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  1. Research

    Opioid-associated iatrogenic withdrawal in critically ill adult patients: a multicenter prospective observational study

    Opioids and benzodiazepines are frequently used in the intensive care unit (ICU). Regular use and prolonged exposure to opioids in ICU patients followed by abrupt tapering or cessation may lead to iatrogenic w...

    Pan Pan Wang, Elaine Huang, Xue Feng, Charles-André Bray, Marc M. Perreault, Philippe Rico, Patrick Bellemare, Paul Murgoi, Céline Gélinas, Annie Lecavalier, Dev Jayaraman, Anne Julie Frenette and David Williamson

    Annals of Intensive Care 2017 7:88

    Published on: 2 September 2017

  2. Research

    Prognostic indicators of survival and survival prediction model following extracorporeal cardiopulmonary resuscitation in patients with sudden refractory cardiac arrest

    Extracorporeal cardiopulmonary resuscitation (ECPR) has been considered in selected candidates with potentially reversible causes during a limited period. Candidate selection and the identification of predicta...

    Sung Woo Lee, Kap Su Han, Jong Su Park, Ji Sung Lee and Su Jin Kim

    Annals of Intensive Care 2017 7:87

    Published on: 30 August 2017

  3. Research

    Validation of transpulmonary thermodilution variables in hemodynamically stable patients with heart diseases

    Transpulmonary thermodilution is recommended in the treatment of critically ill patients presenting with complex shock. However, so far it has not been validated in hemodynamically stable patients with heart d...

    Matthias Peter Hilty, Daniel Peter Franzen, Christophe Wyss, Patric Biaggi and Marco Maggiorini

    Annals of Intensive Care 2017 7:86

    Published on: 22 August 2017

  4. Research

    Lymphopaenia in cardiac arrest patients

    A decrease in circulating lymphocytes has been described as a marker of poor prognosis after septic shock; however, scarce data are available after cardiac arrest (CA). The aim of this study was to evaluate th...

    Paola Villois, David Grimaldi, Savino Spadaro, Claudia Righy Shinotsuka, Vito Fontana, Sabino Scolletta, Federico Franchi, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone

    Annals of Intensive Care 2017 7:85

    Published on: 14 August 2017

  5. Research

    Efficacy and safety of argatroban in patients with acute respiratory distress syndrome and extracorporeal lung support

    Extracorporeal membrane oxygenation (ECMO) or pumpless extracorporeal lung assist (pECLA) requires effective anticoagulation. Knowledge on the use of argatroban in patients with acute respiratory distress synd...

    Mario Menk, Philipp Briem, Björn Weiss, Martina Gassner, David Schwaiberger, Anton Goldmann, Christian Pille and Steffen Weber-Carstens

    Annals of Intensive Care 2017 7:82

    Published on: 3 August 2017

  6. Research

    Assessment of sepsis-induced immunosuppression at ICU discharge and 6 months after ICU discharge

    Increase in mortality and in recurrent infections in the year following ICU discharge continues in survivors of septic shock, even after total clinical recovery from the initial septic event and its complicati...

    Violette Zorio, Fabienne Venet, Benjamin Delwarde, Bernard Floccard, Guillaume Marcotte, Julien Textoris, Guillaume Monneret and Thomas Rimmelé

    Annals of Intensive Care 2017 7:80

    Published on: 2 August 2017

  7. Research

    Feasibility and safety of virtual-reality-based early neurocognitive stimulation in critically ill patients

    Growing evidence suggests that critical illness often results in significant long-term neurocognitive impairments in one-third of survivors. Although these neurocognitive impairments are long-lasting and devas...

    Marc Turon, Sol Fernandez-Gonzalo, Mercè Jodar, Gemma Gomà, Jaume Montanya, David Hernando, Raquel Bailón, Candelaria de Haro, Victor Gomez-Simon, Josefina Lopez-Aguilar, Rudys Magrans, Melcior Martinez-Perez, Joan Carles Oliva and Lluís Blanch

    Annals of Intensive Care 2017 7:81

    Published on: 2 August 2017

  8. Research

    How to reduce cisatracurium consumption in ARDS patients: the TOF-ARDS study

    Neuromuscular blocking agents (NMBAs) have been shown to improve the outcome of the most severely hypoxemic, acute respiratory distress syndrome (ARDS) patients. However, the recommended dosage as well as the ...

    Sami Hraiech, Jean-Marie Forel, Christophe Guervilly, Romain Rambaud, Samuel Lehingue, Mélanie Adda, Pierre Sylla, Sabine Valera, Julien Carvelli, Marc Gainnier, Laurent Papazian and Jérémy Bourenne

    Annals of Intensive Care 2017 7:79

    Published on: 2 August 2017

  9. Research

    Bedside selection of positive end-expiratory pressure by electrical impedance tomography in hypoxemic patients: a feasibility study

    Positive end-expiratory pressure (PEEP) is a key element of mechanical ventilation. It should optimize recruitment, without causing excessive overdistension, but controversy exists on the best method to set it...

    Nilde Eronia, Tommaso Mauri, Elisabetta Maffezzini, Stefano Gatti, Alfio Bronco, Laura Alban, Filippo Binda, Tommaso Sasso, Cristina Marenghi, Giacomo Grasselli, Giuseppe Foti, Antonio Pesenti and Giacomo Bellani

    Annals of Intensive Care 2017 7:76

    Published on: 20 July 2017

  10. Research

    Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

    Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous m...

    Sergey Zakharov, Jan Rulisek, Olga Nurieva, Katerina Kotikova, Tomas Navratil, Martin Komarc, Daniela Pelclova and Knut Erik Hovda

    Annals of Intensive Care 2017 7:77

    Published on: 20 July 2017

  11. Erratum

    Erratum to: Practice of hemodynamic monitoring and management in German, Austrian, and Swiss intensive care units: the multicenter cross-sectional ICU-CardioMan Study

    Sandra Funcke, Michael Sander, Matthias S. Goepfert, Heinrich Groesdonk, Matthias Heringlake, Jan Hirsch, Stefan Kluge, Claus Krenn, Marco Maggiorini, Patrick Meybohm, Cornelie Salzwedel, Bernd Saugel, Gudrun Wagenpfeil, Stefan Wagenpfeil and Daniel A. Reuter

    Annals of Intensive Care 2017 7:75

    Published on: 17 July 2017

    The original article was published in Annals of Intensive Care 2016 6:49

  12. Research

    Effect of insulin infusion line on glycaemic variability in a perioperative high dependency unit (HDU): a prospective randomised controlled trial

    Glucose control is an important issue in post-operative patients. The objective here was to compare two insulin infusion lines by syringe pumps to assess the impact of medical devices on glycaemic variability ...

    Stéphanie Genay, Bertrand Décaudin, Sabine Ethgen, Arnaud Alluin, Elodie Babol, Julien Labreuche, Hélène Behal, Marie-Christine Vantyghem, Pascal Odou and Gilles Lebuffe

    Annals of Intensive Care 2017 7:74

    Published on: 11 July 2017

  13. Research

    Epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an intensive care unit with no single rooms

    The transmission of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBL) is prevented by additional contact precautions, mainly relying on isolation in a single room and hand hygiene. Contact isol...

    Xavier Repessé, Margaux Artiguenave, Sophie Paktoris-Papine, Florence Espinasse, Aurélien Dinh, Cyril Charron, Faten El Sayed, Guillaume Geri and Antoine Vieillard-Baron

    Annals of Intensive Care 2017 7:73

    Published on: 3 July 2017

  14. Research

    Emergence of antimicrobial resistance to Pseudomonas aeruginosa in the intensive care unit: association with the duration of antibiotic exposure and mode of administration

    Antibiotics are frequently used in intensive care units (ICUs), and their use is associated with the emergence of bacterial resistance to antibiotics. The aim of this study was to investigate the association b...

    Erlangga Yusuf, Bruno Van Herendael, Walter Verbrugghe, Margareta Ieven, Emiel Goovaerts, Kristof Bergs, Kristien Wouters, Philippe G. Jorens and Herman Goossens

    Annals of Intensive Care 2017 7:72

    Published on: 29 June 2017

  15. Research

    Moral distress and its contribution to the development of burnout syndrome among critical care providers

    Burnout appears to be common among critical care providers. It is characterized by three components: emotional exhaustion, depersonalization and personal accomplishment. Moral distress is the inability of a mo...

    Renata Rego Lins Fumis, Gustavo Adolpho Junqueira Amarante, Andréia de Fátima Nascimento and José Mauro Vieira Junior

    Annals of Intensive Care 2017 7:71

    Published on: 21 June 2017

  16. Review

    Targeted temperature management in the ICU: guidelines from a French expert panel

    Over the recent period, the use of induced hypothermia has gained an increasing interest for critically ill patients, in particular in brain-injured patients. The term “targeted temperature management” (TTM) h...

    Alain Cariou, Jean-François Payen, Karim Asehnoune, Gerard Audibert, Astrid Botte, Olivier Brissaud, Guillaume Debaty, Sandrine Deltour, Nicolas Deye, Nicolas Engrand, Gilles Francony, Stéphane Legriel, Bruno Levy, Philippe Meyer, Jean-Christophe Orban, Sylvain Renolleau…

    Annals of Intensive Care 2017 7:70

    Published on: 19 June 2017

  17. Research

    Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study

    Patients meeting the Berlin definition for the acute respiratory distress syndrome (ARDS) might lack exposure to one or more “common” risk factors and exhibit different clinical phenotype and outcomes. We aime...

    Nicolas de Prost, Tài Pham, Guillaume Carteaux, Armand Mekontso Dessap, Christian Brun-Buisson, Eddy Fan, Giacomo Bellani, John Laffey, Alain Mercat, Laurent Brochard and Bernard Maître

    Annals of Intensive Care 2017 7:69

    Published on: 19 June 2017

  18. Research

    Systemic antibiotics for preventing ventilator-associated pneumonia in comatose patients: a systematic review and meta-analysis

    Early-onset ventilator-associated pneumonia (EO-VAP) is the leading cause of morbidity and mortality in comatose patients. However, VAP prevention bundles focus mainly on late-onset VAP and may be less effecti...

    Cássia Righy, Pedro Emmanuel Americano do Brasil, Jordi Vallés, Fernando A. Bozza and Ignacio Martin-Loeches

    Annals of Intensive Care 2017 7:67

    Published on: 15 June 2017

  19. Research

    Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid (PlasmaLyte®) in a rat model with severe sepsis

    According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloid...

    Pierre-Yves Olivier, François Beloncle, Valérie Seegers, Maher Tabka, Mathilde Renou de La Bourdonnaye, Alain Mercat, Paul Cales, Daniel Henrion, Peter Radermacher, Lise Piquilloud, Nicolas Lerolle and Pierre Asfar

    Annals of Intensive Care 2017 7:66

    Published on: 14 June 2017

  20. Research

    Venoarterial PCO2-to-arteriovenous oxygen content difference ratio is a poor surrogate for anaerobic metabolism in hemodilution: an experimental study

    The identification of anaerobic metabolism in critically ill patients is a challenging task. Observational studies have suggested that the ratio of venoarterial PCO2 (Pv–aCO2) to arteriovenous oxygen content diff...

    Arnaldo Dubin, Gonzalo Ferrara, Vanina Siham Kanoore Edul, Enrique Martins, Héctor Saúl Canales, Carlos Canullán, Gastón Murias, Mario Omar Pozo and Elisa Estenssoro

    Annals of Intensive Care 2017 7:65

    Published on: 12 June 2017

  21. Research

    Frequency, associated factors and outcome of multi-drug-resistant intensive care unit-acquired pneumonia among patients colonized with extended-spectrum β-lactamase-producing Enterobacteriaceae

    We assessed prevalence, associated factors and prognosis of extended-spectrum beta-lactamase-producing Enterobacteriaceae pneumonia acquired in intensive care unit (ESBL-PE pneumonia) among carriers. Variable...

    Keyvan Razazi, Armand Mekontso Dessap, Guillaume Carteaux, Chloé Jansen, Jean-Winoc Decousser, Nicolas de Prost and Christian Brun-Buisson

    Annals of Intensive Care 2017 7:61

    Published on: 12 June 2017

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