Articles

SARS-CoV-2 post-infective myocarditis: the tip of COVID-19 immune complications?

Recent paediatric cases of acute myocarditis following a SARS-CoV-2 infection have raised the possibility of post-infective complications of COVID-19. This short editorial is reviewing current understanding of...

Authors: Pierre Tissières and Jean-Louis Teboul

Management and prevention of anemia (acute bleeding excluded) in adult critical care patients

Anemia is very common in critical care patients, on admission (affecting about two-thirds of patients), but also during and after their stay, due to repeated blood loss, the effects of inflammation on erythrop...

Authors: Sigismond Lasocki, Frédéric Pène, Hafid Ait-Oufella, Cécile Aubron, Sylvain Ausset, Pierre Buffet, Olivier Huet, Yoann Launey, Matthieu Legrand, Thomas Lescot, Armand Mekontso Dessap, Michael Piagnerelli, Hervé Quintard, Lionel Velly, Antoine Kimmoun and Gérald Chanques

Advanced organ support (ADVOS) in the critically ill: first clinical experience in patients with multiple organ failure

Prevalence of multiple organ failure (MOF) in critically ill patients is increasing and associated mortality remains high. Extracorporeal organ support is a cornerstone in the management of MOF. We report data...

Authors: Valentin Fuhrmann, Theresa Weber, Kevin Roedl, Jasmin Motaabbed, Adel Tariparast, Dominik Jarczak, Aritz Perez Ruiz de Garibay, Johannes Kluwe, Olaf Boenisch, Harald Herkner, John A. Kellum and Stefan Kluge

Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study

COVID-19 ARDS could differ from typical forms of the syndrome.

Authors: J.-L. Diehl, N. Peron, R. Chocron, B. Debuc, E. Guerot, C. Hauw-Berlemont, B. Hermann, J. L. Augy, R. Younan, A. Novara, J. Langlais, L. Khider, N. Gendron, G. Goudot, J.-F. Fagon, T. Mirault…

Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections

In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We designed a prospective ...

Authors: Gennaro De Pascale, Lucia Lisi, Gabriella Maria Pia Ciotti, Maria Sole Vallecoccia, Salvatore Lucio Cutuli, Laura Cascarano, Camilla Gelormini, Giuseppe Bello, Luca Montini, Simone Carelli, Valentina Di Gravio, Mario Tumbarello, Maurizio Sanguinetti, Pierluigi Navarra and Massimo Antonelli

Response to the letter of Morán et al. regarding our use of an inaccurate reference for the maximal dose of vitamin C in G6PD deficiency

Authors: Patrick M. Honore, Herbert D. Spapen, Paul Marik, Willem Boer and Heleen Oudemans-van Straaten

Performances of disseminated intravascular coagulation scoring systems in septic shock patients

There is no gold standard to diagnose septic shock-induced disseminated intravascular coagulation (DIC). The objective of our multicenter prospective study was to assess the performances of the different major...

Authors: Julie Helms, François Severac, Hamid Merdji, Raphaël Clere-Jehl, Bruno François, Emmanuelle Mercier, Jean-Pierre Quenot and Ferhat Meziani

Impact of the perioperative inotropic support in grown-up congenital heart patients undergoing cardiac surgery: a propensity score adjusted analysis

Grown-up congenital heart (GUCH) patients represent a growing population with a high morbidity risk when undergoing reparative surgery. A main preoperative feature is right ventricular failure, which represent...

Authors: Philippe Mauriat, Mirela Bojan, Sylvie Soulie, Hélène Foulgoc, Nadir Tafer and Alexandre Ouattara

Comparison of the proximal and distal approaches for axillary vein catheterization under ultrasound guidance (PANDA) in cardiac surgery patients susceptible to bleeding: a randomized controlled trial

The present study aimed at comparing the success rate and safety of proximal versus distal approach for ultrasound (US)-guided axillary vein catheterization (AVC) in cardiac surgery patients susceptible to ble...

Authors: Ying Su, Jun-yi Hou, Guo-guang Ma, Guang-wei Hao, Jing-chao Luo, Shen-ji Yu, Kai Liu, Ji-li Zheng, Yan Xue, Zhe Luo and Guo-wei Tu

Ultrasound guidance and risk for intravascular catheter-related infections among peripheral arterial catheters: a post-hoc analysis of two large randomized-controlled trials

The impact on infectious risk of ultrasound guidance at insertion remains controversial in short-term arterial catheters (ACs). The present study investigated the association between ultrasound guidance (US) d...

Authors: Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Lila Bouadma, Carole Schwebel, Olivier Mimoz and Jean-François Timsit

Spontaneous breathing, transpulmonary pressure and mathematical trickery

Authors: Luciano Gattinoni, John J. Marini, Mattia Busana, Davide Chiumello and Luigi Camporota

Commentary to “Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review”

Authors: J. M. Morán and I. Herrera-Peco

Clinical outcomes according to cannula configurations in patients with acute respiratory distress syndrome under veno-venous extracorporeal membrane oxygenation: a Korean multicenter study

Recirculation during veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a known drawback that limits sufficient oxygenation. This study aimed to compare the short-term oxygenation and long-term morta...

Authors: Sung Yoon Lim, Soyeon Ahn, Sang-Bum Hong, Chi Ryang Chung, Kyeongman Jeon, Sang-Min Lee, Woo Hyun Cho, Sunghoon Park and Young-Jae Cho

Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review

The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans, secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such as albumin and antithrombin associat...

Authors: Cesar Aldecoa, Juan V. Llau, Xavier Nuvials and Antonio Artigas

Ethical dilemmas due to the Covid-19 pandemic

The devastating pandemic that has stricken the worldwide population induced an unprecedented influx of patients in ICUs, raising ethical concerns not only surrounding triage and withdrawal of life support deci...

Authors: René Robert, Nancy Kentish-Barnes, Alexandre Boyer, Alexandra Laurent, Elie Azoulay and Jean Reignier

Multidisciplinary team approach in acute myocardial infarction patients undergoing veno-arterial extracorporeal membrane oxygenation

Limited data are available on the impact of a specialized extracorporeal membrane oxygenation (ECMO) team on clinical outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shoc...

Authors: David Hong, Ki Hong Choi, Yang Hyun Cho, Su Hyun Cho, So Jin Park, Darae Kim, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Kiick Sung, Hyeon-Cheol Gwon, Eun-Seok Jeon…

Impact of prior antibiotics on infected pancreatic necrosis microbiology in ICU patients: a retrospective cohort study

Recent guidelines advise against prophylactic antibiotics in patients with necrotizing pancreatitis, advocating instead a step-up drainage and necrosectomy strategy with antibiotics as dictated by microbiologi...

Authors: Charlotte Garret, Emmanuel Canet, Stéphane Corvec, David Boutoille, Matthieu Péron, Isabelle Archambeaud, Aurélie Le Thuaut, Jean-Baptiste Lascarrou, Frédéric Douane, Marc Lerhun, Nicolas Regenet, Emmanuel Coron and Jean Reignier

High-dose methotrexate in ICU patients: a retrospective study

High-dose methotrexate (HD-MTX) is commonly used in the treatment of solid tumors and hematological malignancies. Severe toxicities are frequent, leading to organ dysfunction and death. Risk–benefit ratio of u...

Authors: Sandrine Valade, Eric Mariotte, Elie Azoulay and Michael Darmon

Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial

Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sep...

Authors: Shih-Hong Chen, Wing-Sum Chan, Chih-Min Liu, Ching-Tang Chiu, Anne Chao, Vin-Cent Wu, Wang-Huei Sheng, Chien-Heng Lai, Ming-Jiuh Wang and Yu-Chang Yeh

A comparison of nasogastric tube insertion by SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) versus neck flexion lateral pressure in critically ill patients admitted to ICU: a prospective randomized clinical trial

Although many techniques have been introduced to facilitate nasogastric tube (NGT) insertion using anatomic landmarks and a group of devices, there is a lack of general consensus regarding a standard method. T...

Authors: Sarvin Sanaie, Negin Mirzalou, Kamran Shadvar, Samad E. J. Golzari, Hassan Soleimanpour, Ali Shamekh, Deepti Bettampadi, Saeid Safiri and Ata Mahmoodpoor

Caution about early intubation and mechanical ventilation in COVID-19

Authors: Martin J. Tobin, Franco Laghi and Amal Jubran

Response to the authors

Authors: Pauline de Jager and Martin C. J. Kneyber

Letter to the Editor: Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children

Authors: Arpita Chattopadhyay

Amikacin pharmacokinetic/pharmacodynamic in intensive care unit: a prospective database

Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C_max) reaches eight to tenfold the minimal inhibitory concentration (MIC). With an amikacin MIC of 8 mg/L, the C_max

Authors: Elsa Logre, Maya Enser, Sébastien Tanaka, Marie Dubert, Aurore Claudinon, Nathalie Grall, Hervé Mentec, Philippe Montravers and Olivier Pajot

Mucormycosis in intensive care unit: surgery is a major prognostic factor in patients with hematological malignancy

Mucormycosis is an invasive fungal infection, with an increasing incidence especially in patients with hematological malignancies. Its prognosis is poor because of its high invasive power and its intrinsic low...

Authors: Johanna Claustre, Romaric Larcher, Thomas Jouve, Anne-Sophie Truche, Saad Nseir, Julien Cadiet, Yoann Zerbib, Alexandre Lautrette, Jean-Michel Constantin, Pierre-Emmanuel Charles, Cedric Daubin, Remi Coudroy, Jean Dellamonica, Laurent Argaud, Pierre Phelouzat, Damien Contou…

Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China

The ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept all over the world, posing a great pressure on critical care resources due to large number of patients needing critical care. Statements fro...

Authors: You Shang, Chun Pan, Xianghong Yang, Ming Zhong, Xiuling Shang, Zhixiong Wu, Zhui Yu, Wei Zhang, Qiang Zhong, Xia Zheng, Ling Sang, Li Jiang, Jiancheng Zhang, Wei Xiong, Jiao Liu and Dechang Chen

Correction to: Early sepsis markers in patients admitted to intensive care unit with moderate‑to‑severe diabetic ketoacidosis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Florian Blanchard, Judith Charbit, Guillaume Van der Meersch, Benjamin Popoff, Adrien Picod, Regis Cohen, Frank Chemouni, Stephane Gaudry, Helene Bihan and Yves Cohen

COVID-19-associated invasive pulmonary aspergillosis

Authors: Lynn Rutsaert, Nicky Steinfort, Tine Van Hunsel, Peter Bomans, Reinout Naesens, Helena Mertes, Hilde Dits and Niels Van Regenmortel

Journal club in an ICU: rate and factors associated with practice-changing articles. Analysis of 1712 articles read over a 13-year period (2007–2019)

Authors: Damien Contou, Marina Thirion, Olivier Pajot, Gaëtan Plantefève and Hervé Mentec

Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children

A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. Th...

Authors: Marion Grimaud, Julie Starck, Michael Levy, Clémence Marais, Judith Chareyre, Diala Khraiche, Marianne Leruez-Ville, Pierre Quartier, Pierre Louis Léger, Guillaume Geslain, Nada Semaan, Florence Moulin, Matthieu Bendavid, Sandrine Jean, Géraldine Poncelet, Sylvain Renolleau…

Organizational factors associated with adherence to low tidal volume ventilation: a secondary analysis of the CHECKLIST-ICU database

Survival benefit from low tidal volume (V_T) ventilation (LTVV) has been demonstrated for patients with acute respiratory distress syndrome (ARDS), and patients not having ARDS could also benefit from this strateg...

Authors: Thais Dias Midega, Fernando A. Bozza, Flávia Ribeiro Machado, Helio Penna Guimarães, Jorge I. Salluh, Antonio Paulo Nassar Jr., Karina Normílio-Silva, Marcus J. Schultz, Alexandre Biasi Cavalcanti and Ary Serpa Neto

Recruitment pattern of the diaphragm and extradiaphragmatic inspiratory muscles in response to different levels of pressure support

Inappropriate ventilator assist plays an important role in the development of diaphragm dysfunction. Ventilator under-assist may lead to muscle injury, while over-assist may result in muscle atrophy. This prov...

Authors: L. H. Roesthuis, J. G. van der Hoeven, H. W. H. van Hees, W.-J. M. Schellekens, J. Doorduin and L. M. A. Heunks

Duration of prone position sessions: a prospective cohort study

Prone position (PP) is highly recommended in moderate-to-severe ARDS. However, the optimal duration of PP sessions remains unclear. We searched to evaluate the time required to obtain the maximum physiological...

Authors: Sebastien Jochmans, Sandie Mazerand, Jonathan Chelly, Franck Pourcine, Oumar Sy, Nathalie Thieulot-Rolin, Olivier Ellrodt, Emmanuelle Mercier Des Rochettes, Gaël Michaud, Jean Serbource-Goguel, Christophe Vinsonneau, Ly Van Phach Vong and Mehran Monchi

The end-expiratory occlusion test for detecting preload responsiveness: a systematic review and meta-analysis

We performed a systematic review and meta-analysis of studies assessing the end-expiratory occlusion test (EEXPO test)-induced changes in cardiac output (CO) measured by any haemodynamic monitoring device, as ...

Authors: Francesco Gavelli, Rui Shi, Jean-Louis Teboul, Danila Azzolina and Xavier Monnet

Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)

Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid adm...

Authors: Manu L. N. G. Malbrain, Thomas Langer, Djillali Annane, Luciano Gattinoni, Paul Elbers, Robert G. Hahn, Inneke De laet, Andrea Minini, Adrian Wong, Can Ince, David Muckart, Monty Mythen, Pietro Caironi and Niels Van Regenmortel

Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome

Authors: Sami Hraiech, Jérémy Bourenne, Khaldoun Kuteifan, Julie Helms, Julien Carvelli, Marc Gainnier, Ferhat Meziani and Laurent Papazian

Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study

No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock.

Authors: C. Darreau, F. Martino, M. Saint-Martin, S. Jacquier, J. F. Hamel, M. A. Nay, N. Terzi, G. Ledoux, F. Roche-Campo, L. Camous, F. Pene, T. Balzer, F. Bagate, J. Lorber, P. Bouju, C. Marois…

Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome

COVID-19 is an emerging disease of public health concern. While there is no specific recommended treatment for COVID-19, nitric oxide has the potential to be of therapeutic value for managing acute respiratory...

Authors: Jun Kobayashi and Isamu Murata

Microvascular alterations in patients with SARS-COV-2 severe pneumonia

Authors: Elisa Damiani, Andrea Carsetti, Erika Casarotta, Claudia Scorcella, Roberta Domizi, Erica Adrario and Abele Donati

The outbreak of COVID-19 in Mulhouse

Authors: Khaldoun Kuteifan, Pierre Pasquier, Christian Meyer, Jacques Escarment and Odile Theissen

Early sepsis markers in patients admitted to intensive care unit with moderate-to-severe diabetic ketoacidosis

Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicro...

Authors: Florian Blanchard, Judith Charbit, Guillaume Van der Meersch, Benjamin Popoff, Adrien Picod, Regis Cohen, Frank Chemouni, Stephane Gaudry, Helene Bihan and Yves Cohen

Beneficial effect modification on survival outcome of sepsis between ART-123 and polymyxin B‑immobilised haemoperfusion: a nationwide Japanese registry study

Although recently published randomised controlled trials did not confirm significant positive effect of ART-123 or polymyxin B‑immobilised haemoperfusion (PMX-HP) on survival outcome, previous studies using a ...

Authors: Katsunori Mochizuki, Kotaro Mori, Hiroshi Kamijo, Michitaro Ichikawa, Kenichi Nitta and Hiroshi Imamura

Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study

The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Se...

Authors: Mercedes Ibarz, Ariane Boumendil, Lenneke E. M. Haas, Marian Irazabal, Hans Flaatten, Dylan W. de Lange, Alessandro Morandi, Finn H. Andersen, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno…

Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome

A large proportion of patients with a SARS-Cov-2-associated respiratory failure develop an acute respiratory distress syndrome (ARDS). It has been recently suggested that SARS-Cov-2-associated ARDS may differ ...

Authors: François M. Beloncle, Bertrand Pavlovsky, Christophe Desprez, Nicolas Fage, Pierre-Yves Olivier, Pierre Asfar, Jean-Christophe Richard and Alain Mercat

Thenar oxygen saturation (StO₂) alterations during a spontaneous breathing trial predict extubation failure

Weaning from mechanical ventilation (MV) is a cardiovascular stress test. Monitoring the regional oxygenation status has shown promising results in predicting the tolerance to spontaneously breathe in the proc...

Authors: Jaume Mesquida, Guillem Gruartmoner, Cristina Espinal, Jordi Masip, Caroline Sabatier, Ana Villagrá, Hernando Gómez, Michael Pinsky, Francisco Baigorri and Antonio Artigas

One-year survival in acute stroke patients requiring mechanical ventilation: a multicenter cohort study

Most prognostic studies in acute stroke patients requiring invasive mechanical ventilation are outdated and have limitations such as single-center retrospective designs. We aimed to study the association of IC...

Authors: Etienne de Montmollin, Nicolas Terzi, Claire Dupuis, Maité Garrouste-Orgeas, Daniel da Silva, Michaël Darmon, Virginie Laurent, Guillaume Thiéry, Johana Oziel, Guillaume Marcotte, Marc Gainnier, Shidasp Siami, Benjamin Sztrymf, Christophe Adrie, Jean Reignier, Stephane Ruckly…

Tracheostomy in patients with acute respiratory distress syndrome is not related to quality of life, symptoms of psychiatric disorders or return-to-work: the prospective DACAPO cohort study

Acute respiratory distress syndrome (ARDS) is a life-threatening condition that often requires prolonged mechanical ventilation. Tracheostomy is a common procedure with some risks, on the other hand with poten...

Authors: Sebastian Blecha, Magdalena Brandl, Florian Zeman, Frank Dodoo-Schittko, Susanne Brandstetter, Christian Karagiannidis, Thomas Bein and Christian Apfelbacher

Urine NGAL as a biomarker for septic AKI: a critical appraisal of clinical utility—data from the observational FINNAKI study

Neutrophil gelatinase-associated lipocalin (NGAL) is released from kidney tubular cells under stress as well as from neutrophils during inflammation. It has been suggested as a biomarker for acute kidney injur...

Authors: Sanna Törnblom, Sara Nisula, Liisa Petäjä, Suvi T. Vaara, Mikko Haapio, Eero Pesonen and Ville Pettilä

Diagnosis and management of respiratory viruses in critically ill adult patients: an international survey of knowledge and practice among intensivists

In this survey endorsed by the European Society of Intensive Care Medicine (ESICM), we aimed to describe the practice patterns of intensivists worldwide, regarding their diagnosis and management of respiratory...

Authors: Quentin Philippot, Vincent Labbé, Jérémie Pichon, Michel Djibré, Muriel Fartoukh and Guillaume Voiriot

Systematic review and literature appraisal on methodology of conducting and reporting critical-care echocardiography studies: a report from the European Society of Intensive Care Medicine PRICES expert panel

The echocardiography working group of the European Society of Intensive Care Medicine recognized the need to provide structured guidance for future CCE research methodology and reporting based on a systematic ...

Authors: S. Huang, F. Sanfilippo, A. Herpain, M. Balik, M. Chew, F. Clau-Terré, C. Corredor, D. De Backer, N. Fletcher, G. Geri, A. Mekontso-Dessap, A. McLean, A. Morelli, S. Orde, T. Petrinic, M. Slama…