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  1. The data on incidence, clinical presentation, and outcomes of ventilator-associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia requiring mechanical ventilation (MV) a...

    Authors: Charles-Edouard Luyt, Tarek Sahnoun, Melchior Gautier, Pauline Vidal, Sonia Burrel, Marc Pineton de Chambrun, Juliette Chommeloux, Cyrielle Desnos, Jeremy Arzoine, Ania Nieszkowska, Nicolas Bréchot, Matthieu Schmidt, Guillaume Hekimian, David Boutolleau, Jérôme Robert, Alain Combes…

    Citation: Annals of Intensive Care 2020 10:158

    Content type: Research

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  2. Poisoning is one of the leading causes of admission to the emergency department and intensive care unit. A large number of epidemiological changes have occurred over the last years such as the exponential grow...

    Authors: Bruno Mégarbane, Mathieu Oberlin, Jean-Claude Alvarez, Frederic Balen, Sébastien Beaune, Régis Bédry, Anthony Chauvin, Isabelle Claudet, Vincent Danel, Guillaume Debaty, Arnaud Delahaye, Nicolas Deye, Jean-Michel Gaulier, Francis Grossenbacher, Philippe Hantson, Frédéric Jacobs…

    Citation: Annals of Intensive Care 2020 10:157

    Content type: Review

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  3. While the results of previous meta-analyses have shown beneficial effects of corticosteroid therapy on post-extubation stridor and extubation failure in adults, these results might not be generalizable to chil...

    Authors: Satoshi Kimura, JiYoon B. Ahn, Mai Takahashi, Sohee Kwon and Stefania Papatheodorou

    Citation: Annals of Intensive Care 2020 10:155

    Content type: Review

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  4. Haemoadsorption has been described as an effective way to control increased pro- and anti-inflammatory mediators (“cytokine storm”) in septic shock patients. No prospective or randomised clinical study has yet...

    Authors: Gregor A. Schittek, Philipp Zoidl, Michael Eichinger, Simon Orlob, Holger Simonis, Martin Rief, Philipp Metnitz, Tobias Fellinger and Jens Soukup

    Citation: Annals of Intensive Care 2020 10:154

    Content type: Research

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  5. Titration of the continuous distending pressure during a staircase incremental–decremental pressure lung volume optimization maneuver in children on high-frequency oscillatory ventilation is traditionally driv...

    Authors: Pauline de Jager, Johannes G. M. Burgerhof, Alette A. Koopman, Dick G. Markhorst and Martin C. J. Kneyber

    Citation: Annals of Intensive Care 2020 10:153

    Content type: Research

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  6. Assessment and maintenance of end-organ perfusion are key to resuscitation in critical illness, although there are limited direct methods or proxy measures to assess cerebral perfusion. Novel non-invasive meth...

    Authors: E. Courtie, T. Veenith, A. Logan, A. K. Denniston and R. J. Blanch

    Citation: Annals of Intensive Care 2020 10:152

    Content type: Review

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  7. In COVID-19 patients with severe acute respiratory distress syndrome (ARDS), the relatively preserved respiratory system compliance despite severe hypoxemia, with specific pulmonary vascular dysfunction, sugge...

    Authors: François Bagate, Samuel Tuffet, Paul Masi, François Perier, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux, Didier Payen and Armand Mekontso Dessap

    Citation: Annals of Intensive Care 2020 10:151

    Content type: Research

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  8. Persistent hyperlactatemia has been considered as a signal of tissue hypoperfusion in septic shock patients, but multiple non-hypoperfusion-related pathogenic mechanisms could be involved. Therefore, pursuing ...

    Authors: Ricardo Castro, Eduardo Kattan, Giorgio Ferri, Ronald Pairumani, Emilio Daniel Valenzuela, Leyla Alegría, Vanessa Oviedo, Nicolás Pavez, Dagoberto Soto, Magdalena Vera, César Santis, Brusela Astudillo, María Alicia Cid, Sebastian Bravo, Gustavo Ospina-Tascón, Jan Bakker…

    Citation: Annals of Intensive Care 2020 10:150

    Content type: Research

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  9. Empirical antimicrobial therapy (EAT) is a challenge for community-acquired, hospital-acquired and ventilator-associated pneumonia, particularly in the context of the increasing occurrence of third-generation ...

    Authors: Manquat Elsa, Le Dorze Matthieu, Pean De Ponfilly Gauthier, Benmansour Hanaa, Amarsy Rishma, Cambau Emmanuelle, Soyer Benjamin, Chousterman Benjamin Glenn and Jacquier Hervé

    Citation: Annals of Intensive Care 2020 10:149

    Content type: Research

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  10. Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

    Citation: Annals of Intensive Care 2020 10:148

    Content type: Letter to the Editor

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    The original article was published in Annals of Intensive Care 2020 10:36

  11. Authors: Elisa Damiani, Andrea Carsetti, Erika Casarotta, Roberta Domizi, Claudia Scorcella, Erica Adrario and Abele Donati

    Citation: Annals of Intensive Care 2020 10:147

    Content type: Letter to the Editor

    Published on:

    The original article was published in Annals of Intensive Care 2020 10:140

    The original article was published in Annals of Intensive Care 2020 10:95

  12. The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of n...

    Authors: Djamel Mokart, Michael Darmon, Peter Schellongowski, Peter Pickkers, Marcio Soares, Jordi Rello, Philippe R. Bauer, Andry van de Louw, Virginie Lemiale, Fabio Silvio Taccone, Ignacio Martin-Loeches, Jorge Salluh, Katerina Rusinova, Sangeeta Mehta, Massimo Antonelli, Achille Kouatchet…

    Citation: Annals of Intensive Care 2020 10:146

    Content type: Research

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  13. Sepsis is one of the leading causes of death worldwide. The associated incidence, mortality and trends do not differ greatly between documented reports. The purpose of this study was to provide an in-depth des...

    Authors: Claire Dupuis, Lila Bouadma, Stéphane Ruckly, Anne Perozziello, Damien Van-Gysel, Arthur Mageau, Bruno Mourvillier, Etienne de Montmollin, Sébastien Bailly, Gregory Papin, Fabrice Sinnah, Camille Vinclair, Sonia Abid, Romain Sonneville and Jean-François Timsit

    Citation: Annals of Intensive Care 2020 10:145

    Content type: Research

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  14. Patient–ventilator asynchrony is common in mechanically ventilated patients and may be related to adverse outcomes. Few studies have reported the occurrence of asynchrony in brain-injured patients. We aimed to...

    Authors: Xu-Ying Luo, Xuan He, Yi-Min Zhou, Yu-Mei Wang, Jing-Ran Chen, Guang-Qiang Chen, Hong-Liang Li, Yan-Lin Yang, Linlin Zhang and Jian-Xin Zhou

    Citation: Annals of Intensive Care 2020 10:144

    Content type: Research

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  15. Immune checkpoint inhibitors have reshaped the standard of care in oncology. However, they have been associated with potentially life-threatening immune-related adverse events. With the growing indications of ...

    Authors: Adrien Joseph, Audrey Simonaggio, Annabelle Stoclin, Antoine Vieillard-Baron, Guillaume Geri, Stéphane Oudard, Jean-Marie Michot, Olivier Lambotte, Elie Azoulay and Virginie Lemiale

    Citation: Annals of Intensive Care 2020 10:143

    Content type: Research

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  16. Despite advances in the management of bloodstream infections (BSI) caused by Candida spp., the mortality still remains high in critically ill patients. The worldwide epidemiology of yeast-related BSI is subject t...

    Authors: Maria Schroeder, Theresa Weber, Timme Denker, Sarah Winterland, Dominic Wichmann, Holger Rohde, Ann-Kathrin Ozga, Marlene Fischer and Stefan Kluge

    Citation: Annals of Intensive Care 2020 10:142

    Content type: Research

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  17. The average length of stay (LOS) in the intensive care unit (ICU_ALOS) is a helpful parameter summarizing critical bed occupancy. During the outbreak of a novel virus, estimating early a reliable ICU_ALOS esti...

    Authors: Nathanael Lapidus, Xianlong Zhou, Fabrice Carrat, Bruno Riou, Yan Zhao and Gilles Hejblum

    Citation: Annals of Intensive Care 2020 10:135

    Content type: Research

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  18. Citation: Annals of Intensive Care 2020 10:139

    Content type: Letter to the Editor

    Published on:

    The original article was published in Annals of Intensive Care 2020 10:94

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2020 10:141

  19. Persistent swallowing disorders (SD) are non-pulmonary complications of mechanical ventilation (MV). However, there are few clinical studies on persistent SD in critically ill patients undergoing tracheal intu...

    Authors: G. Beduneau, V. Souday, J. C. Richard, J. F. Hamel, D. Carpentier, J. M. Chretien, P. Bouchetemble, L. Laccoureye, A. Astier, V. Tanguy, A. Mercat, F. Beloncle and F. Tamion

    Citation: Annals of Intensive Care 2020 10:138

    Content type: Research

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  20. Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensi...

    Authors: Caroline Claude, Akash Deep, Martin Kneyber, Salman Siddiqui, Sylvain Renolleau, Luc Morin, Emmanuel Jacquemin, Jean-Paul Teglas, Vincent Gajdos, Pierre Tissières and Philippe Durand

    Citation: Annals of Intensive Care 2020 10:137

    Content type: Research

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  21. Early treatment is advocated in the management of patients with suspected sepsis in the emergency department (ED). We sought to understand the association between the ED treatments and outcome in patients admi...

    Authors: Narani Sivayoham, Lesley A. Blake, Shafi E. Tharimoopantavida, Saad Chughtai, Adil N. Hussain and Andrew Rhodes

    Citation: Annals of Intensive Care 2020 10:136

    Content type: Research

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  22. A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear of an imminent saturation of available ICU beds generated the notion that rationing of intensive c...

    Authors: Tommaso Tonetti, Giacomo Grasselli, Alberto Zanella, Giacinto Pizzilli, Roberto Fumagalli, Simone Piva, Luca Lorini, Giorgio Iotti, Giuseppe Foti, Sergio Colombo, Luigi Vivona, Sandra Rossi, Massimo Girardis, Vanni Agnoletti, Anselmo Campagna, Giovanni Gordini…

    Citation: Annals of Intensive Care 2020 10:133

    Content type: Research

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  23. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with current guidelines, mortality remains high in those with septic shock. I...

    Authors: Axel Nierhaus, Giorgio Berlot, Detlef Kindgen-Milles, Eckhard Müller and Massimo Girardis

    Citation: Annals of Intensive Care 2020 10:132

    Content type: Review

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  24. Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS).

    Authors: David Grimaldi, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Stephane Gaudry, Aurelie Gaultier, Alain D’hondt, Julien Higny, Geoffrey Horlait, Sami Hraiech, Laurent Lefebvre, Francois Lejeune, Andre Ly, Michael Piagnerelli, Bertrand Sauneuf…

    Citation: Annals of Intensive Care 2020 10:131

    Content type: Research

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  25. Intra-abdominal hypertension is frequently present in critically ill patients and is an independent predictor for mortality. Risk factors for intra-abdominal hypertension and abdominal compartment syndrome hav...

    Authors: Marije Smit, Bart Koopman, Willem Dieperink, Jan B. F. Hulscher, H. Sijbrand Hofker, Matijs van Meurs and Jan G. Zijlstra

    Citation: Annals of Intensive Care 2020 10:130

    Content type: Research

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  26. Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients.

    Authors: Mehdi Mezidi, Florence Daviet, Paul Chabert, Sami Hraiech, Laurent Bitker, Jean-Marie Forel, Hodane Yonis, Ines Gragueb, Francois Dhelft, Laurent Papazian, Jean-Christophe Richard and Christophe Guervilly

    Citation: Annals of Intensive Care 2020 10:129

    Content type: Letter to the Editor

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  27. About 30% of patients with Guillain-Barré syndrome become ventilator dependent, of whom roughly 75% develop pneumonia. This trial aimed at assessing the impact of early mechanical ventilation (EMV) on pneumoni...

    Authors: Marie-Anne Melone, Nicholas Heming, Paris Meng, Dominique Mompoint, Jerôme Aboab, Bernard Clair, Jerôme Salomon, Tarek Sharshar, David Orlikowski, Sylvie Chevret and Djillali Annane

    Citation: Annals of Intensive Care 2020 10:128

    Content type: Research

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  28. Extracorporeal CO2 removal (ECCO2R) could be a valuable additional modality for invasive mechanical ventilation (IMV) in COPD patients suffering from severe acute exacerbation (AE). We aimed to evaluate in such p...

    Authors: J.-L. Diehl, L. Piquilloud, D. Vimpere, N. Aissaoui, E. Guerot, J. L. Augy, M. Pierrot, D. Hourton, A. Arnoux, C. Richard, J. Mancebo and A. Mercat

    Citation: Annals of Intensive Care 2020 10:126

    Content type: Research

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  29. Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non...

    Authors: Virginie Montiel, Arnaud Robert, Annie Robert, Anas Nabaoui, Tourneux Marie, Natalia Morales Mestre, Maerckx Guillaume, Pierre-François Laterre and Xavier Wittebole

    Citation: Annals of Intensive Care 2020 10:125

    Content type: Research

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  30. Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).

    Authors: Yasser Sakr, Manuela Giovini, Marc Leone, Giacinto Pizzilli, Andreas Kortgen, Michael Bauer, Tommaso Tonetti, Gary Duclos, Laurent Zieleskiewicz, Samuel Buschbeck, V. Marco Ranieri and Elio Antonucci

    Citation: Annals of Intensive Care 2020 10:124

    Content type: Review

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  31. Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the epidemiology of respiratory viruses in this population.

    Authors: Alexandre Elabbadi, Jérémie Pichon, Benoit Visseaux, Aurélie Schnuriger, Lila Bouadma, Quentin Philippot, Juliette Patrier, Vincent Labbé, Stéphane Ruckly, Muriel Fartoukh, Jean-François Timsit and Guillaume Voiriot

    Citation: Annals of Intensive Care 2020 10:123

    Content type: Research

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  32. Multiple screening Duplex ultrasound scans (DUS) are performed in trauma patients at high risk of deep vein thrombosis (DVT) in the intensive care unit (ICU). Intensive care physician performed compression ult...

    Authors: Lloyd Roberts, Tom Rozen, Deirdre Murphy, Adam Lawler, Mark Fitzgerald, Harry Gibbs, Kyle Brooks, Joshua F. Ihle, Tim Leong, Judit Orosz, Eldho Paul and Vinodh Bhagyalakshmi Nanjayya

    Citation: Annals of Intensive Care 2020 10:122

    Content type: Research

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  33. Persistent hypotension is a frequent complication after cardiac surgery with cardiopulmonary bypass (CPB). Midodrine, an orally administered alpha agonist, could potentially reduce intravenous vasopressor use ...

    Authors: Jan-Alexis Tremblay, Philippe Laramée, Yoan Lamarche, André Denault, William Beaubien-Souligny, Anne-Julie Frenette, Loay Kontar, Karim Serri and Emmanuel Charbonney

    Citation: Annals of Intensive Care 2020 10:121

    Content type: Research

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  34. Although mechanical ventilation is a lifesaving treatment, abundant evidence indicates that its prolonged use (1 week or more) promotes respiratory muscle weakness due to both contractile dysfunction and atrop...

    Authors: Paolo Formenti, Michele Umbrello, Martin Dres and Davide Chiumello

    Citation: Annals of Intensive Care 2020 10:120

    Content type: Review

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  35. Data on the prevalence of bacterial and viral co-infections among patients admitted to the ICU for acute respiratory failure related to SARS-CoV-2 pneumonia are lacking. We aimed to assess the rate of bacteria...

    Authors: Damien Contou, Aurore Claudinon, Olivier Pajot, Maïté Micaëlo, Pascale Longuet Flandre, Marie Dubert, Radj Cally, Elsa Logre, Megan Fraissé, Hervé Mentec and Gaëtan Plantefève

    Citation: Annals of Intensive Care 2020 10:119

    Content type: Research

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  36. The French Society of Intensive Care Medicine (SRLF), jointly with the French-Speaking Group of Paediatric Emergency Rooms and Intensive Care Units (GFRUP) and the French-Speaking Association of Paediatric Sur...

    Authors: Jean-François Timsit, Julien Baleine, Louis Bernard, Silvia Calvino-Gunther, Michael Darmon, Jean Dellamonica, Eric Desruennes, Marc Leone, Alain Lepape, Olivier Leroy, Jean-Christophe Lucet, Zied Merchaoui, Olivier Mimoz, Benoit Misset, Jean-Jacques Parienti, Jean-Pierre Quenot…

    Citation: Annals of Intensive Care 2020 10:118

    Content type: Review

    Published on:

  37. Acute Kidney Injury (AKI) is a frequent complication of severe SARS-CoV-2 infection. Multiple mechanisms are involved in COVID-19-associated AKI, from direct viral infection and secondary inflammation to compl...

    Authors: Adrien Joseph, Lara Zafrani, Asma Mabrouki, Elie Azoulay and Michael Darmon

    Citation: Annals of Intensive Care 2020 10:117

    Content type: Research

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  38. Nonintubated chest trauma patients with fractured ribs admitted to the intensive care unit (ICU) are at risk for complications and may require invasive ventilation at some point. Effective pain control is esse...

    Authors: Konstantinos Bachoumas, Albrice Levrat, Aurélie Le Thuaut, Stéphane Rouleau, Samuel Groyer, Hervé Dupont, Paul Rooze, Nathanael Eisenmann, Timothée Trampont, Julien Bohé, Benjamin Rieu, Jean-Charles Chakarian, Aurélie Godard, Laura Frederici, Stephanie Gélinotte, Aurélie Joret…

    Citation: Annals of Intensive Care 2020 10:116

    Content type: Research

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  39. Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact...

    Authors: Marloes M. IJland, Joris Lemson, Johannes G. van der Hoeven and Leo M. A. Heunks

    Citation: Annals of Intensive Care 2020 10:115

    Content type: Research

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  40. Capillary refill time (CRT) may improve more rapidly than lactate in response to increments in systemic flow. Therefore, it can be assessed more frequently during septic shock (SS) resuscitation. Hyperlactatem...

    Authors: Eduardo Kattan, Glenn Hernández, Gustavo Ospina-Tascón, Emilio Daniel Valenzuela, Jan Bakker and Ricardo Castro

    Citation: Annals of Intensive Care 2020 10:114

    Content type: Research

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  41. The objective of this study was to evaluate the ability of endothelial biomarkers to early predict clinical deterioration of patients admitted to the emergency department (ED) with a suspected sepsis. This was...

    Authors: Thomas Lafon, Marie-Angélique Cazalis, Christine Vallejo, Karim Tazarourte, Sophie Blein, Alexandre Pachot, Pierre-François Laterre, Said Laribi and Bruno François

    Citation: Annals of Intensive Care 2020 10:113

    Content type: Research

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  42. Gasping during cardiac arrest is associated with favourable neurological outcomes for out-of-hospital cardiac arrest. Moreover, while extracorporeal cardiopulmonary resuscitation (ECPR) performed for refractor...

    Authors: Naofumi Bunya, Hirofumi Ohnishi, Kenshiro Wada, Ryuichiro Kakizaki, Takehiko Kasai, Nobutaka Nagano, Nobuaki Kokubu, Kei Miyata, Shuji Uemura, Keisuke Harada and Eichi Narimatsu

    Citation: Annals of Intensive Care 2020 10:112

    Content type: Research

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  43. Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but...

    Authors: Caroline Ulfsdotter Nilsson, Peter Bentzer, Linnéa E. Andersson, Sofia A. Björkman, Fredrik P. Hanssson and Thomas Kander

    Citation: Annals of Intensive Care 2020 10:111

    Content type: Research

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  44. The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome among...

    Authors: Elie Azoulay, Jan De Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J. Schaller, Manu Shankar Hari, Mariangela Pellegrini, Michael Darmon, Jozef Kesecioglu and Maurizio Cecconi

    Citation: Annals of Intensive Care 2020 10:110

    Content type: Research

    Published on:

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