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  1. Research

    Low HDL levels in sepsis versus trauma patients in intensive care unit

    The protective cardiovascular effect of high-density lipoproteins (HDLs) is considered to chiefly rely on reverse cholesterol transport from peripheral tissues back to the liver. However, HDL particles display...

    Sébastien Tanaka, Julien Labreuche, Elodie Drumez, Anatole Harrois, Sophie Hamada, Bernard Vigué, David Couret, Jacques Duranteau and Olivier Meilhac

    Annals of Intensive Care 2017 7:60

    Published on: 6 June 2017

  2. Review

    Noninvasive ventilation with helium–oxygen mixture in hypercapnic COPD exacerbation: aggregate meta-analysis of randomized controlled trials

    When used as a driving gas during NIV in hypercapnic COPD exacerbation, a helium–oxygen (He/O2) mixture reduces the work of breathing and gas trapping. The potential for He/O2 to reduce the rate of NIV failure le...

    Fekri Abroug, Lamia Ouanes-Besbes, Zeineb Hammouda, Saoussen Benabidallah, Fahmi Dachraoui, Islem Ouanes and Philippe Jolliet

    Annals of Intensive Care 2017 7:59

    Published on: 6 June 2017

  3. Research

    Omega-3 supplementation in patients with sepsis: a systematic review and meta-analysis of randomized trials

    Nutritional supplementation of omega-3 fatty acids has been proposed to modulate the balance of pro- and anti-inflammatory mediators in sepsis. If proved to improve clinical outcomes in critically ill patients...

    Clara Lu, Sunjay Sharma, Lauralyn McIntyre, Andrew Rhodes, Laura Evans, Saleh Almenawer, Lori Leduc, Derek C. Angus and Waleed Alhazzani

    Annals of Intensive Care 2017 7:58

    Published on: 5 June 2017

  4. Research

    The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock

    Compliance with the clinical practice guidelines of sepsis management has been low. The objective of our study was to describe the results of implementing a multifaceted intervention including an electronic al...

    Yaseen M. Arabi, Hasan M. Al-Dorzi, Ahmed Alamry, Ra’ed Hijazi, Sami Alsolamy, Majid Al Salamah, Hani M. Tamim, Saad Al-Qahtani, Abdulaziz Al-Dawood, Abdellatif M. Marini, Fatimah H. Al Ehnidi, Shihab Mundekkadan, Amal Matroud, Mohamed S. Mohamed and Saadi Taher

    Annals of Intensive Care 2017 7:57

    Published on: 30 May 2017

  5. Research

    Fluid responsiveness predicted by transcutaneous partial pressure of oxygen in patients with circulatory failure: a prospective study

    Significant effort has been devoted to defining parameters for predicting fluid responsiveness. Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of ox...

    Jingyuan Xu, Xiao Peng, Chun Pan, Shixia Cai, Xiwen Zhang, Ming Xue, Yi Yang and Haibo Qiu

    Annals of Intensive Care 2017 7:56

    Published on: 23 May 2017

  6. Research

    Functional outcome of patients with prolonged hypoglycemic encephalopathy

    Little is known about the causes, clinical course and long-term outcome of comatose patients with prolonged hypoglycemic encephalopathy.

    Guillaume Barbara, Bruno Mégarbane, Laurent Argaud, Guillaume Louis, Nicolas Lerolle, Francis Schneider, Stéphane Gaudry, Nicolas Barbarot, Angéline Jamet, Hervé Outin, Sébastien Gibot and Pierre-Edouard Bollaert

    Annals of Intensive Care 2017 7:54

    Published on: 22 May 2017

  7. Research article

    Nasal high flow in management of children with status asthmaticus: a retrospective observational study

    Asthma is the most common obstructive airway disease in children and adults. Nasal high flow (NHF) is a recent device that is now used as a primary support for respiratory distress. Several studies have report...

    Florent Baudin, Alexandra Buisson, Blandine Vanel, Bruno Massenavette, Robin Pouyau and Etienne Javouhey

    Annals of Intensive Care 2017 7:55

    Published on: 22 May 2017

  8. Research

    External validation of SAPS 3 and MPM0-III scores in 48,816 patients from 72 Brazilian ICUs

    The performance of severity-of-illness scores varies in different scenarios and must be validated prior of being used in a specific settings and geographic regions. Moreover, models’ calibration may deteriorat...

    Giulliana Martines Moralez, Ligia Sarmet Cunha Farah Rabello, Thiago Costa Lisboa, Mariza da Fonte Andrade Lima, Rodrigo Marques Hatum, Fernando Vinicius Cesar De Marco, Alessandra Alves, Jorge Eduardo da Silva Soares Pinto, Hélia Beatriz Nunes de Araújo, Grazielle Viana Ramos, Aline Reis Silva, Guilherme Côrtes Fernandes, Guilherme Brenande Alves Faria, Ciro Leite Mendes, Roberto Álvaro Ramos Filho, Valdênia Pereira de Souza…

    Annals of Intensive Care 2017 7:53

    Published on: 18 May 2017

  9. Review

    Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome

    Veno-venous extracorporeal membrane oxygenation (ECMO) for refractory acute respiratory distress syndrome (ARDS) is a rapidly expanding technique. We performed a systematic review and meta-analysis of the most...

    Sergi Vaquer, Candelaria de Haro, Paula Peruga, Joan Carles Oliva and Antonio Artigas

    Annals of Intensive Care 2017 7:51

    Published on: 12 May 2017

  10. Research

    The effect of insulin administration on c-peptide in critically ill patients with type 2 diabetes

    In critically ill patients with permissive hyperglycemia, it is uncertain whether exogenous insulin administration suppresses or enhances c-peptide secretion (a marker of pancreatic beta-cell response). We aim...

    Marco Crisman, Luca Lucchetta, Nora Luethi, Luca Cioccari, Que Lam, Glenn M. Eastwood, Rinaldo Bellomo and Johan Mårtensson

    Annals of Intensive Care 2017 7:50

    Published on: 12 May 2017

  11. Review

    Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference

    The French Intensive Care Society organized its yearly Paris International Conference in intensive care on June 18–19, 2015. The main purpose of this meeting is to gather the best experts in the field in order...

    Rinaldo Bellomo, Claudio Ronco, Ravindra L. Mehta, Pierre Asfar, Julie Boisramé-Helms, Michael Darmon, Jean-Luc Diehl, Jacques Duranteau, Eric A. J. Hoste, Joannes-Boyau Olivier, Matthieu Legrand, Nicolas Lerolle, Manu L. N. G. Malbrain, Johan Mårtensson, Heleen M. Oudemans-van Straaten, Jean-Jacques Parienti…

    Annals of Intensive Care 2017 7:49

    Published on: 4 May 2017

  12. Research

    Circulating bile acids predict outcome in critically ill patients

    Jaundice and cholestatic hepatic dysfunction are frequent findings in critically ill patients associated with increased mortality. Cholestasis in critically ill patients is closely associated with stimulation ...

    Thomas Horvatits, Andreas Drolz, Karoline Rutter, Kevin Roedl, Lies Langouche, Greet Van den Berghe, Günter Fauler, Brigitte Meyer, Martin Hülsmann, Gottfried Heinz, Michael Trauner and Valentin Fuhrmann

    Annals of Intensive Care 2017 7:48

    Published on: 2 May 2017

  13. Research

    Are high nurse workload/staffing ratios associated with decreased survival in critically ill patients? A cohort study

    Despite the central role of nurses in intensive care, a relationship between intensive care nurse workload/staffing ratios and survival has not been clearly established. We determined whether there is a thresh...

    Anna Lee, Yip Sing Leo Cheung, Gavin Matthew Joynt, Czarina Chi Hung Leung, Wai-Tat Wong and Charles David Gomersall

    Annals of Intensive Care 2017 7:46

    Published on: 2 May 2017

  14. Research

    High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial

    Extubation failure is associated with increased morbidity and mortality, but cannot be safely predicted or avoided. High-flow nasal cannula (HFNC) prevents postextubation respiratory failure in low-risk patients.

    Rafael Fernandez, Carles Subira, Fernando Frutos-Vivar, Gemma Rialp, Cesar Laborda, Joan Ramon Masclans, Amanda Lesmes, Luna Panadero and Gonzalo Hernandez

    Annals of Intensive Care 2017 7:47

    Published on: 2 May 2017

  15. Research

    Seawater drowning-associated pneumonia: a 10-year descriptive cohort in intensive care unit

    Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent se...

    Alexandre Robert, Pierre-Éric Danin, Hervé Quintard, Nicolas Degand, Nihal Martis, Denis Doyen, Céline Pulcini, Raymond Ruimy, Carole Ichai, Gilles Bernardin and Jean Dellamonica

    Annals of Intensive Care 2017 7:45

    Published on: 26 April 2017

  16. Research

    The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure

    Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could ben...

    Ignacio Martin-Loeches, Arturo Muriel-Bombín, Ricard Ferrer, Antonio Artigas, Jordi Sole-Violan, Leonardo Lorente, David Andaluz-Ojeda, Adriele Prina-Mello, Ruben Herrán-Monge, Borja Suberviola, Ana Rodriguez-Fernandez, Pedro Merino, Ana M. Loza, Pablo Garcia-Olivares, Eduardo Anton, Eduardo Tamayo…

    Annals of Intensive Care 2017 7:44

    Published on: 20 April 2017

  17. Research

    Outcome of patients with septic shock and high-dose vasopressor therapy

    Despite the dissemination of international guidelines, mortality from septic shock remains high. Norepinephrine is recommended as first-line vasopressor therapy with a target mean arterial pressure of 65 mmHg....

    Thomas Auchet, Marie-Alix Regnier, Nicolas Girerd and Bruno Levy

    Annals of Intensive Care 2017 7:43

    Published on: 20 April 2017

  18. Editorial

    Protocols for the obvious: Where does it start, and stop?

    Protocols can be helpful in specific situations and may have show benefits in clinical trials. So-called evidence based protocols and checklists frequently remind clinicians to do the obvious, but may also co...

    Armand R. J. Girbes and Paul E. Marik

    Annals of Intensive Care 2017 7:42

    Published on: 14 April 2017

  19. Research

    Diagnostic accuracy of quantitative neuromuscular ultrasound for the diagnosis of intensive care unit-acquired weakness: a cross-sectional observational study

    Neuromuscular ultrasound is a noninvasive investigation, which can be easily performed at the bedside on the ICU. A reduction in muscle thickness and increase in echo intensity over time have been described in...

    Esther Witteveen, Juultje Sommers, Luuk Wieske, Jonne Doorduin, Nens van Alfen, Marcus J. Schultz, Ivo N. van Schaik, Janneke Horn and Camiel Verhamme

    Annals of Intensive Care 2017 7:40

    Published on: 5 April 2017

  20. Research

    Earlier versus later initiation of renal replacement therapy among critically ill patients with acute kidney injury: a systematic review and meta-analysis of randomized controlled trials

    Although the optimal timing of initiation of renal replacement therapy (RRT) in critically ill patients with acute kidney injury has been extensively studied in the past, it is still unclear.

    Tai-Shuan Lai, Chih-Chung Shiao, Jian-Jhong Wang, Chun-Te Huang, Pei-Chen Wu, Eric Chueh, Shih-Chieh Jeff Chueh, Kianoush Kashani and Vin-Cent Wu

    Annals of Intensive Care 2017 7:38

    Published on: 5 April 2017

  21. Research

    Patients with ANCA-associated vasculitis admitted to the intensive care unit with acute vasculitis manifestations: a retrospective and comparative multicentric study

    Data for ANCA-associated vasculitis (AAV) patients requiring intensive care are scarce.

    Julien Demiselle, Johann Auchabie, François Beloncle, Philippe Gatault, Steven Grangé, Damien Du Cheyron, Jean Dellamonica, Sonia Boyer, Dimitri Titeca Beauport, Lise Piquilloud, Julien Letheulle, Christophe Guitton, Nicolas Chudeau, Guillaume Geri, François Fourrier, René Robert…

    Annals of Intensive Care 2017 7:39

    Published on: 5 April 2017

  22. Research

    Long-term outcome of patients with liver cirrhosis admitted to a general intensive care unit

    The prevalence of liver cirrhosis is increasing, and many patients have acute conditions requiring consideration of intensive care. This study aims to: (a) report the outcome at 12 months of patients with cirr...

    Alex Warren, Charlotte R. Soulsby, Alex Puxty, Joseph Campbell, Martin Shaw, Tara Quasim, John Kinsella and Joanne McPeake

    Annals of Intensive Care 2017 7:37

    Published on: 4 April 2017

  23. Research

    Are third-generation cephalosporins unavoidable for empirical therapy of community-acquired pneumonia in adult patients who require ICU admission? A retrospective study

    Third-generation cephalosporins (3GCs) are recommended for empirical antibiotic therapy of community-acquired pneumonia (CAP) in patients requiring ICU admission. However, their extensive use could promote the...

    Geoffroy Hariri, Jacques Tankovic, Pierre-Yves Boëlle, Vincent Dubée, Guillaume Leblanc, Claire Pichereau, Simon Bourcier, Naike Bigé, Jean-Luc Baudel, Arnaud Galbois, Hafid Ait-Oufella and Eric Maury

    Annals of Intensive Care 2017 7:35

    Published on: 24 March 2017

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