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  1. We describe a frugal approach (focusing on needs, performance, and costs) to manage a massive influx of COVID-19 patients with acute hypoxemic respiratory failure (AHRF) using the Boussignac valve protected by...

    Authors: Guillaume Carteaux, Manuella Pons, François Morin, Samuel Tuffet, Arnaud Lesimple, Bilal Badat, Anne-Fleur Haudebourg, François Perier, Yvon Deplante, Constance Guillaud, Frédéric Schlemmer, Elena Fois, Nicolas Mongardon, Mehdi Khellaf, Karim Jaffal, Camille Deguillard…

    Citation: Annals of Intensive Care 2021 11:38

    Content type: Research

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  2. The efficacy of high flow nasal canula oxygen therapy (HFNO) to prevent invasive mechanical ventilation (IMV) is not well established in severe coronavirus disease 2019 (COVID-19). The aim of this study was to...

    Authors: Nicolas Bonnet, Olivier Martin, Marouane Boubaya, Vincent Levy, Nathan Ebstein, Philippe Karoubi, Yacine Tandjaoui-Lambiotte, Guillaume Van Der Meersch, Johanna Oziel, Marie Soulie, Mohamed Ghalayini, Anais Winchenne, Jean Ralph Zahar, Passem Ahmed, Stéphane Gaudry and Yves Cohen

    Citation: Annals of Intensive Care 2021 11:37

    Content type: Research

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  3. SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the early twentieth century. Since there is no ...

    Authors: Ludhmila Abrahão Hajjar, Isabela Bispo Santos da Silva Costa, Stephanie Itala Rizk, Bruno Biselli, Brenno Rizerio Gomes, Cristina Salvadori Bittar, Gisele Queiroz de Oliveira, Juliano Pinheiro de Almeida, Mariana Vieira de Oliveira Bello, Cibele Garzillo, Alcino Costa Leme, Moizo Elena, Fernando Val, Marcela de Almeida Lopes, Marcus Vinícius Guimarães Lacerda, José Antonio Franchini Ramires…

    Citation: Annals of Intensive Care 2021 11:36

    Content type: Review

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  4. Improving outcomes of older patients admitted into intensive care units (ICU) is a raising concern. This study aimed at determining which geriatric and ICU parameters were associated with in-hospital and long-...

    Authors: Julien Demiselle, Guillaume Duval, Jean-François Hamel, Anne Renault, Laetitia Bodet-Contentin, Laurent Martin-Lefèvre, Dominique Vivier, Daniel Villers, Montaine Lefèvre, René Robert, Philippe Markowicz, Sylvain Lavoué, Anne Courte, Eddy Lebas, Stéphanie Chevalier, Cédric Annweiler…

    Citation: Annals of Intensive Care 2021 11:35

    Content type: Research

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  5. The effect of cytomegalovirus (CMV) reactivation on the length of mechanical ventilation and mortality in immunocompetent ICU patients requiring invasive mechanical ventilation remains controversial. The main ...

    Authors: Laurent Papazian, Samir Jaber, Sami Hraiech, Karine Baumstarck, Sophie Cayot-Constantin, Nadia Aissaoui, Boris Jung, Marc Leone, Bertrand Souweine, Carole Schwebel, Jérémy Bourenne, Jérôme Allardet-Servent, Toufik Kamel, Qin Lu, Christine Zandotti, Anderson Loundou…

    Citation: Annals of Intensive Care 2021 11:33

    Content type: Research

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  6. The European Society of Pediatric and Neonatal Intensive Care (ESPNIC) developed and validated a definition of pediatric refractory septic shock (RSS), based on two septic shock scores (SSS). Both bedside SSS ...

    Authors: Luc Morin, Karthik Narayanan Ramaswamy, Muralidharan Jayashree, Arun Bansal, Karthi Nallasamy, Pierre Tissieres and Sunit Singhi

    Citation: Annals of Intensive Care 2021 11:32

    Content type: Research

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  7. Mucormycosis is an emerging fungal infection that may lead to multi-organ failure, especially in patients with hematological malignancies (HM). We performed a retrospective, cohort study, in five intensive car...

    Authors: Matthieu Jestin, Elie Azoulay, Frédéric Pène, Fabrice Bruneel, Julien Mayaux, Martin Murgier, Michael Darmon and Sandrine Valade

    Citation: Annals of Intensive Care 2021 11:31

    Content type: Research

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  8. Several randomized clinical trials have shown that non-invasive ventilation (NIV) applied immediately after extubation may prevent reintubation in patients at high-risk of extubation failure. However, most of ...

    Authors: Arnaud W. Thille, Rémi Coudroy, Mai-Anh Nay, Arnaud Gacouin, Maxens Decavèle, Romain Sonneville, François Beloncle, Christophe Girault, Laurence Dangers, Alexandre Lautrette, Quentin Levrat, Anahita Rouzé, Emmanuel Vivier, Jean-Baptiste Lascarrou, Jean-Damien Ricard, Keyvan Razazi…

    Citation: Annals of Intensive Care 2021 11:30

    Content type: Research

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  9. Systemic rheumatic diseases (SRDs) are a group of inflammatory disorders that can require intensive care unit (ICU) admission because of multiorgan involvement with end-organ failure(s). Critically ill SRD pat...

    Authors: Pierre Bay, Guillaume Lebreton, Alexis Mathian, Pierre Demondion, Cyrielle Desnos, Juliette Chommeloux, Guillaume Hékimian, Nicolas Bréchot, Ania Nieszkowska, Matthieu Schmidt, Fleur Cohen-Aubart, Pascal Leprince, Charles-Edouard Luyt, Zahir Amoura, Alain Combes and Marc Pineton de Chambrun

    Citation: Annals of Intensive Care 2021 11:29

    Content type: Research

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  10. Dynamic predictors of fluid responsiveness have shown good performance in mechanically ventilated patients at tidal volumes (Vt) > 8 mL kg−1. Nevertheless, most critically ill conditions demand lower Vt. We sough...

    Authors: Jorge Iván Alvarado Sánchez, Juan Daniel Caicedo Ruiz, Juan José Diaztagle Fernández, William Fernando Amaya Zuñiga, Gustavo Adolfo Ospina-Tascón and Luis Eduardo Cruz Martínez

    Citation: Annals of Intensive Care 2021 11:28

    Content type: Review

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  11. Acute heart failure is a life-threatening clinical condition. Levosimendan is an effective inotropic agent used to maintain cardiac output, but its usage is limited by the lack of evidence in patients with sev...

    Authors: Cze-Ci Chan, Kuang-Tso Lee, Wan-Jing Ho, Yi-Hsin Chan and Pao-Hsien Chu

    Citation: Annals of Intensive Care 2021 11:27

    Content type: Research

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  12. High respiratory drive in mechanically ventilated patients with spontaneous breathing effort may cause excessive lung stress and strain and muscle loading. Therefore, it is important to have a reliable estimat...

    Authors: Lisanne Roesthuis, Maarten van den Berg and Hans van der Hoeven

    Citation: Annals of Intensive Care 2021 11:26

    Content type: Research

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  13. Acute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. However, data on AKI markers such as plasma proenkephalin (P-PENK) and neutrophil gelatinase-associated lipocalin (P-NGAL) in ...

    Authors: Toni Jäntti, Tuukka Tarvasmäki, Veli-Pekka Harjola, Kari Pulkki, Heidi Turkia, Tuija Sabell, Heli Tolppanen, Raija Jurkko, Mari Hongisto, Anu Kataja, Alessandro Sionis, Jose Silva-Cardoso, Marek Banaszewski, Salvatore DiSomma, Alexandre Mebazaa, Mikko Haapio…

    Citation: Annals of Intensive Care 2021 11:25

    Content type: Research

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  14. Diametrically opposed positions exist regarding the deleterious effects of elevated lactate. There are data suggesting that it is a detrimental proxy for tissue hypoperfusion and anaerobic metabolism in sepsis...

    Authors: Nikhil Jagan, Lee E. Morrow, Ryan W. Walters, Robert W. Plambeck, Tej M. Patel, Douglas R. Moore and Mark A. Malesker

    Citation: Annals of Intensive Care 2021 11:24

    Content type: Research

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  15. Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments deve...

    Authors: Hans Flaatten, Bertrand Guidet, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Ariane Boumendil, Muhammed Elhadi, Jesper Fjølner, Michael Joannidis, Christian Jung, Susannah Leaver, Brian Marsh, Rui Moreno, Sandra Oeyen, Yuriy Nalapko, Joerg C. Schefold…

    Citation: Annals of Intensive Care 2021 11:22

    Content type: Research

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  16. Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope thera...

    Authors: Thomas W. L. Scheeren, Jan Bakker, Thomas Kaufmann, Djillali Annane, Pierre Asfar, E. Christiaan Boerma, Maurizio Cecconi, Michelle S. Chew, Bernard Cholley, Maria Cronhjort, Daniel De Backer, Arnaldo Dubin, Martin W. Dünser, Jacques Duranteau, Anthony C. Gordon, Ludhmila A. Hajjar…

    Citation: Annals of Intensive Care 2021 11:21

    Content type: Research

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  17. The aim of this study is to determine whether severe COVID-19 patients harbour a higher risk of ICU-acquired pneumonia.

    Authors: Jean-François Llitjos, Swann Bredin, Jean-Baptiste Lascarrou, Thibaud Soumagne, Mariana Cojocaru, Maxime Leclerc, Arnaud Lepetit, Albin Gouhier, Julien Charpentier, Gaël Piton, Matthieu Faron, Annabelle Stoclin and Frédéric Pène

    Citation: Annals of Intensive Care 2021 11:20

    Content type: Research

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  18. Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict ...

    Authors: Virginie Lemiale, Guillaume Dumas, Alexandre Demoule, Frederic Pène, Achille Kouatchet, Magali Bisbal, Saad Nseir, Laurent Argaud, Loay Kontar, Kada Klouche, Francois Barbier, Amelie Seguin, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet…

    Citation: Annals of Intensive Care 2021 11:17

    Content type: Research

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  19. Evaluation of fluid responsiveness during veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support is crucial. The aim of this study was to investigate whether changes in left ventricular outflow tr...

    Authors: Jing-chao Luo, Ying Su, Li-li Dong, Jun-yi Hou, Xin Li, Ying Zhang, Guo-guang Ma, Ji-li Zheng, Guang-wei Hao, Huan Wang, Yi-jie Zhang, Zhe Luo and Guo-wei Tu

    Citation: Annals of Intensive Care 2021 11:16

    Content type: Research

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  20. The detrimental effects of inotropes are well-known, and in many fields they are only used within a goal-directed therapy approach. Nevertheless, standard management in many centers includes administering inot...

    Authors: Rafael Alves Franco, Juliano Pinheiro de Almeida, Giovanni Landoni, Thomas W. L. Scheeren, Filomena Regina Barbosa Gomes Galas, Julia Tizue Fukushima, Suely Zefferino, Pasquale Nardelli, Marilde de Albuquerque Piccioni, Elisandra Cristina Trevisan Calvo Arita, Clarice Hyesuk Lee Park, Ligia Cristina Camara Cunha, Gisele Queiroz de Oliveira, Isabela Bispo Santos da Silva Costa, Roberto Kalil Filho, Fabio Biscegli Jatene…

    Citation: Annals of Intensive Care 2021 11:15

    Content type: Research

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  21. Thromboprophylaxis of COVID-19 patients is a highly debated issue. We aimed to compare the occurrence of thrombotic/ischemic events in COVID-19 patients with acute respiratory distress syndrome (ARDS) treated ...

    Authors: Julie Helms, François Severac, Hamid Merdji, Maleka Schenck, Raphaël Clere-Jehl, Mathieu Baldacini, Mickaël Ohana, Lélia Grunebaum, Vincent Castelain, Eduardo Anglés-Cano, Laurent Sattler and Ferhat Meziani

    Citation: Annals of Intensive Care 2021 11:14

    Content type: Research

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  22. Regional citrate anticoagulation (RCA) is the gold standard of anticoagulation for continuous renal replacement therapy but is rarely used for intermittent hemodialysis (IHD) in ICU. Few studies assessed the s...

    Authors: Christophe Leroy, Bruno Pereira, Edouard Soum, Claire Bachelier, Elisabeth Coupez, Laure Calvet, Konstantinos Bachoumas, Claire Dupuis, Bertrand Souweine and Alexandre Lautrette

    Citation: Annals of Intensive Care 2021 11:13

    Content type: Research

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  23. Glycaemic control (GC) in intensive care unit is challenging due to significant inter- and intra-patient variability, leading to increased risk of hypoglycaemia. Recent work showed higher insulin resistance in...

    Authors: Vincent Uyttendaele, J. Geoffrey Chase, Jennifer L. Knopp, Rebecca Gottlieb, Geoffrey M. Shaw and Thomas Desaive

    Citation: Annals of Intensive Care 2021 11:12

    Content type: Research

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  24. High-density lipoproteins (HDLs), particles characterized by their reverse cholesterol transport function, display pleiotropic properties, including anti-inflammatory and antioxidant functions. Moreover, all l...

    Authors: Sébastien Tanaka, Jules Stern, Donia Bouzid, Tiphaine Robert, Monique Dehoux, Aurélie Snauwaert, Nathalie Zappella, Maxime Cournot, Brice Lortat-Jacob, Pascal Augustin, Enora Atchade, Alexy Tran-Dinh, Olivier Meilhac and Philippe Montravers

    Citation: Annals of Intensive Care 2021 11:11

    Content type: Research

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  25. The role of artificial and bioartificial liver support systems in acute-on-chronic liver failure (ACLF) is still controversial. We aimed to perform the first network meta-analysis comparing and ranking differe...

    Authors: Klementina Ocskay, Anna Kanjo, Noémi Gede, Zsolt Szakács, Gabriella Pár, Bálint Erőss, Jan Stange, Steffen Mitzner, Péter Hegyi and Zsolt Molnár

    Citation: Annals of Intensive Care 2021 11:10

    Content type: Review

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  26. SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known abou...

    Authors: Jean-Rémi Lavillegrand, Marc Garnier, Agathe Spaeth, Nathalie Mario, Geoffroy Hariri, Antoine Pilon, Enora Berti, Fabienne Fieux, Sara Thietart, Tomas Urbina, Matthieu Turpin, Lucie Darrivière, Muriel Fartoukh, Franck Verdonk, Guillaume Dumas, Alain Tedgui…

    Citation: Annals of Intensive Care 2021 11:9

    Content type: Research

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  27. Little interest has been paid to expiratory muscle strength, and the impact of expiratory muscle weakness on critical outcomes is not known. Very few studies assessed the relationship between maximal expirator...

    Authors: Yann Combret, Guillaume Prieur, Roger Hilfiker, Francis-Edouard Gravier, Pauline Smondack, Olivier Contal, Bouchra Lamia, Tristan Bonnevie and Clément Medrinal

    Citation: Annals of Intensive Care 2021 11:8

    Content type: Research

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  28. Although COPD patients are at higher risk for aspiration when breathing spontaneously, no information is available on the risk for microaspiration in invasively ventilated COPD patients. The aim of our study w...

    Authors: Thècle Degroote, Emmanuelle Jaillette, Jean Reignier, Farid Zerimech, Christophe Girault, Guillaume Brunin, Arnaud Chiche, Jean-Claude Lacherade, Jean-Paul MIRA, Patrice Maboudou, Malika Balduyck and Saad Nseir

    Citation: Annals of Intensive Care 2021 11:7

    Content type: Research

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  29. During the COVID-19 pandemic, creating tools to assess disease severity is one of the most important aspects of reducing the burden on emergency departments. Lung ultrasound has a high accuracy for the diagnos...

    Authors: Julio Cesar Garcia de Alencar, Julio Flavio Meirelles Marchini, Lucas Oliveira Marino, Sabrina Correa da Costa Ribeiro, Cauê Gasparotto Bueno, Victor Paro da Cunha, Felippe Lazar Neto, Rodrigo Antonio Brandão Neto and Heraldo Possolo Souza

    Citation: Annals of Intensive Care 2021 11:6

    Content type: Research

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  30. Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was effective for severe ...

    Authors: Jing Zhang, Xin Rao, Yiming Li, Yuan Zhu, Fang Liu, Guangling Guo, Guoshi Luo, Zhongji Meng, Daniel De Backer, Hui Xiang and Zhiyong Peng

    Citation: Annals of Intensive Care 2021 11:5

    Content type: Research

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  31. Cardiac surgery is known to induce acute endothelial dysfunction, which may be central to the pathophysiology of postoperative complications. Preoperative endothelial dysfunction could also be implicated in th...

    Authors: Stanislas Abrard, Olivier Fouquet, Jérémie Riou, Emmanuel Rineau, Pierre Abraham, Cyril Sargentini, Yannick Bigou, Christophe Baufreton, Sigismond Lasocki and Samir Henni

    Citation: Annals of Intensive Care 2021 11:4

    Content type: Research

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  32. Right ventricular (RV) failure is a common complication in moderate-to-severe acute respiratory distress syndrome (ARDS). RV failure is exacerbated by hypercapnic acidosis and overdistension induced by mechani...

    Authors: Suzanne Goursaud, Xavier Valette, Julien Dupeyrat, Cédric Daubin and Damien du Cheyron

    Citation: Annals of Intensive Care 2021 11:3

    Content type: Research

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  33. Hyperammonemia caused by a disorder of the urea cycle is a rare cause of metabolic encephalopathy that may be underdiagnosed by the adult intensivists because of its rarity. Urea cycle disorders are autosomal ...

    Authors: S. Redant, A. Empain, A. Mugisha, P. Kamgang, R. Attou, P. M. Honoré and D. De Bels

    Citation: Annals of Intensive Care 2021 11:2

    Content type: Review

    Published on:

  34. While much has been reported regarding the clinical course of COVID-19 in children, little is known regarding factors associated with organ dysfunction in pediatric COVID-19. We describe critical illness in pe...

    Authors: Grace Fisler, Stephanie M. Izard, Sareen Shah, Deirdre Lewis, Mundeep K. Kainth, Stefan H. F. Hagmann, Joshua A. Belfer, Lance M. Feld, Fiore Mastroianni, Charlotte L. Kvasnovsky, Christine A. Capone, James Schneider, Todd Sweberg, Charles Schleien and Matthew D. Taylor

    Citation: Annals of Intensive Care 2020 10:171

    Content type: Research

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  35. A post-resuscitation shock occurs in 50–70% of patients who had a cardiac arrest. It is an early and transient complication of the post-resuscitation phase, which frequently leads to multiple-organ failure and...

    Authors: Mathieu Jozwiak, Wulfran Bougouin, Guillaume Geri, David Grimaldi and Alain Cariou

    Citation: Annals of Intensive Care 2020 10:170

    Content type: Review

    Published on:

  36. To contribute to updating the recommendations for brain-dead potential organ donor management.

    Authors: Glauco Adrieno Westphal, Caroline Cabral Robinson, Alexandre Biasi Cavalcanti, Anderson Ricardo Roman Gonçalves, Cátia Moreira Guterres, Cassiano Teixeira, Cinara Stein, Cristiano Augusto Franke, Daiana Barbosa da Silva, Daniela Ferreira Salomão Pontes, Diego Silva Leite Nunes, Edson Abdala, Felipe Dal-Pizzol, Fernando Augusto Bozza, Flávia Ribeiro Machado, Joel de Andrade…

    Citation: Annals of Intensive Care 2020 10:169

    Content type: Research

    Published on:

  37. The collapsibility index of the inferior vena cava (cIVC) has potential for predicting fluid responsiveness in spontaneously breathing patients, but a standardized approach for measuring the inferior vena cava...

    Authors: Morgan Caplan, Arthur Durand, Perrine Bortolotti, Delphine Colling, Julien Goutay, Thibault Duburcq, Elodie Drumez, Anahita Rouze, Saad Nseir, Michael Howsam, Thierry Onimus, Raphael Favory and Sebastien Preau

    Citation: Annals of Intensive Care 2020 10:168

    Content type: Research

    Published on:

  38. Protracted viral shedding is common in hospitalized patients with COVID-19 pneumonia, and up to 40% display signs of pulmonary fibrosis on computed tomography (CT) after hospital discharge. We hypothesized tha...

    Authors: L. Bitker, F. Dhelft, L. Chauvelot, E. Frobert, L. Folliet, M. Mezidi, S. Trouillet-Assant, A. Belot, B. Lina, F. Wallet and J. C. Richard

    Citation: Annals of Intensive Care 2020 10:167

    Content type: Research

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  39. Intensive Care Units (ICU) have sometimes been overwhelmed by the surge of COVID-19 patients. Extending ICU capacity can be limited by the lack of air and oxygen pressure sources available. Transport ventilato...

    Authors: Dominique Savary, Arnaud Lesimple, François Beloncle, François Morin, François Templier, Alexandre Broc, Laurent Brochard, Jean-Christophe Richard and Alain Mercat

    Citation: Annals of Intensive Care 2020 10:166

    Content type: Research

    Published on:

  40. Single-lumen 4Fr or double-lumen 5Fr power injectable peripherally inserted central catheters (PICCs) are not accurate for trans-pulmonary thermodilution (TPTD), since they overestimate cardiac index and other...

    Authors: Sonia D’Arrigo, Claudio Sandroni, Sofia Cacciola, Antonio Maria Dell’Anna, Mauro Pittiruti, Maria Giuseppina Annetta, Cesare Colosimo and Massimo Antonelli

    Citation: Annals of Intensive Care 2020 10:165

    Content type: Research

    Published on:

  41. Citation: Annals of Intensive Care 2020 10:164

    Content type: Letter to the Editor

    Published on:

    The original article was published in Annals of Intensive Care 2020 10:163

  42. Citation: Annals of Intensive Care 2020 10:163

    Content type: Letter to the Editor

    Published on:

    The original article was published in Annals of Intensive Care 2020 10:4

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2020 10:164

  43. There is scarce evidence on the feasibility, safety and resource utilisation of active mobilisation in critically ill patients on extracorporeal life support (ECLS).

    Authors: Stephan Braune, Patrick Bojes, Anne Mecklenburg, Federico Angriman, Gerold Soeffker, Katja Warnke, Dirk Westermann, Stefan Blankenberg, Mathias Kubik, Hermann Reichenspurner and Stefan Kluge

    Citation: Annals of Intensive Care 2020 10:161

    Content type: Research

    Published on:

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