malaria sinc...

    Authors: Jordane Lebut, Bruno Mourvillier, Nicolas Argy, Claire Dupuis, Camille Vinclair, Aguila Radjou, Etienne de Montmollin, Fabrice Sinnah, Juliette Patrier, Clément Le Bihan, Eric Magalahes, Roland Smonig, Eric Kendjo, Marc Thellier, Stéphane Ruckly, Lila Bouadma…

    Citation: Annals of Intensive Care 2020 10:21

    Content type: Research

    Published on:

    The Correction to this article has been published in Annals of Intensive Care 2020 10:29

  24. The influence of socioeconomic status on patient outcomes is unclear. We assessed the impact of socioeconomic deprivation on severity of illness at intensive care unit (ICU) admission, and on the risk of death...

    Authors: Jean-Pierre Quenot, Julie Helms, Guylaine Labro, Auguste Dargent, Nicolas Meunier-Beillard, Elea Ksiazek, Pierre-Edouard Bollaert, Guillaume Louis, Audrey Large, Pascal Andreu, Christophe Bein, Jean-Philippe Rigaud, Pierre Perez, Raphaël Clere-Jehl, Hamid Merdji, Hervé Devilliers…

    Citation: Annals of Intensive Care 2020 10:20

    Content type: Research

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  25. Protective mechanical ventilation is recommended for patients with acute respiratory distress syndrome (ARDS), but it usually requires controlled ventilation and sedation. Using neurally adjusted ventilatory a...

    Authors: Fabia Diniz-Silva, Henrique T. Moriya, Adriano M. Alencar, Marcelo B. P. Amato, Carlos R. R. Carvalho and Juliana C. Ferreira

    Citation: Annals of Intensive Care 2020 10:18

    Content type: Research

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  26. High glycemic variability (GV) is common in critically ill patients; however, the prevalence and mortality association with early GV in patients with sepsis remains unclear.

    Authors: Wen-Cheng Chao, Chien-Hua Tseng, Chieh-Liang Wu, Sou-Jen Shih, Chi-Yuan Yi and Ming-Cheng Chan

    Citation: Annals of Intensive Care 2020 10:17

    Content type: Research

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  27. The US Centers for Disease Control and Prevention (CDC) recently released simplified eSOFA organ dysfunction criteria of Adult Sepsis Event for sepsis surveillance in the US. Our study aimed to compare the pre...

    Authors: Run Dong, Hongcheng Tian, Jianfang Zhou, Li Weng, Xiaoyun Hu, Jinmin Peng, Chunyao Wang, Wei Jiang, Xueping Du, Xiuming Xi, Youzhong An, Meili Duan and Bin Du

    Citation: Annals of Intensive Care 2020 10:14

    Content type: Research

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  28. Protective ventilation is the cornerstone of treatment of patients with the acute respiratory distress syndrome (ARDS); however, no studies have yet established the best ventilatory strategy to adopt when pati...

    Authors: Alessandro Marchioni, Roberto Tonelli, Giulio Rossi, Paolo Spagnolo, Fabrizio Luppi, Stefania Cerri, Elisabetta Cocconcelli, Maria Rosaria Pellegrino, Riccardo Fantini, Luca Tabbì, Ivana Castaniere, Lorenzo Ball, Manu L. N. G. Malbrain, Paolo Pelosi and Enrico Clini

    Citation: Annals of Intensive Care 2020 10:13

    Content type: Review

    Published on:

  29. Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), t...

    Authors: Guillaume Franchineau, Nicolas Bréchot, Guillaume Hekimian, Guillaume Lebreton, Simon Bourcier, Pierre Demondion, Loïc Le Guennec, Ania Nieszkowska, Charles-Edouard Luyt, Alain Combes and Matthieu Schmidt

    Citation: Annals of Intensive Care 2020 10:12

    Content type: Research

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  30. Activation of arginine–vasopressin is one of the hormonal responses to face vasodilation-related hypotension. Released from the post-pituitary gland, vasopressin induces vasoconstriction through the activation...

    Authors: Julien Demiselle, Nicolas Fage, Peter Radermacher and Pierre Asfar

    Citation: Annals of Intensive Care 2020 10:9

    Content type: Review

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  31. Few validated biomarker or clinical score combinations exist which can discriminate between cases of infection and other non-infectious conditions following activation of an in-hospital sepsis code, as well as...

    Authors: Jaume Baldirà, Juan Carlos Ruiz-Rodríguez, Darius Cameron Wilson, Adolf Ruiz-Sanmartin, Alejandro Cortes, Luis Chiscano, Roser Ferrer-Costa, Inma Comas, Nieves Larrosa, Anna Fàbrega, Juan José González-López and Ricard Ferrer

    Citation: Annals of Intensive Care 2020 10:7

    Content type: Research

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  32. The aim of this study was to investigate the concordance between ventilator-associated events (VAE) and ventilator-associated lower respiratory tract infections (VA-LRTI), and their impact on outcome.

    Authors: Olivier Pouly, Sylvain Lecailtel, Sophie Six, Sébastien Préau, Frédéric Wallet, Saad Nseir and Anahita Rouzé

    Citation: Annals of Intensive Care 2020 10:6

    Content type: Research

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  33. Currently, there are no reliable predictors of risk of development and severity of acute kidney injury (AKI) in septic patients. The surfactant protein D (SP-D) polymorphism rs721917C/T is associated with a gr...

    Authors: Jiao Liu, Jianying Yao, Lidi Zhang, Yizhu Chen, Hangxiang Du, Zhenliang Wen and Dechang Chen

    Citation: Annals of Intensive Care 2020 10:5

    Content type: Research

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  34. Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT >...

    Authors: Amol T. Kothekar, Jigeeshu Vasishtha Divatia, Sheila Nainan Myatra, Anand Patil, Manjunath Nookala Krishnamurthy, Harish Mallapura Maheshwarappa, Suhail Sarwar Siddiqui, Murari Gurjar, Sanjay Biswas and Vikram Gota

    Citation: Annals of Intensive Care 2020 10:4

    Content type: Research

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  35. Mortality in acute respiratory distress syndrome (ARDS) remains unacceptably high at approximately 39%. One of the only treatments is supportive: mechanical ventilation. However, improperly set mechanical vent...

    Authors: Gary F. Nieman, Louis A. Gatto, Penny Andrews, Joshua Satalin, Luigi Camporota, Benjamin Daxon, Sarah J. Blair, Hassan Al-khalisy, Maria Madden, Michaela Kollisch-Singule, Hani Aiash and Nader M. Habashi

    Citation: Annals of Intensive Care 2020 10:3

    Content type: Review

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  36. Intubation is a lifesaving procedure that is often performed in intensive care unit (ICU) patients, but leads to serious adverse events in 20–40% of cases. Recent trials aimed to provide guidance about which m...

    Authors: M. Martin, P. Decamps, A. Seguin, C. Garret, L. Crosby, O. Zambon, A. F. Miailhe, E. Canet, J. Reignier and J. B. Lascarrou

    Citation: Annals of Intensive Care 2020 10:2

    Content type: Research

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  37. Intensive care unit (ICU)-acquired weakness and diaphragm dysfunction are frequent conditions, both associated with poor prognosis in critically ill patients. While it is well established that ICU-acquired wea...

    Authors: Clément Saccheri, Elise Morawiec, Julie Delemazure, Julien Mayaux, Bruno-Pierre Dubé, Thomas Similowski, Alexandre Demoule and Martin Dres

    Citation: Annals of Intensive Care 2020 10:1

    Content type: Research

    Published on:

  38. Herpesviridae reactivation among non-immunocompromised critically ill patients is associated with impaired prognosis, especially during acute respiratory distress syndrome (ARDS). However, little is known about h...

    Authors: Sami Hraiech, Eline Bonnardel, Christophe Guervilly, Cyprien Fabre, Anderson Loundou, Jean-Marie Forel, Mélanie Adda, Gabriel Parzy, Guilhem Cavaille, Benjamin Coiffard, Antoine Roch and Laurent Papazian

    Citation: Annals of Intensive Care 2019 9:142

    Content type: Research

    Published on:

  39. Citation: Annals of Intensive Care 2019 9:139

    Content type: Letter to the Editor

    Published on:

    The original article was published in Annals of Intensive Care 2019 9:108

    The Letter to the Editor Response to this article has been published in Annals of Intensive Care 2019 9:140

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